Recombinant Mouse TLR6 Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

The Toll‑like family of molecules serve as pattern recognition receptors that activate the immune system in response to microbial pathogens. Toll‑like receptors (TLRs) are type I transmembrane proteins in either the plasma membrane or the membranes of endosomal structures. TLRs contain a large number of leucine-rich repeats (LRRs) in their extracellular domains (ECD) and a cytoplasmic tail with one signal transducing Toll/IL‑1 receptor (TIR) domain (1, 2). Mature mouse TLR6 (approximately 115 kDa) consists of a 557 amino acid (aa) ECD, a 21 aa transmembrane segment, and a 190 aa cytoplasmic domain (3). Within the ECD, mouse TLR6 shares 73% and 86% aa sequence identity with human and rat TLR6, respectively. TLR6 is expressed on the surface of macrophages, monocytes, neutrophils, dermal endothelial cells, and alveolar epithelial cells in ligand‑independent association with TLR2 (4‑7). TLR2 also associates with TLR1, creating a functional receptor complex with specificity for related microbial ligands (4, 8, 9). TLR6 and TLR2 cooperate in the recognition of acylated bacterial and mycoplasma lipopeptides, peptidoglycans, and glycosylphosphatidylinositols (4‑6, 10‑13). TLR6 plays an important role in the control of Th17 responses and IL‑23 production during allergic inflammation and fungal‑induced asthma (7).

Array 1533-TR

• TLR6 Antibodies
• TLR6 ELISA Kit
• TLR6 Lysate
• TLR6 Proteins
• TLR6 Proteins and Enzymes