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Recombinant Mouse M-CSF Protein, CF

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Recombinant Mouse M-CSF (416-ML) stimulates cell proliferation in the M-NFS-60 mouse myelogenous leukemia lymphoblast cell line in a dose-dependent manner. The ED50 for this effect is 0.5-3 ng/mL.

Recombinant Mouse M-CSF (416-ML) stimulates cell proliferation in the M-NFS-60 mouse myelogenous leukemia lymphoblast cell line in a dose-dependent manner. The ED50 for this effect is 0.5-3 ng/mL.

Product Details

Summary

Reactivity	MuSpecies Glossary
Applications	Bioactivity
Format	Carrier-Free

Order Details

View Available Formulations

Catalog# & Formulation	Size	Price
Standard Formulation 416-ML-010

Carrier Free 416-ML-050/CF

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Recombinant Mouse M-CSF Protein, CF Summary

Details of Functionality	Measured in a cell proliferation assay using M‑NFS‑60 mouse myelogenous leukemia lymphoblast cells. Nakoinz, I. et al. (1990) J. Immunol. 145:860. The ED₅₀ for this effect is 0.5‑3 ng/mL.
Source	E. coli-derived mouse M-CSF protein Lys33-Glu262, with an N-terminal Met
Accession #	Q3U4F9
N-terminal Sequence	Met
Structure / Form	Disulfide-linked homodimer
Protein/Peptide Type	Recombinant Proteins
Gene	Csf1
Purity	>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Note	<1.0 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

Dilutions

Bioactivity

Theoretical MW

26 kDa (monomer).
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

SDS-PAGE

29 kDa, reducing conditions

Publications

Read Publications using
416-ML/CF in the following applications:

Bioassay
482 publications
Cell Culture
71 publications
Differentiation
8 publications
In Vivo
2 publications
Tissue Culture
1 publication

Packaging, Storage & Formulations

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS.
Purity	>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution Instructions	Reconstitute at 100 μg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse M-CSF Protein, CF

colony stimulating factor 1 (macrophage)
CSF1
CSF-1
Lanimostim
macrophage colony stimulating factor
macrophage colony-stimulating factor 1
MCSF
M-CSF
MCSFlanimostim
MGC31930

Background

M-CSF, also known as CSF-1, is a four-alpha -helical-bundle cytokine that is the primary regulator of macrophage survival, proliferation and differentiation (1-3). M-CSF protein is also essential for the survival and proliferation of osteoclast progenitors (1, 4). M-CSF also primes and enhances macrophage killing of tumor cells and microorganisms, regulates the release of cytokines and other inflammatory modulators from macrophages, and stimulates pinocytosis (2, 3). M-CSF increases during pregnancy to support implantation and growth of the decidua and placenta (5). Sources of M-CSF include fibroblasts, activated macrophages, endometrial secretory epithelium, bone marrow stromal cells and activated endothelial cells (1-5). The M-CSF receptor (c-fms) transduces its pleotropic effects and mediates its endocytosis. M-CSF mRNAs of various sizes occur (3-9). Full length mouse M-CSF transcripts encode a 520 amino acid (aa) type I transmembrane (TM) protein with a 462 aa extracellular region, a 21 aa TM domain, and a 37 aa cytoplasmic tail that forms a 140 kDa covalent dimer. Differential processing produces two proteolytically cleaved, secreted dimers. One is an N- and O- glycosylated 86 kDa dimer, while the other is modified by both glycosylation and chondroitin-sulfate proteoglycan (PG) to generate a 200 kDa subunit. Although PG-modified M-CSF protein can circulate, it may be immobilized by attachment to type V collagen (8). Shorter transcripts encode M‑CSF that lacks cleavage and PG sites and produces an N-glycosylated 68 kDa TM dimer and a slowly produced 44 kDa secreted dimer (7). Although forms may vary in activity and half-life, all contain the N-terminal 150 aa portion that is necessary and sufficient for interaction with the M-CSF receptor (10, 11). The first 229 aa of mature mouse M-CSF shares 87%, 83%, 82% and 81% aa identity with corresponding regions of rat, dog, cow and human M-CSF, respectively (12, 13). Human M‑CSF is active in the mouse, but mouse M-CSF is reported to be species-specific.

Pixley, F.J. and E.R. Stanley (2004) Trends Cell Biol. 14:628.
Chitu, V. and E.R. Stanley (2006) Curr. Opin. Immunol. 18:39.
Fixe, P. and V. Praloran (1997) Eur. Cytokine Netw. 8:125.
Ryan, G.R. et al. (2001) Blood 98:74.
Makrigiannakis, A. et al. (2006) Trends Endocrinol. Metab. 17:178.
Nandi, S. et al. (2006) Blood 107:786.
Rettenmier, C.W. and M.F. Roussel (1988) Mol. Cell Biol. 8:5026.
Suzu, S. et al. (1992) J. Biol. Chem. 267:16812.
Manos, M.M. (1988) Mol. Cell. Biol. 8:5035.
Koths, K. (1997) Mol. Reprod. Dev. 46:31.
Jang, M-H. et al. (2006) J. Immunol. 177:4055.
DeLamarter, J.F. et al. (1987) Nucleic Acids Res. 15:2389.
Ladner, M.B. et al. (1988) Proc. Natl. Acad. Sci. USA 85:6706.

Publications for M-CSF (416-ML/CF)(562)

We have publications tested in 5 confirmed species: Human, Mouse, Rat, Feline, Transgenic Mouse.

We have publications tested in 5 applications: Bioassay, Cell Culture, Differentiation, In Vivo, Tissue Culture.

Showing Publications 1 - 10 of 562. Show All 562 Publications.

Publications using 416-ML/CF	Applications	Species
Ge, G;Guo, Q;Zhou, Y;Li, W;Zhang, W;Bai, J;Wang, Q;Tao, H;Wang, W;Wang, Z;Gan, M;Xu, Y;Yang, H;Li, B;Geng, D; GLI1 facilitates collagen-induced arthritis in mice by collaborative regulation of DNA methyltransferases eLife 2023-11-06 [PMID: 37929702] (Bioassay, Mouse)	Bioassay	Mouse
L Gu, Z Wang, H Gu, H Wang, L Liu, WB Zhang Atf4 regulates angiogenic differences between alveolar bone and long bone macrophages by regulating M1 polarization, based on single-cell RNA sequencing, RNA-seq and ATAC-seq analysis Journal of Translational Medicine, 2023-03-14;21(1):193. 2023-03-14 [PMID: 36918894] (Bioassay, Mouse)	Bioassay	Mouse
Williams J, Irwin M, Li Y et al. Osteocyte-Derived CaMKK2 Regulates Osteoclasts and Bone Mass in a Sex-Dependent Manner Through Secreted Calpastatin Preprint 2023-02-01 [PMID: 36902150] (Bioassay, Mouse)	Bioassay	Mouse
X Ji, J Hong, W Yang, M Yao, J Wang, G Jiang, Y Wang, C Li, J Lin, H Mou, C Li, S Li, Y Chen, M Shi, W Wang, F Lu, H Wu, X Zhao, Y Qi, S Yan GSTP1-mediated S-glutathionylation of Pik3r1 is a redox hub that inhibits osteoclastogenesis through regulating autophagic flux Redox Biology, 2023-02-27;61(0):102635. 2023-02-27 [PMID: 36870110] (Bioassay, Mouse)	Bioassay	Mouse
MB Kuhn, HS VandenBerg, AJ Reynolds, MD Carson, AJ Warner, AC LaRue, CM Novince, JD Hathaway-S C3a-C3aR signaling is a novel modulator of skeletal homeostasis Bone Reports, 2023-02-16;18(0):101662. 2023-02-16 [PMID: 36860797] (Bioassay, Mouse, Transgenic Mouse)	Bioassay	Mouse, Transgenic Mouse
K Aso, M Kono, M Kanda, Y Kudo, K Sakiyama, R Hisada, K Karino, Y Ueda, D Nakazawa, Y Fujieda, M Kato, O Amengual, T Atsumi Itaconate ameliorates autoimmunity by modulating T cell imbalance via metabolic and epigenetic reprogramming Nature Communications, 2023-02-27;14(1):984. 2023-02-27 [PMID: 36849508] (Bioassay, Mouse)	Bioassay	Mouse
C Xu, SQ Jin, C Jin, ZH Dai, YH Wu, GL He, HW Ma, CY Xu, WL Fang Cedrol, a Ginger-derived sesquiterpineol, suppresses estrogen-deficient osteoporosis by intervening NFATc1 and reactive oxygen species International immunopharmacology, 2023-02-27;117(0):109893. 2023-02-27 [PMID: 36842234] (Bioassay, Mouse)	Bioassay	Mouse
DM Cauvi, D Hawisher, J Derunes, A De Maio Phosphatidylcholine Liposomes Reprogram Macrophages toward an Inflammatory Phenotype Membranes, 2023-01-21;13(2):. 2023-01-21 [PMID: 36837644] (Bioassay, Mouse)	Bioassay	Mouse
JY Ko, FS Wang, SH Chen, SJ Kuo Micro Ribonucleic Acid-29a (miR-29a) Antagonist Normalizes Bone Metabolism in Osteogenesis Imperfecta (OI) Mice Model Biomedicines, 2023-02-05;11(2):. 2023-02-05 [PMID: 36831000] (Bioassay, Mouse)	Bioassay	Mouse
H Lee, E Kim, S Kim miRNA-Induced Downregulation of IPMK in Macrophages Mediates Lipopolysaccharide-Triggered TLR4 Signaling Biomolecules, 2023-02-09;13(2):. 2023-02-09 [PMID: 36830701] (Bioassay, Mouse)	Bioassay	Mouse
PY Ng, ABP Ribet, Q Guo, BH Mullin, JWY Tan, E Landao-Bas, S Stephens, K Chen, J Yuan, L Abudulai, M Bollen, ETTT Nguyen, J Kular, JM Papadimitr, K Søe, RD Teasdale, J Xu, RG Parton, H Takayanagi, NJ Pavlos Sugar transporter Slc37a2 regulates bone metabolism in mice via a tubular lysosomal network in osteoclasts Nature Communications, 2023-02-21;14(1):906. 2023-02-21 [PMID: 36810735] (Bioassay, Mouse)	Bioassay	Mouse
H Hu, X Wang, Y Huang, B He, J Zhu, K Sun, C Deng, Y Guo, D Hao, B Jian Obacunone inhibits RANKL/M-CSF-mediated osteoclastogenesis by suppressing integrin- FAK-Src signaling Cytokine, 2023-02-15;164(0):156134. 2023-02-15 [PMID: 36804257] (Bioassay, Mouse)	Bioassay	Mouse
J Guo, R Ren, Z Guo, K Sun, J He, J Shao, X Wang Probucol suppresses osteoclastogenesis via activating Nrf2 signaling and ameliorates ovariectomy-induced bone loss International immunopharmacology, 2023-02-07;116(0):109820. 2023-02-07 [PMID: 36758295] (Bioassay, Mouse)	Bioassay	Mouse
N Beckmann, A Neuhaus, S Zurbruegg, P Volkmer, C Patino, S Joller, D Feuerbach, A Doelemeyer, T Schweizer, S Rudin, U Neumann, R Berth, W Frieauff, F Gasparini, DR Shimshek Genetic models of cleavage-reduced and soluble TREM2 reveal distinct effects on myelination and microglia function in the cuprizone model Journal of Neuroinflammation, 2023-02-08;20(1):29. 2023-02-08 [PMID: 36755323] (Bioassay, Mouse)	Bioassay	Mouse
S De Scheppe, JZ Ge, G Crowley, LSS Ferreira, D Garceau, CE Toomey, D Sokolova, J Rueda-Carr, SH Shin, JS Kim, T Childs, T Lashley, JJ Burden, M Sasner, C Sala Frige, S Jung, S Hong Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer's disease Nature Neuroscience, 2023-02-06;0(0):. 2023-02-06 [PMID: 36747024] (Bioassay, Mouse)	Bioassay	Mouse
P Silwal, YJ Kim, YJ Lee, IS Kim, SM Jeon, T Roh, JK Kim, MJ Lee, JY Heo, DS Jo, SH Lee, DH Cho, JM Kim, YT Kwon, EK Jo Chemical mimetics of the N-degron pathway alleviate systemic inflammation by activating mitophagy and immunometabolic remodeling Experimental & Molecular Medicine, 2023-02-01;0(0):. 2023-02-01 [PMID: 36720915] (Bioassay, Mouse)	Bioassay	Mouse
X Hu, SW Wong, K Liang, TH Wu, S Wang, L Wang, J Liu, M Yamauchi, BL Foster, JP Ting, B Zhao, HC Tseng, CC Ko Optineurin regulates NRF2-mediated antioxidant response in a mouse model of Paget's disease of bone Science Advances, 2023-01-27;9(4):eade6998. 2023-01-27 [PMID: 36706179] (Bioassay, Mouse)	Bioassay	Mouse
Y Wang, Z Zhong, M Ma, Y Zhao, C Zhang, Z Qian, B Wang The role played by ailanthone in inhibiting bone metastasis of breast cancer by regulating tumor-bone microenvironment through the RANKL-dependent pathway Frontiers in Pharmacology, 2023-01-05;13(0):1081978. 2023-01-05 [PMID: 36686653] (Cell Culture, Mouse)	Cell Culture	Mouse
Z Wu, X Li, X Chen, X He, Y Chen, L Zhang, Z Li, M Yang, G Yuan, B Shi, N Chen, N Li, H Feng, M Zhou, G Rui, F Xu, R Xu Phosphatidyl Inositol 3-Kinase (PI3K)-Inhibitor CDZ173 protects against LPS-induced osteolysis Frontiers in Pharmacology, 2023-01-06;13(0):1021714. 2023-01-06 [PMID: 36686650] (Cell Culture, Mouse)	Cell Culture	Mouse
F Wang, P Yang, T Wan, C Liu, Y Zhu, X Chen, H Liu Osthole Inhibits M1 Macrophage Polarization and Attenuates Osteolysis in a Mouse Skull Model Oxidative Medicine and Cellular Longevity, 2023-01-12;2023(0):2975193. 2023-01-12 [PMID: 36686380]
J Zhu, Y Ma, J Wang, Y Wang, W Ali, H Zou, H Zhao, X Tong, R Song, Z Liu The Mechanism of Osteoprotegerin-Induced Osteoclast Pyroptosis In Vitro International Journal of Molecular Sciences, 2023-01-12;24(2):. 2023-01-12 [PMID: 36675029] (Cell Culture, Mouse)	Cell Culture	Mouse
J He, L Zheng, X Li, F Huang, S Hu, L Chen, M Jiang, X Lin, H Jiang, Y Zeng, T Ye, D Lin, Q Liu, J Xu, K Chen Obacunone targets macrophage migration inhibitory factor (MIF) to impede osteoclastogenesis and alleviate ovariectomy-induced bone loss Journal of advanced research, 2023-01-16;0(0):. 2023-01-16 [PMID: 36657717] (Bioassay, Mouse)	Bioassay	Mouse
W Zhan, B Ruan, H Dong, C Wang, S Wu, H Yu, X Xu, H Sun, J Cai Isopsoralen suppresses receptor activator of nuclear factor kappa-beta ligand-induced osteoclastogenesis by inhibiting the NF-kappaB signaling PeerJ, 2023-01-10;11(0):e14560. 2023-01-10 [PMID: 36643647] (Bioassay, Mouse)	Bioassay	Mouse
Y Fukawa, K Kayamori, M Tsuchiya, T Ikeda IL-1 Generated by Oral Squamous Cell Carcinoma Stimulates Tumor-Induced and RANKL-Induced Osteoclastogenesis: A Possible Mechanism of Bone Resorption Induced by the Infiltration of Oral Squamous Cell Carcinoma International Journal of Molecular Sciences, 2022-12-30;24(1):. 2022-12-30 [PMID: 36614130] (Cell Culture, Mouse)	Cell Culture	Mouse
J Wang, K Mao, X Cong, H Tan, C Wu, Z Hu, YG Yang, T Sun Nanoparticle delivery of CD40 siRNA suppresses alloimmune responses by inhibiting activation and differentiation of DCs and macrophages Science Advances, 2022-12-21;8(51):eabq3699. 2022-12-21 [PMID: 36542700] (Cell Culture, Mouse)	Cell Culture	Mouse
X Sun, Y Ni, Q Lu, Y Liang, M Gu, X Xue, C Dai Mechanistic target of rapamycin complex 1 orchestrates the interplay between hepatocytes and Kupffer cells to determine the outcome of immune-mediated hepatitis Cell Death & Disease, 2022-12-09;13(12):1031. 2022-12-09 [PMID: 36494334] (Bioassay, Mouse)	Bioassay	Mouse
JM Han, HY Song, KI Kim, WY Park, SH Park, EB Byun, EH Byun Polysaccharides from Annonaï¿½muricata leaves protect against cisplatin?induced cytotoxicity in macrophages by alleviating mitochondrial dysfunction Molecular Medicine Reports, 2022-12-01;27(1):. 2022-12-01 [PMID: 36453199] (Bioassay, Mouse)	Bioassay	Mouse
SMT Rahman, M Aqdas, EW Martin, F Tomassoni, P Songkiatis, KS Oh, S Uderhardt, S Yun, QC Claybourne, RA McDevitt, V Greco, RN Germain, L Tessarollo, MH Sung Double knockin mice show NF-kappaB trajectories in immune signaling and aging Cell Reports, 2022-11-22;41(8):111682. 2022-11-22 [PMID: 36417863] (Bioassay, Transgenic Mouse)	Bioassay	Transgenic Mouse
G Qi, Z Jiang, W Lu, D Li, W Chen, X Yang, L Ding, H Yuan Berbamine inhibits RANKL- and M-CSF-mediated osteoclastogenesis and alleviates ovariectomy-induced bone loss Frontiers in Pharmacology, 2022-11-02;13(0):1032866. 2022-11-02 [PMID: 36408260] (Bioassay, Mouse)	Bioassay	Mouse
H Yeh, M Woodbury, K Ingraham-D, T Ikezu, S Ikezu Microglial WNT5A supports dendritic spines maturation and neuronal firing Brain, Behavior, and Immunity, 2022-11-15;0(0):. 2022-11-15 [PMID: 36395958] (Bioassay, Mouse)	Bioassay	Mouse
Y Cheng, H Liu, J Li, Y Ma, C Song, Y Wang, P Li, Y Chen, Z Zhang Evaluation of culture conditions for osteoclastogenesis in RAW264.7 cells PLoS ONE, 2022-11-17;17(11):e0277871. 2022-11-17 [PMID: 36395187] (Bioassay, Mouse)	Bioassay	Mouse
CY Chang, R You, D Armstrong, A Bandi, YT Cheng, PM Burkhardt, L Becerra-Do, MC Madison, HY Tung, Z Zeng, Y Wu, L Song, PE Phillips, P Porter, JM Knight, N Putluri, X Yuan, DC Marcano, EA McHugh, JM Tour, A Catic, L Maneix, BM Burt, HS Lee, DB Corry, F Kheradmand Chronic exposure to carbon black ultrafine particles reprograms macrophage metabolism and accelerates lung cancer Science Advances, 2022-11-16;8(46):eabq0615. 2022-11-16 [PMID: 36383649] (Bioassay, Transgenic Mouse)	Bioassay	Transgenic Mouse
C Lin, Q Yang, D Guo, J Xie, YS Yang, S Chaugule, N DeSouza, WT Oh, R Li, Z Chen, AA John, Q Qiu, LJ Zhu, MB Greenblatt, S Ghosh, S Li, G Gao, C Haynes, CP Emerson, JH Shim Impaired mitochondrial oxidative metabolism in skeletal progenitor cells leads to musculoskeletal disintegration Nature Communications, 2022-11-11;13(1):6869. 2022-11-11 [PMID: 36369293] (Bioassay, Mouse)	Bioassay	Mouse
G Li, JN Park, HJ Park, JH Suh, HS Choi High Cholesterol-Induced Bone Loss Is Attenuated by Arctiin via an Action in Osteoclasts Nutrients, 2022-10-25;14(21):. 2022-10-25 [PMID: 36364745] (Bioassay, Mouse)	Bioassay	Mouse
HK Kwon, KE Yu, SV Cahill, KD Alder, CM Dussik, SH Kim, L Sharma, J Back, I Oh, FY Lee Concurrent targeting of glycolysis in bacteria and host cell inflammation in septic arthritis Embo Molecular Medicine, 2022-11-10;0(0):e15284. 2022-11-10 [PMID: 36354099] (Bioassay, Mouse)	Bioassay	Mouse
C Drakeford, S Aguila, F Roche, K Hokamp, J Fazavana, MP Cervantes, AM Curtis, HC Hawerkamp, SPS Dhami, H Charles-Me, EE Hackett, A Chion, S Ward, A Ahmad, I Schoen, E Breen, J Keane, R Murphy, RJS Preston, JM O'Sullivan, FJ Sheedy, P Fallon, JS O'Donnell von Willebrand factor links primary hemostasis to innate immunity Nature Communications, 2022-11-03;13(1):6320. 2022-11-03 [PMID: 36329021] (Bioassay, Mouse)	Bioassay	Mouse
K Nagano, K Yamana, H Saito, R Kiviranta, AC Pedroni, D Raval, C Niehrs, F Gori, R Baron R-spondin 3 deletion induces Erk phosphorylation to enhance Wnt signaling and promote bone formation in the appendicular skeleton Elife, 2022-11-02;11(0):. 2022-11-02 [PMID: 36321691] (Bioassay, Mouse)	Bioassay	Mouse
JC Bahr, XY Li, TY Feinberg, L Jiang, SJ Weiss Divergent regulation of basement membrane trafficking by human macrophages and cancer cells Nature Communications, 2022-10-27;13(1):6409. 2022-10-27 [PMID: 36302921] (Bioassay, Mouse)	Bioassay	Mouse
MH Wu, WB Hsu, MH Chen, CS Shi Inhibition of Neddylation Suppresses Osteoclast Differentiation and Function In Vitro and Alleviates Osteoporosis In Vivo Biomedicines, 2022-09-21;10(10):. 2022-09-21 [PMID: 36289618] (Bioassay, Mouse)	Bioassay	Mouse
Z Hu, Y Li, W Yuan, L Jin, WK Leung, C Zhang, Y Yang N6-methyladenosine of Socs1 modulates macrophage inflammatory response in different stiffness environments International journal of biological sciences, 2022-09-11;18(15):5753-5769. 2022-09-11 [PMID: 36263168] (Bioassay, Mouse)	Bioassay	Mouse
F Zhao, J He, J Tang, N Cui, Y Shi, Z Li, S Liu, Y Wang, M Ma, C Zhao, L Luo, L Li Brain milieu induces early microglial maturation through the BAX-Notch axis Nature Communications, 2022-10-17;13(1):6117. 2022-10-17 [PMID: 36253375] (Bioassay, Mouse)	Bioassay	Mouse
AP Shaik, AS Shaik, M Abudawood, A Al Faraj Detection of Radiolabeled Inflammatory Cell Macrophage Subpopulations in Chronic Respiratory Diseases: Results from Preliminary Analyses BioMed Research International, 2022-10-06;2022(0):9470845. 2022-10-06 [PMID: 36246991] (Bioassay, Mouse)	Bioassay	Mouse
JX Sun, KY Zhu, YM Wang, DJ Wang, MZ Zhang, H Sarlus, I Benito-Cue, XQ Zhao, ZF Zou, QY Zhong, Y Feng, S Wu, YQ Wang, RA Harris, J Wang Activation of TRPV1 receptor facilitates myelin repair following demyelination via the regulation of microglial function Acta pharmacologica Sinica, 2022-10-13;0(0):. 2022-10-13 [PMID: 36229601] (Mouse)		Mouse
M Tomimatsu, K Matsumoto, M Ashizuka, S Kumagai, S Tanaka, T Nakae, K Yokota, S Kominami, R Kajiura, D Okuzaki, D Motooka, A Shiraishi, T Abe, H Matsuda, Y Okada, M Maeda, S Seno, M Obana, Y Fujio Myeloid cell-specific ablation of Runx2 gene exacerbates post-infarct cardiac remodeling Scientific Reports, 2022-10-05;12(1):16656. 2022-10-05 [PMID: 36198906] (Cell Culture, Mouse)	Cell Culture	Mouse
Q Li, T Yue, X Du, Z Tang, J Cui, W Wang, W Xia, B Ren, S Kan, C Li, C Wu, X Niu, B Li, K Lin, J Luo, G Chen, Z Wang HSC70 mediated autophagic degradation of oxidized PRL2 is responsible for osteoclastogenesis and inflammatory bone destruction Cell Death and Differentiation, 2022-10-01;0(0):. 2022-10-01 [PMID: 36182990] (Bioassay, Mouse)	Bioassay	Mouse
W Zhu, W Liang, H Lu, L Chang, J Zhang, YE Chen, Y Guo Myeloid TM6SF2 Deficiency Inhibits Atherosclerosis Cells, 2022-09-15;11(18):. 2022-09-15 [PMID: 36139452] (Bioassay, Mouse)	Bioassay	Mouse
J Zhang, S Xu, K Liang, X Cao, Z Ye, W Huang, X Bai, Y Zhang LysM-positive neurons drive Tuberous Sclerosis Complex (TSC)-associated brain lesions Cellular Signalling, 2022-09-15;0(0):110468. 2022-09-15 [PMID: 36115548] (Bioassay, Mouse)	Bioassay	Mouse
T Uchikawa, T Matoba, T Kawahara, I Baba, S Katsuki, JI Koga, Y Hashimoto, R Yamasaki, I Ichi, H Akita, H Tsutsui Dietary 7-ketocholesterol exacerbates myocardial ischemia-reperfusion injury in mice through monocyte/macrophage-mediated inflammation Scientific Reports, 2022-09-01;12(1):14902. 2022-09-01 [PMID: 36050346] (Cell Culture, Mouse)	Cell Culture	Mouse
YF Wang, L Yu, ZL Hu, YF Fang, YY Shen, MF Song, Y Chen Regulation of CCL2 by EZH2 affects tumor-associated macrophages polarization and infiltration in breast cancer Cell Death & Disease, 2022-08-29;13(8):748. 2022-08-29 [PMID: 36038549] (Bioassay, Mouse)	Bioassay	Mouse
J Zhou, Y Mao, X Shi, Y Zhang, X Yu, X Liu, L Diao, X Yang, C Liu, D Liu, X Tan, M Liu Peimine suppresses collagen-induced arthritis, activated fibroblast-like synoviocytes and TNFalpha-induced MAPK pathways International immunopharmacology, 2022-08-24;111(0):109181. 2022-08-24 [PMID: 36027853] (Bioassay, Mouse)	Bioassay	Mouse
M Jiang, ZG Chen, H Li, TT Zhang, MJ Yang, XX Peng, B Peng Succinate and inosine coordinate innate immune response to bacterial infection PloS Pathogens, 2022-08-26;18(8):e1010796. 2022-08-26 [PMID: 36026499] (Cell Culture, Mouse)	Cell Culture	Mouse
Y Inoue, CW Liao, Y Tsunakawa, IL Tsai, S Takahashi, M Hamada Macrophage-Specific, Mafb-Deficient Mice Showed Delayed Skin Wound Healing International Journal of Molecular Sciences, 2022-08-19;23(16):. 2022-08-19 [PMID: 36012611] (Cell Culture, Mouse)	Cell Culture	Mouse
W Chen, P Tang, S Fan, X Jiang A Novel Inhibitor INF 39 Promotes Osteogenesis via Blocking the NLRP3/IL-1beta Axis BioMed Research International, 2022-07-13;2022(0):7250578. 2022-07-13 [PMID: 35872849] (Bioassay, Mouse)	Bioassay	Mouse
Y Wu, H Wen, ZJ Bernstein, KM Hainline, TS Blakney, KL Congdon, DJ Snyder, JH Sampson, L Sanchez-Pe, JH Collier Multiepitope supramolecular peptide nanofibers eliciting coordinated humoral and cellular antitumor immune responses Science Advances, 2022-07-20;8(29):eabm7833. 2022-07-20 [PMID: 35857833] (Bioassay, Mouse)	Bioassay	Mouse
M Tsukasaki, N Komatsu, T Negishi-Ko, NC Huynh, R Muro, Y Ando, Y Seki, A Terashima, W Pluemsakun, T Nitta, T Nakamura, T Nakashima, S Ohba, H Akiyama, K Okamoto, R Baron, H Takayanagi Periosteal stem cells control growth plate stem cells during postnatal skeletal growth Oncogene, 2022-07-18;13(1):4166. 2022-07-18 [PMID: 35851381] (Bioassay, Mouse)	Bioassay	Mouse
T Shi, Y Shi, H Gao, Y Ma, Q Wang, S Shen, X Shao, W Gong, X Chen, J Qin, J Wu, Q Jiang, B Xue Exercised accelerated the production of muscle-derived kynurenic acid in skeletal muscle and alleviated the postmenopausal osteoporosis through the Gpr35/NFkappaB p65 pathway Journal of Orthopaedic Translation, 2022-04-04;35(0):1-12. 2022-04-04 [PMID: 35846727] (Bioassay, Mouse)	Bioassay	Mouse
J Zhou, L Guo, Y Yang, Y Liu, C Zhang Mechanical force regulates root resorption in rats through RANKL and OPG BMC Oral Health, 2022-07-16;22(1):290. 2022-07-16 [PMID: 35842599] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
R Guo, X Jia, Z Ding, G Wang, M Jiang, B Li, S Chen, B Xia, Q Zhang, J Liu, R Zheng, Z Gao, X Xie Loss of MLKL ameliorates liver fibrosis by inhibiting hepatocyte necroptosis and hepatic stellate cell activation Theranostics, 2022-07-04;12(11):5220-5236. 2022-07-04 [PMID: 35836819] (Bioassay, Mouse)	Bioassay	Mouse
J Zou, W Tan, B Li, Z Wang, Y Li, J Zeng, B Jiang, S Yoshida, Y Zhou Interleukin-19 Promotes Retinal Neovascularization in a Mouse Model of Oxygen-Induced Retinopathy Investigative Ophthalmology & Visual Science, 2022-07-08;63(8):9. 2022-07-08 [PMID: 35816041] (Bioassay, Mouse)	Bioassay	Mouse
T Hoyler, B Bannert, C André, D Beck, T Boulay, D Buffet, N Caesar, T Calzascia, J Dawson, D Kyburz, R Hennze, C Huppertz, A Littlewood, P Loetscher, KD Mertz, S Niwa, G Robert, JS Rush, G Ruzzante, S Sarret, T Stein, I Touil, G Wieczorek, G Zipfel, S Hawtin, T Junt Nonhematopoietic IRAK1 drives arthritis via neutrophil chemoattractants JCI Insight, 2022-07-08;7(13):. 2022-07-08 [PMID: 35801586] (Bioassay, Mouse)	Bioassay	Mouse
Z Jie, S Wang, Q Ma, Y Shen, X Zhao, H Yu, Z Xie, C Jiang Pexmetinib suppresses osteoclast formation and breast cancer induced osteolysis via P38/STAT3 signal pathway Journal of Bone Oncology, 2022-06-11;35(0):100439. 2022-06-11 [PMID: 35800294] (Bioassay, Mouse)	Bioassay	Mouse
Q Wang, H Wang, H Yan, H Tian, Y Wang, W Yu, Z Dai, P Chen, Z Liu, R Tang, C Jiang, S Fan, X Liu, X Lin Suppression of osteoclast multinucleation via a posttranscriptional regulation-based spatiotemporally selective delivery system Oncogene, 2022-06-29;8(26):eabn3333. 2022-06-29 [PMID: 35767605] (Bioassay, Mouse)	Bioassay	Mouse
H Qu, R Heinbäck, H Salo, E Ewing, A Espinosa, C Aulin, H Erlandsson Transcriptomic Profiling Reveals That HMGB1 Induces Macrophage Polarization Different from Classical M1 Biomolecules, 2022-06-02;12(6):. 2022-06-02 [PMID: 35740904] (Bioassay, Mouse)	Bioassay	Mouse
D Azimova, N Herrera, L Duvenage, M Voorhies, RA Rodriguez, BC English, JC Hoving, O Rosenberg, A Sil Cbp1, a fungal virulence factor under positive selection, forms an effector complex that drives macrophage lysis Oncogene, 2022-06-22;18(6):e1010417. 2022-06-22 [PMID: 35731824] (Bioassay, Mouse)	Bioassay	Mouse
Y Tian, J Ming Melatonin inhibits osteoclastogenesis via RANKL/OPG suppression mediated by Rev-Erbalpha in osteoblasts Oncogene, 2022-06-21;0(0):. 2022-06-21 [PMID: 35726597] (Bioassay, Mouse)	Bioassay	Mouse
G Cai, Y Xiao, M Yang, Q Guo, T Su, Y Liu, T Jiang, C Li Long noncoding RNA Gm31629 promotes bone regeneration by maintaining bone marrow mesenchymal stem cells activity PeerJ, 2022-06-09;10(0):e13475. 2022-06-09 [PMID: 35702257] (Bioassay, Mouse)	Bioassay	Mouse
H Li, D Qiu, Y Yuan, X Wang, F Wu, H Yang, S Wang, M Ma, Y Qian, B Zhan, X Yang Trichinella spiralis cystatin alleviates polymicrobial sepsis through activating regulatory macrophages Oncogene, 2022-06-09;109(0):108907. 2022-06-09 [PMID: 35691271] (Bioassay, Mouse)	Bioassay	Mouse
MI Alam, M Mae, F Farhana, M Oohira, Y Yamashita, Y Ozaki, E Sakai, A Yoshimura NLRP3 Inflammasome Negatively Regulates RANKL-Induced Osteoclastogenesis of Mouse Bone Marrow Macrophages but Positively Regulates It in the Presence of Lipopolysaccharides Oncogene, 2022-05-29;23(11):. 2022-05-29 [PMID: 35682777] (Bioassay, Mouse)	Bioassay	Mouse
S Lin, A Zhang, L Yuan, Y Wang, C Zhang, J Jiang, H Xu, H Yuan, H Yao, Q Zhang, Y Zhang, M Lou, P Wang, ZN Zhang, B Luan Targeting parvalbumin promotes M2 macrophage polarization and energy expenditure in mice Nature Communications, 2022-06-08;13(1):3301. 2022-06-08 [PMID: 35676256] (Bioassay, Mouse)	Bioassay	Mouse
H Tao, Y Tao, C Yang, W Li, W Zhang, X Li, Y Gu, Y Hong, H Yang, Y Liu, X Yang, D Geng Gut Metabolite Urolithin A Inhibits Osteoclastogenesis and Senile Osteoporosis by Enhancing the Autophagy Capacity of Bone Marrow Macrophages Frontiers in Pharmacology, 2022-05-12;13(0):875611. 2022-05-12 [PMID: 35645801] (Cell Culture, Mouse)	Cell Culture	Mouse
T Ishii, M Ruiz-Torru, K Yamamoto, T Yamaguchi, A Heidari, R Pierrelus, E Leon, S Shindo, M Rawas-Qala, MR Pastore, A Ikeda, S Nakamura, H Mawardi, U Kandalam, P Hardigan, L Witek, PG Coelho, T Kawai Locally Secreted Semaphorin 4D Is Engaged in Both Pathogenic Bone Resorption and Retarded Bone Regeneration in a Ligature-Induced Mouse Model of Periodontitis International Journal of Molecular Sciences, 2022-05-18;23(10):. 2022-05-18 [PMID: 35628440] (Bioassay, Mouse)	Bioassay	Mouse
Y Zhang, M Yang, S Zhang, Z Yang, Y Zhu, Y Wang, Z Chen, X Lv, Z Huang, Y Xie, L Cai BHLHE40 promotes osteoclastogenesis and abnormal bone resorption via c-Fos/NFATc1 Cell & bioscience, 2022-05-26;12(1):70. 2022-05-26 [PMID: 35619122] (Bioassay, Mouse)	Bioassay	Mouse
W Sun, S Guo, Y Li, J Li, C Liu, Y Chen, X Wang, Y Tan, H Tian, C Wang, R Du, G Zhong, S Shi, B Ma, C Qu, J Fu, X Jin, D Zhao, Y Zhan, S Ling, H An, Y Li Anoctamin 1 controls bone resorption by coupling Cl- channel activation with RANKL-RANK signaling transduction Nature Communications, 2022-05-24;13(1):2899. 2022-05-24 [PMID: 35610255] (Bioassay, Mouse)	Bioassay	Mouse
P Cai, S Yan, Y Lu, X Zhou, X Wang, M Wang, Z Yin Carnosol inhibits osteoclastogenesis inï¿½vivo and inï¿½vitro by blocking the RANKL?induced NF?kappaB signaling pathway Molecular Medicine Reports, 2022-05-20;26(1):. 2022-05-20 [PMID: 35593299] (Bioassay, Mouse)	Bioassay	Mouse
N Matsumoto, M Sekiya, GH Sun-Wada, Y Wada, M Nakanishi- The lysosomal V-ATPase a3 subunit is involved in localization of Mon1-Ccz1, the GEF for Rab7, to secretory lysosomes in osteoclasts Scientific Reports, 2022-05-19;12(1):8455. 2022-05-19 [PMID: 35589873] (Bioassay, Mouse)	Bioassay	Mouse
Z Cui, C Feng, J Chen, Y Wang, Q Meng, S Zhao, Y Zhang, D Feng, Z Li, S Sun Network Pharmacology Deciphers the Action of Bioactive Polypeptide in Attenuating Inflammatory Osteolysis via the Suppression of Oxidative Stress and Restoration of Bone Remodeling Balance Oxidative Medicine and Cellular Longevity, 2022-04-14;2022(0):4913534. 2022-04-14 [PMID: 35578727] (Bioassay, Mouse)	Bioassay	Mouse
X Chen, C Li, X Cao, X Jia, X Chen, Z Wang, W Xu, F Dai, S Zhang Mitochondria-targeted supramolecular coordination container encapsulated with exogenous itaconate for synergistic therapy of joint inflammation Theranostics, 2022-04-04;12(7):3251-3272. 2022-04-04 [PMID: 35547753] (Bioassay, Mouse)	Bioassay	Mouse
W Yang, WG Robichaux, FC Mei, W Lin, L Li, S Pan, MA White, Y Chen, X Cheng Epac1 activation by cAMP regulates cellular SUMOylation and promotes the formation of biomolecular condensates Science Advances, 2022-04-20;8(16):eabm2960. 2022-04-20 [PMID: 35442725] (Bioassay, Mouse)	Bioassay	Mouse
Y Gao, H Jin, H Tan, X Cai, Y Sun Erythrocyte-derived extracellular vesicles aggravate inflammation by promoting the proinflammatory macrophage phenotype through TLR4-MyD88-NF-kappaB-MAPK pathway Journal of leukocyte biology, 2022-04-12;0(0):. 2022-04-12 [PMID: 35411633] (Cell Culture, Mouse)	Cell Culture	Mouse
G Li, OJ Sul, R Yu, HS Choi 7-Ketocholesterol-Induced Micro-RNA-107-5p Increases Number and Activity of Osteoclasts by Targeting MKP1 International Journal of Molecular Sciences, 2022-03-28;23(7):. 2022-03-28 [PMID: 35409056] (Cell Culture, Mouse)	Cell Culture	Mouse
T Akasaka, H Hayashi, M Tamai, Y Yoshimura, YI Tagawa, H Miyaji, K Nakanishi, Y Yoshida Osteoclast formation from mouse bone marrow cells on micro/nano-scale patterned surfaces Journal of oral biosciences, 2022-04-07;0(0):. 2022-04-07 [PMID: 35398598] (Bioassay, Mouse)	Bioassay	Mouse
YJ Lee, JK Kim, CH Jung, YJ Kim, EJ Jung, SH Lee, HR Choi, YS Son, SM Shim, SM Jeon, JH Choe, SH Lee, J Whang, KC Sohn, GM Hur, HT Kim, J Yeom, EK Jo, YT Kwon Chemical Modulation of SQSTM1/p62-mediated Xenophagy that Targets a Broad Range of Pathogenic Bacteria Autophagy, 2022-04-05;0(0):. 2022-04-05 [PMID: 35316156] (Cell Culture, Human)	Cell Culture	Human
X Liu, L Diao, Y Zhang, X Yang, J Zhou, Y Mao, X Shi, F Zhao, M Liu Piperlongumine Inhibits Titanium Particles-Induced Osteolysis, Osteoclast Formation, and RANKL-Induced Signaling Pathways International Journal of Molecular Sciences, 2022-03-05;23(5):. 2022-03-05 [PMID: 35270008] (Bioassay, Mouse)	Bioassay	Mouse
Y Ma, R Di, H Zhao, R Song, H Zou, Z Liu P2X7 receptor knockdown suppresses osteoclast differentiation by inhibiting autophagy and Ca2+/calcineurin signaling Molecular Medicine Reports, 2022-03-10;25(5):. 2022-03-10 [PMID: 35266012] (Cell Culture, Mouse)	Cell Culture	Mouse
Q Guo, H Zhao, H Cheng, H Kang, Y Dong, R Peng, M Zhu, Z Fang, F Li Mitochondrial pyruvate carrier blockade results in decreased osteoclastogenesis and bone resorption via regulating mitochondrial energy production The Journal of Biological Chemistry, 2022-03-04;0(0):101775. 2022-03-04 [PMID: 35257748] (Bioassay, Mouse)	Bioassay	Mouse
H Zuo, Y Wan Inhibition of myeloid PD-L1 suppresses osteoclastogenesis and cancer bone metastasis Cancer Gene Therapy, 2022-03-07;0(0):. 2022-03-07 [PMID: 35256753] (Bioassay, Mouse)	Bioassay	Mouse
C Yang, H Tao, H Zhang, Y Xia, J Bai, G Ge, W Li, W Zhang, L Xiao, Y Xu, Z Wang, Y Gu, H Yang, Y Liu, D Geng TET2 regulates osteoclastogenesis by modulating autophagy in OVX-induced bone loss Autophagy, 2022-03-24;0(0):. 2022-03-24 [PMID: 35255774] (Cell Culture, Mouse)	Cell Culture	Mouse
G Shen, X Liu, W Lei, R Duan, Z Yao Plumbagin is a NF-kappaB-Inducing Kinase Inhibitor with Dual Anabolic and Anti-Resorptive Effects that Prevents Menopausal-Related Osteoporosis in Mice The Journal of Biological Chemistry, 2022-02-27;0(0):101767. 2022-02-27 [PMID: 35235833] (Bioassay, Mouse)	Bioassay	Mouse
V Mela, A Sayd Gaban, E O'Neill, S Bechet, A Walsh, MA Lynch The Modulatory Effects of DMF on Microglia in Aged Mice Are Sex-Specific Cells, 2022-02-18;11(4):. 2022-02-18 [PMID: 35203379] (Bioassay, Mouse)	Bioassay	Mouse
JM Kim, YS Yang, J Xie, O Lee, J Kim, J Hong, B Boldyreff, O Filhol, H Chun, MB Greenblatt, G Gao, JH Shim Regulation of sclerostin by the SIRT1 stabilization pathway in osteocytes Cell Death and Differentiation, 2022-02-15;0(0):. 2022-02-15 [PMID: 35169297] (Bioassay, Mouse)	Bioassay	Mouse
J Fierro, J DiPasquale, J Perez, B Chin, Y Chokpapone, AM Tran, A Holden, C Factoriza, N Sivagnanak, R Aguilar, S Mazal, M Lopez, H Dou Dual-sgRNA CRISPR/Cas9 knockout of PD-L1 in human U87 glioblastoma tumor cells inhibits proliferation, invasion, and tumor-associated macrophage polarization Scientific Reports, 2022-02-14;12(1):2417. 2022-02-14 [PMID: 35165339] (Bioassay, Mouse)	Bioassay	Mouse
ZI Mendel, MB Reynolds, BH Abuaita, MX O'Riordan, JA Swanson Amino acids suppress macropinocytosis and promote release of CSF1 receptor in macrophages Journal of Cell Science, 2022-02-21;0(0):. 2022-02-21 [PMID: 35107133] (Cell Culture, Mouse)	Cell Culture	Mouse
W Qiao, D Pan, Y Zheng, S Wu, X Liu, Z Chen, M Wan, S Feng, KMC Cheung, KWK Yeung, X Cao Divalent metal cations stimulate skeleton interoception for new bone formation in mouse injury models Nature Communications, 2022-01-27;13(1):535. 2022-01-27 [PMID: 35087048] (Bioassay, Mouse)	Bioassay	Mouse
KK Richardson, W Ling, K Krager, Q Fu, SD Byrum, R Pathak, N Aykin-Burn, HN Kim Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice International Journal of Molecular Sciences, 2022-01-08;23(2):. 2022-01-08 [PMID: 35054859] (Bioassay, Mouse)	Bioassay	Mouse
SW Shin, YS Hwang Anti-Periodontitis Effect of Ethanol Extracts of Alpinia Katsumadai Seeds Nutrients, 2021-12-28;14(1):. 2021-12-28 [PMID: 35011011] (Bioassay, Mouse)	Bioassay	Mouse
Y Fang, Y Liu, Z Zhao, Y Lu, X Shen, T Zhu, M Hou, F He, H Yang, Y Zhang, Q Shi, X Zhu Bortezomib Rescues Ovariectomy-Induced Bone Loss via SMURF-Mediated Ubiquitination Pathway Oxidative Medicine and Cellular Longevity, 2021-12-31;2021(0):9661200. 2021-12-31 [PMID: 35003523] (Bioassay, Mouse)	Bioassay	Mouse
SJ Hwang, BJ Ahn, MW Shin, YS Song, Y Choi, GT Oh, KW Kim, HJ Lee miR-125a-5p attenuates macrophage-mediated vascular dysfunction by targeting Ninjurin1 Cell Death and Differentiation, 2022-01-01;0(0):. 2022-01-01 [PMID: 34974535] (Bioassay, Mouse)	Bioassay	Mouse
J Gu, X Zhang, C Zhang, Y Li, J Bian, X Liu, Y Yuan, H Zou, X Tong, Z Liu Galectin-3 Contributes to the Inhibitory Effect of lalpha,25-(OH)2D3 on Osteoclastogenesis International Journal of Molecular Sciences, 2021-12-11;22(24):. 2021-12-11 [PMID: 34948130] (Bioassay, Mouse)	Bioassay	Mouse
Y Zou, J Zhang, J Xu, L Fu, Y Xu, X Wang, Z Li, L Zhu, H Sun, H Zheng, J Guo SIRT6 inhibition delays peripheral nerve recovery by suppressing migration, phagocytosis and M2-polarization of macrophages Cell & bioscience, 2021-12-14;11(1):210. 2021-12-14 [PMID: 34906231] (Bioassay, Mouse)	Bioassay	Mouse
C Zhuang, Z Wang, W Chen, H Wang, B Tian, H Lin Jintiange Capsules Ameliorate Osteoarthritis by Modulating Subchondral Bone Remodeling and Protecting Cartilage Against Degradation Frontiers in Pharmacology, 2021-11-11;12(0):762543. 2021-11-11 [PMID: 34858187] (Bioassay, Mouse)	Bioassay	Mouse
M Mae, MI Alam, Y Yamashita, Y Ozaki, K Higuchi, SM Ziauddin, JL Montenegro, E Sakai, T Tsukuba, A Yoshimura The Role of Cytokines Produced via the NLRP3 Inflammasome in Mouse Macrophages Stimulated with Dental Calculus in Osteoclastogenesis International Journal of Molecular Sciences, 2021-11-18;22(22):. 2021-11-18 [PMID: 34830316] (Bioassay, Mouse)	Bioassay	Mouse
Y Zhang, S Zhang, Y Wang, Z Yang, Z Chen, N Wen, M Yang, Z Huang, Y Xie, L Cai ULK1 Suppresses Osteoclast Differentiation and Bone Resorption via Inhibiting Syk-JNK through DOK3 Oxidative Medicine and Cellular Longevity, 2021-11-15;2021(0):2896674. 2021-11-15 [PMID: 34820053] (Bioassay, Mouse)	Bioassay	Mouse
J Amo-Aparic, J Garcia-Gar, I Francos-Qu, A Urpi, A Esteve-Cod, M Gut, A Quintana, R Lopez-Vale Interleukin-4 and interleukin-13 induce different metabolic profiles in microglia and macrophages that relate with divergent outcomes after spinal cord injury Theranostics, 2021-10-03;11(20):9805-9820. 2021-10-03 [PMID: 34815787] (Bioassay, Mouse)	Bioassay	Mouse
E Kim, H Um, J Park, JW Jung, JE Kim, H Lee, EA Shin, Y Pinanga, H Lee, SH Nam, JW Lee TM4SF5-dependent crosstalk between hepatocytes and macrophages to reprogram the inflammatory environment Cell Reports, 2021-11-16;37(7):110018. 2021-11-16 [PMID: 34788612] (Bioassay, Mouse)	Bioassay	Mouse
Z Liu, H Wang, Y Hou, Y Yang, J Jia, J Wu, Z Zuo, T Gao, S Ren, Y Bian, S Liu, J Fu, Y Sun, J Li, M Yamamoto, Q Zhang, Y Xu, J Pi CNC-bZIP protein NFE2L1 regulates osteoclast differentiation in antioxidant-dependent and independent manners Redox Biology, 2021-11-06;48(0):102180. 2021-11-06 [PMID: 34763297] (Bioassay, Mouse)	Bioassay	Mouse
AE Hinman, C Jani, SC Pringle, WR Zhang, N Jain, AJ Martinot, AK Barczak Mycobacterium tuberculosis canonical virulence factors interfere with a late component of the TLR2 response Elife, 2021-11-10;10(0):. 2021-11-10 [PMID: 34755600] (Bioassay, Mouse)	Bioassay	Mouse
RD Hu, W Zhang, L Li, ZQ Zuo, M Ma, JF Ma, TT Yin, CY Gao, SH Yang, ZB Zhao, ZJ Li, GB Qiao, ZX Lian, K Qu Chromatin accessibility analysis identifies the transcription factor ETV5 as a suppressor of adipose tissue macrophage activation in obesity Cell Death & Disease, 2021-10-29;12(11):1023. 2021-10-29 [PMID: 34716308] (Bioassay, Mouse)	Bioassay	Mouse
JM Motta, VM Rumjanek, A Mantovani, M Locati Tumor-Released Products Promote Bone Marrow-Derived Macrophage Survival and Proliferation Biomedicines, 2021-10-04;9(10):. 2021-10-04 [PMID: 34680504] (Differentiation, Differentiation, Mouse)	Differentiation, Differentiation	Mouse
IY Karkache, JR Damodaran, DHH Molstad, KC Mansky, EW Bradley Myeloid Lineage Ablation of Phlpp1 Regulates M-CSF Signaling and Tempers Bone Resorption in Female Mice International Journal of Molecular Sciences, 2021-09-08;22(18):. 2021-09-08 [PMID: 34575866] (Bioassay, Mouse)	Bioassay	Mouse
SN Cho, JA Choi, J Lee, SH Son, SA Lee, TD Nguyen, SY Choi, CH Song Ang II-Induced Hypertension Exacerbates the Pathogenesis of Tuberculosis Cells, 2021-09-19;10(9):. 2021-09-19 [PMID: 34572127] (Bioassay, Mouse)	Bioassay	Mouse
C Liu, G Chen, Y Chen, Y Dang, G Nie, D Wu, J Li, Z Chen, H Yang, D He, X Li, J Sun, J Lu, L Wang Danlou Tablets Inhibit Atherosclerosis in Apolipoprotein E-Deficient Mice by Inducing Macrophage Autophagy: The Role of the PI3K-Akt-mTOR Pathway Frontiers in Pharmacology, 2021-09-08;12(0):724670. 2021-09-08 [PMID: 34566648] (Bioassay, Mouse)	Bioassay	Mouse
S Jiang, NM Maphis, J Binder, D Chisholm, L Weston, W Duran, C Peterson, A Zimmerman, MA Mandell, SD Jett, E Bigio, C Geula, N Mellios, JP Weick, GA Rosenberg, E Latz, MT Heneka, K Bhaskar Proteopathic tau primes and activates interleukin-1beta via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway Cell Reports, 2021-09-21;36(12):109720. 2021-09-21 [PMID: 34551296] (Bioassay, Mouse)	Bioassay	Mouse
H Muto, T Ito, T Tanaka, S Yokoyama, K Yamamoto, N Imai, Y Ishizu, K Maeda, T Honda, T Ishikawa, A Kato, T Ohshiro, F Kano, A Yamamoto, K Sakai, H Hibi, M Ishigami, M Fujishiro Conditioned medium from stem cells derived from human exfoliated deciduous teeth ameliorates NASH via the Gut-Liver axis Scientific Reports, 2021-09-21;11(1):18778. 2021-09-21 [PMID: 34548598] (Bioassay, Mouse)	Bioassay	Mouse
JA Carroll, B Race, K Williams, JF Striebel, B Chesebro Innate immune responses after stimulation with Toll-like receptor agonists in ex vivo microglial cultures and an in vivo model using mice with reduced microglia Journal of Neuroinflammation, 2021-09-06;18(1):194. 2021-09-06 [PMID: 34488805] (Bioassay, Mouse)	Bioassay	Mouse
CR Park, S Paik, YJ Kim, JK Kim, SM Jeon, SH Lee, J Whang, J Cheng, JW Suh, J Cao, G Shetye, SN Chen, J McAlpine, GF Pauli, S Franzblau, S Cho, EK Jo Rufomycin Exhibits Dual Effects Against Mycobacterium abscessus Infection by Inducing Host Defense and Antimicrobial Activities Frontiers in Microbiology, 2021-08-10;12(0):695024. 2021-08-10 [PMID: 34447358] (Bioassay, Mouse)	Bioassay	Mouse
L Janská, L Anandi, NC Kirchberge, ZS Marinkovic, LT Schachtner, G Guzelsoy, C Carmona-Fo The MEMIC is an ex vivo system to model the complexity of the tumor microenvironment Disease Models & Mechanisms, 2021-08-18;14(8):. 2021-08-18 [PMID: 34407185] (Bioassay, Mouse)	Bioassay	Mouse
KH Nilsson, P Henning, ME Shahawy, M Nethander, TL Andersen, C Ejersted, J Wu, KL Gustafsson, A Koskela, J Tuukkanen, PPC Souza, J Tuckermann, M Lorentzon, LE Ruud, T Lehtimäki, JH Tobias, S Zhou, UH Lerner, JB Richards, S Movérare-S, C Ohlsson RSPO3 is important for trabecular bone and fracture risk in mice and humans Nature Communications, 2021-08-13;12(1):4923. 2021-08-13 [PMID: 34389713] (Bioassay, Mouse)	Bioassay	Mouse
C Fang, JW Guo, YJ Wang, XQ Li, H Zhang, J Cui, Y Hu, YY Jing, X Chen, JC Su Diterbutyl phthalate attenuates osteoarthritis in ACLT mice via suppressing ERK/c-fos/NFATc1 pathway, and subsequently inhibiting subchondral osteoclast fusion Acta pharmacologica Sinica, 2021-08-11;0(0):. 2021-08-11 [PMID: 34381182] (Bioassay, Mouse)	Bioassay	Mouse
DK Fix, HA Ekiz, JJ Petrocelli, AM Mckenzie, ZS Mahmassani, RM O'Connell, MJ Drummond Disrupted macrophage metabolic reprogramming in aged soleus muscle during early recovery following disuse atrophy Aging Cell, 2021-08-08;0(0):e13448. 2021-08-08 [PMID: 34365717] (Bioassay, Mouse)	Bioassay	Mouse
MG Dorrington, CJ Bradfield, JB Lack, B Lin, SP John, JJ Liang, T Starr, O Ernst, JL Gross, J Sun, AH Miller, O Steele-Mor, IDC Fraser Correction: Type I IFNs facilitate innate immune control of the opportunistic bacteria Burkholderia cenocepacia in the macrophage cytosol PloS Pathogens, 2021-08-04;17(8):e1009821. 2021-08-04 [PMID: 34347853] (Bioassay, Mouse)	Bioassay	Mouse
X Guo, J Bai, G Ge, Z Wang, Q Wang, K Zheng, H Tao, L Zhang, H Zhang, D Wang, X Zhang, H Li, G Pan, D Geng Bioinspired peptide adhesion on Ti implants alleviates wear particle-induced inflammation and improves interfacial osteogenesis Journal of colloid and interface science, 2021-07-24;605(0):410-424. 2021-07-24 [PMID: 34332414] (Bioassay, Mouse)	Bioassay	Mouse
K Wang, CR Donnelly, C Jiang, Y Liao, X Luo, X Tao, S Bang, A McGinnis, M Lee, MJ Hilton, RR Ji STING suppresses bone cancer pain via immune and neuronal modulation Nature Communications, 2021-07-27;12(1):4558. 2021-07-27 [PMID: 34315904] (Bioassay, Mouse)	Bioassay	Mouse
K Woo, DH Kim, MH Oh, HS Park, CH Choi N-3-Hydroxy Dodecanoyl-DL-homoserine Lactone (OH-dDHL) Triggers Apoptosis of Bone Marrow-Derived Macrophages through the ER- and Mitochondria-Mediated Pathways International Journal of Molecular Sciences, 2021-07-15;22(14):. 2021-07-15 [PMID: 34299184] (Bioassay, Mouse)	Bioassay	Mouse
EB Byun, HY Song, WS Kim, JM Han, HS Seo, SH Park, K Kim, EH Byun Protective Effect of Polysaccharides Extracted from Cudrania tricuspidata Fruit against Cisplatin-Induced Cytotoxicity in Macrophages and a Mouse Model International Journal of Molecular Sciences, 2021-07-13;22(14):. 2021-07-13 [PMID: 34299130] (Bioassay, Mouse)	Bioassay	Mouse
TT Chu, X Tu, K Yang, J Wu, JJ Repa, N Yan Tonic prime-boost of STING signalling mediates Niemann-Pick disease type C Nature, 2021-07-21;0(0):. 2021-07-21 [PMID: 34290407] (Bioassay, Mouse)	Bioassay	Mouse
AS Tooley, D Kazyken, C Bodur, IE Gonzalez, DC Fingar The innate immune kinase TBK1 directly increases mTORC2 activity and downstream signaling to Akt The Journal of Biological Chemistry, 2021-07-08;0(0):100942. 2021-07-08 [PMID: 34245780] (Bioassay, Mouse)	Bioassay	Mouse
MB Uccellini, S Aslam, STH Liu, F Alam, A García-Sas Development of a Macrophage-Based ADCC Assay Vaccines, 2021-06-17;9(6):. 2021-06-17 [PMID: 34204268] (Bioassay, Mouse)	Bioassay	Mouse
Q Lu, C Jiang, J Hou, H Qian, F Chu, W Zhang, M Ye, Z Chen, J Liu, H Yao, J Zhang, J Xu, T Wang, S Fan, Q Wang Patchouli Alcohol Modulates the Pregnancy X Receptor/Toll-like Receptor 4/Nuclear Factor Kappa B Axis to Suppress Osteoclastogenesis Frontiers in Pharmacology, 2021-06-08;12(0):684976. 2021-06-08 [PMID: 34177594] (Cell Culture, Mouse)	Cell Culture	Mouse
J Yang, L Qin, J Huang, Y Li, S Xu, H Wang, S Zhu, J Wang, B Zhu, F Li, W Huang, X Gong, N Hu Astragalus polysaccharide attenuates LPS-related inflammatory osteolysis by suppressing osteoclastogenesis by reducing the MAPK signalling pathway Journal of Cellular and Molecular Medicine, 2021-06-02;0(0):. 2021-06-02 [PMID: 34080298] (Cell Culture, Mouse)	Cell Culture	Mouse
H Salo, H Qu, D Mitsiou, H Aucott, J Han, XM Zhang, C Aulin, H Erlandsson Disulfide and Fully Reduced HMGB1 Induce Different Macrophage Polarization and Migration Patterns Biomolecules, 2021-05-28;11(6):. 2021-05-28 [PMID: 34071440] (Cell Culture, Mouse)	Cell Culture	Mouse
JS Kim, E Cho, SJ Mun, S Kim, SY Kim, DG Kim, W Son, HI Jeon, HK Kim, YJ Jeong, S Jang, HS Kim, CS Yang Multi-Functional MPT Protein as a Therapeutic Agent against Mycobacterium tuberculosis Biomedicines, 2021-05-13;9(5):. 2021-05-13 [PMID: 34068051] (Bioassay, Mouse)	Bioassay	Mouse
KH Kim, YT Lee, Y Park, EJ Ko, YJ Jung, YJ Kim, EK Jo, SM Kang BCG Cell Wall Skeleton As a Vaccine Adjuvant Protects Both Infant and Old-Aged Mice from Influenza Virus Infection Biomedicines, 2021-05-05;9(5):. 2021-05-05 [PMID: 34063125] (Bioassay, Mouse)	Bioassay	Mouse
OJ Sul, G Li, JE Kim, ES Kim, HS Choi 7-ketocholesterol enhances autophagy via the ROS-TFEB signaling pathway in osteoclasts: 7-KC in osteoclasts The Journal of nutritional biochemistry, 2021-05-21;0(0):108783. 2021-05-21 [PMID: 34023424] (Bioassay, Mouse)	Bioassay	Mouse
D Zhang, J Huang, F Wang, H Ding, Y Cui, Y Yang, J Xu, H Luo, Y Gao, L Pan, Y Wu, Y Gong, L Xie, Z Liu, Y Qu, L Zhang, W Liu, W Zhang, S Zhao, Q Yi, T Niu, Y Zheng BMI1 regulates multiple myeloma-associated macrophage's pro-myeloma functions Cell Death & Disease, 2021-05-15;12(5):495. 2021-05-15 [PMID: 33993198] (Bioassay, Mouse)	Bioassay	Mouse
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MG Dorrington, CJ Bradfield, JB Lack, B Lin, JJ Liang, T Starr, O Ernst, JL Gross, J Sun, AH Miller, O Steele-Mor, IDC Fraser Type I IFNs facilitate innate immune control of the opportunistic bacteria Burkholderia cenocepacia in the macrophage cytosol PloS Pathogens, 2021-03-08;17(3):e1009395. 2021-03-08 [PMID: 33684179] (Bioassay, Mouse)	Bioassay	Mouse
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RK Arya, R Goswami, SO Rahaman Mechanotransduction via a TRPV4-Rac1 signaling axis plays a role in multinucleated giant cell formation The Journal of Biological Chemistry, 2020-01-01;296(0):100129. 2020-01-01 [PMID: 33460921] (Bioassay, Mouse)	Bioassay	Mouse
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S Rosendahl, R Sulniute, M Eklund, C Koskinen H, MJO Johansson, E Kindstedt, S Lindquist, P Lundberg CCR3 deficiency is associated with increased osteoclast activity and reduced cortical bone volume in adult male mice The Journal of Biological Chemistry, 2020-12-17;0(0):. 2020-12-17 [PMID: 33303631] (Cell Culture, Mouse)	Cell Culture	Mouse
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Xia W, Jung J, Shun C, Xiong S, Xiong L, Shi X, Mei L, Xiong W Swedish mutant APP suppresses osteoblast differentiation and causes osteoporotic deficit, which are ameliorated by N-acetyl-L-cysteine. J Bone Miner Res, 2013-10-01;28(10):2122-35. 2013-10-01 [PMID: 23649480] (Bioassay, Mouse)	Bioassay	Mouse
Hunter , K E, Palermo , C, Kester , J C, Simpson , K, Li , J-P, Tang , L H, Klimstra , D S, Vlodavsky , I, Joyce , J A Heparanase promotes lymphangiogenesis and tumor invasion in pancreatic neuroendocrine tumors. Oncogene, 2013-05-06;33(14):1799-808. 2013-05-06 [PMID: 23644656] (Bioassay, Mouse)	Bioassay	Mouse
Kim J, Kim W, Lee K, Won C, Kim J, Eum S, Koh W, Shin S Differential immune responses to Segniliparus rotundus and Segniliparus rugosus infection and analysis of their comparative virulence profiles. PLoS ONE, 2013-03-29;8(3):e59646. 2013-03-29 [PMID: 23555735] (Bioassay, Mouse)	Bioassay	Mouse
Yang Z, Grinchuk V, Urban J, Bohl J, Sun R, Notari L, Yan S, Ramalingam T, Keegan A, Wynn T, Shea-Donohue T, Zhao A Macrophages as IL-25/IL-33-responsive cells play an important role in the induction of type 2 immunity. 2013-03-25;0(0):. 2013-03-25 [PMID: 23536877] (Bioassay, Mouse)	Bioassay	Mouse
Elcombe S, Naqvi S, van den Bosch M, Mackenzie K, Cianfanelli F, Brown G, Arthur J Dectin-1 regulates IL-10 production via a MSK1/2 and CREB dependent pathway and promotes the induction of regulatory macrophage markers. PLoS ONE, 2013-03-22;8(3):e60086. 2013-03-22 [PMID: 23533666] (Bioassay, Mouse)	Bioassay	Mouse
Uchiyama R, Yonehara S, Tsutsui H Fas-mediated inflammatory response in Listeria monocytogenes infection. J Immunol, 2013-03-15;190(8):4245-54. 2013-03-15 [PMID: 23509366] (Bioassay, Mouse)	Bioassay	Mouse
Xia W, Tang F, Xiong L, Xiong S, Jung J, Lee D, Li X, Feng X, Mei L, Xiong W Vps35 loss promotes hyperresorptive osteoclastogenesis and osteoporosis via sustained RANKL signaling. J Cell Biol, 2013-03-18;200(6):821-37. 2013-03-18 [PMID: 23509071] (Bioassay, Mouse)	Bioassay	Mouse
Shah P, Fatehchand K, Patel H, Fang H, Justiniano S, Mo X, Jarjoura D, Tridandapani S, Butchar J Toll-like receptor 2 ligands regulate monocyte Fcgamma receptor expression and function. J Biol Chem, 2013-03-15;288(17):12345-52. 2013-03-15 [PMID: 23504312] (Bioassay, Mouse)	Bioassay	Mouse
Choi J, Choi S, Lee S, Lee J, Kim H, Lee S, Lee N Caffeine enhances osteoclast differentiation and maturation through p38 MAP kinase/Mitf and DC-STAMP/CtsK and TRAP pathway. Cell Signal, 2013-02-19;25(5):1222-7. 2013-02-19 [PMID: 23434822] (Bioassay, Mouse)	Bioassay	Mouse
Sandig H, Jobbings C, Roldan N, Whittingham-Dowd J, Orinska Z, Takeuchi O, Akira S, Bulfone-Paus S IL-33 causes selective mast cell tolerance to bacterial cell wall products by inducing IRAK1 degradation. Eur J Immunol, 2013-03-06;43(4):979-88. 2013-03-06 [PMID: 23404570] (Bioassay, Mouse)	Bioassay	Mouse
Ke K, Sul O, Kim W, Lee M, Ko M, Suh J, Kim H, Kim S, Park J, Choi H Overexpression of developmentally regulated GTP-binding protein-2 increases bone loss. Am J Physiol Endocrinol Metab, 2013-01-29;304(7):E703-10. 2013-01-29 [PMID: 23360825] (Bioassay, Mouse)	Bioassay	Mouse
Pau E, Loh C, Minty G, Chang N, Wither J Identification of a lupus-susceptibility locus leading to impaired clearance of apoptotic debris on New Zealand Black chromosome 13. Genes Immun, 2013-01-17;14(3):154-61. 2013-01-17 [PMID: 23328841] (Bioassay, Mouse)	Bioassay	Mouse
Cloning and expression of feline colony stimulating factor receptor (CSF-1R) and analysis of the species specificity of stimulation by colony stimulating factor-1 (CSF-1) and interleukin-34 (IL-34). Cytokine, 2012-12-19;61(2):630-8. 2012-12-19 [PMID: 23260168] (Bioassay, Feline)	Bioassay	Feline
Zou W, Izawa T, Zhu T, Chappel J, Otero K, Monkley S, Critchley D, Petrich B, Morozov A, Ginsberg M, Teitelbaum S Talin1 and Rap1 are critical for osteoclast function. Mol Cell Biol, 2012-12-10;33(4):830-44. 2012-12-10 [PMID: 23230271] (Bioassay, Mouse)	Bioassay	Mouse
Braun T, Lepper J, Ruiz Heiland G, Hofstetter W, Siegrist M, Lezuo P, Gaestel M, Rumpler M, Thaler R, Klaushofer K, Distler J, Schett G, Zwerina J Mitogen-activated protein kinase 2 regulates physiological and pathological bone turnover. J Bone Miner Res, 2013-04-01;28(4):936-47. 2013-04-01 [PMID: 23169443] (Bioassay, Mouse)	Bioassay	Mouse
Lamothe B, Lai Y, Xie M, Schneider M, Darnay B TAK1 is essential for osteoclast differentiation and is an important modulator of cell death by apoptosis and necroptosis. Mol Cell Biol, 2012-11-19;33(3):582-95. 2012-11-19 [PMID: 23166301] (Bioassay, Mouse)	Bioassay	Mouse
Ma , Junqing, Chen , Wei, Zhang , Lijie, Tucker , Byron, Zhu , Guochun, Sasaki , Hajime, Hao , Liang, Wang , Lin, Ci , Honglian, Jiang , Hongbing, Stashenko , Philip, Li , Yi-Ping RNA interference-mediated silencing of Atp6i prevents both periapical bone erosion and inflammation in the mouse model of endodontic disease. Infect Immun, 2013-04-01;81(4):1021-30. 2013-04-01 [PMID: 23166162] (Bioassay, Mouse)	Bioassay	Mouse
Jacome-Galarza C, Lee S, Lorenzo J, Aguila H Identification, characterization, and isolation of a common progenitor for osteoclasts, macrophages, and dendritic cells from murine bone marrow and periphery. J Bone Miner Res, 2013-05-01;28(5):1203-13. 2013-05-01 [PMID: 23165930] (Bioassay, Mouse)	Bioassay	Mouse
Zhao E, Wang L, Dai J, Kryczek I, Wei S, Vatan L, Altuwaijri S, Sparwasser T, Wang G, Keller E, Zou W Regulatory T cells in the bone marrow microenvironment in patients with prostate cancer. Oncoimmunology, 2012-03-01;1(2):152-161. 2012-03-01 [PMID: 22720236] (Bioassay, Mouse)	Bioassay	Mouse
Regulation of innate CD8+ T-cell activation mediated by cytokines. Proc Natl Acad Sci U S A, 2012-06-04;109(25):9971-6. 2012-06-04 [PMID: 22665806] (Bioassay, Mouse)	Bioassay	Mouse
Hassan F, Ren D, Zhang W Role of c-Jun N-terminal protein kinase 1/2 (JNK1/2) in macrophage-mediated MMP-9 production in response to Moraxella catarrhalis lipooligosaccharide (LOS). PLoS ONE, 2012-05-24;7(5):e37912. 2012-05-24 [PMID: 22655080] (Bioassay, Mouse)	Bioassay	Mouse
Hayashi M, Nakashima T, Taniguchi M, Kodama T, Kumanogoh A, Takayanagi H Osteoprotection by semaphorin 3A. Nature, 2012-05-03;485(7396):69-74. 2012-05-03 [PMID: 22522930] (Bioassay, Mouse)	Bioassay	Mouse
Barin JG, Baldeviano GC, Talor MV, Wu L, Ong S, Quader F, Chen P, Zheng D, Caturegli P, Rose NR, Cihakova D Macrophages participate in IL-17-mediated inflammation. Eur. J. Immunol., 2012-01-23;42(3):726-36. 2012-01-23 [PMID: 22161142] (Bioassay, Mouse)	Bioassay	Mouse
Jang HD, Shin JH, Park DR, Hong JH, Yoon K, Ko R, Ko CY, Kim HS, Jeong D, Kim N, Lee SY Inactivation of glycogen synthase kinase-3beta is required for osteoclast differentiation. J. Biol. Chem., 2011-09-23;286(45):39043-50. 2011-09-23 [PMID: 21949120] (Bioassay, Mouse)	Bioassay	Mouse
Fujiwara T, Fukushi J, Yamamoto S, Matsumoto Y, Setsu N, Oda Y, Yamada H, Okada S, Watari K, Ono M, Kuwano M, Kamura S, Iida K, Okada Y, Koga M, Iwamoto Y Macrophage infiltration predicts a poor prognosis for human ewing sarcoma. Am. J. Pathol., 2011-07-21;179(3):1157-70. 2011-07-21 [PMID: 21771572] (Bioassay, Mouse)	Bioassay	Mouse
Cook BD, Liu S, Evans T Smad1 signaling restricts hematopoietic potential after promoting hemangioblast commitment. Blood, 2011-04-22;117(24):6489-97. 2011-04-22 [PMID: 21515822] (Bioassay, Mouse)	Bioassay	Mouse
Kulkarni RN, Bakker AD, Everts V, Klein-Nulend J Inhibition of osteoclastogenesis by mechanically loaded osteocytes: involvement of MEPE. Calcif. Tissue Int., 2010-08-20;87(5):461-8. 2010-08-20 [PMID: 20725825] (Bioassay, Mouse)	Bioassay	Mouse
Zhang G, Wang J, Kelly J B7-h3 augments the inflammatory response and is associated with human sepsis. J. Immunol., 2010-08-09;185(6):3677-84. 2010-08-09 [PMID: 20696859] (Bioassay, Mouse)	Bioassay	Mouse
Scapini P, Hu Y, Chu CL Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice. J. Exp. Med., 2010-07-12;207(8):1757-73. 2010-07-12 [PMID: 20624892] (Bioassay, Mouse)	Bioassay	Mouse
Shanmugarajan S, Beeson CC, Reddy SV Osteoclast inhibitory peptide-1 binding to the Fc gammaRIIB inhibits osteoclast differentiation. Endocrinology, 2010-07-07;151(9):4389-99. 2010-07-07 [PMID: 20610564] (Bioassay, Mouse)	Bioassay	Mouse
Wang L, Zhao R, Shi X, Wei T, Halloran BP, Clark DJ, Jacobs CR, Kingery WS Substance P stimulates bone marrow stromal cell osteogenic activity, osteoclast differentiation, and resorption activity in vitro. Bone, 2009-04-18;45(2):309-20. 2009-04-18 [PMID: 19379851] (Bioassay, Mouse)	Bioassay	Mouse
Kiuru M, Solomon J, Ghali B, van der Meulen M, Crystal RG, Hidaka C Transient overexpression of sonic hedgehog alters the architecture and mechanical properties of trabecular bone. J. Bone Miner. Res., 2009-09-01;24(9):1598-607. 2009-09-01 [PMID: 19338448] (Bioassay, Mouse)	Bioassay	Mouse
Binder NB, Niederreiter B, Hoffmann O, Stange R, Pap T, Stulnig TM, Mack M, Erben RG, Smolen JS, Redlich K Estrogen-dependent and C-C chemokine receptor-2-dependent pathways determine osteoclast behavior in osteoporosis. Nat. Med., 2009-03-29;15(4):417-24. 2009-03-29 [PMID: 19330010] (Bioassay, Mouse)	Bioassay	Mouse
Jinushi M, Nakazaki Y, Carrasco DR, Draganov D, Souders N, Johnson M, Mihm MC, Dranoff G Milk fat globule EGF-8 promotes melanoma progression through coordinated Akt and twist signaling in the tumor microenvironment. Cancer Res., 2008-11-01;68(21):8889-98. 2008-11-01 [PMID: 18974133] (Bioassay, Mouse)	Bioassay	Mouse
Walker EC, McGregor NE, Poulton IJ, Pompolo S, Allan EH, Quinn JM, Gillespie MT, Martin TJ, Sims NA Cardiotrophin-1 is an osteoclast-derived stimulus of bone formation required for normal bone remodeling. J. Bone Miner. Res., 2008-12-01;23(12):2025-32. 2008-12-01 [PMID: 18665789] (Bioassay, Mouse)	Bioassay	Mouse
Krum SA, Miranda-Carboni GA, Hauschka PV, Carroll JS, Lane TF, Freedman LP, Brown M Estrogen protects bone by inducing Fas ligand in osteoblasts to regulate osteoclast survival. EMBO J., 2008-01-24;27(3):535-45. 2008-01-24 [PMID: 18219273] (Bioassay, Mouse)	Bioassay	Mouse
O'Sullivan S, Naot D, Callon K, Porteous F, Horne A, Wattie D, Watson M, Cornish J, Browett P, Grey A Imatinib promotes osteoblast differentiation by inhibiting PDGFR signaling and inhibits osteoclastogenesis by both direct and stromal cell-dependent mechanisms. J. Bone Miner. Res., 2007-11-01;22(11):1679-89. 2007-11-01 [PMID: 17663639] (Bioassay, Mouse)	Bioassay	Mouse
Islam S, Hassan F, Tumurkhuu G, Dagvadorj J, Koide N, Naiki Y, Mori I, Yoshida T, Yokochi T Bacterial lipopolysaccharide induces osteoclast formation in RAW 264.7 macrophage cells. Biochem. Biophys. Res. Commun., 2007-06-12;360(2):346-51. 2007-06-12 [PMID: 17597583] (Bioassay, Mouse)	Bioassay	Mouse
Niki Y, Takaishi H, Takito J, Miyamoto T, Kosaki N, Matsumoto H, Toyama Y, Tada N Administration of cyclooxygenase-2 inhibitor reduces joint inflammation but exacerbates osteopenia in IL-1 alpha transgenic mice due to GM-CSF overproduction. J. Immunol., 2007-07-01;179(1):639-46. 2007-07-01 [PMID: 17579086] (Bioassay, Mouse)	Bioassay	Mouse
Kovacic N, Lukic IK, Grcevic D, Katavic V, Croucher P, Marusic A The Fas/Fas ligand system inhibits differentiation of murine osteoblasts but has a limited role in osteoblast and osteoclast apoptosis. J. Immunol., 2007-03-15;178(6):3379-89. 2007-03-15 [PMID: 17339432] (Bioassay, Mouse)	Bioassay	Mouse
Johansson MK, de Vries TJ, Schoenmaker T, Ehinger M, Brun AC, Fasth A, Karlsson S, Everts V, Richter J Hematopoietic stem cell-targeted neonatal gene therapy reverses lethally progressive osteopetrosis in oc/oc mice. Blood, 2007-03-01;109(12):5178-85. 2007-03-01 [PMID: 17332244] (Bioassay, Mouse)	Bioassay	Mouse
Nakanishi M, Niidome T, Matsuda S, Akaike A, Kihara T, Sugimoto H Microglia-derived interleukin-6 and leukaemia inhibitory factor promote astrocytic differentiation of neural stem/progenitor cells. Eur. J. Neurosci., 2007-02-01;25(3):649-58. 2007-02-01 [PMID: 17328769] (Bioassay, Rat)	Bioassay	Rat
Mohamedali KA, Poblenz AT, Sikes CR, Navone NM, Thorpe PE, Darnay BG, Rosenblum MG Inhibition of prostate tumor growth and bone remodeling by the vascular targeting agent VEGF121/rGel. Cancer Res., 2006-11-15;66(22):10919-28. 2006-11-15 [PMID: 17108129] (Bioassay, Mouse)	Bioassay	Mouse
Jia D, O'Brien CA, Stewart SA, Manolagas SC, Weinstein RS Glucocorticoids act directly on osteoclasts to increase their life span and reduce bone density. Endocrinology, 2006-08-24;147(12):5592-9. 2006-08-24 [PMID: 16935844] (Bioassay, Mouse)	Bioassay	Mouse
Kim SY, Nguyen AD, Gao JL, Murphy PM, Mansfield BC, Chou JY Bone marrow-derived cells require a functional glucose 6-phosphate transporter for normal myeloid functions. J. Biol. Chem., 2006-08-04;281(39):28794-801. 2006-08-04 [PMID: 16891306] (Bioassay, Mouse)	Bioassay	Mouse
de Vries TJ, Schoenmaker T, Wattanaroonwong N, van den Hoonaard M, Nieuwenhuijse A, Beertsen W, Everts V Gingival fibroblasts are better at inhibiting osteoclast formation than periodontal ligament fibroblasts. J. Cell. Biochem., 2006-05-15;98(2):370-82. 2006-05-15 [PMID: 16440316] (Bioassay, Mouse)	Bioassay	Mouse
Conway</LastName><ForeNam JG</Initia, Conway JG, McDonald B, Parham J, Keith B, Rusnak DW, Shaw E, Jansen M, Lin P, Payne A, Crosby RM, Johnson JH, Frick L, Lin MH, Depee S, Tadepalli S, Votta B, James I, Fuller K, Chambers TJ, Kull FC, Chamberlain SD, Hutchins JT Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580. Proc. Natl. Acad. Sci. U.S.A., 2005-10-25;102(44):16078-83. 2005-10-25 [PMID: 16249345] (In Vivo, Mouse)	In Vivo	Mouse
Gevrey JC, Isaac BM, Cox D Syk is required for monocyte/macrophage chemotaxis to CX3CL1 (Fractalkine). J. Immunol., 2005-09-15;175(6):3737-45. 2005-09-15 [PMID: 16148119] (Bioassay, Mouse)	Bioassay	Mouse
Ponomarev ED, Novikova M, Maresz K, Shriver LP, Dittel BN Development of a culture system that supports adult microglial cell proliferation and maintenance in the resting state. J. Immunol. Methods, 2005-04-26;300(1):32-46. 2005-04-26 [PMID: 15893321] (Bioassay, Mouse)	Bioassay	Mouse
Sharif MN, Tassiulas I, Hu Y, Mecklenbrauker I, Tarakhovsky A, Ivashkiv LB IFN-alpha priming results in a gain of proinflammatory function by IL-10: implications for systemic lupus erythematosus pathogenesis. J. Immunol., 2004-05-15;172(10):6476-81. 2004-05-15 [PMID: 15128840] (Bioassay, Mouse)	Bioassay	Mouse
Miller YI, Viriyakosol S, Binder CJ, Feramisco JR, Kirkland TN, Witztum JL Minimally modified LDL binds to CD14, induces macrophage spreading via TLR4/MD-2, and inhibits phagocytosis of apoptotic cells. J. Biol. Chem., 2002-11-06;278(3):1561-8. 2002-11-06 [PMID: 12424240] (Bioassay, Mouse)	Bioassay	Mouse
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