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Recombinant Mouse M-CSF Protein

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Recombinant Mouse M-CSF Protein (Catalog # 416-ML) has a molecular weight (MW) of 50.7 kDa as analyzed by SEC-MALS, suggesting that this protein is a homodimer.

Recombinant Mouse M-CSF Protein (Catalog # 416-ML) has a molecular weight (MW) of 50.7 kDa as analyzed by SEC-MALS, suggesting that this protein is a homodimer.

Recombinant Mouse M-CSF (416-ML) stimulates cell proliferation in the M-NFS-60 mouse myelogenous leukemia lymphoblast cell line in a dose-dependent manner. The ED50 for this effect is 0.5-3 ng/mL.

Product Details

Summary

Reactivity	MuSpecies Glossary
Applications	Bioactivity

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Catalog# & Formulation	Size	Price
Carrier Free 416-ML-010/CF

Carrier Free 416-ML-050/CF

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Recombinant Mouse M-CSF Protein Summary

Additional Information	Analyzed by SEC-MALS
Details of Functionality	Measured in a cell proliferation assay using M‑NFS‑60 mouse myelogenous leukemia lymphoblast cells. Nakoinz, I. et al. (1990) J. Immunol. 145:860. The ED₅₀ for this effect is 0.5‑3 ng/mL.
Source	E. coli-derived mouse M-CSF protein Lys33-Glu262, with an N-terminal Met
Accession #	Q3U4F9
N-terminal Sequence	Met
Structure / Form	Disulfide-linked homodimer
Protein/Peptide Type	Recombinant Proteins
Gene	Csf1
Purity	>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Note	<1.0 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

Dilutions

Bioactivity

Theoretical MW

26 kDa (monomer).
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

SDS-PAGE

29 kDa, reducing conditions

Reviewed Applications

Read 2 Reviews rated 5

using
416-ML in the following application:

Cell Proliferation
Stem/Immune cell maintenance or differentiation

Publications

Read Publications using
416-ML in the following applications:

Bioassay
517 publications
Cell Culture
75 publications
Differentiation
8 publications
In Vivo
2 publications
Tissue Culture
1 publication

Packaging, Storage & Formulations

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Purity	>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution Instructions	Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse M-CSF Protein

colony stimulating factor 1 (macrophage)
CSF1
CSF-1
Lanimostim
macrophage colony stimulating factor
macrophage colony-stimulating factor 1
MCSF
M-CSF
MCSFlanimostim
MGC31930

Background

M-CSF, also known as CSF-1, is a four-alpha -helical-bundle cytokine that is the primary regulator of macrophage survival, proliferation and differentiation (1-3). M-CSF protein is also essential for the survival and proliferation of osteoclast progenitors (1, 4). M-CSF also primes and enhances macrophage killing of tumor cells and microorganisms, regulates the release of cytokines and other inflammatory modulators from macrophages, and stimulates pinocytosis (2, 3). M-CSF increases during pregnancy to support implantation and growth of the decidua and placenta (5). Sources of M-CSF include fibroblasts, activated macrophages, endometrial secretory epithelium, bone marrow stromal cells and activated endothelial cells (1-5). The M-CSF receptor (c-fms) transduces its pleotropic effects and mediates its endocytosis. M-CSF mRNAs of various sizes occur (3-9). Full length mouse M-CSF transcripts encode a 520 amino acid (aa) type I transmembrane (TM) protein with a 462 aa extracellular region, a 21 aa TM domain, and a 37 aa cytoplasmic tail that forms a 140 kDa covalent dimer. Differential processing produces two proteolytically cleaved, secreted dimers. One is an N- and O- glycosylated 86 kDa dimer, while the other is modified by both glycosylation and chondroitin-sulfate proteoglycan (PG) to generate a 200 kDa subunit. Although PG-modified M-CSF protein can circulate, it may be immobilized by attachment to type V collagen (8). Shorter transcripts encode M‑CSF that lacks cleavage and PG sites and produces an N-glycosylated 68 kDa TM dimer and a slowly produced 44 kDa secreted dimer (7). Although forms may vary in activity and half-life, all contain the N-terminal 150 aa portion that is necessary and sufficient for interaction with the M-CSF receptor (10, 11). The first 229 aa of mature mouse M-CSF shares 87%, 83%, 82% and 81% aa identity with corresponding regions of rat, dog, cow and human M-CSF, respectively (12, 13). Human M‑CSF is active in the mouse, but mouse M-CSF is reported to be species-specific.

Pixley, F.J. and E.R. Stanley (2004) Trends Cell Biol. 14:628.
Chitu, V. and E.R. Stanley (2006) Curr. Opin. Immunol. 18:39.
Fixe, P. and V. Praloran (1997) Eur. Cytokine Netw. 8:125.
Ryan, G.R. et al. (2001) Blood 98:74.
Makrigiannakis, A. et al. (2006) Trends Endocrinol. Metab. 17:178.
Nandi, S. et al. (2006) Blood 107:786.
Rettenmier, C.W. and M.F. Roussel (1988) Mol. Cell Biol. 8:5026.
Suzu, S. et al. (1992) J. Biol. Chem. 267:16812.
Manos, M.M. (1988) Mol. Cell. Biol. 8:5035.
Koths, K. (1997) Mol. Reprod. Dev. 46:31.
Jang, M-H. et al. (2006) J. Immunol. 177:4055.
DeLamarter, J.F. et al. (1987) Nucleic Acids Res. 15:2389.
Ladner, M.B. et al. (1988) Proc. Natl. Acad. Sci. USA 85:6706.

Publications for M-CSF (416-ML)(601)

We have publications tested in 5 confirmed species: Human, Mouse, Rat, Feline, Transgenic Mouse.

We have publications tested in 5 applications: Bioassay, Cell Culture, Differentiation, In Vivo, Tissue Culture.

Showing Publications 1 - 10 of 601. Show All 601 Publications.

Publications using 416-ML	Applications	Species
Hong, G;Zhou, L;Zheng, G;Zheng, X;Chen, Z;He, W;Wei, Q; A novel Glycyrrhiza glabra extract liquiritin targeting NFATc1 activity and ROS levels to counteract ovariectomy-induced osteoporosis and bone loss in murine model Frontiers in pharmacology 2023-11-08 [PMID: 38026985] (Bioassay, Mouse)	Bioassay	Mouse
Dai, J;Hu, Z;Zeng, F;Gong, X;Tang, H;Deng, J;Li, J;Dong, S; Osteoclast-derived exosomal miR-212-3p suppressed the anabolism and accelerated the catabolism of chondrocytes in osteoarthritis by targeting TGF-?1/Smad2 signaling Archives of biochemistry and biophysics 2023-11-23 [PMID: 38000494] (Bioassay, Mouse)	Bioassay	Mouse
Yu, X;Hu, J;Yang, X;Xu, Q;Chen, H;Zhan, P;Zhang, B; Sesamin inhibits RANKL-induced osteoclastogenesis and attenuates LPS-induced osteolysis via suppression of ERK and NF-?B signalling pathways Journal of cellular and molecular medicine 2023-11-21 [PMID: 37988238] (Bioassay, Mouse)	Bioassay	Mouse
Li, R;Chen, B;Kubota, A;Hanna, A;Humeres, C;Hernandez, SC;Liu, Y;Ma, R;Tuleta, I;Huang, S;Venugopal, H;Zhu, F;Su, K;Li, J;Zhang, J;Zheng, D;Frangogiannis, NG; Protective effects of macrophage-specific integrin ?5 in myocardial infarction are associated with accentuated angiogenesis Nature communications 2023-11-20 [PMID: 37985764] (Bioassay, Mouse)	Bioassay	Mouse
Lima Teixeira, JF;Henning, P;Cintra Magalhães, FA;Coletto-Nunes, G;Floriano-Marcelino, T;Westerlund, A;Movérare-Skrtic, S;Oliveira, GJPL;Lerner, UH;Souza, PPC; Osteoprotective effect by interleukin-4 (IL-4) on lipoprotein-induced periodontitis Cytokine 2023-10-26 [PMID: 37898012] (Bioassay, Mouse)	Bioassay	Mouse
Ribeiro, MSP;Venturini, LGR;Speck-Hernandez, CA;Alabarse, PVG;Xavier, T;Taira, TM;Rodrigues, LFD;Cunha, FQ;Fukada, SY; AMPK?1 negatively regulates osteoclastogenesis and mitigate pathological bone loss The Journal of biological chemistry 2023-10-21 [PMID: 37871745] (Bioassay, Mouse)	Bioassay	Mouse
Wu, L;Yin, W;Wen, J;Wang, S;Li, H;Wang, X;Zhang, W;Duan, S;Zhu, Q;Gao, E;Wu, S;Zhan, B;Zhou, R;Yang, X; Excretory/secretory products from Trichinella spiralis adult worms ameliorate myocardial infarction by inducing M2 macrophage polarization in a mouse model Parasites & vectors 2023-10-16 [PMID: 37845695] (Bioassay, Mouse)	Bioassay	Mouse
Jeong, C;Lee, CH;Lee, Y;Seo, J;Wang, W;Park, KH;Oh, E;Cho, Y;Park, C;Son, YJ;Yoon Park, JH;Kang, H;Lee, KW; Ulmus macrocarpa Hance trunk bark extracts inhibit RANKL-induced osteoclast differentiation and prevent ovariectomy-induced osteoporosis in mice Journal of ethnopharmacology 2023-10-13 [PMID: 37839769] (Bioassay, Mouse)	Bioassay	Mouse
Adrian, M;Weber, M;Tsai, MC;Glock, C;Kahn, OI;Phu, L;Cheung, TK;Meilandt, WJ;Rose, CM;Hoogenraad, CC; Polarized microtubule remodeling transforms the morphology of reactive microglia and drives cytokine release Nature communications 2023-10-09 [PMID: 37813836] (Bioassay, Mouse)	Bioassay	Mouse
Dissing-Olesen, L;Walker, AJ;Feng, Q;Barr, HJ;Walker, AC;Xie, L;Wilton, DK;Das, I;Benowitz, LI;Stevens, B; FEAST: A flow cytometry-based toolkit for interrogating microglial engulfment of synaptic and myelin proteins Nature communications 2023-09-27 [PMID: 37758703] (Bioassay, Mouse)	Bioassay	Mouse
Rohatgi, N;Zou, W;Li, Y;Cho, K;Collins, PL;Tycksen, E;Pandey, G;DeSelm, CJ;Patti, GJ;Dey, A;Teitelbaum, SL; BAP1 promotes osteoclast function by metabolic reprogramming Nature communications 2023-09-22 [PMID: 37740028] (Bioassay, Mouse)	Bioassay	Mouse
Kim, JA;Lim, S;Ihn, HJ;Kim, JE;Yea, K;Moon, J;Choi, H;Park, EK; Britanin inhibits titanium wear particle?induced osteolysis and osteoclastogenesis Molecular medicine reports 2023-11-01 [PMID: 37732549] (Bioassay, Mouse)	Bioassay	Mouse
Minns, MS;Liboro, K;Lima, TS;Abbondante, S;Miller, BA;Marshall, ME;Tran Chau, J;Roistacher, A;Rietsch, A;Dubyak, GR;Pearlman, E; NLRP3 selectively drives IL-1? secretion by Pseudomonas aeruginosa infected neutrophils and regulates corneal disease severity Nature communications 2023-09-20 [PMID: 37730693] (Bioassay, Mouse)	Bioassay	Mouse
Zhao, L;Song, R;Liu, Y; Glycolytic metabolite phosphoenolpyruvate protects host from viral infection through promoting AATK expression European journal of immunology 2023-09-19 [PMID: 37724936] (Bioassay, Mouse)	Bioassay	Mouse
Sun, H;Wang, S;Tan, W;Li, Y;Ren, Q;Liu, Y;Huang, Y;Shi, C;Li, J; Echinococcus granulosus promotes bone resorption by increasing osteoclasts differentiation Acta tropica 2023-09-16 [PMID: 37722448] (Bioassay, Mouse)	Bioassay	Mouse
Zhang, M;Chen, J;Zhang, H;Dong, H;Yue, Y;Wang, S; Interleukin-10 increases macrophage-mediated chemotherapy resistance via FABP5 signaling in multiple myeloma International immunopharmacology 2023-09-02 [PMID: 37666065] (Bioassay, Mouse)	Bioassay	Mouse
Lee, J;Lee, SA;Son, SH;Choi, JA;Nguyen, TD;Kim, J;Son, D;Song, CH; Impaired mitophagy induces antimicrobial responses in macrophages infected with Mycobacterium tuberculosis Cell & bioscience 2023-08-30 [PMID: 37649112] (Bioassay, Mouse)	Bioassay	Mouse
Maisuria, R;Norton, A;Shao, C;Bradley, EW;Mansky, K; Conditional Loss of MEF2C Expression in Osteoclasts Leads to a Sex-Specific Osteopenic Phenotype International journal of molecular sciences 2023-08-11 [PMID: 37628864] (Cell Culture, Mouse)	Cell Culture	Mouse
Kim, SY;Kim, YJ;Kim, S;Momeni, M;Lee, A;Treanor, A;Kim, S;Kim, RH;Park, NH; GV1001 Inhibits the Severity of the Ligature-Induced Periodontitis and the Vascular Lipid Deposition Associated with the Periodontitis in Mice International journal of molecular sciences 2023-08-08 [PMID: 37628753] (Bioassay, Mouse)	Bioassay	Mouse
Shimizu, K;Kikuta, J;Ohta, Y;Uchida, Y;Miyamoto, Y;Morimoto, A;Yari, S;Sato, T;Kamakura, T;Oshima, K;Imai, R;Liu, YC;Okuzaki, D;Hara, T;Motooka, D;Emoto, N;Inohara, H;Ishii, M; Single-cell transcriptomics of human cholesteatoma identifies an activin A-producing osteoclastogenic fibroblast subset inducing bone destruction Nature communications 2023-08-03 [PMID: 37537159] (Cell Culture, Mouse)	Cell Culture	Mouse
Namangkalakul, W;Nagai, S;Jin, C;Nakahama, KI;Yoshimoto, Y;Ueha, S;Akiyoshi, K;Matsushima, K;Nakashima, T;Takechi, M;Iseki, S; Augmented effect of fibroblast growth factor 18 in bone morphogenetic protein 2-induced calvarial bone healing by activation of CCL2/CCR2 axis on M2 macrophage polarization Journal of tissue engineering 2023-07-26 [PMID: 37529250] (Bioassay, Mouse)	Bioassay	Mouse
Yu, L;Xu, L;Chu, H;Peng, J;Sacharidou, A;Hsieh, HH;Weinstock, A;Khan, S;Ma, L;Durán, JGB;McDonald, J;Nelson, ER;Park, S;McDonnell, DP;Moore, KJ;Huang, LJ;Fisher, EA;Mineo, C;Huang, L;Shaul, PW; Macrophage-to-endothelial cell crosstalk by the cholesterol metabolite 27HC promotes atherosclerosis in male mice Nature communications 2023-07-25 [PMID: 37491347] (Bioassay, Mouse)	Bioassay	Mouse
Desai, S;Lång, P;Näreoja, T;Windahl, SH;Andersson, G; RANKL-dependent osteoclast differentiation and gene expression in bone marrow-derived cells from adult mice is sexually dimorphic Bone reports 2023-12-01 [PMID: 37485233] (Bioassay, Mouse)	Bioassay	Mouse
Fu, J;Li, S;Ma, H;Yang, J;Pagnotti, GM;Brown, LM;Weiss, SJ;Mapara, MY;Lentzsch, S; The checkpoint inhibitor PD-1H/VISTA controls osteoclast-mediated multiple myeloma bone disease Nature communications 2023-07-17 [PMID: 37460553] (Bioassay, Mouse)	Bioassay	Mouse
Toejing, P;Sakunrangsit, N;Pho-On, P;Phetkong, C;Leelahavanichkul, A;Sridurongrit, S;Greenblatt, MB;Lotinun, S; Accelerated Bone Loss in Transgenic Mice Expressing Constitutively Active TGF-beta Receptor Type I International journal of molecular sciences 2023-06-28 [PMID: 37445982] (Bioassay, Mouse)	Bioassay	Mouse
Puppo, M;Valluru, MK;Croset, M;Ceresa, D;Iuliani, M;Khan, A;Wicinski, J;Charafe-Jauffret, E;Ginestier, C;Pantano, F;Ottewell, PD;Clézardin, P; MiR-662 is associated with metastatic relapse in early-stage breast cancer and promotes metastasis by stimulating cancer cell stemness British journal of cancer 2023-07-13 [PMID: 37443350] (Cell Culture)	Cell Culture
Jeong, C;Cho, YJ;Lee, Y;Wang, W;Park, KH;Roh, E;Lee, CH;Son, YJ;Park, JHY;Kang, H;Lee, KW; Discovery and optimized extraction of the anti-osteoclastic agent epicatechin-7-O-beta -D-apiofuranoside from Ulmus macrocarpa Hance bark Scientific reports 2023-07-09 [PMID: 37423923] (Cell Culture, Mouse)	Cell Culture	Mouse
Cheemalavagu, N;Shoger, KE;Cao, YM;Michalides, BA;Botta, SA;Faeder, JR;Gottschalk, RA; Predicting gene level sensitivity to JAK-STAT signaling perturbation using a mechanistic-to-machine learning framework bioRxiv : the preprint server for biology 2023-05-20 [PMID: 37292918] (Bioassay, Mouse)	Bioassay	Mouse
Yang, Q;Guo, J;Zheng, J;Chen, Y;Zou, B;Li, R;Ding, Z;Wang, Y;Li, L;Chen, Z;Mo, L;Liang, Q;Chen, F;Li, X; Polyphyllin VII protects from breast cancer-induced osteolysis by suppressing osteoclastogenesis via c-Fos/NFATc1 signaling International immunopharmacology 2023-05-28 [PMID: 37253315] (Bioassay, Mouse)	Bioassay	Mouse
Banskota, S;Wang, H;Kwon, YH;Gautam, J;Haq, S;Grondin, J;Steinberg, GR;Khan, WI; Inhibition of NADPH Oxidase (NOX) 2 Mitigates Colitis in Mice with Impaired Macrophage AMPK Function Biomedicines 2023-05-14 [PMID: 37239114] (Bioassay, Mouse)	Bioassay	Mouse
Lu, Y;Zhang, H;Pan, H;Zhang, Z;Zeng, H;Xie, H;Yin, J;Tang, W;Lin, R;Zeng, C;Cai, D; Expression pattern analysis of m6A regulators reveals IGF2BP3 as a key modulator in osteoarthritis synovial macrophages Journal of translational medicine 2023-05-22 [PMID: 37217897] (Bioassay, Mouse)	Bioassay	Mouse
Arpa, L;Batlle, C;Jiang, P;Caelles, C;Lloberas, J;Celada, A; Distinct Responses to IL4 in Macrophages Mediated by JNK Cells 2023-04-11 [PMID: 37190036] (Bioassay, Mouse)	Bioassay	Mouse
Kim, SY;Sapkota, A;Bae, YJ;Choi, SH;Bae, HJ;Kim, HJ;Cho, YE;Choi, YY;An, JY;Cho, SY;Hong, SH;Choi, JW;Park, SJ; The Anti-Atopic Dermatitis Effects of Mentha arvensis Essential Oil Are Involved in the Inhibition of the NLRP3 Inflammasome in DNCB-Challenged Atopic Dermatitis BALB/c Mice International journal of molecular sciences 2023-04-23 [PMID: 37175425] (Bioassay, Mouse)	Bioassay	Mouse
Zhao, J;Li, J;Xu, A;Xu, Y;He, F;Mao, Y; IRAK4 inhibition: an effective strategy for immunomodulating peri-implant osseointegration via reciprocally-shifted polarization in the monocyte-macrophage lineage cells BMC oral health 2023-05-08 [PMID: 37158847] (Bioassay, Mouse)	Bioassay	Mouse
Cheu, JW;Chiu, DK;Kwan, KK;Yang, C;Yuen, VW;Goh, CC;Chui, NN;Shen, W;Law, CT;Li, Q;Zhang, MS;Bao, MH;Wong, BP;Chan, CY;Liu, CX;Sit, GF;Ooi, ZY;Deng, H;Tse, AP;Ng, IO;Wong, CC; Hypoxia-inducible factor orchestrates adenosine metabolism to promote liver cancer development Science advances 2023-05-05 [PMID: 37146141] (Bioassay, Mouse)	Bioassay	Mouse
Stavre, Z;Kim, JM;Yang, YS;N�ndel, K;Chaugule, S;Sato, T;Park, KH;Gao, G;Gravallese, EM;Shim, JH; Schnurri-3 inhibition suppresses bone and joint damage in models of rheumatoid arthritis Proceedings of the National Academy of Sciences of the United States of America 2023-05-09 [PMID: 37141171] (Bioassay, Mouse)	Bioassay	Mouse
Y Yu, M Wang, XW Li, J Mao, YJ Zhu, N Wang, LH Yin, ZL Guo, H Cai, T Li, TT Liang, J Cui, T Zhou Meloxicam inhibits STING phosphorylation and alleviates intracellular DNA-mediated autoimmune responses Cell & bioscience, 2023-04-29;13(1):76. 2023-04-29 [PMID: 37120570] (Bioassay, Mouse)	Bioassay	Mouse
X Wang, L Ji, J Wang, C Liu Matrix stiffness regulates osteoclast fate through integrin-dependent mechanotransduction Bioactive materials, 2023-03-30;27(0):138-153. 2023-03-30 [PMID: 37064801] (Bioassay, Mouse)	Bioassay	Mouse
Y Yang, M Li, B Zhou, X Jiang, D Zhang, H Luo Graphene oxide/gallium nanoderivative as a multifunctional modulator of osteoblastogenesis and osteoclastogenesis for the synergistic therapy of implant-related bone infection Bioactive materials, 2022-07-21;25(0):594-614. 2022-07-21 [PMID: 37056253] (Bioassay, Mouse)	Bioassay	Mouse
S MacLauchla, P Kushwaha, A Tai, J Chen, C Manning, G Swarnkar, Y Abu-Amer, KA Fitzgerald, S Sharma, EM Gravallese STING-dependent interferon signatures restrict osteoclast differentiation and bone loss in mice Proceedings of the National Academy of Sciences of the United States of America, 2023-04-06;120(15):e2210409120. 2023-04-06 [PMID: 37023130] (Bioassay, Mouse)	Bioassay	Mouse
L Gu, Z Wang, H Gu, H Wang, L Liu, WB Zhang Atf4 regulates angiogenic differences between alveolar bone and long bone macrophages by regulating M1 polarization, based on single-cell RNA sequencing, RNA-seq and ATAC-seq analysis Journal of Translational Medicine, 2023-03-14;21(1):193. 2023-03-14 [PMID: 36918894] (Bioassay, Mouse)	Bioassay	Mouse
Williams J, Irwin M, Li Y et al. Osteocyte-Derived CaMKK2 Regulates Osteoclasts and Bone Mass in a Sex-Dependent Manner Through Secreted Calpastatin Preprint 2023-02-01 [PMID: 36902150] (Bioassay, Mouse)	Bioassay	Mouse
X Ji, J Hong, W Yang, M Yao, J Wang, G Jiang, Y Wang, C Li, J Lin, H Mou, C Li, S Li, Y Chen, M Shi, W Wang, F Lu, H Wu, X Zhao, Y Qi, S Yan GSTP1-mediated S-glutathionylation of Pik3r1 is a redox hub that inhibits osteoclastogenesis through regulating autophagic flux Redox Biology, 2023-02-27;61(0):102635. 2023-02-27 [PMID: 36870110] (Bioassay, Mouse)	Bioassay	Mouse
MB Kuhn, HS VandenBerg, AJ Reynolds, MD Carson, AJ Warner, AC LaRue, CM Novince, JD Hathaway-S C3a-C3aR signaling is a novel modulator of skeletal homeostasis Bone Reports, 2023-02-16;18(0):101662. 2023-02-16 [PMID: 36860797] (Bioassay, Mouse, Transgenic Mouse)	Bioassay	Mouse, Transgenic Mouse
K Aso, M Kono, M Kanda, Y Kudo, K Sakiyama, R Hisada, K Karino, Y Ueda, D Nakazawa, Y Fujieda, M Kato, O Amengual, T Atsumi Itaconate ameliorates autoimmunity by modulating T cell imbalance via metabolic and epigenetic reprogramming Nature Communications, 2023-02-27;14(1):984. 2023-02-27 [PMID: 36849508] (Bioassay, Mouse)	Bioassay	Mouse
C Xu, SQ Jin, C Jin, ZH Dai, YH Wu, GL He, HW Ma, CY Xu, WL Fang Cedrol, a Ginger-derived sesquiterpineol, suppresses estrogen-deficient osteoporosis by intervening NFATc1 and reactive oxygen species International immunopharmacology, 2023-02-27;117(0):109893. 2023-02-27 [PMID: 36842234] (Bioassay, Mouse)	Bioassay	Mouse
DM Cauvi, D Hawisher, J Derunes, A De Maio Phosphatidylcholine Liposomes Reprogram Macrophages toward an Inflammatory Phenotype Membranes, 2023-01-21;13(2):. 2023-01-21 [PMID: 36837644] (Bioassay, Mouse)	Bioassay	Mouse
JY Ko, FS Wang, SH Chen, SJ Kuo Micro Ribonucleic Acid-29a (miR-29a) Antagonist Normalizes Bone Metabolism in Osteogenesis Imperfecta (OI) Mice Model Biomedicines, 2023-02-05;11(2):. 2023-02-05 [PMID: 36831000] (Bioassay, Mouse)	Bioassay	Mouse
H Lee, E Kim, S Kim miRNA-Induced Downregulation of IPMK in Macrophages Mediates Lipopolysaccharide-Triggered TLR4 Signaling Biomolecules, 2023-02-09;13(2):. 2023-02-09 [PMID: 36830701] (Bioassay, Mouse)	Bioassay	Mouse
PY Ng, ABP Ribet, Q Guo, BH Mullin, JWY Tan, E Landao-Bas, S Stephens, K Chen, J Yuan, L Abudulai, M Bollen, ETTT Nguyen, J Kular, JM Papadimitr, K Søe, RD Teasdale, J Xu, RG Parton, H Takayanagi, NJ Pavlos Sugar transporter Slc37a2 regulates bone metabolism in mice via a tubular lysosomal network in osteoclasts Nature Communications, 2023-02-21;14(1):906. 2023-02-21 [PMID: 36810735] (Bioassay, Mouse)	Bioassay	Mouse
H Hu, X Wang, Y Huang, B He, J Zhu, K Sun, C Deng, Y Guo, D Hao, B Jian Obacunone inhibits RANKL/M-CSF-mediated osteoclastogenesis by suppressing integrin- FAK-Src signaling Cytokine, 2023-02-15;164(0):156134. 2023-02-15 [PMID: 36804257] (Bioassay, Mouse)	Bioassay	Mouse
J Guo, R Ren, Z Guo, K Sun, J He, J Shao, X Wang Probucol suppresses osteoclastogenesis via activating Nrf2 signaling and ameliorates ovariectomy-induced bone loss International immunopharmacology, 2023-02-07;116(0):109820. 2023-02-07 [PMID: 36758295] (Bioassay, Mouse)	Bioassay	Mouse
N Beckmann, A Neuhaus, S Zurbruegg, P Volkmer, C Patino, S Joller, D Feuerbach, A Doelemeyer, T Schweizer, S Rudin, U Neumann, R Berth, W Frieauff, F Gasparini, DR Shimshek Genetic models of cleavage-reduced and soluble TREM2 reveal distinct effects on myelination and microglia function in the cuprizone model Journal of Neuroinflammation, 2023-02-08;20(1):29. 2023-02-08 [PMID: 36755323] (Bioassay, Mouse)	Bioassay	Mouse
S De Scheppe, JZ Ge, G Crowley, LSS Ferreira, D Garceau, CE Toomey, D Sokolova, J Rueda-Carr, SH Shin, JS Kim, T Childs, T Lashley, JJ Burden, M Sasner, C Sala Frige, S Jung, S Hong Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer's disease Nature Neuroscience, 2023-02-06;0(0):. 2023-02-06 [PMID: 36747024] (Bioassay, Mouse)	Bioassay	Mouse
P Silwal, YJ Kim, YJ Lee, IS Kim, SM Jeon, T Roh, JK Kim, MJ Lee, JY Heo, DS Jo, SH Lee, DH Cho, JM Kim, YT Kwon, EK Jo Chemical mimetics of the N-degron pathway alleviate systemic inflammation by activating mitophagy and immunometabolic remodeling Experimental & Molecular Medicine, 2023-02-01;0(0):. 2023-02-01 [PMID: 36720915] (Bioassay, Mouse)	Bioassay	Mouse
X Hu, SW Wong, K Liang, TH Wu, S Wang, L Wang, J Liu, M Yamauchi, BL Foster, JP Ting, B Zhao, HC Tseng, CC Ko Optineurin regulates NRF2-mediated antioxidant response in a mouse model of Paget's disease of bone Science Advances, 2023-01-27;9(4):eade6998. 2023-01-27 [PMID: 36706179] (Bioassay, Mouse)	Bioassay	Mouse
Y Wang, Z Zhong, M Ma, Y Zhao, C Zhang, Z Qian, B Wang The role played by ailanthone in inhibiting bone metastasis of breast cancer by regulating tumor-bone microenvironment through the RANKL-dependent pathway Frontiers in Pharmacology, 2023-01-05;13(0):1081978. 2023-01-05 [PMID: 36686653] (Cell Culture, Mouse)	Cell Culture	Mouse
Z Wu, X Li, X Chen, X He, Y Chen, L Zhang, Z Li, M Yang, G Yuan, B Shi, N Chen, N Li, H Feng, M Zhou, G Rui, F Xu, R Xu Phosphatidyl Inositol 3-Kinase (PI3K)-Inhibitor CDZ173 protects against LPS-induced osteolysis Frontiers in Pharmacology, 2023-01-06;13(0):1021714. 2023-01-06 [PMID: 36686650] (Cell Culture, Mouse)	Cell Culture	Mouse
F Wang, P Yang, T Wan, C Liu, Y Zhu, X Chen, H Liu Osthole Inhibits M1 Macrophage Polarization and Attenuates Osteolysis in a Mouse Skull Model Oxidative Medicine and Cellular Longevity, 2023-01-12;2023(0):2975193. 2023-01-12 [PMID: 36686380]
J Zhu, Y Ma, J Wang, Y Wang, W Ali, H Zou, H Zhao, X Tong, R Song, Z Liu The Mechanism of Osteoprotegerin-Induced Osteoclast Pyroptosis In Vitro International Journal of Molecular Sciences, 2023-01-12;24(2):. 2023-01-12 [PMID: 36675029] (Cell Culture, Mouse)	Cell Culture	Mouse
J He, L Zheng, X Li, F Huang, S Hu, L Chen, M Jiang, X Lin, H Jiang, Y Zeng, T Ye, D Lin, Q Liu, J Xu, K Chen Obacunone targets macrophage migration inhibitory factor (MIF) to impede osteoclastogenesis and alleviate ovariectomy-induced bone loss Journal of advanced research, 2023-01-16;0(0):. 2023-01-16 [PMID: 36657717] (Bioassay, Mouse)	Bioassay	Mouse
W Zhan, B Ruan, H Dong, C Wang, S Wu, H Yu, X Xu, H Sun, J Cai Isopsoralen suppresses receptor activator of nuclear factor kappa-beta ligand-induced osteoclastogenesis by inhibiting the NF-kappaB signaling PeerJ, 2023-01-10;11(0):e14560. 2023-01-10 [PMID: 36643647] (Bioassay, Mouse)	Bioassay	Mouse
Y Fukawa, K Kayamori, M Tsuchiya, T Ikeda IL-1 Generated by Oral Squamous Cell Carcinoma Stimulates Tumor-Induced and RANKL-Induced Osteoclastogenesis: A Possible Mechanism of Bone Resorption Induced by the Infiltration of Oral Squamous Cell Carcinoma International Journal of Molecular Sciences, 2022-12-30;24(1):. 2022-12-30 [PMID: 36614130] (Cell Culture, Mouse)	Cell Culture	Mouse
J Wang, K Mao, X Cong, H Tan, C Wu, Z Hu, YG Yang, T Sun Nanoparticle delivery of CD40 siRNA suppresses alloimmune responses by inhibiting activation and differentiation of DCs and macrophages Science Advances, 2022-12-21;8(51):eabq3699. 2022-12-21 [PMID: 36542700] (Cell Culture, Mouse)	Cell Culture	Mouse
X Sun, Y Ni, Q Lu, Y Liang, M Gu, X Xue, C Dai Mechanistic target of rapamycin complex 1 orchestrates the interplay between hepatocytes and Kupffer cells to determine the outcome of immune-mediated hepatitis Cell Death & Disease, 2022-12-09;13(12):1031. 2022-12-09 [PMID: 36494334] (Bioassay, Mouse)	Bioassay	Mouse
JM Han, HY Song, KI Kim, WY Park, SH Park, EB Byun, EH Byun Polysaccharides from Annonaï¿½muricata leaves protect against cisplatin?induced cytotoxicity in macrophages by alleviating mitochondrial dysfunction Molecular Medicine Reports, 2022-12-01;27(1):. 2022-12-01 [PMID: 36453199] (Bioassay, Mouse)	Bioassay	Mouse
SMT Rahman, M Aqdas, EW Martin, F Tomassoni, P Songkiatis, KS Oh, S Uderhardt, S Yun, QC Claybourne, RA McDevitt, V Greco, RN Germain, L Tessarollo, MH Sung Double knockin mice show NF-kappaB trajectories in immune signaling and aging Cell Reports, 2022-11-22;41(8):111682. 2022-11-22 [PMID: 36417863] (Bioassay, Transgenic Mouse)	Bioassay	Transgenic Mouse
G Qi, Z Jiang, W Lu, D Li, W Chen, X Yang, L Ding, H Yuan Berbamine inhibits RANKL- and M-CSF-mediated osteoclastogenesis and alleviates ovariectomy-induced bone loss Frontiers in Pharmacology, 2022-11-02;13(0):1032866. 2022-11-02 [PMID: 36408260] (Bioassay, Mouse)	Bioassay	Mouse
H Yeh, M Woodbury, K Ingraham-D, T Ikezu, S Ikezu Microglial WNT5A supports dendritic spines maturation and neuronal firing Brain, Behavior, and Immunity, 2022-11-15;0(0):. 2022-11-15 [PMID: 36395958] (Bioassay, Mouse)	Bioassay	Mouse
Y Cheng, H Liu, J Li, Y Ma, C Song, Y Wang, P Li, Y Chen, Z Zhang Evaluation of culture conditions for osteoclastogenesis in RAW264.7 cells PLoS ONE, 2022-11-17;17(11):e0277871. 2022-11-17 [PMID: 36395187] (Bioassay, Mouse)	Bioassay	Mouse
CY Chang, R You, D Armstrong, A Bandi, YT Cheng, PM Burkhardt, L Becerra-Do, MC Madison, HY Tung, Z Zeng, Y Wu, L Song, PE Phillips, P Porter, JM Knight, N Putluri, X Yuan, DC Marcano, EA McHugh, JM Tour, A Catic, L Maneix, BM Burt, HS Lee, DB Corry, F Kheradmand Chronic exposure to carbon black ultrafine particles reprograms macrophage metabolism and accelerates lung cancer Science Advances, 2022-11-16;8(46):eabq0615. 2022-11-16 [PMID: 36383649] (Bioassay, Transgenic Mouse)	Bioassay	Transgenic Mouse
C Lin, Q Yang, D Guo, J Xie, YS Yang, S Chaugule, N DeSouza, WT Oh, R Li, Z Chen, AA John, Q Qiu, LJ Zhu, MB Greenblatt, S Ghosh, S Li, G Gao, C Haynes, CP Emerson, JH Shim Impaired mitochondrial oxidative metabolism in skeletal progenitor cells leads to musculoskeletal disintegration Nature Communications, 2022-11-11;13(1):6869. 2022-11-11 [PMID: 36369293] (Bioassay, Mouse)	Bioassay	Mouse
G Li, JN Park, HJ Park, JH Suh, HS Choi High Cholesterol-Induced Bone Loss Is Attenuated by Arctiin via an Action in Osteoclasts Nutrients, 2022-10-25;14(21):. 2022-10-25 [PMID: 36364745] (Bioassay, Mouse)	Bioassay	Mouse
HK Kwon, KE Yu, SV Cahill, KD Alder, CM Dussik, SH Kim, L Sharma, J Back, I Oh, FY Lee Concurrent targeting of glycolysis in bacteria and host cell inflammation in septic arthritis Embo Molecular Medicine, 2022-11-10;0(0):e15284. 2022-11-10 [PMID: 36354099] (Bioassay, Mouse)	Bioassay	Mouse
C Drakeford, S Aguila, F Roche, K Hokamp, J Fazavana, MP Cervantes, AM Curtis, HC Hawerkamp, SPS Dhami, H Charles-Me, EE Hackett, A Chion, S Ward, A Ahmad, I Schoen, E Breen, J Keane, R Murphy, RJS Preston, JM O'Sullivan, FJ Sheedy, P Fallon, JS O'Donnell von Willebrand factor links primary hemostasis to innate immunity Nature Communications, 2022-11-03;13(1):6320. 2022-11-03 [PMID: 36329021] (Bioassay, Mouse)	Bioassay	Mouse
K Nagano, K Yamana, H Saito, R Kiviranta, AC Pedroni, D Raval, C Niehrs, F Gori, R Baron R-spondin 3 deletion induces Erk phosphorylation to enhance Wnt signaling and promote bone formation in the appendicular skeleton Elife, 2022-11-02;11(0):. 2022-11-02 [PMID: 36321691] (Bioassay, Mouse)	Bioassay	Mouse
JC Bahr, XY Li, TY Feinberg, L Jiang, SJ Weiss Divergent regulation of basement membrane trafficking by human macrophages and cancer cells Nature Communications, 2022-10-27;13(1):6409. 2022-10-27 [PMID: 36302921] (Bioassay, Mouse)	Bioassay	Mouse
MH Wu, WB Hsu, MH Chen, CS Shi Inhibition of Neddylation Suppresses Osteoclast Differentiation and Function In Vitro and Alleviates Osteoporosis In Vivo Biomedicines, 2022-09-21;10(10):. 2022-09-21 [PMID: 36289618] (Bioassay, Mouse)	Bioassay	Mouse
Z Hu, Y Li, W Yuan, L Jin, WK Leung, C Zhang, Y Yang N6-methyladenosine of Socs1 modulates macrophage inflammatory response in different stiffness environments International journal of biological sciences, 2022-09-11;18(15):5753-5769. 2022-09-11 [PMID: 36263168] (Bioassay, Mouse)	Bioassay	Mouse
F Zhao, J He, J Tang, N Cui, Y Shi, Z Li, S Liu, Y Wang, M Ma, C Zhao, L Luo, L Li Brain milieu induces early microglial maturation through the BAX-Notch axis Nature Communications, 2022-10-17;13(1):6117. 2022-10-17 [PMID: 36253375] (Bioassay, Mouse)	Bioassay	Mouse
AP Shaik, AS Shaik, M Abudawood, A Al Faraj Detection of Radiolabeled Inflammatory Cell Macrophage Subpopulations in Chronic Respiratory Diseases: Results from Preliminary Analyses BioMed Research International, 2022-10-06;2022(0):9470845. 2022-10-06 [PMID: 36246991] (Bioassay, Mouse)	Bioassay	Mouse
JX Sun, KY Zhu, YM Wang, DJ Wang, MZ Zhang, H Sarlus, I Benito-Cue, XQ Zhao, ZF Zou, QY Zhong, Y Feng, S Wu, YQ Wang, RA Harris, J Wang Activation of TRPV1 receptor facilitates myelin repair following demyelination via the regulation of microglial function Acta pharmacologica Sinica, 2022-10-13;0(0):. 2022-10-13 [PMID: 36229601] (Mouse)		Mouse
M Tomimatsu, K Matsumoto, M Ashizuka, S Kumagai, S Tanaka, T Nakae, K Yokota, S Kominami, R Kajiura, D Okuzaki, D Motooka, A Shiraishi, T Abe, H Matsuda, Y Okada, M Maeda, S Seno, M Obana, Y Fujio Myeloid cell-specific ablation of Runx2 gene exacerbates post-infarct cardiac remodeling Scientific Reports, 2022-10-05;12(1):16656. 2022-10-05 [PMID: 36198906] (Cell Culture, Mouse)	Cell Culture	Mouse
Q Li, T Yue, X Du, Z Tang, J Cui, W Wang, W Xia, B Ren, S Kan, C Li, C Wu, X Niu, B Li, K Lin, J Luo, G Chen, Z Wang HSC70 mediated autophagic degradation of oxidized PRL2 is responsible for osteoclastogenesis and inflammatory bone destruction Cell Death and Differentiation, 2022-10-01;0(0):. 2022-10-01 [PMID: 36182990] (Bioassay, Mouse)	Bioassay	Mouse
W Zhu, W Liang, H Lu, L Chang, J Zhang, YE Chen, Y Guo Myeloid TM6SF2 Deficiency Inhibits Atherosclerosis Cells, 2022-09-15;11(18):. 2022-09-15 [PMID: 36139452] (Bioassay, Mouse)	Bioassay	Mouse
J Zhang, S Xu, K Liang, X Cao, Z Ye, W Huang, X Bai, Y Zhang LysM-positive neurons drive Tuberous Sclerosis Complex (TSC)-associated brain lesions Cellular Signalling, 2022-09-15;0(0):110468. 2022-09-15 [PMID: 36115548] (Bioassay, Mouse)	Bioassay	Mouse
T Uchikawa, T Matoba, T Kawahara, I Baba, S Katsuki, JI Koga, Y Hashimoto, R Yamasaki, I Ichi, H Akita, H Tsutsui Dietary 7-ketocholesterol exacerbates myocardial ischemia-reperfusion injury in mice through monocyte/macrophage-mediated inflammation Scientific Reports, 2022-09-01;12(1):14902. 2022-09-01 [PMID: 36050346] (Cell Culture, Mouse)	Cell Culture	Mouse
YF Wang, L Yu, ZL Hu, YF Fang, YY Shen, MF Song, Y Chen Regulation of CCL2 by EZH2 affects tumor-associated macrophages polarization and infiltration in breast cancer Cell Death & Disease, 2022-08-29;13(8):748. 2022-08-29 [PMID: 36038549] (Bioassay, Mouse)	Bioassay	Mouse
J Zhou, Y Mao, X Shi, Y Zhang, X Yu, X Liu, L Diao, X Yang, C Liu, D Liu, X Tan, M Liu Peimine suppresses collagen-induced arthritis, activated fibroblast-like synoviocytes and TNFalpha-induced MAPK pathways International immunopharmacology, 2022-08-24;111(0):109181. 2022-08-24 [PMID: 36027853] (Bioassay, Mouse)	Bioassay	Mouse
M Jiang, ZG Chen, H Li, TT Zhang, MJ Yang, XX Peng, B Peng Succinate and inosine coordinate innate immune response to bacterial infection PloS Pathogens, 2022-08-26;18(8):e1010796. 2022-08-26 [PMID: 36026499] (Cell Culture, Mouse)	Cell Culture	Mouse
Y Inoue, CW Liao, Y Tsunakawa, IL Tsai, S Takahashi, M Hamada Macrophage-Specific, Mafb-Deficient Mice Showed Delayed Skin Wound Healing International Journal of Molecular Sciences, 2022-08-19;23(16):. 2022-08-19 [PMID: 36012611] (Cell Culture, Mouse)	Cell Culture	Mouse
W Chen, P Tang, S Fan, X Jiang A Novel Inhibitor INF 39 Promotes Osteogenesis via Blocking the NLRP3/IL-1beta Axis BioMed Research International, 2022-07-13;2022(0):7250578. 2022-07-13 [PMID: 35872849] (Bioassay, Mouse)	Bioassay	Mouse
Y Wu, H Wen, ZJ Bernstein, KM Hainline, TS Blakney, KL Congdon, DJ Snyder, JH Sampson, L Sanchez-Pe, JH Collier Multiepitope supramolecular peptide nanofibers eliciting coordinated humoral and cellular antitumor immune responses Science Advances, 2022-07-20;8(29):eabm7833. 2022-07-20 [PMID: 35857833] (Bioassay, Mouse)	Bioassay	Mouse
M Tsukasaki, N Komatsu, T Negishi-Ko, NC Huynh, R Muro, Y Ando, Y Seki, A Terashima, W Pluemsakun, T Nitta, T Nakamura, T Nakashima, S Ohba, H Akiyama, K Okamoto, R Baron, H Takayanagi Periosteal stem cells control growth plate stem cells during postnatal skeletal growth Oncogene, 2022-07-18;13(1):4166. 2022-07-18 [PMID: 35851381] (Bioassay, Mouse)	Bioassay	Mouse
T Shi, Y Shi, H Gao, Y Ma, Q Wang, S Shen, X Shao, W Gong, X Chen, J Qin, J Wu, Q Jiang, B Xue Exercised accelerated the production of muscle-derived kynurenic acid in skeletal muscle and alleviated the postmenopausal osteoporosis through the Gpr35/NFkappaB p65 pathway Journal of Orthopaedic Translation, 2022-04-04;35(0):1-12. 2022-04-04 [PMID: 35846727] (Bioassay, Mouse)	Bioassay	Mouse
J Zhou, L Guo, Y Yang, Y Liu, C Zhang Mechanical force regulates root resorption in rats through RANKL and OPG BMC Oral Health, 2022-07-16;22(1):290. 2022-07-16 [PMID: 35842599] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
R Guo, X Jia, Z Ding, G Wang, M Jiang, B Li, S Chen, B Xia, Q Zhang, J Liu, R Zheng, Z Gao, X Xie Loss of MLKL ameliorates liver fibrosis by inhibiting hepatocyte necroptosis and hepatic stellate cell activation Theranostics, 2022-07-04;12(11):5220-5236. 2022-07-04 [PMID: 35836819] (Bioassay, Mouse)	Bioassay	Mouse
J Zou, W Tan, B Li, Z Wang, Y Li, J Zeng, B Jiang, S Yoshida, Y Zhou Interleukin-19 Promotes Retinal Neovascularization in a Mouse Model of Oxygen-Induced Retinopathy Investigative Ophthalmology & Visual Science, 2022-07-08;63(8):9. 2022-07-08 [PMID: 35816041] (Bioassay, Mouse)	Bioassay	Mouse
T Hoyler, B Bannert, C André, D Beck, T Boulay, D Buffet, N Caesar, T Calzascia, J Dawson, D Kyburz, R Hennze, C Huppertz, A Littlewood, P Loetscher, KD Mertz, S Niwa, G Robert, JS Rush, G Ruzzante, S Sarret, T Stein, I Touil, G Wieczorek, G Zipfel, S Hawtin, T Junt Nonhematopoietic IRAK1 drives arthritis via neutrophil chemoattractants JCI Insight, 2022-07-08;7(13):. 2022-07-08 [PMID: 35801586] (Bioassay, Mouse)	Bioassay	Mouse
Z Jie, S Wang, Q Ma, Y Shen, X Zhao, H Yu, Z Xie, C Jiang Pexmetinib suppresses osteoclast formation and breast cancer induced osteolysis via P38/STAT3 signal pathway Journal of Bone Oncology, 2022-06-11;35(0):100439. 2022-06-11 [PMID: 35800294] (Bioassay, Mouse)	Bioassay	Mouse
Q Wang, H Wang, H Yan, H Tian, Y Wang, W Yu, Z Dai, P Chen, Z Liu, R Tang, C Jiang, S Fan, X Liu, X Lin Suppression of osteoclast multinucleation via a posttranscriptional regulation-based spatiotemporally selective delivery system Oncogene, 2022-06-29;8(26):eabn3333. 2022-06-29 [PMID: 35767605] (Bioassay, Mouse)	Bioassay	Mouse
H Qu, R Heinbäck, H Salo, E Ewing, A Espinosa, C Aulin, H Erlandsson Transcriptomic Profiling Reveals That HMGB1 Induces Macrophage Polarization Different from Classical M1 Biomolecules, 2022-06-02;12(6):. 2022-06-02 [PMID: 35740904] (Bioassay, Mouse)	Bioassay	Mouse
D Azimova, N Herrera, L Duvenage, M Voorhies, RA Rodriguez, BC English, JC Hoving, O Rosenberg, A Sil Cbp1, a fungal virulence factor under positive selection, forms an effector complex that drives macrophage lysis Oncogene, 2022-06-22;18(6):e1010417. 2022-06-22 [PMID: 35731824] (Bioassay, Mouse)	Bioassay	Mouse
Y Tian, J Ming Melatonin inhibits osteoclastogenesis via RANKL/OPG suppression mediated by Rev-Erbalpha in osteoblasts Oncogene, 2022-06-21;0(0):. 2022-06-21 [PMID: 35726597] (Bioassay, Mouse)	Bioassay	Mouse
G Cai, Y Xiao, M Yang, Q Guo, T Su, Y Liu, T Jiang, C Li Long noncoding RNA Gm31629 promotes bone regeneration by maintaining bone marrow mesenchymal stem cells activity PeerJ, 2022-06-09;10(0):e13475. 2022-06-09 [PMID: 35702257] (Bioassay, Mouse)	Bioassay	Mouse
H Li, D Qiu, Y Yuan, X Wang, F Wu, H Yang, S Wang, M Ma, Y Qian, B Zhan, X Yang Trichinella spiralis cystatin alleviates polymicrobial sepsis through activating regulatory macrophages Oncogene, 2022-06-09;109(0):108907. 2022-06-09 [PMID: 35691271] (Bioassay, Mouse)	Bioassay	Mouse
MI Alam, M Mae, F Farhana, M Oohira, Y Yamashita, Y Ozaki, E Sakai, A Yoshimura NLRP3 Inflammasome Negatively Regulates RANKL-Induced Osteoclastogenesis of Mouse Bone Marrow Macrophages but Positively Regulates It in the Presence of Lipopolysaccharides Oncogene, 2022-05-29;23(11):. 2022-05-29 [PMID: 35682777] (Bioassay, Mouse)	Bioassay	Mouse
S Lin, A Zhang, L Yuan, Y Wang, C Zhang, J Jiang, H Xu, H Yuan, H Yao, Q Zhang, Y Zhang, M Lou, P Wang, ZN Zhang, B Luan Targeting parvalbumin promotes M2 macrophage polarization and energy expenditure in mice Nature Communications, 2022-06-08;13(1):3301. 2022-06-08 [PMID: 35676256] (Bioassay, Mouse)	Bioassay	Mouse
H Tao, Y Tao, C Yang, W Li, W Zhang, X Li, Y Gu, Y Hong, H Yang, Y Liu, X Yang, D Geng Gut Metabolite Urolithin A Inhibits Osteoclastogenesis and Senile Osteoporosis by Enhancing the Autophagy Capacity of Bone Marrow Macrophages Frontiers in Pharmacology, 2022-05-12;13(0):875611. 2022-05-12 [PMID: 35645801] (Cell Culture, Mouse)	Cell Culture	Mouse
T Ishii, M Ruiz-Torru, K Yamamoto, T Yamaguchi, A Heidari, R Pierrelus, E Leon, S Shindo, M Rawas-Qala, MR Pastore, A Ikeda, S Nakamura, H Mawardi, U Kandalam, P Hardigan, L Witek, PG Coelho, T Kawai Locally Secreted Semaphorin 4D Is Engaged in Both Pathogenic Bone Resorption and Retarded Bone Regeneration in a Ligature-Induced Mouse Model of Periodontitis International Journal of Molecular Sciences, 2022-05-18;23(10):. 2022-05-18 [PMID: 35628440] (Bioassay, Mouse)	Bioassay	Mouse
Y Zhang, M Yang, S Zhang, Z Yang, Y Zhu, Y Wang, Z Chen, X Lv, Z Huang, Y Xie, L Cai BHLHE40 promotes osteoclastogenesis and abnormal bone resorption via c-Fos/NFATc1 Cell & bioscience, 2022-05-26;12(1):70. 2022-05-26 [PMID: 35619122] (Bioassay, Mouse)	Bioassay	Mouse
W Sun, S Guo, Y Li, J Li, C Liu, Y Chen, X Wang, Y Tan, H Tian, C Wang, R Du, G Zhong, S Shi, B Ma, C Qu, J Fu, X Jin, D Zhao, Y Zhan, S Ling, H An, Y Li Anoctamin 1 controls bone resorption by coupling Cl- channel activation with RANKL-RANK signaling transduction Nature Communications, 2022-05-24;13(1):2899. 2022-05-24 [PMID: 35610255] (Bioassay, Mouse)	Bioassay	Mouse
P Cai, S Yan, Y Lu, X Zhou, X Wang, M Wang, Z Yin Carnosol inhibits osteoclastogenesis inï¿½vivo and inï¿½vitro by blocking the RANKL?induced NF?kappaB signaling pathway Molecular Medicine Reports, 2022-05-20;26(1):. 2022-05-20 [PMID: 35593299] (Bioassay, Mouse)	Bioassay	Mouse
N Matsumoto, M Sekiya, GH Sun-Wada, Y Wada, M Nakanishi- The lysosomal V-ATPase a3 subunit is involved in localization of Mon1-Ccz1, the GEF for Rab7, to secretory lysosomes in osteoclasts Scientific Reports, 2022-05-19;12(1):8455. 2022-05-19 [PMID: 35589873] (Bioassay, Mouse)	Bioassay	Mouse
Z Cui, C Feng, J Chen, Y Wang, Q Meng, S Zhao, Y Zhang, D Feng, Z Li, S Sun Network Pharmacology Deciphers the Action of Bioactive Polypeptide in Attenuating Inflammatory Osteolysis via the Suppression of Oxidative Stress and Restoration of Bone Remodeling Balance Oxidative Medicine and Cellular Longevity, 2022-04-14;2022(0):4913534. 2022-04-14 [PMID: 35578727] (Bioassay, Mouse)	Bioassay	Mouse
X Chen, C Li, X Cao, X Jia, X Chen, Z Wang, W Xu, F Dai, S Zhang Mitochondria-targeted supramolecular coordination container encapsulated with exogenous itaconate for synergistic therapy of joint inflammation Theranostics, 2022-04-04;12(7):3251-3272. 2022-04-04 [PMID: 35547753] (Bioassay, Mouse)	Bioassay	Mouse
W Yang, WG Robichaux, FC Mei, W Lin, L Li, S Pan, MA White, Y Chen, X Cheng Epac1 activation by cAMP regulates cellular SUMOylation and promotes the formation of biomolecular condensates Science Advances, 2022-04-20;8(16):eabm2960. 2022-04-20 [PMID: 35442725] (Bioassay, Mouse)	Bioassay	Mouse
Y Gao, H Jin, H Tan, X Cai, Y Sun Erythrocyte-derived extracellular vesicles aggravate inflammation by promoting the proinflammatory macrophage phenotype through TLR4-MyD88-NF-kappaB-MAPK pathway Journal of leukocyte biology, 2022-04-12;0(0):. 2022-04-12 [PMID: 35411633] (Cell Culture, Mouse)	Cell Culture	Mouse
G Li, OJ Sul, R Yu, HS Choi 7-Ketocholesterol-Induced Micro-RNA-107-5p Increases Number and Activity of Osteoclasts by Targeting MKP1 International Journal of Molecular Sciences, 2022-03-28;23(7):. 2022-03-28 [PMID: 35409056] (Cell Culture, Mouse)	Cell Culture	Mouse
T Akasaka, H Hayashi, M Tamai, Y Yoshimura, YI Tagawa, H Miyaji, K Nakanishi, Y Yoshida Osteoclast formation from mouse bone marrow cells on micro/nano-scale patterned surfaces Journal of oral biosciences, 2022-04-07;0(0):. 2022-04-07 [PMID: 35398598] (Bioassay, Mouse)	Bioassay	Mouse
YJ Lee, JK Kim, CH Jung, YJ Kim, EJ Jung, SH Lee, HR Choi, YS Son, SM Shim, SM Jeon, JH Choe, SH Lee, J Whang, KC Sohn, GM Hur, HT Kim, J Yeom, EK Jo, YT Kwon Chemical Modulation of SQSTM1/p62-mediated Xenophagy that Targets a Broad Range of Pathogenic Bacteria Autophagy, 2022-04-05;0(0):. 2022-04-05 [PMID: 35316156] (Cell Culture, Human)	Cell Culture	Human
X Liu, L Diao, Y Zhang, X Yang, J Zhou, Y Mao, X Shi, F Zhao, M Liu Piperlongumine Inhibits Titanium Particles-Induced Osteolysis, Osteoclast Formation, and RANKL-Induced Signaling Pathways International Journal of Molecular Sciences, 2022-03-05;23(5):. 2022-03-05 [PMID: 35270008] (Bioassay, Mouse)	Bioassay	Mouse
Y Ma, R Di, H Zhao, R Song, H Zou, Z Liu P2X7 receptor knockdown suppresses osteoclast differentiation by inhibiting autophagy and Ca2+/calcineurin signaling Molecular Medicine Reports, 2022-03-10;25(5):. 2022-03-10 [PMID: 35266012] (Cell Culture, Mouse)	Cell Culture	Mouse
Q Guo, H Zhao, H Cheng, H Kang, Y Dong, R Peng, M Zhu, Z Fang, F Li Mitochondrial pyruvate carrier blockade results in decreased osteoclastogenesis and bone resorption via regulating mitochondrial energy production The Journal of Biological Chemistry, 2022-03-04;0(0):101775. 2022-03-04 [PMID: 35257748] (Bioassay, Mouse)	Bioassay	Mouse
H Zuo, Y Wan Inhibition of myeloid PD-L1 suppresses osteoclastogenesis and cancer bone metastasis Cancer Gene Therapy, 2022-03-07;0(0):. 2022-03-07 [PMID: 35256753] (Bioassay, Mouse)	Bioassay	Mouse
C Yang, H Tao, H Zhang, Y Xia, J Bai, G Ge, W Li, W Zhang, L Xiao, Y Xu, Z Wang, Y Gu, H Yang, Y Liu, D Geng TET2 regulates osteoclastogenesis by modulating autophagy in OVX-induced bone loss Autophagy, 2022-03-24;0(0):. 2022-03-24 [PMID: 35255774] (Cell Culture, Mouse)	Cell Culture	Mouse
G Shen, X Liu, W Lei, R Duan, Z Yao Plumbagin is a NF-kappaB-Inducing Kinase Inhibitor with Dual Anabolic and Anti-Resorptive Effects that Prevents Menopausal-Related Osteoporosis in Mice The Journal of Biological Chemistry, 2022-02-27;0(0):101767. 2022-02-27 [PMID: 35235833] (Bioassay, Mouse)	Bioassay	Mouse
V Mela, A Sayd Gaban, E O'Neill, S Bechet, A Walsh, MA Lynch The Modulatory Effects of DMF on Microglia in Aged Mice Are Sex-Specific Cells, 2022-02-18;11(4):. 2022-02-18 [PMID: 35203379] (Bioassay, Mouse)	Bioassay	Mouse
JM Kim, YS Yang, J Xie, O Lee, J Kim, J Hong, B Boldyreff, O Filhol, H Chun, MB Greenblatt, G Gao, JH Shim Regulation of sclerostin by the SIRT1 stabilization pathway in osteocytes Cell Death and Differentiation, 2022-02-15;0(0):. 2022-02-15 [PMID: 35169297] (Bioassay, Mouse)	Bioassay	Mouse
J Fierro, J DiPasquale, J Perez, B Chin, Y Chokpapone, AM Tran, A Holden, C Factoriza, N Sivagnanak, R Aguilar, S Mazal, M Lopez, H Dou Dual-sgRNA CRISPR/Cas9 knockout of PD-L1 in human U87 glioblastoma tumor cells inhibits proliferation, invasion, and tumor-associated macrophage polarization Scientific Reports, 2022-02-14;12(1):2417. 2022-02-14 [PMID: 35165339] (Bioassay, Mouse)	Bioassay	Mouse
ZI Mendel, MB Reynolds, BH Abuaita, MX O'Riordan, JA Swanson Amino acids suppress macropinocytosis and promote release of CSF1 receptor in macrophages Journal of Cell Science, 2022-02-21;0(0):. 2022-02-21 [PMID: 35107133] (Cell Culture, Mouse)	Cell Culture	Mouse
W Qiao, D Pan, Y Zheng, S Wu, X Liu, Z Chen, M Wan, S Feng, KMC Cheung, KWK Yeung, X Cao Divalent metal cations stimulate skeleton interoception for new bone formation in mouse injury models Nature Communications, 2022-01-27;13(1):535. 2022-01-27 [PMID: 35087048] (Bioassay, Mouse)	Bioassay	Mouse
KK Richardson, W Ling, K Krager, Q Fu, SD Byrum, R Pathak, N Aykin-Burn, HN Kim Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice International Journal of Molecular Sciences, 2022-01-08;23(2):. 2022-01-08 [PMID: 35054859] (Bioassay, Mouse)	Bioassay	Mouse
SW Shin, YS Hwang Anti-Periodontitis Effect of Ethanol Extracts of Alpinia Katsumadai Seeds Nutrients, 2021-12-28;14(1):. 2021-12-28 [PMID: 35011011] (Bioassay, Mouse)	Bioassay	Mouse
Y Fang, Y Liu, Z Zhao, Y Lu, X Shen, T Zhu, M Hou, F He, H Yang, Y Zhang, Q Shi, X Zhu Bortezomib Rescues Ovariectomy-Induced Bone Loss via SMURF-Mediated Ubiquitination Pathway Oxidative Medicine and Cellular Longevity, 2021-12-31;2021(0):9661200. 2021-12-31 [PMID: 35003523] (Bioassay, Mouse)	Bioassay	Mouse
SJ Hwang, BJ Ahn, MW Shin, YS Song, Y Choi, GT Oh, KW Kim, HJ Lee miR-125a-5p attenuates macrophage-mediated vascular dysfunction by targeting Ninjurin1 Cell Death and Differentiation, 2022-01-01;0(0):. 2022-01-01 [PMID: 34974535] (Bioassay, Mouse)	Bioassay	Mouse
J Gu, X Zhang, C Zhang, Y Li, J Bian, X Liu, Y Yuan, H Zou, X Tong, Z Liu Galectin-3 Contributes to the Inhibitory Effect of lalpha,25-(OH)2D3 on Osteoclastogenesis International Journal of Molecular Sciences, 2021-12-11;22(24):. 2021-12-11 [PMID: 34948130] (Bioassay, Mouse)	Bioassay	Mouse
Y Zou, J Zhang, J Xu, L Fu, Y Xu, X Wang, Z Li, L Zhu, H Sun, H Zheng, J Guo SIRT6 inhibition delays peripheral nerve recovery by suppressing migration, phagocytosis and M2-polarization of macrophages Cell & bioscience, 2021-12-14;11(1):210. 2021-12-14 [PMID: 34906231] (Bioassay, Mouse)	Bioassay	Mouse
C Zhuang, Z Wang, W Chen, H Wang, B Tian, H Lin Jintiange Capsules Ameliorate Osteoarthritis by Modulating Subchondral Bone Remodeling and Protecting Cartilage Against Degradation Frontiers in Pharmacology, 2021-11-11;12(0):762543. 2021-11-11 [PMID: 34858187] (Bioassay, Mouse)	Bioassay	Mouse
M Mae, MI Alam, Y Yamashita, Y Ozaki, K Higuchi, SM Ziauddin, JL Montenegro, E Sakai, T Tsukuba, A Yoshimura The Role of Cytokines Produced via the NLRP3 Inflammasome in Mouse Macrophages Stimulated with Dental Calculus in Osteoclastogenesis International Journal of Molecular Sciences, 2021-11-18;22(22):. 2021-11-18 [PMID: 34830316] (Bioassay, Mouse)	Bioassay	Mouse
Y Zhang, S Zhang, Y Wang, Z Yang, Z Chen, N Wen, M Yang, Z Huang, Y Xie, L Cai ULK1 Suppresses Osteoclast Differentiation and Bone Resorption via Inhibiting Syk-JNK through DOK3 Oxidative Medicine and Cellular Longevity, 2021-11-15;2021(0):2896674. 2021-11-15 [PMID: 34820053] (Bioassay, Mouse)	Bioassay	Mouse
J Amo-Aparic, J Garcia-Gar, I Francos-Qu, A Urpi, A Esteve-Cod, M Gut, A Quintana, R Lopez-Vale Interleukin-4 and interleukin-13 induce different metabolic profiles in microglia and macrophages that relate with divergent outcomes after spinal cord injury Theranostics, 2021-10-03;11(20):9805-9820. 2021-10-03 [PMID: 34815787] (Bioassay, Mouse)	Bioassay	Mouse
E Kim, H Um, J Park, JW Jung, JE Kim, H Lee, EA Shin, Y Pinanga, H Lee, SH Nam, JW Lee TM4SF5-dependent crosstalk between hepatocytes and macrophages to reprogram the inflammatory environment Cell Reports, 2021-11-16;37(7):110018. 2021-11-16 [PMID: 34788612] (Bioassay, Mouse)	Bioassay	Mouse
Z Liu, H Wang, Y Hou, Y Yang, J Jia, J Wu, Z Zuo, T Gao, S Ren, Y Bian, S Liu, J Fu, Y Sun, J Li, M Yamamoto, Q Zhang, Y Xu, J Pi CNC-bZIP protein NFE2L1 regulates osteoclast differentiation in antioxidant-dependent and independent manners Redox Biology, 2021-11-06;48(0):102180. 2021-11-06 [PMID: 34763297] (Bioassay, Mouse)	Bioassay	Mouse
AE Hinman, C Jani, SC Pringle, WR Zhang, N Jain, AJ Martinot, AK Barczak Mycobacterium tuberculosis canonical virulence factors interfere with a late component of the TLR2 response Elife, 2021-11-10;10(0):. 2021-11-10 [PMID: 34755600] (Bioassay, Mouse)	Bioassay	Mouse
RD Hu, W Zhang, L Li, ZQ Zuo, M Ma, JF Ma, TT Yin, CY Gao, SH Yang, ZB Zhao, ZJ Li, GB Qiao, ZX Lian, K Qu Chromatin accessibility analysis identifies the transcription factor ETV5 as a suppressor of adipose tissue macrophage activation in obesity Cell Death & Disease, 2021-10-29;12(11):1023. 2021-10-29 [PMID: 34716308] (Bioassay, Mouse)	Bioassay	Mouse
JM Motta, VM Rumjanek, A Mantovani, M Locati Tumor-Released Products Promote Bone Marrow-Derived Macrophage Survival and Proliferation Biomedicines, 2021-10-04;9(10):. 2021-10-04 [PMID: 34680504] (Differentiation, Differentiation, Mouse)	Differentiation, Differentiation	Mouse
IY Karkache, JR Damodaran, DHH Molstad, KC Mansky, EW Bradley Myeloid Lineage Ablation of Phlpp1 Regulates M-CSF Signaling and Tempers Bone Resorption in Female Mice International Journal of Molecular Sciences, 2021-09-08;22(18):. 2021-09-08 [PMID: 34575866] (Bioassay, Mouse)	Bioassay	Mouse
SN Cho, JA Choi, J Lee, SH Son, SA Lee, TD Nguyen, SY Choi, CH Song Ang II-Induced Hypertension Exacerbates the Pathogenesis of Tuberculosis Cells, 2021-09-19;10(9):. 2021-09-19 [PMID: 34572127] (Bioassay, Mouse)	Bioassay	Mouse
C Liu, G Chen, Y Chen, Y Dang, G Nie, D Wu, J Li, Z Chen, H Yang, D He, X Li, J Sun, J Lu, L Wang Danlou Tablets Inhibit Atherosclerosis in Apolipoprotein E-Deficient Mice by Inducing Macrophage Autophagy: The Role of the PI3K-Akt-mTOR Pathway Frontiers in Pharmacology, 2021-09-08;12(0):724670. 2021-09-08 [PMID: 34566648] (Bioassay, Mouse)	Bioassay	Mouse
S Jiang, NM Maphis, J Binder, D Chisholm, L Weston, W Duran, C Peterson, A Zimmerman, MA Mandell, SD Jett, E Bigio, C Geula, N Mellios, JP Weick, GA Rosenberg, E Latz, MT Heneka, K Bhaskar Proteopathic tau primes and activates interleukin-1beta via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway Cell Reports, 2021-09-21;36(12):109720. 2021-09-21 [PMID: 34551296] (Bioassay, Mouse)	Bioassay	Mouse
H Muto, T Ito, T Tanaka, S Yokoyama, K Yamamoto, N Imai, Y Ishizu, K Maeda, T Honda, T Ishikawa, A Kato, T Ohshiro, F Kano, A Yamamoto, K Sakai, H Hibi, M Ishigami, M Fujishiro Conditioned medium from stem cells derived from human exfoliated deciduous teeth ameliorates NASH via the Gut-Liver axis Scientific Reports, 2021-09-21;11(1):18778. 2021-09-21 [PMID: 34548598] (Bioassay, Mouse)	Bioassay	Mouse
JA Carroll, B Race, K Williams, JF Striebel, B Chesebro Innate immune responses after stimulation with Toll-like receptor agonists in ex vivo microglial cultures and an in vivo model using mice with reduced microglia Journal of Neuroinflammation, 2021-09-06;18(1):194. 2021-09-06 [PMID: 34488805] (Bioassay, Mouse)	Bioassay	Mouse
CR Park, S Paik, YJ Kim, JK Kim, SM Jeon, SH Lee, J Whang, J Cheng, JW Suh, J Cao, G Shetye, SN Chen, J McAlpine, GF Pauli, S Franzblau, S Cho, EK Jo Rufomycin Exhibits Dual Effects Against Mycobacterium abscessus Infection by Inducing Host Defense and Antimicrobial Activities Frontiers in Microbiology, 2021-08-10;12(0):695024. 2021-08-10 [PMID: 34447358] (Bioassay, Mouse)	Bioassay	Mouse
L Janská, L Anandi, NC Kirchberge, ZS Marinkovic, LT Schachtner, G Guzelsoy, C Carmona-Fo The MEMIC is an ex vivo system to model the complexity of the tumor microenvironment Disease Models & Mechanisms, 2021-08-18;14(8):. 2021-08-18 [PMID: 34407185] (Bioassay, Mouse)	Bioassay	Mouse
KH Nilsson, P Henning, ME Shahawy, M Nethander, TL Andersen, C Ejersted, J Wu, KL Gustafsson, A Koskela, J Tuukkanen, PPC Souza, J Tuckermann, M Lorentzon, LE Ruud, T Lehtimäki, JH Tobias, S Zhou, UH Lerner, JB Richards, S Movérare-S, C Ohlsson RSPO3 is important for trabecular bone and fracture risk in mice and humans Nature Communications, 2021-08-13;12(1):4923. 2021-08-13 [PMID: 34389713] (Bioassay, Mouse)	Bioassay	Mouse
C Fang, JW Guo, YJ Wang, XQ Li, H Zhang, J Cui, Y Hu, YY Jing, X Chen, JC Su Diterbutyl phthalate attenuates osteoarthritis in ACLT mice via suppressing ERK/c-fos/NFATc1 pathway, and subsequently inhibiting subchondral osteoclast fusion Acta pharmacologica Sinica, 2021-08-11;0(0):. 2021-08-11 [PMID: 34381182] (Bioassay, Mouse)	Bioassay	Mouse
DK Fix, HA Ekiz, JJ Petrocelli, AM Mckenzie, ZS Mahmassani, RM O'Connell, MJ Drummond Disrupted macrophage metabolic reprogramming in aged soleus muscle during early recovery following disuse atrophy Aging Cell, 2021-08-08;0(0):e13448. 2021-08-08 [PMID: 34365717] (Bioassay, Mouse)	Bioassay	Mouse
MG Dorrington, CJ Bradfield, JB Lack, B Lin, SP John, JJ Liang, T Starr, O Ernst, JL Gross, J Sun, AH Miller, O Steele-Mor, IDC Fraser Correction: Type I IFNs facilitate innate immune control of the opportunistic bacteria Burkholderia cenocepacia in the macrophage cytosol PloS Pathogens, 2021-08-04;17(8):e1009821. 2021-08-04 [PMID: 34347853] (Bioassay, Mouse)	Bioassay	Mouse
X Guo, J Bai, G Ge, Z Wang, Q Wang, K Zheng, H Tao, L Zhang, H Zhang, D Wang, X Zhang, H Li, G Pan, D Geng Bioinspired peptide adhesion on Ti implants alleviates wear particle-induced inflammation and improves interfacial osteogenesis Journal of colloid and interface science, 2021-07-24;605(0):410-424. 2021-07-24 [PMID: 34332414] (Bioassay, Mouse)	Bioassay	Mouse
K Wang, CR Donnelly, C Jiang, Y Liao, X Luo, X Tao, S Bang, A McGinnis, M Lee, MJ Hilton, RR Ji STING suppresses bone cancer pain via immune and neuronal modulation Nature Communications, 2021-07-27;12(1):4558. 2021-07-27 [PMID: 34315904] (Bioassay, Mouse)	Bioassay	Mouse
K Woo, DH Kim, MH Oh, HS Park, CH Choi N-3-Hydroxy Dodecanoyl-DL-homoserine Lactone (OH-dDHL) Triggers Apoptosis of Bone Marrow-Derived Macrophages through the ER- and Mitochondria-Mediated Pathways International Journal of Molecular Sciences, 2021-07-15;22(14):. 2021-07-15 [PMID: 34299184] (Bioassay, Mouse)	Bioassay	Mouse
EB Byun, HY Song, WS Kim, JM Han, HS Seo, SH Park, K Kim, EH Byun Protective Effect of Polysaccharides Extracted from Cudrania tricuspidata Fruit against Cisplatin-Induced Cytotoxicity in Macrophages and a Mouse Model International Journal of Molecular Sciences, 2021-07-13;22(14):. 2021-07-13 [PMID: 34299130] (Bioassay, Mouse)	Bioassay	Mouse
TT Chu, X Tu, K Yang, J Wu, JJ Repa, N Yan Tonic prime-boost of STING signalling mediates Niemann-Pick disease type C Nature, 2021-07-21;0(0):. 2021-07-21 [PMID: 34290407] (Bioassay, Mouse)	Bioassay	Mouse
AS Tooley, D Kazyken, C Bodur, IE Gonzalez, DC Fingar The innate immune kinase TBK1 directly increases mTORC2 activity and downstream signaling to Akt The Journal of Biological Chemistry, 2021-07-08;0(0):100942. 2021-07-08 [PMID: 34245780] (Bioassay, Mouse)	Bioassay	Mouse
MB Uccellini, S Aslam, STH Liu, F Alam, A García-Sas Development of a Macrophage-Based ADCC Assay Vaccines, 2021-06-17;9(6):. 2021-06-17 [PMID: 34204268] (Bioassay, Mouse)	Bioassay	Mouse
Q Lu, C Jiang, J Hou, H Qian, F Chu, W Zhang, M Ye, Z Chen, J Liu, H Yao, J Zhang, J Xu, T Wang, S Fan, Q Wang Patchouli Alcohol Modulates the Pregnancy X Receptor/Toll-like Receptor 4/Nuclear Factor Kappa B Axis to Suppress Osteoclastogenesis Frontiers in Pharmacology, 2021-06-08;12(0):684976. 2021-06-08 [PMID: 34177594] (Cell Culture, Mouse)	Cell Culture	Mouse
J Yang, L Qin, J Huang, Y Li, S Xu, H Wang, S Zhu, J Wang, B Zhu, F Li, W Huang, X Gong, N Hu Astragalus polysaccharide attenuates LPS-related inflammatory osteolysis by suppressing osteoclastogenesis by reducing the MAPK signalling pathway Journal of Cellular and Molecular Medicine, 2021-06-02;0(0):. 2021-06-02 [PMID: 34080298] (Cell Culture, Mouse)	Cell Culture	Mouse
H Salo, H Qu, D Mitsiou, H Aucott, J Han, XM Zhang, C Aulin, H Erlandsson Disulfide and Fully Reduced HMGB1 Induce Different Macrophage Polarization and Migration Patterns Biomolecules, 2021-05-28;11(6):. 2021-05-28 [PMID: 34071440] (Cell Culture, Mouse)	Cell Culture	Mouse
JS Kim, E Cho, SJ Mun, S Kim, SY Kim, DG Kim, W Son, HI Jeon, HK Kim, YJ Jeong, S Jang, HS Kim, CS Yang Multi-Functional MPT Protein as a Therapeutic Agent against Mycobacterium tuberculosis Biomedicines, 2021-05-13;9(5):. 2021-05-13 [PMID: 34068051] (Bioassay, Mouse)	Bioassay	Mouse
KH Kim, YT Lee, Y Park, EJ Ko, YJ Jung, YJ Kim, EK Jo, SM Kang BCG Cell Wall Skeleton As a Vaccine Adjuvant Protects Both Infant and Old-Aged Mice from Influenza Virus Infection Biomedicines, 2021-05-05;9(5):. 2021-05-05 [PMID: 34063125] (Bioassay, Mouse)	Bioassay	Mouse
OJ Sul, G Li, JE Kim, ES Kim, HS Choi 7-ketocholesterol enhances autophagy via the ROS-TFEB signaling pathway in osteoclasts: 7-KC in osteoclasts The Journal of nutritional biochemistry, 2021-05-21;0(0):108783. 2021-05-21 [PMID: 34023424] (Bioassay, Mouse)	Bioassay	Mouse
D Zhang, J Huang, F Wang, H Ding, Y Cui, Y Yang, J Xu, H Luo, Y Gao, L Pan, Y Wu, Y Gong, L Xie, Z Liu, Y Qu, L Zhang, W Liu, W Zhang, S Zhao, Q Yi, T Niu, Y Zheng BMI1 regulates multiple myeloma-associated macrophage's pro-myeloma functions Cell Death & Disease, 2021-05-15;12(5):495. 2021-05-15 [PMID: 33993198] (Bioassay, Mouse)	Bioassay	Mouse
H Chen, G Shen, Q Shang, P Zhang, D Yu, X Yu, Z Zhang, W Zhao, Z Wu, F Tang, Liang, X Jiang, H Ren Plastrum testudinis extract suppresses osteoclast differentiation via the NF-&kappaB signaling pathway and ameliorates senile osteoporosis Journal of ethnopharmacology, 2021-05-08;276(0):114195. 2021-05-08 [PMID: 33974944] (Bioassay, Mouse)	Bioassay	Mouse
Y Liang, X Sun, M Wang, Q Lu, M Gu, L Zhou, Q Hou, M Tan, S Wang, X Xue, C Dai PP2Ac&alpha promotes macrophage accumulation and activation to exacerbate tubular cell death and kidney fibrosis through activating Rap1 and TNF&alpha production Cell Death and Differentiation, 2021-05-01;0(0):. 2021-05-01 [PMID: 33934104] (Bioassay, Mouse)	Bioassay	Mouse
N Li, X Li, K Zheng, J Bai, W Zhang, H Sun, G Ge, W Wang, Z Wang, Y Gu, Y Xue, Y Xu, D Geng, J Zhou Inhibition of Sirtuin 3 prevents titanium particle-induced bone resorption and osteoclastsogenesis via suppressing ERK and JNK signaling International journal of biological sciences, 2021-04-03;17(5):1382-1394. 2021-04-03 [PMID: 33867853] (Bioassay, Mouse)	Bioassay	Mouse
P Xue, X Hu, E Chang, L Wang, M Chen, TH Wu, DJ Lee, BL Foster, HC Tseng, CC Ko Deficiency of optineurin enhances osteoclast differentiation by attenuating the NRF2-mediated antioxidant response Experimental & Molecular Medicine, 2021-04-16;0(0):. 2021-04-16 [PMID: 33864025] (Bioassay, Mouse)	Bioassay	Mouse
MJ Strowitzki, G Kimmer, JS Wehrmann, AS Ritter, P Radhakrish, VM Opitz, C Tuffs, M Biller, J Kugler, U Keppler, JM Harnoss, J Klose, T Schmidt, A Blanco, CT Taylor, M Schneider Inhibition of HIF-prolyl hydroxylases improves healing of intestinal anastomoses JCI Insight, 2021-03-30;0(0):. 2021-03-30 [PMID: 33784253] (Bioassay, Mouse)	Bioassay	Mouse
X Liu, Y Chai, G Liu, W Su, Q Guo, X Lv, P Gao, B Yu, G Ferbeyre, X Cao, M Wan Osteoclasts protect bone blood vessels against senescence through the angiogenin/plexin-B2 axis Nature Communications, 2021-03-23;12(1):1832. 2021-03-23 [PMID: 33758201] (Bioassay, Mouse)	Bioassay	Mouse
MG Dorrington, CJ Bradfield, JB Lack, B Lin, JJ Liang, T Starr, O Ernst, JL Gross, J Sun, AH Miller, O Steele-Mor, IDC Fraser Type I IFNs facilitate innate immune control of the opportunistic bacteria Burkholderia cenocepacia in the macrophage cytosol PloS Pathogens, 2021-03-08;17(3):e1009395. 2021-03-08 [PMID: 33684179] (Bioassay, Mouse)	Bioassay	Mouse
S Huo, X Liu, S Zhang, Z Lyu, J Zhang, Y Wang, B Nie, B Yue p300/CBP inhibitor A-485 inhibits the differentiation of osteoclasts and protects against osteoporotic bone loss International immunopharmacology, 2021-02-21;94(0):107458. 2021-02-21 [PMID: 33626422] (Bioassay, Mouse, Rat)	Bioassay	Mouse, Rat
Y Chen, B Wei, P Xu, H Tang, L Yang, Y Wang, Y Fu, X Yang, Y Mao Schistosomaï¿½japonicum cystatin suppresses osteoclastogenesis via manipulating the NF?&kappaB signaling pathway Molecular Medicine Reports, 2021-02-12;23(4):. 2021-02-12 [PMID: 33576450] (Bioassay, Mouse)	Bioassay	Mouse
M Kawakami, H Yasuda, D Nishida, A Katakura, T Mizoguchi Development of a method for the identification of receptor activator of nuclear factor-&kappaB+ populations in vivo Journal of oral biosciences, 2021-01-28;0(0):. 2021-01-28 [PMID: 33516894] (Bioassay, Mouse)	Bioassay	Mouse
RK Arya, R Goswami, SO Rahaman Mechanotransduction via a TRPV4-Rac1 signaling axis plays a role in multinucleated giant cell formation The Journal of Biological Chemistry, 2020-01-01;296(0):100129. 2020-01-01 [PMID: 33460921] (Bioassay, Mouse)	Bioassay	Mouse
AE Engler, AB Ysasi, RMF Pihl, C Villacorta, HM Heston, HMK Richardson, BR Thapa, NR Moniz, AC Belkina, SA Mazzilli, JR Rock Airway-Associated Macrophages in Homeostasis and Repair Cell Reports, 2020-12-29;33(13):108553. 2020-12-29 [PMID: 33378665] (Bioassay, Transgenic Mouse)	Bioassay	Transgenic Mouse
G Cerrato, M Leduc, K Müller, P Liu, L Zhao, J Humeau, W Xie, S Zhang, O Kepp, A Sauvat, G Kroemer Oleate-induced aggregation of LC3 at the trans-Golgi network is linked to a protein trafficking blockade Cell Death and Differentiation, 2020-12-17;0(0):. 2020-12-17 [PMID: 33335289] (Cell Culture, Mouse)	Cell Culture	Mouse
G Gupta, Z Mou, P Jia, R Sharma, R Zayats, SM Viana, L Shan, A Barral, VS Boaventura, TT Murooka, A Soussi-Gou, CI de Oliveir, JE Uzonna The Long Pentraxin 3 (PTX3) Suppresses Immunity to Cutaneous Leishmaniasis by Regulating CD4+ T Helper Cell Response Cell Reports, 2020-12-15;33(11):108513. 2020-12-15 [PMID: 33326783]
MJ Park, JA Baek, SY Kim, KA Jung, JW Choi, SH Park, SK Kwok, ML Cho Myeloid-derived suppressor cells therapy enhance immunoregulatory properties in acute graft versus host disease with combination of regulatory T cells Journal of Translational Medicine, 2020-12-14;18(1):483. 2020-12-14 [PMID: 33317573] (Bioassay, Mouse)	Bioassay	Mouse
Z Liu, Y Li, F Guo, C Zhang, G Song, J Yang, D Chen Tetrandrine Inhibits Titanium Particle-Induced Inflammatory Osteolysis through the Nuclear Factor-&kappaB Pathway Mediators of Inflammation, 2020-11-27;2020(0):1926947. 2020-11-27 [PMID: 33312069] (Cell Culture, Mouse)	Cell Culture	Mouse
S Rosendahl, R Sulniute, M Eklund, C Koskinen H, MJO Johansson, E Kindstedt, S Lindquist, P Lundberg CCR3 deficiency is associated with increased osteoclast activity and reduced cortical bone volume in adult male mice The Journal of Biological Chemistry, 2020-12-17;0(0):. 2020-12-17 [PMID: 33303631] (Cell Culture, Mouse)	Cell Culture	Mouse
X Tong, M Chen, R Song, H Zhao, J Bian, J Gu, Z Liu Overexpression of c-Fos reverses osteoprotegerin-mediated suppression of osteoclastogenesis by increasing the Beclin1-induced autophagy Journal of Cellular and Molecular Medicine, 2020-12-04;0(0):. 2020-12-04 [PMID: 33277741] (Cell Culture, Mouse)	Cell Culture	Mouse
SY Kim, D Kim, S Kim, D Lee, SJ Mun, E Cho, W Son, K Jang, CS Yang Mycobacterium tuberculosis Rv2626c-derived peptide as a therapeutic agent for sepsis Embo Molecular Medicine, 2020-12-01;12(12):e12497. 2020-12-01 [PMID: 33258196] (Cell Culture, Mouse)	Cell Culture	Mouse
L Wang, L Han, P Xue, X Hu, SW Wong, M Deng, HC Tseng, BW Huang, CC Ko Dopamine suppresses osteoclast differentiation via cAMP/PKA/CREB pathway Cell Signal, 2020-11-24;78(0):109847. 2020-11-24 [PMID: 33242564] (Bioassay, Mouse)	Bioassay	Mouse
M Timmen, H Hidding, M Götte, TE Khassawna, D Kronenberg, R Stange The heparan sulfate proteoglycan Syndecan-1 influences local bone cell communication via the RANKL/OPG axis Sci Rep, 2020-11-25;10(1):20510. 2020-11-25 [PMID: 33239699] (Cell Culture, Mouse)	Cell Culture	Mouse
G Yang, W Song, J Xu, JL Postoak, F Cheng, J Martinez, J Zhang, L Wu, L Van Kaer Pik3c3 deficiency in myeloid cells imparts partial resistance to experimental autoimmune encephalomyelitis associated with reduced IL-1&beta production Cell Mol Immunol, 2020-11-24;0(0):. 2020-11-24 [PMID: 33235386] (Cell Culture, Mouse)	Cell Culture	Mouse
Y Yang, Z Guo, W Chen, X Wang, M Cao, X Han, K Zhang, B Teng, J Cao, W Wu, P Cao, C Huang, Z Qiu M2 macrophage-derived exosomes promote angiogenesis and growth of pancreatic ductal adenocarcinoma by targeting E2F2 Mol Ther, 2020-11-20;0(0):. 2020-11-20 [PMID: 33221435] (Cell Culture, Mouse)	Cell Culture	Mouse
T Okui, M Hiasa, S Ryumon, K Ono, Y Kunisada, S Ibaragi, A Sasaki, GD Roodman, FA White, T Yoneda The HMGB1/RAGE axis induces bone pain associated with colonization of 4T1 mouse breast cancer in bone Journal of Bone Oncology, 2020-10-28;26(0):100330. 2020-10-28 [PMID: 33204606] (Cell Culture, Mouse)	Cell Culture	Mouse
CH Lee, A Sapkota, BP Gaire, JW Choi NLRP3 Inflammasome Activation Is Involved in LPA1-Mediated Brain Injury after Transient Focal Cerebral Ischemia Int J Mol Sci, 2020-11-14;21(22):. 2020-11-14 [PMID: 33202644] (Cell Culture, Mouse)	Cell Culture	Mouse
JS Kim, SJ Mun, E Cho, D Kim, W Son, HI Jeon, HK Kim, K Jang, CS Yang Toxoplasma gondii GRA9 Regulates the Activation of NLRP3 Inflammasome to Exert Anti-Septic Effects in Mice Int J Mol Sci, 2020-11-10;21(22):. 2020-11-10 [PMID: 33182702] (Cell Culture, Mouse)	Cell Culture	Mouse
L Xiao, M Zhong, Y Huang, J Zhu, W Tang, D Li, J Shi, A Lu, H Yang, D Geng, H Li, Z Wang Puerarin alleviates osteoporosis in the ovariectomy-induced mice by suppressing osteoclastogenesis via inhibition of TRAF6/ROS-dependent MAPK/NF-&kappaB signaling pathways Aging (Albany NY), 2020-11-07;12(21):21706-21729. 2020-11-07 [PMID: 33176281] (Cell Culture, Mouse)	Cell Culture	Mouse
AT Holdbrooks, KE Ankenbauer, J Hwang, SL Bellis Regulation of inflammatory signaling by the ST6Gal-I sialyltransferase PLoS ONE, 2020-11-09;15(11):e0241850. 2020-11-09 [PMID: 33166339] (Cell Culture, Mouse)	Cell Culture	Mouse
S Lee, SJ Bush, S Thorne, N Mawson, C Farquharso, GT Bergkvist Transcriptomic profiling of feline teeth highlights the role of matrix metalloproteinase 9 (MMP9) in tooth resorption Sci Rep, 2020-11-03;10(1):18958. 2020-11-03 [PMID: 33144645] (Cell Culture, Feline)	Cell Culture	Feline
S Yonebayash, K Tajiri, N Murakoshi, D Xu, S Li, D Feng, Y Okabe, Z Yuan, Z Song, K Aonuma, A Shibuya, K Aonuma, M Ieda MAIR-II deficiency ameliorates cardiac remodelling post-myocardial infarction by suppressing TLR9-mediated macrophage activation J Cell Mol Med, 2020-11-02;0(0):. 2020-11-02 [PMID: 33140535] (Cell Culture, Mouse)	Cell Culture	Mouse
B Chu, S Chen, X Zheng, J Ye, X Cheng, L Zhang, D Guo, P Wang, D Hong, Z Hong Nepetin inhibits osteoclastogenesis by inhibiting RANKL-induced activation of NF-&kappaB and MAPK signalling pathway, and autophagy J Cell Mol Med, 2020-11-01;0(0):. 2020-11-01 [PMID: 33135301] (Cell Culture, Mouse)	Cell Culture	Mouse
N Hagan, JL Kane, D Grover, L Woodworth, C Madore, J Saleh, J Sancho, J Liu, Y Li, J Proto, M Zelic, A Mahan, M Kothe, AA Scholte, M Fitzgerald, B Gisevius, A Haghikia, O Butovsky, D Ofengeim CSF1R signaling is a regulator of pathogenesis in progressive MS Cell Death Dis, 2020-10-23;11(10):904. 2020-10-23 [PMID: 33097690] (Bioassay, Mouse)	Bioassay	Mouse
DHH Molstad, AM Mattson, DL Begun, JJ Westendorf, EW Bradley Hdac3 regulates bone modeling by suppressing osteoclast responsiveness to RANKL J Biol Chem, 2020-01-01;0(0):. 2020-01-01 [PMID: 33012705] (Bioassay, Mouse)	Bioassay	Mouse
J Peng, K Zhao, J Zhu, Y Wang, P Sun, Q Yang, T Zhang, W Han, W Hu, W Yang, J Ruan, Y Qian Sarsasapogenin Suppresses RANKL-Induced Osteoclastogenesis in vitro and Prevents Lipopolysaccharide-Induced Bone Loss in vivo Drug Des Devel Ther, 2020-08-24;14(0):3435-3447. 2020-08-24 [PMID: 32943842] (Bioassay, Mouse)	Bioassay	Mouse
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C Sun, SY Chen RGC32 Promotes Bleomycin-Induced Systemic Sclerosis in a Murine Disease Model by Modulating Classically Activated Macrophage Function J. Immunol., 2018-03-05;0(0):. 2018-03-05 [PMID: 29507108] (Bioassay, Mouse)	Bioassay	Mouse
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M Zhang, L Chun, V Sandoval, H Graor, J Myers, J Nthale, P Rauhe, Z Senders, K Choong, AY Huang, J Kim Systemic administration of ?-glucan of 200ï¿½kDa modulates melanoma microenvironment and suppresses metastatic cancer Oncoimmunology, 2017-10-30;7(2):e1387347. 2017-10-30 [PMID: 29308312] (Cell Culture, Mouse)	Cell Culture	Mouse
S Lucas, Y Omata, J Hofmann, M Böttcher, A Iljazovic, K Sarter, O Albrecht, O Schulz, B Krishnacou, G Krönke, M Herrmann, D Mougiakako, T Strowig, G Schett, MM Zaiss Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss Nat Commun, 2018-01-04;9(1):55. 2018-01-04 [PMID: 29302038] (Bioassay, Mouse)	Bioassay	Mouse
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J Ahn, S Son, SC Oliveira, GN Barber STING-Dependent Signaling Underlies IL-10 Controlled Inflammatory Colitis Cell Rep, 2017-12-26;21(13):3873-3884. 2017-12-26 [PMID: 29281834] (Bioassay, Mouse)	Bioassay	Mouse
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JH Oh, NK Lee Up-Regulation of RANK Expression via ERK1/2 by Insulin Contributes to the Enhancement of Osteoclast Differentiation Mol. Cells, 2017-05-22;40(5):371-377. 2017-05-22 [PMID: 28535663] (Bioassay, Mouse)	Bioassay	Mouse
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HH Chen, H Yuan, H Cho, Y Feng, S Ngoy, AT Kumar, R Liao, W Chao, L Josephson, DE Sosnovik Theranostic Nucleic Acid Binding Nanoprobe Exerts Anti-inflammatory and Cytoprotective Effects in Ischemic Injury Theranostics, 2017-02-08;7(4):814-825. 2017-02-08 [PMID: 28382156] (Bioassay, Mouse)	Bioassay	Mouse
OC Olson, H Kim, DF Quail, EA Foley, JA Joyce Tumor-Associated Macrophages Suppress the Cytotoxic Activity of Antimitotic Agents Cell Rep, 2017-04-04;19(1):101-113. 2017-04-04 [PMID: 28380350] (Bioassay, Mouse)	Bioassay	Mouse
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HJ Koh, YR Kim, JS Kim, JS Yun, K Jang, CS Yang Toxoplasma gondii GRA7-Targeted ASC and PLD1 Promote Antibacterial Host Defense via PKCï¿½ PLoS Pathog, 2017-01-26;13(1):e1006126. 2017-01-26 [PMID: 28125719] (Bioassay, Mouse)	Bioassay	Mouse
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Johansson MK, de Vries TJ, Schoenmaker T, Ehinger M, Brun AC, Fasth A, Karlsson S, Everts V, Richter J Hematopoietic stem cell-targeted neonatal gene therapy reverses lethally progressive osteopetrosis in oc/oc mice. Blood, 2007-03-01;109(12):5178-85. 2007-03-01 [PMID: 17332244] (Bioassay, Mouse)	Bioassay	Mouse
Nakanishi M, Niidome T, Matsuda S, Akaike A, Kihara T, Sugimoto H Microglia-derived interleukin-6 and leukaemia inhibitory factor promote astrocytic differentiation of neural stem/progenitor cells. Eur. J. Neurosci., 2007-02-01;25(3):649-58. 2007-02-01 [PMID: 17328769] (Bioassay, Rat)	Bioassay	Rat
Mohamedali KA, Poblenz AT, Sikes CR, Navone NM, Thorpe PE, Darnay BG, Rosenblum MG Inhibition of prostate tumor growth and bone remodeling by the vascular targeting agent VEGF121/rGel. Cancer Res., 2006-11-15;66(22):10919-28. 2006-11-15 [PMID: 17108129] (Bioassay, Mouse)	Bioassay	Mouse
Jia D, O'Brien CA, Stewart SA, Manolagas SC, Weinstein RS Glucocorticoids act directly on osteoclasts to increase their life span and reduce bone density. Endocrinology, 2006-08-24;147(12):5592-9. 2006-08-24 [PMID: 16935844] (Bioassay, Mouse)	Bioassay	Mouse
Kim SY, Nguyen AD, Gao JL, Murphy PM, Mansfield BC, Chou JY Bone marrow-derived cells require a functional glucose 6-phosphate transporter for normal myeloid functions. J. Biol. Chem., 2006-08-04;281(39):28794-801. 2006-08-04 [PMID: 16891306] (Bioassay, Mouse)	Bioassay	Mouse
de Vries TJ, Schoenmaker T, Wattanaroonwong N, van den Hoonaard M, Nieuwenhuijse A, Beertsen W, Everts V Gingival fibroblasts are better at inhibiting osteoclast formation than periodontal ligament fibroblasts. J. Cell. Biochem., 2006-05-15;98(2):370-82. 2006-05-15 [PMID: 16440316] (Bioassay, Mouse)	Bioassay	Mouse
Conway</LastName><ForeNam JG</Initia, Conway JG, McDonald B, Parham J, Keith B, Rusnak DW, Shaw E, Jansen M, Lin P, Payne A, Crosby RM, Johnson JH, Frick L, Lin MH, Depee S, Tadepalli S, Votta B, James I, Fuller K, Chambers TJ, Kull FC, Chamberlain SD, Hutchins JT Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580. Proc. Natl. Acad. Sci. U.S.A., 2005-10-25;102(44):16078-83. 2005-10-25 [PMID: 16249345] (In Vivo, Mouse)	In Vivo	Mouse
Gevrey JC, Isaac BM, Cox D Syk is required for monocyte/macrophage chemotaxis to CX3CL1 (Fractalkine). J. Immunol., 2005-09-15;175(6):3737-45. 2005-09-15 [PMID: 16148119] (Bioassay, Mouse)	Bioassay	Mouse
Ponomarev ED, Novikova M, Maresz K, Shriver LP, Dittel BN Development of a culture system that supports adult microglial cell proliferation and maintenance in the resting state. J. Immunol. Methods, 2005-04-26;300(1):32-46. 2005-04-26 [PMID: 15893321] (Bioassay, Mouse)	Bioassay	Mouse
Sharif MN, Tassiulas I, Hu Y, Mecklenbrauker I, Tarakhovsky A, Ivashkiv LB IFN-alpha priming results in a gain of proinflammatory function by IL-10: implications for systemic lupus erythematosus pathogenesis. J. Immunol., 2004-05-15;172(10):6476-81. 2004-05-15 [PMID: 15128840] (Bioassay, Mouse)	Bioassay	Mouse
Miller YI, Viriyakosol S, Binder CJ, Feramisco JR, Kirkland TN, Witztum JL Minimally modified LDL binds to CD14, induces macrophage spreading via TLR4/MD-2, and inhibits phagocytosis of apoptotic cells. J. Biol. Chem., 2002-11-06;278(3):1561-8. 2002-11-06 [PMID: 12424240] (Bioassay, Mouse)	Bioassay	Mouse
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Reviews for M-CSF (416-ML) (2) 52

Average Rating: 5

(Based on 2 reviews)

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reviewed by:
Walter Jackson

CellProlif

02/22/2021

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Application	Cell Proliferation
Lot	ME4819091
Comments	It worked well in the proliferation and differentiation of mouse bone marrow cells in vitro.

Stem/Immune cell maintenance or differentiation M-CSF 416-ML

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Verified Customer

Stem/Immune cell maintenance or differentiation

09/09/2019

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Application	Stem/Immune cell maintenance or differentiation
Lot	ME4619021
Comments	Excellent activity in cell culture. Effective in differentiating mouse bone marrow cells into BMDMs. Adhesion and cell health are very good for this timepoint. Price was also acceptable for the product, given comparables.

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Preparing murine IFNAR-/- bone marrow macrophages for viral infection/entry studies.

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	Walter Jackson 02/22/2021
Application:	CellProlif
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Stem/Immune cell maintenance or differentiation M-CSF 416-ML

	Verified Customer 09/09/2019
Application:	Stem/Immune cell maintenance or differentiation
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Gene Symbol	Csf1
Uniprot	Q3U4F9()

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