Recombinant Mouse CRISP-2 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CRISP-2, also known as Tpx-1, is one of several CRISPs (cysteine-rich secretory proteins) that contain 16 invariant cysteine residues and show structural homology to snake, insect, and lizard venom proteins. These proteins consist of an N-terminal SCP/CAP domain, a hinge region, and a cysteine-rich CRISP domain. CRISPs are expressed in discrete but overlapping regions of the male reproductive tract and play a role in spermatozoa adhesion with Sertoli cells and oocytes, decapacitation, and the acrosome reaction (1, 2). Mature mouse CRISP‑2 shares 73% and 86% aa sequence identity with human and rat CRISP-2, respectively (3). CRISP-2 is expressed in late pachytene spermatocytes, round and elongated spermatids, and mature spermatozoa (4, 5). It is found in cytoplasmic granulated bodies and in association with Gametogenetin 1, SHTAP, outer dense fibers of the tail, and the acrosome (5-9). CRISP-2 is involved in spermatocyte interactions with Sertoli cells as well as in sperm-egg fusion (7, 8, 10). It regulates calcium flux during sperm capacitation by increasing or decreasing the open time of the ryanodine receptors RyR1 and RyR2, respectively (11).

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: ThT Fluorescence.

Showing Publication 1 - 1 of 1.

Publication using 4576-CR	Applications	Species
J Sheng, NK Olrichs, WJ Geerts, X Li, AU Rehman, BM Gadella, DV Kaloyanova, B Helms Zinc binding regulates amyloid-like aggregation of GAPR-1 Biosci. Rep., 2019-02-12;0(0):. 2019-02-12 [PMID: 30700571] (ThT Fluorescence, Mouse)	ThT Fluorescence	Mouse

Array 4576-CR

• CRISP-2 Antibodies
• CRISP-2 ELISA Kits
• CRISP-2 Lysates
• CRISP-2 Proteins
• CRISP-2 Proteins and Enzyme