CRISP-1 Antibody (840017) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Cysteine-rich Secretory Protein 1 (CRISP‑1), also known as Acidic Epididymal Glycoprotein 1 (AEG1) and Sperm‑Coating Glycoprotein 1 (SCP1), is a 29-32 kDa (26.4 kDa predicted) protein that is involved in male reproductive biology (1, 2). CRISPs belong to the CAP superfamily of molecules that also includes several snake, insect, and lizard venom proteins (3). Structurally, CRISPs consist of an N-terminal SCP/CAP domain, a hinge region, and a Cys-rich domain with 16 invariant cysteine residues (4). CRISPs are expressed in discrete but overlapping regions of the male reproductive tract and play a role in spermatozoa adhesion with Sertoli cells and oocytes, decapacitation, and the acrosomal reaction (1). Expression patterns, genomic structure, and sequence conservation indicate that the likely ortholog of human CRISP-1 in mouse and rat is CRISP-4 (5, 6). Mature mouse CRISP-1 shares 68% amino acid (aa) sequence identity with rat CRISP-1. It shares 55%, 73%, and 43% aa sequence identity with mouse CRISP-2, -3, and -4, respectively. Rodent CRISP-1 is secreted by the epididymal epithelium and associates with the surface of spermatozoa in the epididymis where it inhibits capacitation (7-9). It is released from the sperm cell surface once capacitation begins in the female reproductive tract or in vitro (10). CRISP-1 is involved in the interaction of spermatozoa with the oocyte zona pellucida as well as in the fusion of sperm and egg (11, 12). CRISP-1 is additionally expressed in the lower medulla of hair shafts and under androgen control in the submandibular salivary glands of male mice (13-15).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: Western Blot.

Showing Publication 1 - 1 of 1.

Publication using MAB4675	Applications	Species
X Zhang, L Wang, Y Ma, Y Wang, H Liu, M Liu, L Qin, J Li, C Jiang, X Zhang, X Shan, Y Liu, J Li, Y Li, R Zheng, Y Sun, J Sun, X Leng, Y Liang, F Zhang, X Jiang, Y Yang, Y Shen CEP128 is involved in spermatogenesis in humans and mice Nature Communications, 2022-03-16;13(1):1395. 2022-03-16 [PMID: 35296684] (Western Blot, Mouse)	Western Blot	Mouse

Array MAB4675

• CRISP-1 Antibodies
• CRISP-1 Lysate
• CRISP-1 Proteins
• CRISP-1 Proteins and Enzyme