Recombinant Human Thrombospondin-3 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Thrombospondin-3 (TSP-3) is a 140-150 kDa heparin-binding protein in the thrombospondin family of matricellular adhesion proteins. Within this family, TSP-3, TSP-4, and TSP-5/COMP are secreted as pentamers, while TSP-1 and TSP-2 are homotrimeric (1). TSP-3 contains an N-terminal Laminin G-like globular domain, a flexible linker region, multiple tandem EGF-like repeats, multiple tandem TSP type-3 repeats, and a globular TSP C-terminal domain (2). Alternative splicing of human TSP-3 generates a short isoform with a deletion of approximately half of the Laminin-like domain and a portion of the linker. Mature human TSP-3 shares 98% and 97% amino acid sequence identity with mouse and rat TSP-3, respectively. In the disulfide-linked TSP-3 pentamer, the Laminin-like domains are clustered while the C-terminal globular domains are extended (3). TSP-3 is expressed during mouse embryogenesis in the brain, dorsal root ganglia, cartilage, lung, and gut (4, 5). In postnatal mice it is most highly expressed in the lung (6). TSP-3 is involved in the columnar organization of chondrocytes in developing growth plates of long bones (7). It is up-regulated in metastatic osteosarcoma and in the corneal stroma during wound healing (8, 9).

We have publications tested in 2 confirmed species: Human, Rat.

We have publications tested in 1 application: Bioassay.

Showing Publication 1 - 1 of 1.

Publication using 8390-TH	Applications	Species
TG Schips, D Vanhoutte, A Vo, RN Correll, MJ Brody, H Khalil, J Karch, A Tjondrokoe, MA Sargent, M Maillet, RS Ross, JD Molkentin Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability Nat Commun, 2019-01-08;10(1):76. 2019-01-08 [PMID: 30622267] (Bioassay, Human, Rat)	Bioassay	Human, Rat

Array 8390-TH

• Thrombospondin-3 Antibodies
• Thrombospondin-3 Lysate
• Thrombospondin-3 Protein
• Thrombospondin-3 Proteins and Enzyme