Recombinant Mouse CCL5/RANTES Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CCL5, also known as RANTES (Regulated upon Activation, Normal T cell Expressed and presumably Secreted), is an 8 kDa beta -chemokine that plays a primary role in the inflammatory immune response by means of its ability to attract and activate leukocytes (1 - 3). Human and mouse RANTES exhibit cross-species activity on human and mouse cells (4). Mature mouse CCL5 shares 100% aa sequence identity with rat CCL5 and 75% - 88% with canine, cotton rat, feline, and human CCL5 (5). CCL5 is secreted by many cell types at inflammatory sites, and it exerts a wide range of activities through the receptors CCR1, CCR3, CCR4, and CCR5 (6, 7). Inflammatory responses can be impaired by the sequestration of CCL5 by the cytomegalovirus protein US28 (8). In humans, CCR5 binding to CCL5 inhibits the infectivity of R5 (M-tropic) but not X4 (T-tropic) strains of HIV-1 (9). The two N-terminal residues of CCL5 can be removed by CD26/DPPIV, generating a protein that functions as a chemotaxis inhibitor and more effectively blocks M-tropic HIV-1 infection of monocytes (10). Oligomerization of CCL5 on glycosaminoglycans is required for CCR1-mediated leukocyte adhesion and activation as well as CCL5’s interaction with the chemokine CXCL4/PF4 (11 - 13). The deposition of CCL5 on activated vascular endothelial cells is crucial for monocyte adhesion to damaged vasculature, but CCL5 oligomerization is not required for the extravasation of adherent leukocytes (14 - 16). CCL5 is upregulated in breast cancer and promotes tumor progression through the attraction of proinflammatory macrophages in addition to its actions on tumor cells, stromal cells, and the vasculature (17).

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 5 applications: Binding Assay, Bioassay, ELISA (Standard), In Vivo, Neutralization.

Showing Publications 1 - 10 of 20. Show All 20 Publications. Collapse Publications.

Publications using 478-MR/CF	Applications	Species
J Lin, Y Xu, P Guo, YJ Chen, J Zhou, M Xia, B Tan, X Liu, H Feng, Y Chen CCL5/CCR5-mediated peripheral inflammation exacerbates blood?brain barrier disruption after intracerebral hemorrhage in mice Journal of Translational Medicine, 2023-03-14;21(1):196. 2023-03-14 [PMID: 36918921] (Bioassay, Mouse)	Bioassay	Mouse
Z Su, J Brooks, J Pelker, T Andreyeva, H Sobon, R Gifford, M Powers, J Wang, C Dower, M Hegen, D Messing, AD Sheehan, JJ Brennan Studies with neutralizing antibodies suggest CXCL8-mediated neutrophil activation is independent of C-C motif chemokine receptor-like 2 (CCRL2) ligand binding function PLoS ONE, 2023-01-20;18(1):e0280590. 2023-01-20 [PMID: 36662882] (Bioassay, Human)	Bioassay	Human
MH Ho, CH Yen, TH Hsieh, TJ Kao, JY Chiu, YH Chiang, BJ Hoffer, WC Chang, SY Chou CCL5 via GPX1 activation protects hippocampal memory function after mild traumatic brain injury Redox Biology, 2021-07-17;46(0):102067. 2021-07-17 [PMID: 34315111] (In Vivo, Mouse)	In Vivo	Mouse
R Ajoy, YC Lo, MH Ho, YY Chen, Y Wang, YH Chen, C Jing-Yuan, CA Changou, YC Hsiung, HM Chen, TH Chang, CY Lee, YH Chiang, WC Chang, B Hoffer, SY Chou CCL5 promotion of bioenergy metabolism is crucial for hippocampal synapse complex and memory formation Molecular Psychiatry, 2021-04-30;0(0):. 2021-04-30 [PMID: 33931731] (Bioassay, Mouse)	Bioassay	Mouse
Y Lin, Y Chen, W Feng, R Hua, J Zhang, Y Huo, H Jiang, B Yin, X Yang Neddylation pathway alleviates chronic pancreatitis by reducing HIF1&alpha-CCL5-dependent macrophage infiltration Cell Death & Disease, 2021-03-15;12(3):273. 2021-03-15 [PMID: 33723230] (Neutralization, Mouse)	Neutralization	Mouse
S Sharif, N Ueda, Y Nakatani, LM Wise, S Clifton, Z Lateef, AA Mercer, SB Fleming Chemokine-Binding Proteins Encoded by Parapoxvirus of Red Deer of New Zealand Display Evidence of Gene Duplication and Divergence of Ligand Specificity Front Microbiol, 2019-06-25;10(0):1421. 2019-06-25 [PMID: 31293551] (Binding Assay, Mouse)	Binding Assay	Mouse
JP Böttcher, E Bonavita, P Chakravart, H Blees, M Cabeza-Cab, S Sammicheli, NC Rogers, E Sahai, S Zelenay, C Reis E Sou NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control Cell, 2018-02-08;172(5):1022-1037.e14. 2018-02-08 [PMID: 29429633] (Bioassay, Mouse)	Bioassay	Mouse
JW Lee, A Hoshino, K Inoue, T Saitou, S Uehara, Y Kobayashi, S Ueha, K Matsushima, A Yamaguchi, Y Imai, T Iimura The HIV co-receptor CCR5 regulates osteoclast function Nat Commun, 2017-12-20;8(1):2226. 2017-12-20 [PMID: 29263385] (Bioassay, Mouse)	Bioassay	Mouse
N Suffee, C Le Visage, H Hlawaty, R Aid-Launai, V Vanneaux, J Larghero, O Haddad, O Oudar, N Charnaux, A Sutton Pro-angiogenic effect of RANTES-loaded polysaccharide-based microparticles for a mouse ischemia therapy Sci Rep, 2017-10-16;7(1):13294. 2017-10-16 [PMID: 29038476] (In Vivo, Mouse)	In Vivo	Mouse
Y Pan, LJ Smithson, Y Ma, D Hambardzum, DH Gutmann Ccl5 establishes an autocrine high-grade glioma growth regulatory circuit critical for mesenchymal glioblastoma survival Oncotarget, 2017-05-16;0(0):. 2017-05-16 [PMID: 28380429] (Bioassay, Mouse)	Bioassay	Mouse
SW Huang, C Walker, J Pennock, K Else, W Muller, MJ Daniels, C Pellegrini, D Brough, G Lopez-Cast, SM Cruickshan P2X7 receptor-dependent tuning of gut epithelial responses to infection Immunol. Cell Biol, 2016-08-25;95(2):178-188. 2016-08-25 [PMID: 27559003] (Bioassay, Mouse)	Bioassay	Mouse
Costa M, de Negreiros C, Bornstein V, Valente R, Mengel J, Henriques M, Benjamim C, Penido C Murine IL-17+ Vgamma4 T lymphocytes accumulate in the lungs and play a protective role during severe sepsis. BMC Immunol, 2015-06-03;16(0):36. 2015-06-03 [PMID: 26037291] (Bioassay, Mouse)	Bioassay	Mouse
Sottnik J, Dai J, Zhang H, Campbell B, Keller E Tumor-induced pressure in the bone microenvironment causes osteocytes to promote the growth of prostate cancer bone metastases. Cancer Res, 2015-04-08;75(11):2151-8. 2015-04-08 [PMID: 25855383] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
Yang L, Brooks C, Xiao S, Sabbisetti V, Yeung M, Hsiao L, Ichimura T, Kuchroo V, Bonventre J KIM-1-mediated phagocytosis reduces acute injury to the kidney. J Clin Invest, 2015-03-09;125(4):1620-36. 2015-03-09 [PMID: 25751064] (ELISA (Standard), Mouse)	ELISA (Standard)	Mouse
Sato S, Zhang X The Friend leukaemia virus integration 1 (Fli-1) transcription factor affects lupus nephritis development by regulating inflammatory cell infiltration into the kidney. Clin Exp Immunol, 2014-07-01;177(1):102-9. 2014-07-01 [PMID: 24580413] (Bioassay, Mouse)	Bioassay	Mouse
Kimura , Kenichi, Nagano , Masumi, Salazar , Georgina, Yamashita , Toshihar, Tsuboi , Ikki, Mishima , Hajime, Matsushita , Shonosuk, Sato , Fujio, Yamagata , Kenji, Ohneda , Osamu The role of CCL5 in the ability of adipose tissue-derived mesenchymal stem cells to support repair of ischemic regions. Stem Cells Dev, 2013-12-14;23(5):488-501. 2013-12-14 [PMID: 24171667] (In Vivo, Mouse)	In Vivo	Mouse
Wintges K, Beil F, Albers J, Jeschke A, Schweizer M, Claass B, Tiegs G, Amling M, Schinke T Impaired bone formation and increased osteoclastogenesis in mice lacking chemokine (C-C motif) ligand 5 (Ccl5). J Bone Miner Res, 2013-10-01;28(10):2070-80. 2013-10-01 [PMID: 23553711] (Bioassay, Mouse)	Bioassay	Mouse
Kim J, Natarajan S, Vaickus LJ, Bouchard JC, Beal D, Cruikshank WW, Remick DG Diesel exhaust particulates exacerbate asthma-like inflammation by increasing CXC chemokines. Am. J. Pathol., 2011-10-01;179(6):2730-9. 2011-10-01 [PMID: 21967814] (ELISA (Standard))	ELISA (Standard)
Binder NB, Niederreiter B, Hoffmann O, Stange R, Pap T, Stulnig TM, Mack M, Erben RG, Smolen JS, Redlich K Estrogen-dependent and C-C chemokine receptor-2-dependent pathways determine osteoclast behavior in osteoporosis. Nat. Med., 2009-03-29;15(4):417-24. 2009-03-29 [PMID: 19330010] (Bioassay, Mouse)	Bioassay	Mouse
Chou SY, Weng JY, Lai HL, Liao F, Sun SH, Tu PH, Dickson DW, Chern Y Expanded-polyglutamine huntingtin protein suppresses the secretion and production of a chemokine (CCL5/RANTES) by astrocytes. J. Neurosci., 2008-03-26;28(13):3277-90. 2008-03-26 [PMID: 18367595] (Bioassay, Mouse)	Bioassay	Mouse
Show All 20 Publications. Collapse Publications.

Array 478-MR/CF

• CCL5/RANTES Antibodies
• CCL5/RANTES Antibody Pair
• CCL5/RANTES ELISA Kit
• CCL5/RANTES Lysate
• CCL5/RANTES Proteins
• CCL5/RANTES ELISAs
• CCL5/RANTES Proteins and Enzymes