Recombinant Human VEGF 165 Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult (1-3). It is a member of the PDGF family that is characterized by the presence of eight conserved cysteine residues and a cystine knot structure (4). Humans express alternately spliced isoforms of 121, 145, 165, 183, 189, and 206 amino acids (aa) in length (4). VEGF₁₆₅ appears to be the most abundant and potent isoform, followed by VEGF₁₂₁ and VEGF₁₈₉ (3, 4). Isoforms other than VEGF₁₂₁ contain basic heparin-binding regions and are not freely diffusible (4). Human VEGF₁₆₅ shares 88% aa sequence identity with corresponding regions of mouse and rat, 96% with porcine, 95% with canine, and 93% with feline, equine and bovine VEGF, respectively. VEGF binds the type I transmembrane receptor tyrosine kinases VEGF R1 (also called Flt-1) and VEGF R2 (Flk-1/KDR) on endothelial cells (4). Although VEGF affinity is highest for binding to VEGF R1, VEGF R2 appears to be the primary mediator of VEGF angiogenic activity (3, 4). VEGF₁₆₅ binds the semaphorin receptor, Neuropilin-1 and promotes complex formation with VEGF R2 (5). VEGF is required during embryogenesis to regulate the proliferation, migration, and survival of endothelial cells (3, 4). In adults, VEGF functions mainly in wound healing and the female reproductive cycle (3). Pathologically, it is involved in tumor angiogenesis and vascular leakage (6, 7). Circulating VEGF levels correlate with disease activity in autoimmune diseases such as rheumatoid arthritis, multiple sclerosis and systemic lupus erythematosus (8). VEGF is induced by hypoxia and cytokines such as IL-1, IL-6, IL-8, oncostatin M and TNF-alpha (3, 4, 9).

Due to its role in angiogenesis of blood vessels, tumor and stroma cells use VEGF to stimulate formation of blood vessels and the proliferation and survival of endothelial cells. Specific immunotherapies targeting the VEGF signaling pathway include the recombinant antibody against VEGF (Bevacizumab), antibodies targeting the main VEGF receptor (VEGFR2), and small molecule inhibitors against VEGF receptor tyrosine kinases (10). Immune checkpoint inhibitors are an important tool in cancer therapies as tumor cells can hijack immune checkpoint signals to evade detection by immune cells. In addition to stimulating the formation of tumor blood vessels, VEGF has immunosuppressive effects by acting on dendritic cells to block their antigen-presenting and T cell stimulatory functions. Targeting VEGF in combination with other immune checkpoint ligands or receptors may prove more effective in immunotherapy approaches to certain cancer types (11). Because of its role in the formation of blood vessels, VEGF is also an important factor in skeletal development where blood supply and vascularization are crucial. This has made VEGF an important molecule in regenerative studies for bone repair as sustained release of VEGF has been shown to improve the efficiency of bone regeneration (12).

In differentiation protocols for stems cells, VEGF is a commonly added growth factor for the transformation of induced pluripotent stem cells into hematopoietic progenitor cells used to make Natural Killer cells (13, 14). VEGF has also been used to transform intermediate mesoderm into kidney glomerular podocytes or stem cell-derived liver spheres (15, 16). VEGF may also be used in assistance of stem cell transplantations by supporting angiogenesis at sites of stem cell transplants or as a honing tool for adipose-derived mesenchymal stem cells or bone marrow stem cells to migrate to (17, 18).

We have publications tested in 20 confirmed species: Human, Mouse, Rat, Avian - Quail, Bovine, Canine, Chicken, N/A, Porcine, Primate - Callitrix jacchus (Common Marmoset), Primate - Chlorocebus sabaeus (Green Monkey), Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque), Primate - Macaca mulatta (Rhesus Macaque), Rabbit, Rats, Sheep, Transgenic Mouse, Transgenic Rabbit, Xenopus, Zebrafish.

We have publications tested in 21 applications: Binding Analysis, Binding Assay, Bioassay, Cell Culture, Differentiation, ELISA, ELISA (Capture), ELISA (Standard), ELISA Capture, ELISA Development, Immunoassay Development, Immunoassay Standard, In Vivo, In vivo assay, Mass Spectrometry, Organ Culture, Quantum Dot, Stimulation, Surface Plasmon Resonance, Surface Plasmon Resonance (SPR, Western Blot.

Showing Publications 1 - 10 of 449. Show All 449 Publications. Collapse Publications.

Publications using 293-VE	Applications	Species
Keller, S;Kunz, U;Schmid, U;Beusmans, J;Büchert, M;He, M;Jayadeva, G;Le Tourneau, C;Luedtke, D;Niessen, HG;Oum'hamed, Z;Pleiner, S;Wang, X;Graeser, R; Comprehensive biomarker and modeling approach to support dose finding for BI 836880, a VEGF/Ang-2 inhibitor Journal of translational medicine 2024-10-14 [PMID: 39402675] (Mass Spectrometry, N/A)	Mass Spectrometry	N/A
Lee, H;Xie, T;Kang, B;Yu, X;Schaffter, SW;Schulman, R; Plug-and-play protein biosensors using aptamer-regulated in vitro transcription Nature communications 2024-09-12 [PMID: 39266511] (Bioassay, Human)	Bioassay	Human
Lekkala, VKR;Shrestha, S;Al Qaryoute, A;Dhinoja, S;Acharya, P;Raheem, A;Jagadeeswaran, P;Lee, MY; Enhanced Maturity and Functionality of Vascularized Human Liver Organoids through 3D Bioprinting and Pillar Plate Culture bioRxiv : the preprint server for biology 2024-08-22 [PMID: 39229042] (Bioassay, Human)	Bioassay	Human
Xu, W;Wang, Z;Liu, T;Ma, X;Jiao, M;Zhao, W;Yu, L;Hua, Y;Cai, Z;Li, J;Zhang, T; Eurycomanone inhibits osteosarcoma growth and metastasis by suppressing GRP78 expression Journal of ethnopharmacology 2024-08-18 [PMID: 39163893] (Bioassay, Human)	Bioassay	Human
Kent, GM;Atkins, MH;Lung, B;Nikitina, A;Fernandes, IM;Kwan, JJ;Andrews, TS;MacParland, SA;Keller, GM;Gage, BK; Human liver sinusoidal endothelial cells support the development of functional human pluripotent stem cell-derived Kupffer cells Cell reports 2024-08-14 [PMID: 39146183] (Bioassay, Human)	Bioassay	Human
Bisson, JA;Gordillo, M;Kumar, R;de Silva, N;Yang, E;Banks, KM;Shi, ZD;Lee, K;Yang, D;Chung, WK;Huangfu, D;Evans, T; GATA6 regulates WNT and BMP programs to pattern precardiac mesoderm during the earliest stages of human cardiogenesis bioRxiv : the preprint server for biology 2024-07-11 [PMID: 39026742] (Bioassay, Human)	Bioassay	Human
Moon, SY;Kim, HJ;Kim, JK;Kim, J;Choi, JS;Won, SY;Park, K;Lee, SHS; An examination of the mechanisms driving the therapeutic effects of an AAV expressing a soluble variant of VEGF receptor-1 PloS one 2024-07-11 [PMID: 38990973] (ELISA Capture, Human)	ELISA Capture	Human
Landau, S;Zhao, Y;Hamidzada, H;Kent, GM;Okhovatian, S;Lu, RXZ;Liu, C;Wagner, KT;Cheung, K;Shawky, SA;Vosoughi, D;Beroncal, EL;Fernandes, I;Cummins, CL;Andreazza, AC;Keller, GM;Epelman, S;Radisic, M; Primitive macrophages enable long-term vascularization of human heart-on-a-chip platforms Cell stem cell 2024-06-20 [PMID: 38908380] (Bioassay, Human)	Bioassay	Human
??, Ö;Wang, X;Reddy, JS;Min, Y;Yilmaz, E;Bhattarai, P;Patel, T;Bergman, J;Quicksall, Z;Heckman, MG;Tutor-New, FQ;Can Demirdogen, B;White, L;Koga, S;Krause, V;Inoue, Y;Kanekiyo, T;Cosacak, MI;Nelson, N;Lee, AJ;Vardarajan, B;Mayeux, R;Kouri, N;Deniz, K;Carnwath, T;Oatman, SR;Lewis-Tuffin, LJ;Nguyen, T;Alzheimer’s Disease Neuroimaging Initiative, ;Carrasquillo, MM;Graff-Radford, J;Petersen, RC;Jr Jack, CR;Kantarci, K;Murray, ME;Nho, K;Saykin, AJ;Dickson, DW;Kizil, C;Allen, M;Ertekin-Taner, N; Gliovascular transcriptional perturbations in Alzheimer's disease reveal molecular mechanisms of blood brain barrier dysfunction Nature communications 2024-06-20 [PMID: 38902234] (Bioassay, Human)	Bioassay	Human
Paul, SK;Oshima, M;Patil, A;Sone, M;Kato, H;Maezawa, Y;Kaneko, H;Fukuyo, M;Rahmutulla, B;Ouchi, Y;Tsujimura, K;Nakanishi, M;Kaneda, A;Iwama, A;Yokote, K;Eto, K;Takayama, N; Retrotransposons in Werner syndrome-derived macrophages trigger type I interferon-dependent inflammation in an atherosclerosis model Nature communications 2024-06-10 [PMID: 38858384] (Bioassay, Human)	Bioassay	Human
Lee, JG;Yon, JM;Kim, G;Lee, SG;Kim, CY;Cheong, SA;Kim, HY;Yu, J;Kim, K;Sung, YH;Yoo, HJ;Woo, DC;Rho, JK;Ha, CH;Pack, CG;Oh, SH;Lim, JS;Han, YM;Hong, EJ;Seong, JK;Lee, HW;Lee, SW;Lee, KU;Kim, CJ;Nam, SY;Cho, YS;Baek, IJ; PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development Nature communications 2024-02-19 [PMID: 38374152] (Bioassay, Human)	Bioassay	Human
Romanzi, A;Milosa, F;Marcelli, G;Critelli, RM;Lasagni, S;Gigante, I;Dituri, F;Schepis, F;Cadamuro, M;Giannelli, G;Fabris, L;Villa, E; Angiopoietin-2 and the Vascular Endothelial Growth Factor Promote Migration and Invasion in Hepatocellular Carcinoma- and Intrahepatic Cholangiocarcinoma-Derived Spheroids Biomedicines 2023-12-30 [PMID: 38255193] (Stimulation, Human)	Stimulation	Human
Chaube, B;Citrin, KM;Sahraei, M;Singh, AK;de Urturi, DS;Ding, W;Pierce, RW;Raaisa, R;Cardone, R;Kibbey, R;Fernández-Hernando, C;Suárez, Y; Suppression of angiopoietin-like 4 reprograms endothelial cell metabolism and inhibits angiogenesis Nature communications 2023-12-12 [PMID: 38086791] (Bioassay, Human)	Bioassay	Human
Urban, L;Novák, Š;?oma, M;Dvo?ánková, B;Lacina, L;Šáchová, J;Hradilová, M;Svato?ová, P;Kolá?, M;Strnad, H;B?ezinová, J;Smetana, K;Gál, P;Szabo, P; Unravelling heterogeneous effects of cancer?associated fibroblasts on poor prognosis markers in breast cancer EM?G3 cell line: In vitro?targeted treatment (anti?IL-6, anti?VEGF-A, anti?MFGE8) based on transcriptomic profiling Oncology reports 2024-01-01 [PMID: 37975220] (Bioassay, Human)	Bioassay	Human
Abu El-Asrar, AM;Nawaz, MI;Ahmad, A;Dillemans, L;Siddiquei, M;Allegaert, E;Gikandi, PW;De Hertogh, G;Opdenakker, G;Struyf, S; CD40 Ligand-CD40 Interaction Is an Intermediary between Inflammation and Angiogenesis in Proliferative Diabetic Retinopathy International journal of molecular sciences 2023-10-25 [PMID: 37958563] (Bioassay, Human)	Bioassay	Human
Friese-Hamim, M;Ortiz-Ruiz, MJ;Bogatyrova, O;Keil, M;Rohdich, F;Blume, B;Leuthner, B;Czauderna, F;Hahn, D;Jabs, J;Jaehrling, F;Heinrich, T;Kellner, R;Chan, K;Tong, AHY;Wienke, D;Moffat, J;Blaukat, A;Zenke, FT; Novel Methionine Aminopeptidase 2 Inhibitor M8891 Synergizes with VEGF Receptor Inhibitors to Inhibit Tumor Growth of Renal Cell Carcinoma Models Molecular cancer therapeutics 2023-11-08 [PMID: 37940144] (In vivo assay, Transgenic Mouse)	In vivo assay	Transgenic Mouse
Kang, DH;Kim, Y;Min, S;Lee, SY;Chung, KY;Baek, IJ;Kwon, K;Jo, H;Kang, SW; Blood flow patterns switch VEGFR2 activity through differential S-nitrosylation and S-oxidation Cell reports 2023-10-31 [PMID: 37910508] (Bioassay, Human)	Bioassay	Human
Lee, H;Xie, T;Yu, X;Schaffter, SW;Schulman, R; Plug-and-play protein biosensors using aptamer-regulated in vitro transcription bioRxiv : the preprint server for biology 2023-08-14 [PMID: 37645783] (Bioassay, Human)	Bioassay	Human
Maduabuchi, WO;Tansi, FL;Heller, R;Hilger, I; Hyperthermia Influences the Secretion Signature of Tumor Cells and Affects Endothelial Cell Sprouting Biomedicines 2023-08-12 [PMID: 37626752] (Bioassay, Human)	Bioassay	Human
S Yaylaci, E Dinç, B Ayd?n, AB Tekinay, MO Guler Peptide Nanofiber System for Sustained Delivery of Anti-VEGF Proteins to the Eye Vitreous Pharmaceutics, 2023-04-18;15(4):. 2023-04-18 [PMID: 37111749] (ELISA Capture, Rabbit)	ELISA Capture	Rabbit
A Gehrlein, V Udayar, N Anastasi, ML Morella, I Ruf, D Brugger, S von der Ma, R Thoma, A Rufer, D Heer, N Pfahler, A Jochner, J Niewoehner, L Wolf, M Fueth, M Ebeling, R Villaseñor, Y Zhu, MC Deen, X Shan, Z Ehsaei, V Taylor, E Sidransky, DJ Vocadlo, PO Freskgård, R Jagasia Targeting neuronal lysosomal dysfunction caused by beta-glucocerebrosidase deficiency with an enzyme-based brain shuttle construct Nature Communications, 2023-04-12;14(1):2057. 2023-04-12 [PMID: 37045813] (Bioassay, Human)	Bioassay	Human
E Lee, EA Lee, E Kong, H Chon, M Llaiqui-Co, CH Park, BY Park, NR Kang, JS Yoo, HS Lee, HS Kim, SH Park, SW Choi, D Vestweber, JH Lee, P Kim, WS Lee, I Kim An agonistic anti-Tie2 antibody suppresses the normal-to-tumor vascular transition in the glioblastoma invasion zone Experimental & Molecular Medicine, 2023-02-24;55(2):470-484. 2023-02-24 [PMID: 36828931] (Bioassay, Human)	Bioassay	Human
L Feige, T Kozaki, G Dias de Me, V Guillemot, F Larrous, F Ginhoux, H Bourhy Susceptibilities of CNS Cells towards Rabies Virus Infection Is Linked to Cellular Innate Immune Responses Viruses, 2022-12-29;15(1):. 2022-12-29 [PMID: 36680128] (Bioassay, Human)	Bioassay	Human
T Keratibumr, W Srisuthtay, O Wanachewin, J Klangjorho, T Phitak, P Pothacharo, TH Shwe, P Kongtawele Sesamin Attenuates VEGFA-Induced Angiogenesis via Inhibition of Src and FAK Signaling in Chick Chorioallantoic Membrane Model and Human Endothelial EA.hy926 Cells Biomedicines, 2023-01-11;11(1):. 2023-01-11 [PMID: 36672695] (Cell Culture, Human)	Cell Culture	Human
Y Ichiyama, R Matsumoto, S Obata, O Sawada, Y Saishin, M Kakinoki, T Sawada, M Ohji Assessment of mouse VEGF neutralization by ranibizumab and aflibercept PLoS ONE, 2022-12-21;17(12):e0278951. 2022-12-21 [PMID: 36542626] (Western Blot, N/A)	Western Blot	N/A
T Otsuka, T Masuda, Y Takahashi, A Suzuki, A Uemura, R Arakawa, T Okabe, A Naito Effect of triamcinolone acetonide on retinal inflammation and angiogenesis induced by pericyte depletion in mouse Journal of pharmacological sciences, 2022-10-23;151(1):28-36. 2022-10-23 [PMID: 36522120] (Bioassay, Human)	Bioassay	Human
H Zhang, B Li, J Ding, R Ye, Z Xu, Q Zhang, S Feng, Q Jiang, W Zhu, B Yan DCZ19931, a novel multi-targeting kinase inhibitor, inhibits ocular neovascularization Scientific Reports, 2022-12-13;12(1):21539. 2022-12-13 [PMID: 36513701] (Cell Culture, Human)	Cell Culture	Human
JE Kaserman, RB Werder, F Wang, T Matte, MI Higgins, M Dodge, J Lindstrom-, P Bawa, A Hinds, E Bullitt, IS Caballero, X Shi, RE Gerszten, N Brunetti-P, M Liesa, C Villacorta, AN Hollenberg, DN Kotton, AA Wilson Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity Cell Reports, 2022-12-06;41(10):111775. 2022-12-06 [PMID: 36476855] (Bioassay, Human)	Bioassay	Human
JP Borges, RSR Sætra, A Volchuk, M Bugge, P Devant, B Sporsheim, BR Kilburn, CL Evavold, JC Kagan, NM Goldenberg, TH Flo, BE Steinberg Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death Elife, 2022-12-05;11(0):. 2022-12-05 [PMID: 36468682] (Cell Culture, Mouse)	Cell Culture	Mouse
SM Lee, JW Lee, I Kim, DC Woo, CG Pack, YH Sung, IJ Baek, CH Jung, YH Kim, CH Ha Angiogenic adipokine C1q-TNF-related protein 9 ameliorates myocardial infarction via histone deacetylase 7-mediated MEF2 activation Science Advances, 2022-12-02;8(48):eabq0898. 2022-12-02 [PMID: 36459558] (Bioassay, Human)	Bioassay	Human
XY Cui, B Stavik, B Thiede, PM Sandset, SM Kanse FSAP Protects against Histone-Mediated Increase in Endothelial Permeability In Vitro International Journal of Molecular Sciences, 2022-11-08;23(22):. 2022-11-08 [PMID: 36430180] (Bioassay, Human)	Bioassay	Human
JA Oo, K Pálfi, T Warwick, I Wittig, C Prieto-Gar, V Matkovic, I Tomaškovi?, F Boos, J Izquierdo, T Teichmann, K Petriukov, S Haydar, L Maegdefess, Z Wu, MD Pham, J Krishnan, AH Baker, S Günther, HD Ulrich, I Dikic, MS Leisegang, RP Brandes Long non-coding RNA PCAT19 safeguards DNA in quiescent endothelial cells by preventing uncontrolled phosphorylation of RPA2 Cell Reports, 2022-11-15;41(7):111670. 2022-11-15 [PMID: 36384122] (Bioassay, Human)	Bioassay	Human
SH Choi, MJ Park, H Kim Inhibitor of differentiation 1 in U87MG glioblastoma cells promotes HUVEC sprouting through endothelin-1 Oncology Letters, 2022-09-27;24(5):413. 2022-09-27 [PMID: 36245828] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
H Wang, B Keepers, Y Qian, Y Xie, M Colon, J Liu, L Qian Cross-lineage potential of Ascl1 uncovered by comparing diverse reprogramming regulatomes Cell Stem Cell, 2022-10-06;29(10):1491-1504.e9. 2022-10-06 [PMID: 36206732] (Bioassay, Mouse)	Bioassay	Mouse
S Wei, Z Li, Q Shi, X Luan, X Yuan, Y Li, C Guo, X Wu, C Shi, G Di Collagen?binding vascular endothelial growth factor (CBD?VEGF) promotes liver regeneration in murine partial hepatectomy Molecular Medicine Reports, 2022-09-07;26(5):. 2022-09-07 [PMID: 36069236] (In Vivo, Mouse)	In Vivo	Mouse
D Yang, J Gomez-Garc, S Funakoshi, T Tran, I Fernandes, GD Bader, MA Laflamme, GM Keller Modeling human multi-lineage heart field development with pluripotent stem cells Cell Stem Cell, 2022-09-01;29(9):1382-1401.e8. 2022-09-01 [PMID: 36055193] (Bioassay, Human)	Bioassay	Human
SY Lee, JH Park, KH Cho, H Kim, HK Shin Isolinderalactone inhibits glioblastoma cell supernatant-induced angiogenesis Oncology Letters, 2022-08-02;24(4):328. 2022-08-02 [PMID: 36039052] (Bioassay, Human)	Bioassay	Human
R Jing, I Scarfo, MA Najia, E Lummertz d, A Han, M Sanborn, T Bingham, C Kubaczka, DK Jha, M Falchetti, TM Schlaeger, TE North, MV Maus, GQ Daley EZH1 repression generates mature iPSC-derived CAR T�cells with enhanced antitumor activity Cell Stem Cell, 2022-08-04;29(8):1181-1196.e6. 2022-08-04 [PMID: 35931029] (Bioassay, Human)	Bioassay	Human
B Hwang, Y Gho, H Kim, S Lee, SA Hong, TJ Lee, SC Myung, SJ Yun, YH Choi, WJ Kim, SK Moon Rosa hybrida Petal Extract Exhibits Antitumor Effects by Abrogating Tumor Progression and Angiogenesis in Bladder Cancer Both In Vivo and In Vitro Integrative cancer therapies, 2022-01-01;21(0):1534735422111. 2022-01-01 [PMID: 35912937] (Bioassay, Human)	Bioassay	Human
SL Lu, H Omori, Y Zhou, YS Lin, CC Liu, JJ Wu, T Noda VEGF-Mediated Augmentation of Autophagic and Lysosomal Activity in Endothelial Cells Defends against Intracellular Streptococcus pyogenes MBio, 2022-07-05;0(0):e0123322. 2022-07-05 [PMID: 35862783] (Bioassay, Human)	Bioassay	Human
N Gioelli, LJ Neilson, N Wei, G Villari, W Chen, B Kuhle, M Ehling, F Maione, S Willox, S Brundu, D Avanzato, G Koulouras, M Mazzone, E Giraudo, XL Yang, D Valdembri, S Zanivan, G Serini Neuropilin 1 and its inhibitory ligand mini-tryptophanyl-tRNA synthetase inversely regulate VE-cadherin turnover and vascular permeability Nature Communications, 2022-07-20;13(1):4188. 2022-07-20 [PMID: 35858913] (Bioassay, Human)	Bioassay	Human
Y Tsujisaka, T Hatani, C Okubo, R Ito, A Kimura, M Narita, K Chonabayas, S Funakoshi, A Lucena-Cac, T Toyoda, K Osafune, T Kimura, H Saito, Y Yoshida Purification of human iPSC-derived cells at large scale using microRNA switch and magnetic-activated cell sorting Stem Cell Reports, 2022-06-09;0(0):. 2022-06-09 [PMID: 35688152] (Bioassay, Human)	Bioassay	Human
Y Cheng, A Medina, Z Yao, M Basu, JP Natekar, J Lang, E Sanchez, MB Nkembo, C Xu, X Qian, PTT Nguyen, Z Wen, H Song, GL Ming, M Kumar, MA Brinton, MMH Li, H Tang Intrinsic antiviral immunity of barrier cells revealed by an iPSC-derived blood-brain barrier cellular model Cell Reports, 2022-05-31;39(9):110885. 2022-05-31 [PMID: 35649379] (Bioassay, Human)	Bioassay	Human
HL Deissler, M Rehak, A Wolf Impairment of the Retinal Endothelial Cell Barrier Induced by Long-Term Treatment with VEGF-A165 No Longer Depends on the Growth Factor's Presence Biomolecules, 2022-05-23;12(5):. 2022-05-23 [PMID: 35625661] (Bovine)		Bovine
Q Lian, K Zhang, Z Zhang, F Duan, L Guo, W Luo, BW Mok, A Thakur, X Ke, P Motallebne, V Nicolaescu, J Chen, CY Ma, X Zhou, S Han, T Han, W Zhang, AY Tan, T Zhang, X Wang, D Xu, J Xiang, A Xu, C Liao, FP Huang, YW Chen, J Na, G Randall, HF Tse, Z Chen, Y Chen, HJ Chen Differential effects of macrophage subtypes on SARS-CoV-2 infection in a human pluripotent stem cell-derived model Nature Communications, 2022-04-19;13(1):2028. 2022-04-19 [PMID: 35440562] (Bioassay, Human)	Bioassay	Human
BK Gage, S Merlin, C Olgasi, A Follenzi, GM Keller Therapeutic correction of hemophilia A by transplantation of hPSC-derived liver sinusoidal endothelial cell progenitors Cell Reports, 2022-04-05;39(1):110621. 2022-04-05 [PMID: 35385743] (Bioassay, Human)	Bioassay	Human
Salokas K, Liu X, Ohman T, Chowdhury I, Gawriyski L, Keskitalo S, Varjosalo M Physical and functional interactome atlas of human receptor tyrosine kinases. EMBO Rep, 2022-04-05;23(6):e54041. 2022-04-05 [PMID: 35384245] (Bioassay, Human)	Bioassay	Human
M Willems, P Sebetaenha, I Gies, V Vloeberghs, H Tournaye, D Van Saen, E Goossens Intratesticular xenografting of Klinefelter pre-pubertal testis tissue as potential model to study testicular fibrosis Reproductive biomedicine online, 2022-01-31;0(0):. 2022-01-31 [PMID: 35282995] (Cell Culture, Human)	Cell Culture	Human
Z Wang, HP McWilliams, H Reza, JR Ostberg, W Chen, X Wang, C Huynh, V Vyas, WC Chang, R Starr, JR Wagner, B Aguilar, X Yang, X Wu, J Wang, W Chen, E Koelker-Wo, CS Seet, A Montel-Hag, GM Crooks, SJ Forman, CE Brown 3D-organoid culture supports differentiation of human CAR+ iPSCs into highly functional CAR T�cells Cell Stem Cell, 2022-03-11;0(0):. 2022-03-11 [PMID: 35278370] (Bioassay, Human)	Bioassay	Human
DC Kirman, B Renganatha, WK Chui, MW Chen, NA Kaya, R Ge Cell surface nucleolin is a novel ADAMTS5 receptor mediating endothelial cell apoptosis Cell Death & Disease, 2022-02-23;13(2):172. 2022-02-23 [PMID: 35197459] (Bioassay, Human)	Bioassay	Human
TC Ho, SI Yeh, SL Chen, TW Chu, YP Tsao A short peptide derived from pigment epithelial-derived factor exhibits an angioinhibitory effect BMC ophthalmology, 2022-02-22;22(1):88. 2022-02-22 [PMID: 35193548] (Bioassay, Human)	Bioassay	Human
S Rosano, S Parab, A Noghero, D Corà, F Bussolino Long Non-Coding RNA LINC02802 Regulates In Vitro Sprouting Angiogenesis by Sponging microRNA-486-5p International Journal of Molecular Sciences, 2022-01-31;23(3):. 2022-01-31 [PMID: 35163581] (Bioassay, Human)	Bioassay	Human
AM Abu El-Asr, A Ahmad, MI Nawaz, MM Siddiquei, A De Zutter, L Vanbrabant, PW Gikandi, G Opdenakker, S Struyf Tissue Inhibitor of Metalloproteinase-3 Ameliorates Diabetes-Induced Retinal Inflammation Frontiers in Physiology, 2022-01-10;12(0):807747. 2022-01-10 [PMID: 35082694] (Bioassay, Human)	Bioassay	Human
A Hunziker, I Glas, MO Pohl, S Stertz Phosphoproteomic profiling of influenza virus entry reveals infection-triggered filopodia induction counteracted by dynamic cortactin phosphorylation Cell Reports, 2022-01-25;38(4):110306. 2022-01-25 [PMID: 35081340] (Bioassay, Human)	Bioassay	Human
A Das, D Ash, AY Fouda, V Sudhahar, YM Kim, Y Hou, FZ Hudson, BK Stansfield, RB Caldwell, M McMenamin, R Littlejohn, H Su, MR Regan, BJ Merrill, LB Poole, JH Kaplan, T Fukai, M Ushio-Fuka Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis Nature Cell Biology, 2022-01-13;24(1):35-50. 2022-01-13 [PMID: 35027734] (Bioassay, Human)	Bioassay	Human
JH Wang, CL Tseng, FL Lin, J Chen, EH Hsieh, S Lama, YF Chuang, S Kumar, L Zhu, MB McGuinness, J Hernandez, L Tu, PY Wang, GS Liu Topical application of TAK1 inhibitor encapsulated by gelatin particle alleviates corneal neovascularization Theranostics, 2022-01-01;12(2):657-674. 2022-01-01 [PMID: 34976206] (Bioassay, Human)	Bioassay	Human
M Ling, L Quan, X Lai, L Lang, F Li, X Yang, Y Fu, S Feng, X Yi, C Zhu, P Gao, X Zhu, L Wang, G Shu, Q Jiang, S Wang VEGFB Promotes Myoblasts Proliferation and Differentiation through VEGFR1-PI3K/Akt Signaling Pathway International Journal of Molecular Sciences, 2021-12-12;22(24):. 2021-12-12 [PMID: 34948148] (Bioassay, Mouse)	Bioassay	Mouse
R Belvedere, E Morretta, N Novizio, S Morello, O Bruno, C Brullo, A Petrella The Pyrazolyl-Urea Gege3 Inhibits the Activity of ANXA1 in the Angiogenesis Induced by the Pancreatic Cancer Derived EVs Biomolecules, 2021-11-24;11(12):. 2021-11-24 [PMID: 34944403] (Bioassay, Human)	Bioassay	Human
P Li, Q Li, N Biswas, H Xin, T Diemer, L Liu, L Perez Guti, G Paternostr, C Piermarocc, S Domanskyi, RK Wang, N Ferrara LIF, a mitogen for choroidal endothelial cells, protects the choriocapillaris: implications for prevention of geographic atrophy Embo Molecular Medicine, 2021-11-15;0(0):e14511. 2021-11-15 [PMID: 34779136] (Bioassay, In Vivo, Bovine, Mouse)	Bioassay, In Vivo	Bovine, Mouse
RC Jiang, XY Zheng, SL Yang, HJ Shi, JH Xi, YJ Zou, HQ Dou, YJ Wang, Y Qin, XL Zhang, Q Xiao CD146 mediates the anti-apoptotic role of Netrin-1 in endothelial progenitor cells under hypoxic conditions Molecular Medicine Reports, 2021-11-05;25(1):. 2021-11-05 [PMID: 34738629] (Bioassay, Mouse)	Bioassay	Mouse
M Moncayo-Do, GA Rico-Llano, DA Garzón-Alv, J Becerra, R Visser, MR Fontanilla The Effect of Pore Directionality of Collagen Scaffolds on Cell Differentiation and In Vivo Osteogenesis Polymers, 2021-09-20;13(18):. 2021-09-20 [PMID: 34578088] (In Vivo, Rats)	In Vivo	Rats
JAF Silva, X Qi, MB Grant, ME Boulton Spatial and temporal VEGF receptor intracellular trafficking in microvascular and macrovascular endothelial cells Scientific Reports, 2021-08-30;11(1):17400. 2021-08-30 [PMID: 34462507] (Bioassay, Human)	Bioassay	Human
H Yasuda, M Tanaka, A Nishinaka, S Nakamura, M Shimazawa, H Hara Role of Activating Transcription Factor 4 in Murine Choroidal Neovascularization Model International Journal of Molecular Sciences, 2021-08-18;22(16):. 2021-08-18 [PMID: 34445595] (Bioassay, Human)	Bioassay	Human
Y Wang, Y Zhu, Y Gu, M Ma, Y Wang, S Qi, Y Zeng, R Zhu, X Wang, P Yu, J Xu, Y Shu, FX Yu Stabilization of Motin family proteins in NF2-deficient cells prevents full activation of YAP/TAZ and rapid tumorigenesis Cell Reports, 2021-08-24;36(8):109596. 2021-08-24 [PMID: 34433060] (Bioassay, Mouse)	Bioassay	Mouse
S Ma, LS Mangala, W Hu, E Bayaktar, A Yokoi, W Hu, S Pradeep, S Lee, PD Piehowski, A Villar-Pra, SY Wu, MH McGuire, OD Lara, C Rodriguez-, CJ LaFargue, NB Jennings, KD Rodland, T Liu, V Kundra, PT Ram, S Ramakrishn, G Lopez-Bere, RL Coleman, AK Sood CD63-mediated cloaking of VEGF in small extracellular vesicles contributes to anti-VEGF therapy resistance Cell Reports, 2021-08-17;36(7):109549. 2021-08-17 [PMID: 34407412] (Bioassay, Human)	Bioassay	Human
P Ebner-Peki, L Krisch, M Wolf, S Hochmann, A Hoog, B Vári, K Muigg, R Poupardin, C Scharler, S Schmidhube, E Russe, H Stachelsch, A Schneeberg, K Schallmose, D Strunk Self-assembly of differentiated progenitor cells facilitates spheroid human skin organoid formation and planar skin regeneration Theranostics, 2021-07-25;11(17):8430-8447. 2021-07-25 [PMID: 34373751] (Bioassay, Human)	Bioassay	Human
AM Abu El-Asr, MI Nawaz, A Ahmad, MM Siddiquei, E Allegaert, PW Gikandi, G De Hertogh, G Opdenakker CD146/Soluble CD146 Pathway Is a Novel Biomarker of Angiogenesis and Inflammation in Proliferative Diabetic Retinopathy Investigative Ophthalmology & Visual Science, 2021-07-01;62(9):32. 2021-07-01 [PMID: 34293080] (Bioassay, Human)	Bioassay	Human
M Richards, S Pal, E Sjöberg, P Martinsson, L Venkatrama, L Claesson-W Intra-vessel heterogeneity establishes enhanced sites of macromolecular leakage downstream of laminin &alpha5 Cell Reports, 2021-06-22;35(12):109268. 2021-06-22 [PMID: 34161758] (Bioassay, Human)	Bioassay	Human
H Iseoka, S Miyagawa, Y Sakai, Y Sawa Cardiac fibrosis models using human induced pluripotent stem cell-derived cardiac tissues allow anti-fibrotic drug screening in vitro Stem Cell Research, 2021-06-11;54(0):102420. 2021-06-11 [PMID: 34126557] (Bioassay, Human)	Bioassay	Human
L Martin, P Bouvet, N Chounlamou, C Watrin, R Besançon, D Pinatel, D Meyronet, J Honnorat, A Buisson, PA Salin, C Meissirel VEGF counteracts amyloid-&beta-induced synaptic dysfunction Cell Reports, 2021-05-11;35(6):109121. 2021-05-11 [PMID: 33979625] (Bioassay, ELISA Capture, Human)	Bioassay, ELISA Capture	Human
MG Dallinga, YI Habani, AWM Schimmel, GM Dallinga-T, CJF van Noorde, I Klaassen, RO Schlingema The Role of Heparan Sulfate and Neuropilin 2 in VEGFA Signaling in Human Endothelial Tip Cells and Non-Tip Cells during Angiogenesis In Vitro Cells, 2021-04-16;10(4):. 2021-04-16 [PMID: 33923753] (Cell Culture, Human)	Cell Culture	Human
CH Dreyer, NR Jørgensen, S Overgaard, L Qin, M Ding Vascular Endothelial Growth Factor and Mesenchymal Stem Cells Revealed Similar Bone Formation to Allograft in a Sheep Model BioMed Research International, 2021-03-03;2021(0):6676609. 2021-03-03 [PMID: 33763484] (Bioassay, Sheep)	Bioassay	Sheep
J Wu, M Kong, Y Lou, L Li, C Yang, H Xu, Y Cui, H Hao, Z Liu Simultaneous Activation of Erk1/2 and Akt Signaling is Critical for Formononetin-Induced Promotion of Endothelial Function Frontiers in Pharmacology, 2021-01-11;11(0):608518. 2021-01-11 [PMID: 33505313] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
IO Zabroski, MA Nugent Lipid Raft Association Stabilizes VEGF Receptor 2 in Endothelial Cells International Journal of Molecular Sciences, 2021-01-14;22(2):. 2021-01-14 [PMID: 33466887] (Bioassay, Bovine)	Bioassay	Bovine
M Souidi, Y Sleiman, I Acimovic, J Pribyl, A Charrabi, V Baecker, V Scheuerman, M Pesl, S Jelinkova, P Skladal, P Dvorak, A Lacampagne, V Rotrekl, AC Meli Oxygen Is an Ambivalent Factor for the Differentiation of Human Pluripotent Stem Cells in Cardiac 2D Monolayer and 3D Cardiac Spheroids International Journal of Molecular Sciences, 2021-01-11;22(2):. 2021-01-11 [PMID: 33440843] (Bioassay, Human)	Bioassay	Human
C Zhong, P Li, S Argade, L Liu, A Chilla', W Liang, H Xin, B Eliceiri, B Choudhury, N Ferrara Inhibition of protein glycosylation is a novel pro-angiogenic strategy that acts via activation of stress pathways Nature Communications, 2020-12-10;11(1):6330. 2020-12-10 [PMID: 33303737] (Cell Culture, Human)	Cell Culture	Human
Z Wang, M Cui, AM Shah, W Tan, N Liu, R Bassel-Dub, EN Olson Cell-Type-Specific Gene Regulatory Networks Underlying Murine Neonatal Heart Regeneration at Single-Cell Resolution Cell Reports, 2020-12-08;33(10):108472. 2020-12-08 [PMID: 33296652] (Bioassay, Human)	Bioassay	Human
E Ristori, V Cicaloni, L Salvini, L Tinti, C Tinti, M Simons, F Corti, S Donnini, M Ziche Amyloid-&beta Precursor Protein APP Down-Regulation Alters Actin Cytoskeleton-Interacting Proteins in Endothelial Cells Cells, 2020-11-19;9(11):. 2020-11-19 [PMID: 33228083] (Bioassay, Human)	Bioassay	Human
J Shen, J Kim, SY Tzeng, K Ding, Z Hafiz, D Long, J Wang, JJ Green, PA Campochiar Suprachoroidal gene transfer with nonviral nanoparticles Science Advances, 2020-07-03;6(27):. 2020-07-03 [PMID: 32937452] (Bioassay, Rat)	Bioassay	Rat
Z Wei, R Schnellman, HC Pruitt, S Gerecht Hydrogel Network Dynamics Regulate Vascular Morphogenesis Cell Stem Cell, 2020-09-14;0(0):. 2020-09-14 [PMID: 32931729] (Bioassay, Human)	Bioassay	Human
SB Mamer, A Wittenkell, PI Imoukhuede VEGF-A splice variants bind VEGFRs with differential affinities Sci Rep, 2020-09-02;10(1):14413. 2020-09-02 [PMID: 32879419] (Bioassay, N/A, Human)	Bioassay	N/A, Human
DH Shin, JY Jo, SH Kim, M Choi, C Han, BK Choi, SS Kim Midkine Is a Potential Therapeutic Target of Tumorigenesis, Angiogenesis, and Metastasis in Non-Small Cell Lung Cancer Cancers (Basel), 2020-08-24;12(9):. 2020-08-24 [PMID: 32847073] (Bioassay, Human)	Bioassay	Human
F Duan, L Guo, L Yang, Y Han, A Thakur, BE Nilsson-Pa, P Wang, Z Zhang, CY Ma, X Zhou, T Han, T Zhang, X Wang, D Xu, X Duan, J Xiang, HF Tse, C Liao, W Luo, FP Huang, YW Chen, T Evans, RE Schwartz, B tenOever, DD Ho, S Chen, Q Lian, HJ Chen Modeling COVID-19 with Human Pluripotent Stem Cell-Derived Cells Reveals Synergistic Effects of Anti-inflammatory Macrophages with ACE2 Inhibition Against SARS-CoV-2 Res Sq, 2020-09-15;0(0):. 2020-09-15 [PMID: 32839764] (Bioassay, Human)	Bioassay	Human
L Yang, Y Han, BE Nilsson-Pa, V Gupta, P Wang, X Duan, X Tang, J Zhu, Z Zhao, F Jaffré, T Zhang, TW Kim, O Harschnitz, D Redmond, S Houghton, C Liu, A Naji, G Ciceri, S Guttikonda, Y Bram, DT Nguyen, M Cioffi, V Chandar, DA Hoagland, Y Huang, J Xiang, H Wang, D Lyden, A Borczuk, HJ Chen, L Studer, FC Pan, DD Ho, BR tenOever, T Evans, RE Schwartz, S Chen A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids Cell Stem Cell, 2020-06-19;27(1):125-136.e7. 2020-06-19 [PMID: 32579880] (Bioassay, Human)	Bioassay	Human
L Yang, Y Han, BE Nilsson-Pa, V Gupta, P Wang, X Duan, X Tang, J Zhu, Z Zhao, F Jaffré, T Zhang, TW Kim, O Harschnitz, D Redmond, S Houghton, C Liu, A Naji, G Ciceri, S Guttikonda, Y Bram, DT Nguyen, M Cioffi, V Chandar, DA Hoagland, Y Huang, J Xiang, H Wang, D Lyden, A Borczuk, HJ Chen, L Studer, FC Pan, DD Ho, BR tenOever, T Evans, RE Schwartz, S Chen A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids Cell Stem Cell, 2020;27(1):125-136.e7. 2020 [PMID: 32579880] (Bioassay, Human)	Bioassay	Human
H Zhu, RH Blum, D Bernareggi, EH Ask, Z Wu, HJ Hoel, Z Meng, C Wu, KL Guan, KJ Malmberg, DS Kaufman Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In�Vivo Persistence and Enhances Anti-tumor Activity Cell Stem Cell, 2020-06-11;0(0):. 2020-06-11 [PMID: 32531207] (Bioassay, Human)	Bioassay	Human
Z Hu, I Cano, KL Saez-Torre, ME LeBlanc, M Saint-Geni, YS Ng, P Argüeso, PA D'Amore Elements of the Endomucin Extracellular Domain Essential for VEGF-Induced VEGFR2 Activity Cells, 2020-06-05;9(6):. 2020-06-05 [PMID: 32517158] (Cell Culture, Human)	Cell Culture	Human
K Watanabe, Y Taketomi, Y Miki, K Kugiyama, M Murakami Group V secreted phospholipase A2 plays a protective role against aortic dissection J. Biol. Chem., 2020-06-01;295(30):10092-10111. 2020-06-01 [PMID: 32482892] (Cell Culture, Human)	Cell Culture	Human
WH Hu, HY Wang, YT Xia, DK Dai, QP Xiong, TT Dong, R Duan, GK Chan, QW Qin, KW Tsim Kaempferol, a Major Flavonoid in Ginkgo Folium, Potentiates Angiogenic Functions in Cultured Endothelial Cells by Binding to Vascular Endothelial Growth Factor Front Pharmacol, 2020-04-28;11(0):526. 2020-04-28 [PMID: 32410995] (Bioassay, Human)	Bioassay	Human
R Kumar, AM Mani, NK Singh, GN Rao PKC?-JunB axis via upregulation of VEGFR3 expression mediates hypoxia-induced pathological retinal neovascularization Cell Death Dis, 2020-05-07;11(5):325. 2020-05-07 [PMID: 32382040] (Bioassay, Mouse)	Bioassay	Mouse
G Wang, MR de Vries, WMPJ Sol, AM van Oevere, HC de Boer, AJ van Zonnev, PHA Quax, TJ Rabelink, BM van den Be Loss of Endothelial Glycocalyx Hyaluronan Impairs Endothelial Stability and Adaptive Vascular Remodeling After Arterial Ischemia Cells, 2020-03-29;9(4):. 2020-03-29 [PMID: 32235347] (Bioassay, Human)	Bioassay	Human
M Díaz-Corán, CM Lin, S Liebner, DA Antonetti Norrin restores blood-retinal barrier properties after vascular endothelial growth factor-induced permeability J. Biol. Chem., 2020-02-21;0(0):. 2020-02-21 [PMID: 32086377] (Bioassay, Bovine)	Bioassay	Bovine
F Li, Z Liu, H Sun, C Li, W Wang, L Ye, C Yan, J Tian, H Wang PCC0208017, a novel small-molecule inhibitor of MARK3/MARK4, suppresses glioma progression in�vitro and in�vivo Acta Pharm Sin B, 2019-09-18;10(2):289-300. 2019-09-18 [PMID: 32082974] (Bioassay, Human)	Bioassay	Human
H Iseoka, S Miyagawa, A Saito, A Harada, Y Sawa Role and therapeutic effects of skeletal muscle-derived non-myogenic cells in a rat myocardial infarction model Stem Cell Res Ther, 2020-02-18;11(1):69. 2020-02-18 [PMID: 32070429] (Cell Culture, Human)	Cell Culture	Human
F Njau, N Shushakova, H Schenk, VC Wulfmeyer, R Bollin, J Menne, H Haller Calcium dobesilate reduces VEGF signaling by interfering with heparan sulfate binding site and protects from vascular complications in diabetic mice PLoS ONE, 2020-01-14;15(1):e0218494. 2020-01-14 [PMID: 31935212] (Human)		Human
S Matsushima, A Shimizu, M Kondo, H Asano, N Ueno, H Nakayama, N Sato, M Komeno, H Ogita, M Kurokawa-S Anosmin-1 activates vascular endothelial growth factor receptor and its related signaling pathway for olfactory bulb angiogenesis Sci Rep, 2020-01-13;10(1):188. 2020-01-13 [PMID: 31932617] (Binding Analysis, Human)	Binding Analysis	Human
K Matsuura, M Wada, K Sakaguchi, Y Matsuhashi, T Shimizu Adequate taylor couette flow-mediated shear stress is useful for dissociating human iPS cell-derived cell aggregates Regen Ther, 2019-04-25;12(0):6-13. 2019-04-25 [PMID: 31890761] (Bioassay, Human)	Bioassay	Human
J Li, F Tang, R Li, Z Chen, SM Lee, C Fu, J Zhang, GP Leung Dietary compound glycyrrhetinic acid suppresses tumor angiogenesis and growth by modulating antiangiogenic and proapoptotic pathways in vitro and in vivo J. Nutr. Biochem., 2019-11-09;77(0):108268. 2019-11-09 [PMID: 31830590] (Bioassay, Human)	Bioassay	Human
L Wan, Y Zhao, Q Zhang, G Gao, S Zhang, Y Gao, X Chen, X Qian Alkaloid extract of Corydalis yanhusuo inhibits angiogenesis via targeting vascular endothelial growth factor receptor signaling BMC Complement Altern Med, 2019-12-10;19(1):359. 2019-12-10 [PMID: 31823762] (Bioassay, In Vivo, Chicken, Human)	Bioassay, In Vivo	Chicken, Human
L Koehler, G Ruiz-Gómez, K Balamuruga, S Rother, J Freyse, S Möller, M Schnabelra, S Köhling, S Djordjevic, D Scharnwebe, J Rademann, MT Pisabarro, V Hintze Dual Action of Sulfated Hyaluronan on Angiogenic Processes in Relation to Vascular Endothelial Growth Factor-A Sci Rep, 2019-12-02;9(1):18143. 2019-12-02 [PMID: 31792253] (Bioassay, Surface Plasmon Resonance (SPR, Human)	Bioassay, Surface Plasmon Resonance (SPR	Human
L Wan, M Lovett, ME Warchol, JS Stone Vascular endothelial growth factor is required for regeneration of auditory hair cells in the avian inner ear Hear. Res., 2019-11-08;385(0):107839. 2019-11-08 [PMID: 31760261] (Organ Culture, Chicken)	Organ Culture	Chicken
WH Hu, GK Chan, R Duan, HY Wang, XP Kong, TT Dong, KW Tsim Synergy of Ginkgetin and Resveratrol in Suppressing VEGF-Induced Angiogenesis: A Therapy in Treating Colorectal Cancer Cancers (Basel), 2019-11-20;11(12):. 2019-11-20 [PMID: 31757048] (Cell Culture, Human)	Cell Culture	Human
H Nagano, C Tomida, N Yamagishi, S Teshima-Ko VEGFR-1 Regulates EGF-R to Promote Proliferation in Colon Cancer Cells Int J Mol Sci, 2019-11-09;20(22):. 2019-11-09 [PMID: 31717527] (Bioassay, Human)	Bioassay	Human
T Ikuno, S Ito, T Inoue Human induced pluripotent stem cell-derived mast cells useful for in vitro mast cell activation assay exhibiting phenotypes and morphological characteristics of human mast cells J Toxicol Sci, 2019-01-01;44(11):789-797. 2019-01-01 [PMID: 31708535] (Cell Culture, Human)	Cell Culture	Human
B Hwang, SS Shin, JH Song, YH Choi, WJ Kim, SK Moon Carnosine exerts antitumor activity against bladder cancers in vitro and in vivo via suppression of angiogenesis J. Nutr. Biochem., 2019-09-01;74(0):108230. 2019-09-01 [PMID: 31683101] (Bioassay, Human)	Bioassay	Human
GL Tiemeier, G Wang, SJ Dumas, WMPJ Sol, MC Avramut, T Karakach, VV Orlova, CW van den Be, CL Mummery, P Carmeliet, BM van den Be, TJ Rabelink Closing the Mitochondrial Permeability Transition Pore in hiPSC-Derived Endothelial Cells Induces Glycocalyx Formation and Functional Maturation Stem Cell Reports, 2019-10-31;13(5):803-816. 2019-10-31 [PMID: 31680061] (Cell Culture, Human)	Cell Culture	Human
M Oh, SB Rho, C Son, K Park, SY Song Non-proteolytic calpain-6 interacts with VEGFA and promotes angiogenesis by increasing VEGF secretion Sci Rep, 2019-10-31;9(1):15771. 2019-10-31 [PMID: 31673071] (Bioassay, Human)	Bioassay	Human
P Deshors, C Toulas, F Arnauduc, L Malric, A Siegfried, Y Nicaise, A Lemarié, D Larrieu, M Tosolini, E Cohen-Jona, M Courtade-S, SM Evrard Ionizing radiation induces endothelial transdifferentiation of glioblastoma stem-like cells through the Tie2 signaling pathway Cell Death Dis, 2019-10-28;10(11):816. 2019-10-28 [PMID: 31659157] (Bioassay, Human)	Bioassay	Human
J Grajcarek, J Monlong, Y Nishinaka-, M Nakamura, M Nagai, S Matsuo, D Lougheed, H Sakurai, MK Saito, G Bourque, K Woltjen Genome-wide microhomologies enable precise template-free editing of biologically relevant deletion mutations Nat Commun, 2019-10-24;10(1):4856. 2019-10-24 [PMID: 31649251] (Bioassay, Human)	Bioassay	Human
W Liang, P Han, EH Kim, J Mak, R Zhang, AG Torrente, JI Goldhaber, E Marbán, HC Cho Canonical Wnt signaling promotes pacemaker cell specification of cardiac mesodermal cells derived from mouse and human embryonic stem cells Stem Cells, 2019-12-30;0(0):. 2019-12-30 [PMID: 31648393] (Bioassay, Mouse)	Bioassay	Mouse
M Marie, P Gondouin, D Pagan, C Barrau, T Villette, J Sahel, S Picaud Blue-violet light decreases VEGFa production in an in vitro model of AMD PLoS ONE, 2019-10-23;14(10):e0223839. 2019-10-23 [PMID: 31644596] (Bioassay, Porcine)	Bioassay	Porcine
T Liu, Y Li, H Su, H Zhang, D Jones, HJ Zhou, W Ji, W Min Nuclear localization of the tyrosine kinase BMX mediates VEGFR2 expression J. Cell. Mol. Med., 2019-10-23;0(0):. 2019-10-23 [PMID: 31642192] (Bioassay, Human)	Bioassay	Human
SP Chaki, R Barhoumi, GM Rivera Nck adapter proteins promote podosome biogenesis facilitating extracellular matrix degradation and cancer invasion Cancer Med, 2019-10-22;0(0):. 2019-10-22 [PMID: 31638742] (Bioassay, Human)	Bioassay	Human
AB Cerezo, M Labrador, A Gutiérrez, R Hornedo-Or, AM Troncoso, MC Garcia-Par Anti-VEGF Signalling Mechanism in HUVECs by Melatonin, Serotonin, Hydroxytyrosol and Other Bioactive Compounds Nutrients, 2019-10-11;11(10):. 2019-10-11 [PMID: 31614459] (Bioassay, Human)	Bioassay	Human
TW Chung, EY Kim, HJ Choi, CW Han, SB Jang, KJ Kim, L Jin, YJ Koh, KT Ha 6'-Sialylgalactose inhibits vascular endothelial growth factor receptor 2-mediated angiogenesis Exp. Mol. Med., 2019-10-11;51(10):120. 2019-10-11 [PMID: 31604908] (Bioassay, In Vivo, Human, Mouse)	Bioassay, In Vivo	Human, Mouse
D Tsiros, CE Sheehy, S Pecchia, MA Nugent Heparin potentiates Avastin-mediated inhibition of VEGF binding to fibronectin and rescues Avastin activity at acidic pH J. Biol. Chem., 2019-10-10;0(0):. 2019-10-10 [PMID: 31601651] (Bioassay, Human, Porcine)	Bioassay	Human, Porcine
HJ Lim, J Park, JY Um, SS Lee, HJ Kwak Zileuton, a 5-Lipoxygenase Inhibitor, Exerts Anti-Angiogenic Effect by Inducing Apoptosis of HUVEC via BK Channel Activation Cells, 2019-09-30;8(10):. 2019-09-30 [PMID: 31575085] (Bioassay, In Vivo, Human, Mouse)	Bioassay, In Vivo	Human, Mouse
CD Lowery, W Blosser, M Dowless, M Renschler, LV Perez, J Stephens, B Pytowski, H Wasserstro, LF Stancato, B Falcon Anti-VEGFR2 therapy delays growth of preclinical pediatric tumor models and enhances anti-tumor activity of chemotherapy Oncotarget, 2019-09-17;10(53):5523-5533. 2019-09-17 [PMID: 31565186] (Bioassay, Human)	Bioassay	Human
Q Mei, A Bansal, MKG Jayakumar, Z Zhang, J Zhang, H Huang, D Yu, CJA Ramachandr, DJ Hausenloy, TW Soong, Y Zhang Manipulating energy migration within single lanthanide activator for switchable upconversion emissions towards bidirectional photoactivation Nat Commun, 2019-09-27;10(1):4416. 2019-09-27 [PMID: 31562321] (Bioassay, Human)	Bioassay	Human
H Lv, Z Nan, P Jiang, Z Wang, M Song, H Ding, D Liu, G Zhao, Y Zheng, Y Hu Vascular endothelial growth factor 165 inhibits pro-fibrotic differentiation of stromal cells via the DLL4/Notch4/smad7 pathway Cell Death Dis, 2019-09-12;10(9):681. 2019-09-12 [PMID: 31515487] (Bioassay, Human)	Bioassay	Human
Y Ma, KN Su, D Pfau, VS Rao, X Wu, X Hu, L Leng, X Du, M Piecychna, K Bedi, SG Campbell, A Eichmann, JM Testani, KB Margulies, R Bucala, LH Young Cardiomyocyte d-dopachrome tautomerase protects against heart failure JCI Insight, 2019-09-05;4(17):. 2019-09-05 [PMID: 31484822] (Bioassay, Human)	Bioassay	Human
L Messerschm, S Fischer, P Wiedemann, A Bringmann, M Hollborn Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation Mol. Vis., 2019-06-30;25(0):329-344. 2019-06-30 [PMID: 31341381] (Bioassay, Human)	Bioassay	Human
K Njah, S Chakrabort, B Qiu, S Arumugam, A Raju, AV Pobbati, M Lakshmanan, V Tergaonkar, G Thibault, X Wang, W Hong A Role of Agrin in Maintaining the Stability of Vascular Endothelial Growth Factor Receptor-2 during Tumor Angiogenesis Cell Rep, 2019-07-23;28(4):949-965.e7. 2019-07-23 [PMID: 31340156] (Bioassay, Human)	Bioassay	Human
T Jia, J Ciccione, T Jacquet, M Maurel, T Montheil, A Mehdi, J Martinez, B Eymin, G Subra, JL Coll The presence of PEG on nanoparticles presenting the c[RGDfK]- and/or ATWLPPR peptides deeply affects the RTKs-AKT-GSK3?-eNOS signaling pathway and endothelial cells survival Int J Pharm, 2019-07-09;568(0):118507. 2019-07-09 [PMID: 31299336] (Bioassay, Human)	Bioassay	Human
H Gao, J Chen, T Chen, Y Wang, Y Song, Y Dong, S Zhao, RF Machado MicroRNA410 Inhibits Pulmonary Vascular Remodeling via Regulation of Nicotinamide Phosphoribosyltransferase Sci Rep, 2019-07-09;9(1):9949. 2019-07-09 [PMID: 31289307] (Cell Culture, Human)	Cell Culture	Human
S Pecha, K Yorgan, M Röhl, B Geertz, A Hansen, F Weinberger, S Sehner, H Ehmke, H Reichenspu, T Eschenhage, AP Schwoerer Human iPS cell-derived engineered heart tissue does not affect ventricular arrhythmias in a guinea pig cryo-injury model Sci Rep, 2019-07-08;9(1):9831. 2019-07-08 [PMID: 31285568] (Cell Culture, Human)	Cell Culture	Human
Ohta R, Sugimura R, Niwa A, Saito M Hemogenic Endothelium Differentiation from Human Pluripotent Stem Cells in A Feeder- and Xeno-free Defined Condition. J Vis Exp, 2019-06-16;0(148):. 2019-06-16 [PMID: 31259914] (Bioassay, Human)	Bioassay	Human
M Nasri, M Ritter, P Mir, B Dannenmann, N Aghaallaei, D Amend, V Makaryan, Y Xu, B Fletcher, R Bernhard, I Steiert, K Hahnel, J Berger, I Koch, B Sailer, K Hipp, C Zeidler, M Klimiankou, B Bajoghli, DC Dale, K Welte, J Skokowa CRISPR/Cas9 mediated ELANE knockout enables neutrophilic maturation of primary hematopoietic stem and progenitor cells and induced pluripotent stem cells of severe congenital neutropenia patients Haematologica, 2019-06-27;0(0):. 2019-06-27 [PMID: 31248972] (Bioassay, Human)	Bioassay	Human
H Yang, DH Jung, HW Lee Therapeutic effect of Cnidium officinale Makino extract on ovariectomized hind-limb ischemic mice Integr Med Res, 2019-05-04;8(2):107-115. 2019-05-04 [PMID: 31193479] (Bioassay, Human)	Bioassay	Human
GA Weiner, SH Shah, CM Angelopoul, AB Bartakova, RS Pulido, A Murphy, E Nudleman, R Daneman, JL Goldberg Cholinergic neural activity directs retinal layer-specific angiogenesis and blood retinal barrier formation Nat Commun, 2019-06-06;10(1):2477. 2019-06-06 [PMID: 31171770] (Bioassay, Mouse)	Bioassay	Mouse
G Genet, K Boyé, T Mathivet, R Ola, F Zhang, A Dubrac, J Li, N Genet, L Henrique G, L Benedetti, S Künzel, L Pibouin-Fr, JL Thomas, A Eichmann Endophilin-A2 dependent VEGFR2 endocytosis promotes sprouting angiogenesis Nat Commun, 2019-05-28;10(1):2350. 2019-05-28 [PMID: 31138815] (Cell Culture, Human)	Cell Culture	Human
S Nakamura, T Noguchi, Y Inoue, S Sakurai, A Nishinaka, Y Hida, T Masuda, Y Nakagami, N Horai, H Tsusaki, H Hara, M Shimazawa Nrf2 Activator RS9 Suppresses Pathological Ocular Angiogenesis and Hyperpermeability Invest. Ophthalmol. Vis. Sci., 2019-05-01;60(6):1943-1952. 2019-05-01 [PMID: 31050722] (Bioassay, Human)	Bioassay	Human
E Ntemou, P Kadam, S Van Laere, D Van Saen, E Vicini, E Goossens Effect of recombinant human vascular endothelial growth factor on testis tissue xenotransplants from prepubertal boys: a three-case study Reprod. Biomed. Online, 2019-03-12;0(0):. 2019-03-12 [PMID: 31005581] (Bioassay, Human)	Bioassay	Human
B Mair, J Tomic, SN Masud, P Tonge, A Weiss, M Usaj, AHY Tong, JJ Kwan, KR Brown, E Titus, M Atkins, KSK Chan, L Munsie, A Habsid, H Han, M Kennedy, B Cohen, G Keller, J Moffat Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies Cell Rep, 2019-04-09;27(2):599-615.e12. 2019-04-09 [PMID: 30970261] (Differentiation, Differentiation, Human)	Differentiation, Differentiation	Human
LM Muellerlei, B Buxbaum, B Nell, DA Fux In-vitro binding analysis of anti-human vascular endothelial growth factor antibodies bevacizumab and aflibercept with canine, feline, and equine vascular endothelial growth factor Res. Vet. Sci., 2019-03-22;124(0):233-238. 2019-03-22 [PMID: 30933891] (ELISA, Western Blot, Human)	ELISA, Western Blot	Human
S Jauhiainen, JP Laakkonen, K Ketola, PI Toivanen, T Nieminen, T Ninchoji, AL Levonen, MU Kaikkonen, S Ylä-Herttu Axon Guidance-Related Factor FLRT3 Regulates VEGF-Signaling and Endothelial Cell Function Front Physiol, 2019-03-12;10(0):224. 2019-03-12 [PMID: 30930791] (Bioassay, Human)	Bioassay	Human
O Lyros, AK Lamprecht, L Nie, R Thieme, K Götzel, M Gasparri, G Haasler, P Rafiee, R Shaker, I Gockel Dickkopf-1 (DKK1) promotes tumor growth via Akt-phosphorylation and independently of Wnt-axis in Barrett's associated esophageal adenocarcinoma Am J Cancer Res, 2019-02-01;9(2):330-346. 2019-02-01 [PMID: 30906632] (Bioassay, Human)	Bioassay	Human
T Emi, K Michaud, E Orton, G Santilli, C Linh, M O'Connell, F Issa, S Kennedy Ultrasonic Generation of Pulsatile and Sequential Therapeutic Delivery Profiles from Calcium-Crosslinked Alginate Hydrogels Molecules, 2019-03-16;24(6):. 2019-03-16 [PMID: 30884862] (Bioassay)	Bioassay
NW Pensa, AS Curry, MS Reddy, SL Bellis The addition of a polyglutamate domain to the angiogenic QK peptide improves peptide coupling to bone graft materials leading to enhanced endothelial cell activation PLoS ONE, 2019-03-11;14(3):e0213592. 2019-03-11 [PMID: 30856221] (Bioassay, Human)	Bioassay	Human
H Xu, B Wang, M Ono, A Kagita, K Fujii, N Sasakawa, T Ueda, P Gee, M Nishikawa, M Nomura, F Kitaoka, T Takahashi, K Okita, Y Yoshida, S Kaneko, A Hotta Targeted Disruption of HLA Genes via CRISPR-Cas9 Generates iPSCs with Enhanced Immune Compatibility Cell Stem Cell, 2019-03-07;0(0):. 2019-03-07 [PMID: 30853558] (Bioassay, Human)	Bioassay	Human
T Colunga, M Hayworth, S Kre beta , DM Reynolds, L Chen, KL Nazor, J Baur, AM Singh, JF Loring, M Metzger, S Dalton Human Pluripotent Stem Cell-Derived Multipotent Vascular Progenitors of the Mesothelium Lineage Have Utility in Tissue Engineering and Repair Cell Rep, 2019-03-05;26(10):2566-2579.e10. 2019-03-05 [PMID: 30840882] (Bioassay, Human)	Bioassay	Human
S Aghaabdoll, R Ahangari C, D Norouzian, F Davami, MR Asadi Kara, F Torkashvan, G Vaseghi, R Moazzami, S Latif Diza Enhancing bioactivity, physicochemical, and pharmacokinetic properties of a nano-sized, anti-VEGFR2 Adnectin, through PASylation technology Sci Rep, 2019-02-27;9(1):2978. 2019-02-27 [PMID: 30814652] (Bioassay, Human)	Bioassay	Human
N Muraoka, K Nara, F Tamura, H Kojima, H Yamakawa, T Sadahiro, K Miyamoto, M Isomi, S Haginiwa, H Tani, S Kurotsu, R Osakabe, S Torii, S Shimizu, H Okano, Y Sugimoto, K Fukuda, M Ieda Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming Nat Commun, 2019-02-20;10(1):674. 2019-02-20 [PMID: 30787297] (Bioassay, Mouse)	Bioassay	Mouse
S Pehrsson, M Hölttä, G Linhardt, RF Danielson, L Carlsson Rapid Production of Human VEGF-A following Intradermal Injection of Modified VEGF-A mRNA Demonstrated by Cutaneous Microdialysis in the Rabbit and Pig In Vivo Biomed Res Int, 2019-01-15;2019(0):3915851. 2019-01-15 [PMID: 30766883] (Immunoassay Standard, Transgenic Rabbit)	Immunoassay Standard	Transgenic Rabbit
E Ito, S Miyagawa, M Takeda, A Kawamura, A Harada, H Iseoka, S Yajima, N Sougawa, N Mochizuki-, S Yasuda, Y Sato, Y Sawa Tumorigenicity assay essential for facilitating safety studies of hiPSC-derived cardiomyocytes for clinical application Sci Rep, 2019-02-13;9(1):1881. 2019-02-13 [PMID: 30760836] (Bioassay, Human)	Bioassay	Human
NJ Grimsey, Y Lin, R Narala, CC Rada, H Mejia-Pena, J Trejo G protein-coupled receptors activate p38 MAPK via a non-canonical TAB1-TAB2 and TAB1-TAB3 dependent pathway in endothelial cells J. Biol. Chem., 2019-02-13;0(0):. 2019-02-13 [PMID: 30760523] (Bioassay, Human)	Bioassay	Human
S Ashraf, S Bell, C O'Leary, P Canning, I Micu, JA Fernandez, M O'Hare, P Barabas, H McCauley, DP Brazil, AW Stitt, JG McGeown, TM Curtis CAMKII as a therapeutic target for growth factor-induced retinal and choroidal neovascularisation JCI Insight, 2019-03-21;0(0):. 2019-03-21 [PMID: 30721154] (Bioassay, Human)	Bioassay	Human
T Karnezis, R Farnsworth, NC Harris, SP Williams, C Caesar, DJ Byrne, P Herle, ML Macheda, R Shayan, YF Zhang, S Yazar, SJ Takouridis, C Gerard, S Fox, MG Achen, SA Stacker CCL27/CCL28-CCR10 CHEMOKINE SIGNALING MEDIATES MIGRATION OF LYMPHATIC ENDOTHELIAL CELLS Cancer Res., 2019-02-01;0(0):. 2019-02-01 [PMID: 30709930] (In Vivo, Mouse)	In Vivo	Mouse
C Abou Fayca, S Gazzeri, B Eymin A VEGF-A/SOX2/SRSF2 network controls VEGFR1 pre-mRNA alternative splicing in lung carcinoma cells Sci Rep, 2019-01-23;9(1):336. 2019-01-23 [PMID: 30674935] (Bioassay, Human)	Bioassay	Human
M Ye, Q Ni, H Qi, X Qian, J Chen, X Guo, M Li, Y Zhao, G Xue, H Deng, L Zhang Exosomes Derived from Human Induced Pluripotent Stem Cells-Endothelia Cells Promotes Postnatal Angiogenesis in Mice Bearing Ischemic Limbs Int. J. Biol. Sci., 2019-01-01;15(1):158-168. 2019-01-01 [PMID: 30662356] (Bioassay, Human)	Bioassay	Human
S Stephenson, MA Care, I Fan, A Zougman, DR Westhead, GM Doody, RM Tooze Growth Factor-like Gene Regulation Is Separable from Survival and Maturation in Antibody-Secreting Cells J. Immunol., 2019-01-14;202(4):1287-1300. 2019-01-14 [PMID: 30642980] (Bioassay, Human)	Bioassay	Human
R Jin, G Song, J Chai, X Gou, G Yuan, Z Chen Effects of concentrated growth factor on proliferation, migration, and differentiation of human dental pulp stem cells in vitro J Tissue Eng, 2018-12-21;9(0):2041731418817. 2018-12-21 [PMID: 30622693] (Bioassay, Human)	Bioassay	Human
Y Jang, J Choi, N Park, J Kang, M Kim, Y Kim, JH Ju Development of immunocompatible pluripotent stem cells via CRISPR-based human leukocyte antigen engineering Exp. Mol. Med., 2019-01-07;51(1):3. 2019-01-07 [PMID: 30617277] (Bioassay, Human)	Bioassay	Human
MB Huynh, MO Ouidja, S Chantepie, G Carpentier, A Maïza, G Zhang, J Vilares, R Raisman-Vo, D Papy-Garci Glycosaminoglycans from Alzheimer's disease hippocampus have altered capacities to bind and regulate growth factors activities and to bind tau PLoS ONE, 2019-01-04;14(1):e0209573. 2019-01-04 [PMID: 30608949] (ELISA Development, Human)	ELISA Development	Human
GA Rodrigues, M Mason, LA Christie, C Hansen, LM Hernandez, J Burke, KA Luhrs, TC Hohman Functional Characterization of Abicipar-Pegol, an Anti-VEGF DARPin Therapeutic That Potently Inhibits Angiogenesis and Vascular Permeability Invest. Ophthalmol. Vis. Sci., 2018-12-03;59(15):5836-5846. 2018-12-03 [PMID: 30535424] (Bioassay, Human)	Bioassay	Human
R Grishanin, B Vuillemeno, P Sharma, A Keravala, J Greengard, C Gelfman, M Blumenkran, M Lawrence, W Hu, S Kiss, M Gasmi Preclinical Evaluation of ADVM-022, a Novel Gene Therapy Approach to Treating Wet Age-Related Macular Degeneration Mol. Ther., 2018-11-13;0(0):. 2018-11-13 [PMID: 30528929] (ELISA (Capture), Primate - Chlorocebus sabaeus (Green Monkey))	ELISA (Capture)	Primate - Chlorocebus sabaeus (Green Monkey)
S Masuda, K Matsuura, T Shimizu Preparation of iPS cell-derived CD31+ endothelial cells using three-dimensional suspension culture Regen Ther, 2018-07-07;9(0):1-9. 2018-07-07 [PMID: 30525069] (Bioassay, Human)	Bioassay	Human
RD Makin, I Apicella, Y Nagasaka, H Kaneko, SD Turner, N Kerur, J Ambati, BD Gelfand RF/6A Chorioretinal Cells Do Not Display Key Endothelial Phenotypes Invest. Ophthalmol. Vis. Sci., 2018-12-03;59(15):5795-5802. 2018-12-03 [PMID: 30508043] (Bioassay, Human)	Bioassay	Human
N Sun, B Ning, KM Hansson, AC Bruce, SA Seaman, C Zhang, M Rikard, CA DeRosa, CL Fraser, M Wågberg, R Fritsche-D, J Wikström, KR Chien, A Lundahl, M Hölttä, LG Carlsson, SM Peirce, S Hu Modified VEGF-A mRNA induces sustained multifaceted microvascular response and accelerates diabetic wound healing Sci Rep, 2018-11-30;8(1):17509. 2018-11-30 [PMID: 30504800] (In Vivo, Mouse)	In Vivo	Mouse
A Minagawa, T Yoshikawa, M Yasukawa, A Hotta, M Kunitomo, S Iriguchi, M Takiguchi, Y Kassai, E Imai, Y Yasui, Y Kawai, R Zhang, Y Uemura, H Miyoshi, M Nakanishi, A Watanabe, A Hayashi, K Kawana, T Fujii, T Nakatsura, S Kaneko Enhancing T Cell Receptor Stability in Rejuvenated iPSC-Derived T Cells Improves Their Use in Cancer Immunotherapy Cell Stem Cell, 2018-11-15;0(0):. 2018-11-15 [PMID: 30449714] (Bioassay, Human)	Bioassay	Human
BJ Hamilton, D Tse, RV Stan Phorbol esters induce PLVAP expression via VEGF and additional secreted molecules in MEK1-dependent and p38, JNK and PI3K/Akt-independent manner J. Cell. Mol. Med., 2018-11-05;0(0):. 2018-11-05 [PMID: 30394679] (Bioassay, Human)	Bioassay	Human
HC Wang, P Wang, YW Chen, Y Zhang Bevacizumab or fibronectin gene editing inhibits the osteoclastogenic effects of fibroblasts derived from human radicular cysts Acta Pharmacol. Sin., 2018-10-31;0(0):. 2018-10-31 [PMID: 30382180] (Bioassay, Mouse)	Bioassay	Mouse
LJ Luo, TY Lin, CH Yao, PY Kuo, M Matsusaki, SG Harroun, CC Huang, JY Lai Dual-functional gelatin-capped silver nanoparticles for antibacterial and antiangiogenic treatment of bacterial keratitis J Colloid Interface Sci, 2018-10-17;536(0):112-126. 2018-10-17 [PMID: 30366177] (Bioassay, Human)	Bioassay	Human
A Boudria, C Abou Fayca, T Jia, S Gout, M Keramidas, C Didier, N Lemaître, S Manet, JL Coll, AC Toffart, D Moro-Sibil, C Albiges-Ri, V Josserand, E Faurobert, C Brambilla, E Brambilla, S Gazzeri, B Eymin VEGF165b, a splice variant of VEGF-A, promotes lung tumor progression and escape from anti-angiogenic therapies through a ?1 integrin/VEGFR autocrine loop Oncogene, 2018-09-07;0(0):. 2018-09-07 [PMID: 30194450] (Bioassay, Human)	Bioassay	Human
LS Pane, FG Fulcoli, A Cirino, A Altomonte, R Ferrentino, M Bilio, A Baldini Tbx1 represses Mef2c gene expression and is correlated with histone 3 deacetylation of the anterior heart field enhancer Dis Model Mech, 2018-08-30;11(9):. 2018-08-30 [PMID: 30166330] (Bioassay, Human)	Bioassay	Human
K Koefoed, J Skat-Rørda, P Andersen, CB Warzecha, M Pye, TA Andersen, KD Ajbro, E Bendsen, M Narimatsu, F Vilhardt, LB Pedersen, JL Wrana, RH Anderson, K Møllgård, ST Christense, LA Larsen The E3 ubiquitin ligase SMURF1 regulates cell-fate specification and outflow tract septation during mammalian heart development Sci Rep, 2018-06-22;8(1):9542. 2018-06-22 [PMID: 29934521] (Bioassay, Human)	Bioassay	Human
SM Bestall, RP Hulse, Z Blackley, M Swift, N Ved, K Paton, N Beazley-Lo, DO Bates, LF Donaldson Sensory neuronal sensitisation occurs through HMGB-1/ RAGE and TRPV1 in high glucose conditions J. Cell. Sci., 2018-07-26;0(0):. 2018-07-26 [PMID: 29930087] (In Vivo, Rat)	In Vivo	Rat
N Ueda, Y Uemura, R Zhang, S Kitayama, S Iriguchi, Y Kawai, Y Yasui, M Tatsumi, T Ueda, TY Liu, Y Mizoro, C Okada, A Watanabe, M Nakanishi, S Senju, Y Nishimura, K Kuzushima, H Kiyoi, T Naoe, S Kaneko Generation of TCR-Expressing Innate Lymphoid-like Helper Cells that Induce Cytotoxic T Cell-Mediated Anti-leukemic Cell Response Stem Cell Reports, 2018-05-24;0(0):. 2018-05-24 [PMID: 29805109] (Bioassay, Human)	Bioassay	Human
L Alabdi, M He, Q Yang, AB Norvil, H Gowher The transcription factor Vezf1 represses the expression of the antiangiogenic factor d2 in endothelial cells J. Biol. Chem., 2018-05-24;0(0):. 2018-05-24 [PMID: 29794136] (Bioassay, Human)	Bioassay	Human
X Guo, Y Xu, Z Wang, Y Wu, J Chen, G Wang, C Lu, W Jia, J Xi, S Zhu, Z Jiapaer, X Wan, Z Liu, S Gao, J Kang A Linc1405/Eomes Complex Promotes Cardiac Mesoderm Specification and Cardiogenesis Cell Stem Cell, 2018-05-10;0(0):. 2018-05-10 [PMID: 29754779] (Bioassay, Mouse)	Bioassay	Mouse
L Corsuto, S Rother, L Koehler, E Bedini, S Moeller, M Schnabelra, V Hintze, C Schiraldi, D Scharnwebe Sulfation degree not origin of chondroitin sulfate derivatives modulates keratinocyte response Carbohydr Polym, 2018-03-01;191(0):53-64. 2018-03-01 [PMID: 29661321] (Bioassay, Human)	Bioassay	Human
S Conroy, FAE Kruyt, M Wagemakers, KPL Bhat, WFA den Dunnen IL-8 associates with a pro-angiogenic and mesenchymal subtype in glioblastoma Oncotarget, 2018-02-28;9(21):15721-15731. 2018-02-28 [PMID: 29644004] (Bioassay, Human)	Bioassay	Human
E Groppa, S Brkic, A Uccelli, G Wirth, P Korpisalo-, M Filippova, B Dasen, V Sacchi, MG Muraro, M Trani, S Reginato, R Gianni-Bar, S Ylä-Herttu, A Banfi EphrinB2/EphB4 signaling regulates non-sprouting angiogenesis by VEGF EMBO Rep., 2018-04-11;0(0):. 2018-04-11 [PMID: 29643120] (Cell Culture, Human)	Cell Culture	Human
N Seo, A Polozova, M Zhang, Z Yates, S Cao, H Li, S Kuhns, G Maher, HJ McBride, J Liu Analytical and functional similarity of Amgen biosimilar ABP 215 to bevacizumab MAbs, 2018-04-20;0(0):1-58. 2018-04-20 [PMID: 29553864] (ELISA Capture, Human)	ELISA Capture	Human
Z Pan, J Zhuang, C Ji, Z Cai, W Liao, Z Huang Curcumin inhibits hepatocellular carcinoma growth by targeting VEGF expression Oncol Lett, 2018-02-07;15(4):4821-4826. 2018-02-07 [PMID: 29552121] (Bioassay, Mouse)	Bioassay	Mouse
YC Lin, CY Liu, R Kannagi, RB Yang Inhibition of Endothelial SCUBE2 (Signal Peptide-CUB-EGF Domain-Containing Protein 2), a Novel VEGFR2 (Vascular Endothelial Growth Factor Receptor 2) Coreceptor, Suppresses Tumor Angiogenesis Arterioscler. Thromb. Vasc. Biol., 2018-03-15;0(0):. 2018-03-15 [PMID: 29545238] (Bioassay, Human)	Bioassay	Human
DJ LaValley, MR Zanotelli, F Bordeleau, W Wang, SC Schwager, CA Reinhart-K Matrix Stiffness Enhances VEGFR-2 Internalization, Signaling, and Proliferation in Endothelial Cells Converg Sci Phys Oncol, 2017-11-29;3(0):. 2017-11-29 [PMID: 29531793] (Bioassay, Human)	Bioassay	Human
M Chen, T Qiu, J Wu, Y Yang, GD Wright, M Wu, R Ge Extracellular anti-angiogenic proteins augment an endosomal protein trafficking pathway to reach mitochondria and execute apoptosis in HUVECs Cell Death Differ., 2018-03-09;0(0):. 2018-03-09 [PMID: 29523874] (Bioassay, Human)	Bioassay	Human
MQ Wentink, HMW Verheul, AW Griffioen, KA Schafer, S McPherson, RJ Early, HJ van der Vl, TD de Gruijl A safety and immunogenicity study of immunization with hVEGF26-104/RFASE in cynomolgus monkeys Vaccine, 2018-03-05;0(0):. 2018-03-05 [PMID: 29519591] (Bioassay, Mouse)	Bioassay	Mouse
DGP van IJzend, S Sleijfer, H Gelderblom, FALM Eskens, GJ van Leende, K Szuhai, JVMG Bovee Telatinib is an effective targeted therapy for pseudomyogenic hemangioendothelioma Clin. Cancer Res., 2018-03-06;0(0):. 2018-03-06 [PMID: 29511030] (Bioassay, Human)	Bioassay	Human
KB Neves, FJ Rios, L van der Me, R Alves-Lope, AC Cameron, M Volpe, AC Montezano, C Savoia, RM Touyz VEGFR (Vascular Endothelial Growth Factor Receptor) Inhibition Induces Cardiovascular Damage via Redox-Sensitive Processes Hypertension, 2018-02-26;71(4):638-647. 2018-02-26 [PMID: 29483228] (Bioassay, Human)	Bioassay	Human
L Zhang, Z Lv, J Xu, C Chen, Q Ge, P Li, D Wei, Z Wu, X Sun MicroRNA-134 inhibits osteosarcoma angiogenesis and proliferation by targeting the VEGFA/VEGFR1 pathway FEBS J., 2018-03-23;0(0):. 2018-03-23 [PMID: 29474747] (Bioassay, Human)	Bioassay	Human
JM Dave, T Mirabella, SD Weatherbee, DM Greif Pericyte ALK5/TIMP3 Axis Contributes to Endothelial Morphogenesis in the Developing Brain Dev. Cell, 2018-02-15;0(0):. 2018-02-15 [PMID: 29456135] (Bioassay, Human)	Bioassay	Human
H Tian, JJ Huang, C Golzio, X Gao, M Hector-Gre, N Katsanis, GC Blobe Endoglin interacts with VEGFR2 to promote angiogenesis FASEB J., 2018-01-11;0(0):fj201700867RR. 2018-01-11 [PMID: 29401587] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
J Richter, EG Stanley, ES Ng, AG Elefanty, D Traver, K Willert WNT9A Is a Conserved Regulator of Hematopoietic Stem and Progenitor Cell Development Genes (Basel), 2018-01-29;9(2):. 2018-01-29 [PMID: 29382179] (Bioassay, Human)	Bioassay	Human
S Gogalic, U Sauer, S Doppler, C Preininger Investigating Colorimetric Protein Array Assay Schemes for Detection of Recurrence of Bladder Cancer Biosensors (Basel), 2018-01-24;8(1):. 2018-01-24 [PMID: 29364182] (Human)		Human
H Alsaffar, N Martino, JP Garrett, AP Adam Interleukin-6 promotes a sustained loss of endothelial barrier function via Janus kinase-mediated STAT3 phosphorylation and de novo protein synthesis Am. J. Physiol., Cell Physiol., 2018-01-10;0(0):. 2018-01-10 [PMID: 29351406] (Bioassay, Human)	Bioassay	Human
B Zhang, CY Wei, KK Chang, JJ Yu, WJ Zhou, HL Yang, J Shao, JJ Yu, MQ Li, F Xie TSLP promotes angiogenesis of human umbilical vein endothelial cells by strengthening the crosstalk between cervical cancer cells and eosinophils Oncol Lett, 2017-10-03;14(6):7483-7488. 2017-10-03 [PMID: 29344192] (Bioassay, Human)	Bioassay	Human
L Varinská, L Fáber, M Kello, E Petrovová, ? Balážová, P Solár, M ?oma, P Urdzík, J Mojžiš, E Švajdlenka, P Mu?aji, P Gál ?-Escin Effectively Modulates HUVECS Proliferation and Tube Formation Molecules, 2018-01-17;23(1):. 2018-01-17 [PMID: 29342121] (Bioassay, Human)	Bioassay	Human
R Jalili, J Horecka, JR Swartz, RW Davis, HHJ Persson Streamlined circular proximity ligation assay provides high stringency and compatibility with low-affinity antibodies Proc. Natl. Acad. Sci. U.S.A., 2018-01-16;0(0):. 2018-01-16 [PMID: 29339495] (Bioassay)	Bioassay
CL Duran, CA Abbey, KJ Bayless Establishment of a three-dimensional model to study human uterine angiogenesis Mol. Hum. Reprod., 2018-02-01;0(0):. 2018-02-01 [PMID: 29329415] (Bioassay, Human)	Bioassay	Human
KC Wheeler, MK Jena, BS Pradhan, N Nayak, S Das, CD Hsu, DS Wheeler, K Chen, NR Nayak VEGF may contribute to macrophage recruitment and M2 polarization in the decidua PLoS ONE, 2018-01-11;13(1):e0191040. 2018-01-11 [PMID: 29324807] (Bioassay, Human)	Bioassay	Human
J Cao, M Ehling, S März, J Seebach, K Tarbashevi, T Sixta, ME Pitulescu, AC Werner, B Flach, E Montanez, E Raz, RH Adams, H Schnittler Polarized actin and VE-cadherin dynamics regulate junctional remodelling and cell migration during sprouting angiogenesis Nat Commun, 2017-12-20;8(1):2210. 2017-12-20 [PMID: 29263363] (Bioassay, Human)	Bioassay	Human
S Seo, W Suh Antiangiogenic effect of dasatinib in murine models of oxygen-induced retinopathy and laser-induced choroidal neovascularization Mol. Vis., 2017-11-24;23(0):823-831. 2017-11-24 [PMID: 29225458] (Bioassay, Human)	Bioassay	Human
SB Mamer, S Chen, JC Weddell, A Palasz, A Wittenkell, M Kumar, PI Imoukhuede Discovery of High-Affinity PDGF-VEGFR Interactions: Redefining RTK Dynamics Sci Rep, 2017-11-27;7(1):16439. 2017-11-27 [PMID: 29180757] (Surface Plasmon Resonance, Human)	Surface Plasmon Resonance	Human
M Nagao, JL Hamilton, R Kc, AD Berendsen, X Duan, CW Cheong, X Li, HJ Im, BR Olsen Vascular Endothelial Growth Factor in Cartilage Development and Osteoarthritis Sci Rep, 2017-10-12;7(1):13027. 2017-10-12 [PMID: 29026147] (In Vivo, Mouse)	In Vivo	Mouse
GA Howe, K Kazda, CL Addison MicroRNA-30b controls endothelial cell capillary morphogenesis through regulation of transforming growth factor beta 2 PLoS ONE, 2017-10-04;12(10):e0185619. 2017-10-04 [PMID: 28977001] (Bioassay, Human)	Bioassay	Human
Z Liu, S Yan, J Wang, Y Xu, Y Wang, S Zhang, X Xu, Q Yang, X Zeng, Y Zhou, X Gu, S Lu, Z Fu, DJ Fulton, NL Weintraub, RB Caldwell, W Zhang, C Wu, XL Liu, JF Chen, A Ahmad, I Kaddour-Dj, M Al-Shabraw, Q Li, X Jiang, Y Sun, A Sodhi, L Smith, M Hong, Y Huo Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis Nat Commun, 2017-09-19;8(1):584. 2017-09-19 [PMID: 28928465] (Bioassay, Human)	Bioassay	Human
LA Murray, DM Habiel, M Hohmann, A Camelo, H Shang, Y Zhou, AL Coelho, X Peng, M Gulati, B Crestani, MA Sleeman, T Mustelin, MW Moore, C Ryu, AD Osafo-Addo, JA Elias, CG Lee, B Hu, JD Herazo-May, DA Knight, CM Hogaboam, EL Herzog Antifibrotic role of vascular endothelial growth factor in pulmonary fibrosis JCI Insight, 2017-08-17;2(16):. 2017-08-17 [PMID: 28814671] (Bioassay, Human)	Bioassay	Human
JH Lee, SI Protze, Z Laksman, PH Backx, GM Keller Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations Cell Stem Cell, 2017-08-03;21(2):179-194.e4. 2017-08-03 [PMID: 28777944] (Bioassay, Human)	Bioassay	Human
BK Hong, S You, SA Yoo, D Park, D Hwang, CS Cho, WU Kim MicroRNA-143 and -145 modulate the phenotype of synovial fibroblasts in rheumatoid arthritis Exp. Mol. Med., 2017-08-04;49(8):e363. 2017-08-04 [PMID: 28775366] (Bioassay, Human)	Bioassay	Human
HL Deissler, GK Lang, GE Lang Inhibition of Single Routes of Intracellular Signaling is Not Sufficient to Neutralize the Biphasic Disturbance of a Retinal Endothelial Cell Barrier Induced by VEGF-A165 Cell. Physiol. Biochem., 2017-07-18;42(4):1493-1513. 2017-07-18 [PMID: 28719888] (Bioassay, Bovine)	Bioassay	Bovine
KL Kim, W Suh Apatinib, an Inhibitor of Vascular Endothelial Growth Factor Receptor 2, Suppresses Pathologic Ocular Neovascularization in Mice Invest. Ophthalmol. Vis. Sci., 2017-07-01;58(9):3592-3599. 2017-07-01 [PMID: 28715845] (Bioassay, Human)	Bioassay	Human
AE van der Wi, IMC Vogels, CJF van Noorde, I Klaassen, RO Schlingema TNF?-Induced Disruption of the Blood-Retinal Barrier In Vitro Is Regulated by Intracellular 3',5'-Cyclic Adenosine Monophosphate Levels Invest. Ophthalmol. Vis. Sci., 2017-07-01;58(9):3496-3505. 2017-07-01 [PMID: 28715583] (Bioassay, Bovine)	Bioassay	Bovine
S Chen, X Wu, J Hu, G Dai, A Rong, G Guo PM2.5 exposure decreases viability, migration and angiogenesis in human umbilical vein endothelial cells and human microvascular endothelial cells Mol Med Rep, 2017-06-29;0(0):. 2017-06-29 [PMID: 28677750] (Bioassay, Human)	Bioassay	Human
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Esquibies A, Karihaloo A, Quaggin S, Bazzy-Asaad A, Cantley L Heparin binding VEGF isoforms attenuate hyperoxic embryonic lung growth retardation via a FLK1-neuropilin-1-PKC dependent pathway. Respir Res, 2014-03-19;15(0):32. 2014-03-19 [PMID: 24641672] (Bioassay, Mouse)	Bioassay	Mouse
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Sharghi-Namini S, Tan E, Ong L, Ge R, Asada H Dll4-containing exosomes induce capillary sprout retraction in a 3D microenvironment. Sci Rep, 2014-02-07;4(0):4031. 2014-02-07 [PMID: 24504253] (Bioassay, Human)	Bioassay	Human
Choi , Seo-hyun, Lee , Hae-June, Jin , Yeung Ba, Jang , Junho, Kang , Ga-young, Lee , Minyoung, Kim , Chun-Ho, Kim , Joon, Yoon , Sam S, Lee , Yun-sil, Lee , Yoon-Jin MMP9 processing of HSPB1 regulates tumor progression. PLoS ONE, 2014-01-20;9(1):e85509. 2014-01-20 [PMID: 24465581] (Bioassay)	Bioassay
Grafton K, Moir L, Black J, Hansbro N, Hansbro P, Burgess J, Oliver B LF-15 & T7, synthetic peptides derived from tumstatin, attenuate aspects of airway remodelling in a murine model of chronic OVA-induced allergic airway disease. PLoS ONE, 2014-01-15;9(1):e85655. 2014-01-15 [PMID: 24454912] (Bioassay, Human)	Bioassay	Human
Kim , Young So, Jung , Seung-Hy, Jung , Dong Ho, Choi , So-Jin, Lee , Yu-Ri, Kim , Jin Sook Gas6 stimulates angiogenesis of human retinal endothelial cells and of zebrafish embryos via ERK1/2 signaling. PLoS ONE, 2014-01-07;9(1):e83901. 2014-01-07 [PMID: 24409287] (In Vivo, Zebrafish)	In Vivo	Zebrafish
Ahn S, Ahn J, Park S, Kim H, Hwang D, Park J, Park J, Chung J, Park K, Woo S Intraocular pharmacokinetics of ranibizumab in vitrectomized versus nonvitrectomized eyes. Invest Ophthalmol Vis Sci, 2014-01-29;55(1):567-73. 2014-01-29 [PMID: 24398088] (Bioassay, Human)	Bioassay	Human
Smith A, Bowers S, Stratman A, Davis G Hematopoietic stem cell cytokines and fibroblast growth factor-2 stimulate human endothelial cell-pericyte tube co-assembly in 3D fibrin matrices under serum-free defined conditions. PLoS ONE, 2013-12-31;8(12):e85147. 2013-12-31 [PMID: 24391990] (Bioassay, Human)	Bioassay	Human
Chislock , Elizabet, Pendergast , Ann Mari Abl family kinases regulate endothelial barrier function in vitro and in mice. PLoS ONE, 2013-12-19;8(12):e85231. 2013-12-19 [PMID: 24367707] (Bioassay, Human)	Bioassay	Human
Pandey , Ram Nare, Wang , Tim Sen, Tadjuidje , Emmanuel, McDonald , Matthew, Rettie , Allan E, Hegde , Rashmi S Structure-activity relationships of benzbromarone metabolites and derivatives as EYA inhibitory anti-angiogenic agents. PLoS ONE, 2013-12-18;8(12):e84582. 2013-12-18 [PMID: 24367676] (Bioassay, Mouse)	Bioassay	Mouse
Ashino S, Takeda K, Li H, Taylor V, Joetham A, Pine P, Gelfand E Janus kinase 1/3 signaling pathways are key initiators of TH2 differentiation and lung allergic responses. J Allergy Clin Immunol, 2013-12-22;133(4):1162-74. 2013-12-22 [PMID: 24365136] (Bioassay, Human)	Bioassay	Human
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Fan J, Ponferrada V, Sato T, Vemaraju S, Fruttiger M, Gerhardt H, Ferrara N, Lang R Crim1 maintains retinal vascular stability during development by regulating endothelial cell Vegfa autocrine signaling. Development, 2013-12-18;141(2):448-59. 2013-12-18 [PMID: 24353059] (Bioassay, Human)	Bioassay	Human
Wang , Jing, Kang , Qin-shu, Lv , Xiao-gua, Song , Jia, Zhan , Na, Dong , Wei-guo, Huang , Wei-hua Simple patterned nanofiber scaffolds and its enhanced performance in immunoassay. PLoS ONE, 2013-12-10;8(12):e82888. 2013-12-10 [PMID: 24340065] (Immunoassay Development, Human)	Immunoassay Development	Human
Wen , Donghai, Huang , Xinzhong, Zhang , Min, Zhang , Liying, Chen , Jing, Gu , Yong, Hao , Chuan-Mi Resveratrol attenuates diabetic nephropathy via modulating angiogenesis. PLoS ONE, 2013-12-03;8(12):e82336. 2013-12-03 [PMID: 24312656] (Bioassay, Human)	Bioassay	Human
Yi K, Jung S, Cho G, Seol H, Hong S, Oh M, Kim H Effects of sFlt-1 and alpha 2-macroglobulin on vascular endothelial growth factor-induced endothelin-1 upregulation in human microvascular endothelial cells. Placenta, 2013-09-25;35(1):64-9. 2013-09-25 [PMID: 24231447] (Bioassay, Human)	Bioassay	Human
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Aranguren X, Agirre X, Beerens M, Coppiello G, Uriz M, Vandersmissen I, Benkheil M, Panadero J, Aguado N, Pascual-Montano A, Segura V, Prosper F, Luttun A Unraveling a novel transcription factor code determining the human arterial-specific endothelial cell signature. Blood, 2013-10-09;122(24):3982-92. 2013-10-09 [PMID: 24108462] (In Vivo, Human)	In Vivo	Human
Morishima , Tatsuya, Watanabe , Ken-ichi, Niwa , Akira, Hirai , Hideyo, Saida , Satoshi, Tanaka , Takayuki, Kato , Itaru, Umeda , Katsutsu, Hiramatsu , Hidefumi, Saito , Megumu K, Matsubara , Kousaku, Adachi , Souichi, Kobayashi , Masao, Nakahata , Tatsutos, Heike , Toshio Genetic correction of HAX1 in induced pluripotent stem cells from a patient with severe congenital neutropenia improves defective granulopoiesis. Haematologica, 2013-08-23;99(1):19-27. 2013-08-23 [PMID: 23975175] (Bioassay, Human)	Bioassay	Human
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Tang , W, Yu , F, Yao , H, Cui , X, Jiao , Y, Lin , L, Chen , J, Yin , D, Song , E, Liu , Q miR-27a regulates endothelial differentiation of breast cancer stem like cells. Oncogene, 2013-06-10;33(20):2629-38. 2013-06-10 [PMID: 23752185] (Bioassay, Human)	Bioassay	Human
Zhang G, Panigrahy D, Mahakian L, Yang J, Liu J, Stephen Lee K, Wettersten H, Ulu A, Hu X, Tam S, Hwang S, Ingham E, Kieran M, Weiss R, Ferrara K, Hammock B Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis. Proc Natl Acad Sci U S A, 2013-04-03;110(16):6530-5. 2013-04-03 [PMID: 23553837] (Bioassay, Human)	Bioassay	Human
Chang A, Sohn R, Lu Z, Arbeit J, Lapi S Detection of rapalog-mediated therapeutic response in renal cancer xenografts using (6)(4)Cu-bevacizumab immunoPET. PLoS ONE, 2013-03-14;8(0):U821. 2013-03-14 [PMID: 23516584] (Bioassay, Human)	Bioassay	Human
Stoll S, Bartsch S, Kroll J HOXC9 regulates formation of parachordal lymphangioplasts and the thoracic duct in zebrafish via stabilin 2. PLoS ONE, 2013-03-06;8(3):e58311. 2013-03-06 [PMID: 23484014] (Bioassay, Human)	Bioassay	Human
Song S, Jung W, Kim K, Hong W, Kim H, Lee K, Lee K, Suh W Distinct transcriptional profiles of angioblasts derived from human embryonic stem cells. Exp Cell Res, 2013-02-28;319(8):1136-45. 2013-02-28 [PMID: 23458169] (Bioassay, Human)	Bioassay	Human
Tannetta D, Dragovic R, Gardiner C, Redman C, Sargent I Characterisation of syncytiotrophoblast vesicles in normal pregnancy and pre-eclampsia: expression of Flt-1 and endoglin. PLoS ONE, 2013-02-20;8(2):e56754. 2013-02-20 [PMID: 23437230] (Bioassay, Human)	Bioassay	Human
Su , Yu-Ting, Gao , Chengzhu, Liu , Yu, Guo , Shuang, Wang , Anthony, Wang , Benlian, Erdjument-Bromage , Hediye, Miyagi , Masaru, Tempst , Paul, Kao , Hung-Yin Monoubiquitination of filamin B regulates vascular endothelial growth factor-mediated trafficking of histone deacetylase 7. Mol Cell Biol, 2013-02-11;33(8):1546-60. 2013-02-11 [PMID: 23401860] (Bioassay, Human)	Bioassay	Human
You C, Sandalcioglu I, Dammann P, Felbor U, Sure U, Zhu Y Loss of CCM3 impairs DLL4-Notch signalling: implication in endothelial angiogenesis and in inherited cerebral cavernous malformations. J Cell Mol Med, 2013-02-07;17(3):407-18. 2013-02-07 [PMID: 23388056] (Bioassay, Human)	Bioassay	Human
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Kumar S, Sharghi-Namini S, Rao N, Ge R ADAMTS5 functions as an anti-angiogenic and anti-tumorigenic protein independent of its proteoglycanase activity. Am J Pathol, 2012-07-13;181(3):1056-68. 2012-07-13 [PMID: 22796434] (Bioassay, Human)	Bioassay	Human
Highly invasive melanoma cells activate the vascular endothelium via an MMP-2/integrin alphavbeta5-induced secretion of VEGF-A. Am. J. Pathol., 2012-05-31;181(2):693-705. 2012-05-31 [PMID: 22659470] (Bioassay, Human)	Bioassay	Human
Hisatomi T, Nakao S, Murakami Y, Noda K, Nakazawa T, Notomi S, Connolly E, She H, Almulki L, Ito Y, Vavvas DG, Ishibashi T, Miller JW The regulatory roles of apoptosis-inducing factor in the formation and regression processes of ocular neovascularization. Am. J. Pathol., 2012-05-19;181(1):53-61. 2012-05-19 [PMID: 22613025] (In Vivo, Mouse)	In Vivo	Mouse
Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT. Blood, 2012-05-08;119(26):6278-87. 2012-05-08 [PMID: 22569400] (Bioassay, Human)	Bioassay	Human
Sisto M, Lisi S, Lofrumento DD, D'Amore M, Frassanito MA, Ribatti D Sjogren's syndrome pathological neovascularization is regulated by VEGF-A-stimulated TACE-dependent crosstalk between VEGFR2 and NF-kappaB. Genes Immun., 2012-04-19;13(5):411-20. 2012-04-19 [PMID: 22513453] (Bioassay, Chicken, Human)	Bioassay	Chicken, Human
van Meeteren LA, Thorikay M, Bergqvist S, Pardali E, Stampino CG, Hu-Lowe D, Goumans MJ, ten Dijke P Anti-human activin receptor-like kinase 1 (ALK1) antibody attenuates bone morphogenetic protein 9 (BMP9)-induced ALK1 signaling and interferes with endothelial cell sprouting. J. Biol. Chem., 2012-04-05;287(22):18551-61. 2012-04-05 [PMID: 22493445] (Bioassay, Human)	Bioassay	Human
Dupuy S, Lambert M, Zucman D, Choukem SP, Tognarelli S, Pages C, Lebbe C, Caillat-Zucman S Human Herpesvirus 8 (HHV8) sequentially shapes the NK cell repertoire during the course of asymptomatic infection and Kaposi sarcoma. PLoS Pathog., 2012-01-12;8(1):e1002486. 2012-01-12 [PMID: 22253598] (Bioassay, Human)	Bioassay	Human
Niwa A, Heike T, Umeda K A novel serum-free monolayer culture for orderly hematopoietic differentiation of human pluripotent cells via mesodermal progenitors. PLoS ONE, 2011-07-27;6(7):e22261. 2011-07-27 [PMID: 21818303] (Bioassay, Human)	Bioassay	Human
Yang F, Tang X, Riquelme E, Behrens C, Nilsson MB, Giri U, Varella-Garcia M, Byers LA, Lin HY, Wang J, Raso MG, Girard L, Coombes K, Lee JJ, Herbst RS, Minna JD, Heymach JV, Wistuba II Increased VEGFR-2 Gene Copy Is Associated with Chemoresistance and Shorter Survival in Patients with Non-Small-Cell Lung Carcinoma Who Receive Adjuvant Chemotherapy. Cancer Res., 2011-07-01;71(16):5512-5521. 2011-07-01 [PMID: 21724587] (Bioassay, Human)	Bioassay	Human
Goyal A, Pal N, Concannon M, Paul M, Doran M, Poluzzi C, Sekiguchi K, Whitelock JM, Neill T, Iozzo RV Endorepellin, the angiostatic module of perlecan, interacts with both the alpha2beta1 integrin and vascular endothelial growth factor receptor 2 (VEGFR2): a dual receptor antagonism. J. Biol. Chem., 2011-05-19;286(29):25947-62. 2011-05-19 [PMID: 21596751] (Binding Assay, Human)	Binding Assay	Human
Lee HK, Chauhan SK, Kay E Flt-1 regulates vascular endothelial cell migration via a protein tyrosine kinase-7-dependent pathway. Blood, 2011-04-01;117(21):5762-71. 2011-04-01 [PMID: 21460247] (Bioassay, Human)	Bioassay	Human
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Pirotte S, Lamour V, Lambert V, Alvarez Gonzalez ML, Ormenese S, Noel A, Mottet D, Castronovo V, Bellahcene A Dentin matrix protein 1 induces membrane expression of VE-cadherin on endothelial cells and inhibits VEGF-induced angiogenesis by blocking VEGFR-2 phosphorylation. Blood, 2010-12-29;117(8):2515-26. 2010-12-29 [PMID: 21190990] (Bioassay, Human)	Bioassay	Human
Delgado VM, Nugnes LG, Colombo LL, Troncoso MF, Fernandez MM, Malchiodi EL, Frahm I, Croci DO, Compagno D, Rabinovich GA, Wolfenstein-Todel C, Elola MT Modulation of endothelial cell migration and angiogenesis: a novel function for the "tandem-repeat" lectin galectin-8. FASEB J., 2010-09-27;25(1):242-54. 2010-09-27 [PMID: 20876211] (Bioassay, Human)	Bioassay	Human
Brunckhorst MK, Wang H, Lu R, Yu Q Angiopoietin-4 promotes glioblastoma progression by enhancing tumor cell viability and angiogenesis. Cancer Res., 2010-09-07;70(18):7283-93. 2010-09-07 [PMID: 20823154] (Bioassay, Human)	Bioassay	Human
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Ding W, Knox TR, Tschumper RC Platelet-derived growth factor (PDGF)-PDGF receptor interaction activates bone marrow-derived mesenchymal stromal cells derived from chronic lymphocytic leukemia: implications for an angiogenic switch. Blood, 2010-07-06;116(16):2984-93. 2010-07-06 [PMID: 20606160] (Bioassay, Human)	Bioassay	Human
Cocco C, Giuliani N, Di Carlo E Interleukin-27 acts as multifunctional antitumor agent in multiple myeloma. Clin. Cancer Res., 2010-06-29;16(16):4188-97. 2010-06-29 [PMID: 20587591] (Bioassay, Human)	Bioassay	Human
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Westenbrink BD, Ruifrok WP, Voors AA Vascular endothelial growth factor is crucial for erythropoietin-induced improvement of cardiac function in heart failure. Cardiovasc. Res., 2010-02-05;87(1):30-9. 2010-02-05 [PMID: 20139114] (Bioassay, Rat)	Bioassay	Rat
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Jung DW, Che ZM, Kim J, Kim K, Kim KY, Williams D, Kim J Tumor-stromal crosstalk in invasion of oral squamous cell carcinoma: a pivotal role of CCL7. Int. J. Cancer, 2010-07-15;127(2):332-44. 2010-07-15 [PMID: 19937793] (Bioassay, Human)	Bioassay	Human
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Findley CM, Mitchell RG, Duscha BD, Annex BH, Kontos CD Plasma levels of soluble Tie2 and vascular endothelial growth factor distinguish critical limb ischemia from intermittent claudication in patients with peripheral arterial disease. J. Am. Coll. Cardiol., 2008-07-29;52(5):387-93. 2008-07-29 [PMID: 18652948] (Bioassay, Human)	Bioassay	Human
Shin JW, Huggenberger R, Detmar M Transcriptional profiling of VEGF-A and VEGF-C target genes in lymphatic endothelium reveals endothelial-specific molecule-1 as a novel mediator of lymphangiogenesis. Blood, 2008-07-09;112(6):2318-26. 2008-07-09 [PMID: 18614759] (Bioassay, Human)	Bioassay	Human
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Zhu C, Ying D, Mi J, Li L, Zeng W, Hou C, Sun J, Yuan W, Wen C, Zhang W Development of anti-atherosclerotic tissue-engineered blood vessel by A20-regulated endothelial progenitor cells seeding decellularized vascular matrix. Biomaterials, 2008-06-01;29(17):2628-36. 2008-06-01 [PMID: 18377984] (Bioassay, Human)	Bioassay	Human
Clerin V, Shih HH, Deng N, Hebert G, Resmini C, Shields KM, Feldman JL, Winkler A, Albert L, Maganti V, Wong A, Paulsen JE, Keith JC, Vlasuk GP, Pittman DD Expression of the cysteine protease legumain in vascular lesions and functional implications in atherogenesis. Atherosclerosis, 2008-02-21;0(0):. 2008-02-21 [PMID: 18377911] (Bioassay, Human)	Bioassay	Human
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Narazaki M, Segarra M, Tosato G Sulfated polysaccharides identified as inducers of neuropilin-1 internalization and functional inhibition of VEGF165 and semaphorin3A. Blood, 2008-02-13;111(8):4126-36. 2008-02-13 [PMID: 18272814] (Bioassay, In Vivo, Human, Mouse)	Bioassay, In Vivo	Human, Mouse
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You JJ, Yang CH, Huang JS, Chen MS, Yang CM Fractalkine, a CX3C chemokine, as a mediator of ocular angiogenesis. Invest. Ophthalmol. Vis. Sci., 2007-11-01;48(11):5290-8. 2007-11-01 [PMID: 17962485] (Bioassay, Bovine, Human)	Bioassay	Bovine, Human
Lu J, Jiang W, Yang JH, Chang PY, Walterscheid JP, Chen HH, Marcelli M, Tang D, Lee YT, Liao WS, Yang CY, Chen CH Electronegative LDL impairs vascular endothelial cell integrity in diabetes by disrupting fibroblast growth factor 2 (FGF2) autoregulation. Diabetes, 2007-10-24;57(1):158-66. 2007-10-24 [PMID: 17959932] (Bioassay, Bovine)	Bioassay	Bovine
Singh A, Satchell SC, Neal CR Glomerular endothelial glycocalyx constitutes a barrier to protein permeability. J. Am. Soc. Nephrol., 2007-10-17;18(11):2885-93. 2007-10-17 [PMID: 17942961] (Bioassay, Human)	Bioassay	Human
Rogers MS, Christensen KA, Birsner AE, Short SM, Wigelsworth DJ, Collier RJ, D'Amato RJ Mutant anthrax toxin B moiety (protective antigen) inhibits angiogenesis and tumor growth. Cancer Res., 2007-10-15;67(20):9980-5. 2007-10-15 [PMID: 17942931] (Bioassay, In Vivo, Human, Mouse)	Bioassay, In Vivo	Human, Mouse
Jaalouk DE, Ozawa MG, Sun J, Lahdenranta J, Schlingemann RO, Pasqualini R, Arap W The original Pathologische Anatomie Leiden-Endothelium monoclonal antibody recognizes a vascular endothelial growth factor binding site within neuropilin-1. Cancer Res., 2007-10-15;67(20):9623-9. 2007-10-15 [PMID: 17942890] (Bioassay)	Bioassay
Yeh WL, Lin CJ, Fu WM Enhancement of glucose transporter expression of brain endothelial cells by vascular endothelial growth factor derived from glioma exposed to hypoxia. Mol. Pharmacol., 2007-10-17;73(1):170-7. 2007-10-17 [PMID: 17942749] (Bioassay, Rat)	Bioassay	Rat
Isakova IA, Baker K, Dutreil M, Dufour J, Gaupp D, Phinney DG Age- and dose-related effects on MSC engraftment levels and anatomical distribution in the central nervous systems of nonhuman primates: identification of novel MSC subpopulations that respond to guidance cues in brain. Stem Cells, 2007-10-11;25(12):3261-70. 2007-10-11 [PMID: 17932418] (Bioassay, Primate - Macaca mulatta (Rhesus Macaque))	Bioassay	Primate - Macaca mulatta (Rhesus Macaque)
Todd J, Freese B, Lu A, Held D, Morey J, Livingston R, Goix P Ultrasensitive flow-based immunoassays using single-molecule counting. Clin. Chem., 2007-09-21;53(11):1990-5. 2007-09-21 [PMID: 17890441] (ELISA (Standard))	ELISA (Standard)
Lin YL, Liang YC, Chiang BL Placental growth factor down-regulates type 1 T helper immune response by modulating the function of dendritic cells. J. Leukoc. Biol., 2007-08-30;82(6):1473-80. 2007-08-30 [PMID: 17761954] (Bioassay, Human)	Bioassay	Human
Kilic N, Oliveira-Ferrer L, Neshat-Vahid S, Irmak S, Obst-Pernberg K, Wurmbach JH, Loges S, Kilic E, Weil J, Lauke H, Tilki D, Singer BB, Ergun S Lymphatic reprogramming of microvascular endothelial cells by CEA-related cell adhesion molecule-1 via interaction with VEGFR-3 and Prox1. Blood, 2007-08-30;110(13):4223-33. 2007-08-30 [PMID: 17761831] (Bioassay, Human)	Bioassay	Human
Bogatkevich GS, Ludwicka-Bradley A, Highland KB, Hant F, Nietert PJ, Singleton CB, Feghali-Bostwick CA, Silver RM Impairment of the antifibrotic effect of hepatocyte growth factor in lung fibroblasts from African Americans: possible role in systemic sclerosis. Arthritis Rheum., 2007-07-01;56(7):2432-42. 2007-07-01 [PMID: 17599773] (Bioassay, Human)	Bioassay	Human
Pan Q, Chathery Y, Wu Y, Rathore N, Tong RK, Peale F, Bagri A, Tessier-Lavigne M, Koch AW, Watts RJ Neuropilin-1 binds to VEGF121 and regulates endothelial cell migration and sprouting. J. Biol. Chem., 2007-06-16;282(33):24049-56. 2007-06-16 [PMID: 17575273] (Surface Plasmon Resonance, Human)	Surface Plasmon Resonance	Human
Kissel CK, Lehmann R, Assmus B, Aicher A, Honold J, Fischer-Rasokat U, Heeschen C, Spyridopoulos I, Dimmeler S, Zeiher AM Selective functional exhaustion of hematopoietic progenitor cells in the bone marrow of patients with postinfarction heart failure. J. Am. Coll. Cardiol., 2007-06-04;49(24):2341-9. 2007-06-04 [PMID: 17572250] (Bioassay, Human)	Bioassay	Human
Tsao PN, Chan FT, Wei SC, Hsieh WS, Chou HC, Su YN, Chen CY, Hsu WM, Hsieh FJ, Hsu SM Soluble vascular endothelial growth factor receptor-1 protects mice in sepsis. Crit. Care Med., 2007-08-01;35(8):1955-60. 2007-08-01 [PMID: 17568329] (In Vivo, Mouse)	In Vivo	Mouse
Yeh WL, Lu DY, Lin CJ, Liou HC, Fu WM Inhibition of hypoxia-induced increase of blood-brain barrier permeability by YC-1 through the antagonism of HIF-1alpha accumulation and VEGF expression. Mol. Pharmacol., 2007-05-18;72(2):440-9. 2007-05-18 [PMID: 17513385] (Bioassay, Rat)	Bioassay	Rat
Kamstock D, Elmslie R, Thamm D Evaluation of a xenogeneic VEGF vaccine in dogs with soft tissue sarcoma. Cancer Immunol. Immunother., 2007-02-14;56(8):1299-309. 2007-02-14 [PMID: 17502972] (ELISA (Capture), In Vivo, Canine)	ELISA (Capture), In Vivo	Canine
Ball SG, Shuttleworth CA, Kielty CM Vascular endothelial growth factor can signal through platelet-derived growth factor receptors. J. Cell Biol., 2007-04-30;177(3):489-500. 2007-04-30 [PMID: 17470632] (Bioassay, Human)	Bioassay	Human
Riccioni R, Diverio D, Mariani G, Buffolino S, Riti V, Saulle E, Petrucci E, Cedrone M, Lo-Coco F, Foa R, Peschle C, Testa U Expression of Tie-2 and other receptors for endothelial growth factors in acute myeloid leukemias is associated with monocytic features of leukemic blasts. Stem Cells, 2007-04-19;25(8):1862-71. 2007-04-19 [PMID: 17446561] (Bioassay, Human)	Bioassay	Human
Srivastava AS, Nedelcu E, Esmaeli-Azad B, Mishra R, Carrier E Thrombopoietin enhances generation of CD34+ cells from human embryonic stem cells. Stem Cells, 2007-03-22;25(6):1456-61. 2007-03-22 [PMID: 17379761] (Bioassay, Human)	Bioassay	Human
Rajesh</LastName><ForeNam D</Initial, Rajesh D, Chinnasamy N, Mitalipov SM, Wolf DP, Slukvin I, Thomson JA, Shaaban AF Differential requirements for hematopoietic commitment between human and rhesus embryonic stem cells. Stem Cells, 2007-02-01;25(2):490-9. 2007-02-01 [PMID: 17284653] (Bioassay, Mouse)	Bioassay	Mouse
Babinska A, Azari BM, Salifu MO, Liu R, Jiang XC, Sobocka MB, Boo D, Al Khoury G, Deitch JS, Marmur JD, Ehrlich YH, Kornecki E The F11 receptor (F11R/JAM-A) in atherothrombosis: overexpression of F11R in atherosclerotic plaques. Thromb. Haemost., 2007-02-01;97(2):272-81. 2007-02-01 [PMID: 17264957] (Bioassay, Human)	Bioassay	Human
Rusk A, McKeegan E, Haviv F, Majest S, Henkin J, Khanna C Preclinical evaluation of antiangiogenic thrombospondin-1 peptide mimetics, ABT-526 and ABT-510, in companion dogs with naturally occurring cancers. Clin. Cancer Res., 2006-12-15;12(24):7444-55. 2006-12-15 [PMID: 17189418] (Bioassay, Canine, Human)	Bioassay	Canine, Human
Werdich XQ, Penn JS Specific involvement of SRC family kinase activation in the pathogenesis of retinal neovascularization. Invest. Ophthalmol. Vis. Sci., 2006-11-01;47(11):5047-56. 2006-11-01 [PMID: 17065526] (Bioassay, Human)	Bioassay	Human
Kim KL, Shin IS, Kim JM, Choi JH, Byun J, Jeon ES, Suh W, Kim DK Interaction between Tie receptors modulates angiogenic activity of angiopoietin2 in endothelial progenitor cells. Cardiovasc. Res., 2006-08-07;72(3):394-402. 2006-08-07 [PMID: 17054925] (Bioassay, Human)	Bioassay	Human
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Lake AC, Vassy R, Di Benedetto M, Lavigne D, Le Visage C, Perret GY, Letourneur D Low molecular weight fucoidan increases VEGF165-induced endothelial cell migration by enhancing VEGF165 binding to VEGFR-2 and NRP1. J. Biol. Chem., 2006-10-06;281(49):37844-52. 2006-10-06 [PMID: 17028197] (Bioassay, Human)	Bioassay	Human
Kim BK, Kim SE, Shim JH, Woo DH, Gil JE, Kim SK, Kim JH Neurogenic effect of vascular endothelial growth factor during germ layer formation of human embryonic stem cells. FEBS Lett., 2006-10-02;580(25):5869-74. 2006-10-02 [PMID: 17027979] (Bioassay, Human)	Bioassay	Human
Yamagata M, Rook SL, Sassa Y, Ma RC, Geraldes P, Goddard L, Clermont A, Gao B, Salti H, Gundel R, White M, Feener EP, Aiello LP, King GL Bactericidal/permeability-increasing protein&apos;s signaling pathways and its retinal trophic and anti-angiogenic effects. FASEB J., 2006-10-01;20(12):2058-67. 2006-10-01 [PMID: 17012258] (Bioassay, Bovine)	Bioassay	Bovine
Zeng L, Rahrmann E, Hu Q, Lund T, Sandquist L, Felten M, O'Brien TD, O'Brien TD, Zhang J, Verfaillie C Multipotent adult progenitor cells from swine bone marrow. Stem Cells, 2006-08-24;24(11):2355-66. 2006-08-24 [PMID: 16931778] (Bioassay, Porcine)	Bioassay	Porcine
Lai WK, Sun PJ, Zhang J, Jennings A, Lalor PF, Hubscher S, McKeating JA, Adams DH Expression of DC-SIGN and DC-SIGNR on human sinusoidal endothelium: a role for capturing hepatitis C virus particles. Am. J. Pathol., 2006-07-01;169(1):200-8. 2006-07-01 [PMID: 16816373] (Bioassay, Human)	Bioassay	Human
Ren WP, Markel DC, Zhang R, Peng X, Wu B, Monica H, Wooley PH Association between UHMWPE particle-induced inflammatory osteoclastogenesis and expression of RANKL, VEGF, and Flt-1 in vivo. Biomaterials, 2006-06-30;27(30):5161-9. 2006-06-30 [PMID: 16814378] (In Vivo, Mouse)	In Vivo	Mouse
Sreekumar PG, Kannan R, de Silva AT, Burton R, Ryan SJ, Hinton DR Thiol regulation of vascular endothelial growth factor-A and its receptors in human retinal pigment epithelial cells. Biochem. Biophys. Res. Commun., 2006-06-12;346(4):1200-6. 2006-06-12 [PMID: 16793007] (Western Blot)	Western Blot
Kiyono M, Shibuya M Inhibitory Smad transcription factors protect arterial endothelial cells from apoptosis induced by BMP4. Oncogene, 2006-05-29;25(54):7131-7. 2006-05-29 [PMID: 16732319] (Bioassay, Human)	Bioassay	Human
Kurita R, Sasaki E, Yokoo T, Hiroyama T, Takasugi K, Imoto H, Izawa K, Dong Y, Hashiguchi T, Soda Y, Maeda T, Suehiro Y, Tanioka Y, Nakazaki Y, Tani K Tal1/Scl gene transduction using a lentiviral vector stimulates highly efficient hematopoietic cell differentiation from common marmoset (Callithrix jacchus) embryonic stem cells. Stem Cells, 2006-05-25;24(9):2014-22. 2006-05-25 [PMID: 16728561] (Bioassay, Primate - Callitrix jacchus (Common Marmoset))	Bioassay	Primate - Callitrix jacchus (Common Marmoset)
Hiroyama T, Miharada K, Aoki N, Fujioka T, Sudo K, Danjo I, Nagasawa T, Nakamura Y Long-lasting in vitro hematopoiesis derived from primate embryonic stem cells. Exp. Hematol., 2006-06-01;34(6):760-9. 2006-06-01 [PMID: 16728281] (Bioassay, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque))	Bioassay	Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
Clermont AC, Cahill M, Salti H, Rook SL, Rask-Madsen C, Goddard L, Wong JS, Bursell D, Bursell SE, Aiello LP Hepatocyte growth factor induces retinal vascular permeability via MAP-kinase and PI-3 kinase without altering retinal hemodynamics. Invest. Ophthalmol. Vis. Sci., 2006-06-01;47(6):2701-8. 2006-06-01 [PMID: 16723489] (In Vivo, Rat)	In Vivo	Rat
Getmanova EV, Chen Y, Bloom L, Gokemeijer J, Shamah S, Warikoo V, Wang J, Ling V, Sun L Antagonists to human and mouse vascular endothelial growth factor receptor 2 generated by directed protein evolution in vitro. Chem. Biol., 2006-05-01;13(5):549-56. 2006-05-01 [PMID: 16720276] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
Favier B, Alam A, Barron P, Bonnin J, Laboudie P, Fons P, Mandron M, Herault JP, Neufeld G, Savi P, Herbert JM, Bono F Neuropilin-2 interacts with VEGFR-2 and VEGFR-3 and promotes human endothelial cell survival and migration. Blood, 2006-04-18;108(4):1243-50. 2006-04-18 [PMID: 16621967] (Bioassay, Human)	Bioassay	Human
Moreno MJ, Ball M, Andrade MF, McDermid A, Stanimirovic DB Insulin-like growth factor binding protein-4 (IGFBP-4) is a novel anti-angiogenic and anti-tumorigenic mediator secreted by dibutyryl cyclic AMP (dB-cAMP)-differentiated glioblastoma cells. Glia, 2006-06-01;53(8):845-57. 2006-06-01 [PMID: 16586492] (Bioassay, Human)	Bioassay	Human
Nozaki M, Sakurai E, Raisler BJ, Baffi JZ, Witta J, Ogura Y, Brekken RA, Sage EH, Ambati BK, Ambati J Loss of SPARC-mediated VEGFR-1 suppression after injury reveals a novel antiangiogenic activity of VEGF-A. J. Clin. Invest., 2006-02-01;116(2):422-9. 2006-02-01 [PMID: 16453023] (In Vivo, Mouse)	In Vivo	Mouse
Bates DO, MacMillan PP, Manjaly JG, Qiu Y, Hudson SJ, Bevan HS, Hunter AJ, Soothill PW, Read M, Donaldson LF, Harper SJ The endogenous anti-angiogenic family of splice variants of VEGF, VEGFxxxb, are down-regulated in pre-eclamptic placentae at term. Clin. Sci., 2006-05-01;110(5):575-85. 2006-05-01 [PMID: 16451124] (Western Blot)	Western Blot
Tsigkos S, Zhou Z, Kotanidou A, Fulton D, Zakynthinos S, Roussos C, Papapetropoulos A Regulation of Ang2 release by PTEN/PI3-kinase/Akt in lung microvascular endothelial cells. J. Cell. Physiol., 2006-05-01;207(2):506-11. 2006-05-01 [PMID: 16447257] (Bioassay, Bovine)	Bioassay	Bovine
Anghelina M, Krishnan P, Moldovan L, Moldovan NI Monocytes/macrophages cooperate with progenitor cells during neovascularization and tissue repair: conversion of cell columns into fibrovascular bundles. Am. J. Pathol., 2006-02-01;168(2):529-41. 2006-02-01 [PMID: 16436667] (In Vivo, Mouse)	In Vivo	Mouse
Narazaki M, Tosato G Ligand-induced internalization selects use of common receptor neuropilin-1 by VEGF165 and semaphorin3A. Blood, 2006-01-19;107(10):3892-901. 2006-01-19 [PMID: 16424390] (ELISA (Standard))	ELISA (Standard)
Carr AN, Howard BW, Yang HT, Eby-Wilkens E, Loos P, Varbanov A, Qu A, DeMuth JP, Davis MG, Proia A, Terjung RL, Peters KG Efficacy of systemic administration of SDF-1 in a model of vascular insufficiency: support for an endothelium-dependent mechanism. Cardiovasc. Res., 2006-01-10;69(4):925-35. 2006-01-10 [PMID: 16409996] (In Vivo, Rat)	In Vivo	Rat
Jung Y, Wang J, Schneider A, Sun YX, Koh-Paige AJ, Osman NI, McCauley LK, Taichman RS Regulation of SDF-1 (CXCL12) production by osteoblasts; a possible mechanism for stem cell homing. Bone, 2005-12-05;38(4):497-508. 2005-12-05 [PMID: 16337237] (Bioassay, Human)	Bioassay	Human
Cross SS, Yang Z, Brown NJ, Balasubramanian SP, Evans CA, Woodward JK, Neville-Webbe HL, Lippitt JM, Reed MW, Coleman RE, Holen I Osteoprotegerin (OPG)--a potential new role in the regulation of endothelial cell phenotype and tumour angiogenesis? Int. J. Cancer, 2006-04-15;118(8):1901-8. 2006-04-15 [PMID: 16287088] (Bioassay, Human)	Bioassay	Human
Bagley RG, Weber W, Rouleau C, Teicher BA Pericytes and endothelial precursor cells: cellular interactions and contributions to malignancy. Cancer Res., 2005-11-01;65(21):9741-50. 2005-11-01 [PMID: 16266995] (Bioassay, Human)	Bioassay	Human
Curbishley SM, Eksteen B, Gladue RP, Lalor P, Adams DH CXCR 3 activation promotes lymphocyte transendothelial migration across human hepatic endothelium under fluid flow. Am. J. Pathol., 2005-09-01;167(3):887-99. 2005-09-01 [PMID: 16127166] (Bioassay, Human)	Bioassay	Human
Trevino JG, Summy JM, Gray MJ, Nilsson MB, Lesslie DP, Baker CH, Gallick GE Expression and activity of SRC regulate interleukin-8 expression in pancreatic adenocarcinoma cells: implications for angiogenesis. Cancer Res., 2005-08-15;65(16):7214-22. 2005-08-15 [PMID: 16103072] (In Vivo, Mouse)	In Vivo	Mouse
Voisine P, Bianchi C, Khan TA, Ruel M, Xu SH, Feng J, Li J, Malik T, Rosinberg A, Sellke FW Normalization of coronary microvascular reactivity and improvement in myocardial perfusion by surgical vascular endothelial growth factor therapy combined with oral supplementation of l-arginine in a porcine model of endothelial dysfunction. J. Thorac. Cardiovasc. Surg., 2005-06-01;129(6):1414-20. 2005-06-01 [PMID: 15942586] (In Vivo, Porcine)	In Vivo	Porcine
Puxeddu I, Alian A, Piliponsky AM, Ribatti D, Panet A, Levi-Schaffer F Human peripheral blood eosinophils induce angiogenesis. Int. J. Biochem. Cell Biol., 2005-03-01;37(3):628-36. 2005-03-01 [PMID: 15618019] (Bioassay, Chicken, Rat)	Bioassay	Chicken, Rat
Sun JF, Phung T, Shiojima I, Felske T, Upalakalin JN, Feng D, Kornaga T, Dor T, Dvorak AM, Walsh K, Benjamin LE Microvascular patterning is controlled by fine-tuning the Akt signal. Proc. Natl. Acad. Sci. U.S.A., 2004-12-20;102(1):128-33. 2004-12-20 [PMID: 15611473] (Bioassay, Bovine)	Bioassay	Bovine
Dikov MM, Ohm JE, Ray N, Tchekneva EE, Burlison J, Moghanaki D, Nadaf S, Carbone DP Differential roles of vascular endothelial growth factor receptors 1 and 2 in dendritic cell differentiation. J. Immunol., 2005-01-01;174(1):215-22. 2005-01-01 [PMID: 15611243] (Bioassay, Mouse)	Bioassay	Mouse
Eubank TD, Roberts R, Galloway M, Wang Y, Cohn DE, Marsh CB GM-CSF induces expression of soluble VEGF receptor-1 from human monocytes and inhibits angiogenesis in mice. Immunity, 2004-12-01;21(6):831-42. 2004-12-01 [PMID: 15589171] (In Vivo, Mouse)	In Vivo	Mouse
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Satchell SC, Anderson KL, Mathieson PW Angiopoietin 1 and vascular endothelial growth factor modulate human glomerular endothelial cell barrier properties. J. Am. Soc. Nephrol., 2004-03-01;15(3):566-74. 2004-03-01 [PMID: 14978158] (Bioassay, Human)	Bioassay	Human
Suzuki O, Bishop AT, Sunagawa T, Katsube K, Friedrich PF VEGF-promoted surgical angiogenesis in necrotic bone. Microsurgery, 2004-01-01;24(1):85-91. 2004-01-01 [PMID: 14748033] (In Vivo, Rabbit)	In Vivo	Rabbit
Usui T, Ishida S, Yamashiro K, Kaji Y, Poulaki V, Moore J, Moore T, Amano S, Horikawa Y, Dartt D, Golding M, Shima DT, Adamis AP VEGF164(165) as the pathological isoform: differential leukocyte and endothelial responses through VEGFR1 and VEGFR2. Invest. Ophthalmol. Vis. Sci., 2004-02-01;45(2):368-74. 2004-02-01 [PMID: 14744874] (Bioassay, Human)	Bioassay	Human
Caine GJ, Blann AD, Stonelake PS, Ryan P, Lip GY Plasma angiopoietin-1, angiopoietin-2 and Tie-2 in breast and prostate cancer: a comparison with VEGF and Flt-1. Eur. J. Clin. Invest., 2003-10-01;33(10):883-90. 2003-10-01 [PMID: 14511360] (ELISA (Standard))	ELISA (Standard)
Danet GH, Pan Y, Luongo JL, Bonnet DA, Simon MC Expansion of human SCID-repopulating cells under hypoxic conditions. J. Clin. Invest., 2003-07-01;112(1):126-35. 2003-07-01 [PMID: 12840067] (Bioassay, Human)	Bioassay	Human
Fuller T, Korff T, Kilian A, Dandekar G, Augustin HG Forward EphB4 signaling in endothelial cells controls cellular repulsion and segregation from ephrinB2 positive cells. J. Cell. Sci., 2003-05-06;116(0):2461-70. 2003-05-06 [PMID: 12734395] (Bioassay, Human)	Bioassay	Human
Mogi K, Goto M, Ohno E, Azumi Y, Takeuchi S, Toyoizumi R Xenopus neurula left-right asymmetry is respeficied by microinjecting TGF-beta5 protein. Int. J. Dev. Biol., 2003-02-01;47(1):15-29. 2003-02-01 [PMID: 12653248] (In Vivo, Xenopus)	In Vivo	Xenopus
Maynard SE, Min JY, Merchan J, Lim KH, Mondal S, Stillman IE, Epstein FH, Karumanchi SA Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J. Clin. Invest., 2003-03-01;111(5):649-58. 2003-03-01 [PMID: 12618519] (Bioassay, Human)	Bioassay	Human
Masood R, Kundra A, Zhu S, Xia G, Scalia P, Smith DL, Gill PS Malignant mesothelioma growth inhibition by agents that target the VEGF and VEGF-C autocrine loops. Int. J. Cancer, 2003-05-01;104(5):603-10. 2003-05-01 [PMID: 12594815] (Bioassay, Human)	Bioassay	Human
Barbour AP, Reeder JA, Walsh MD, Fawcett J, Antalis TM, Gotley DC Expression of the CD44v2-10 isoform confers a metastatic phenotype: importance of the heparan sulfate attachment site CD44v3. Cancer Res., 2003-02-15;63(4):887-92. 2003-02-15 [PMID: 12591743] (Binding Assay, Human)	Binding Assay	Human
Keane MP, Donnelly SC, Belperio JA, Goodman RB, Dy M, Burdick MD, Fishbein MC, Strieter RM Imbalance in the expression of CXC chemokines correlates with bronchoalveolar lavage fluid angiogenic activity and procollagen levels in acute respiratory distress syndrome. J. Immunol., 2002-12-01;169(11):6515-21. 2002-12-01 [PMID: 12444162] (ELISA (Standard))	ELISA (Standard)
Argraves WS, Larue AC, Fleming PA, Drake CJ VEGF signaling is required for the assembly but not the maintenance of embryonic blood vessels. Dev. Dyn., 2002-11-01;225(3):298-304. 2002-11-01 [PMID: 12412012] (Bioassay, In Vivo, Avian - Quail, Mouse)	Bioassay, In Vivo	Avian - Quail, Mouse
Lee S, 107340, Zheng M, Kim B, Rouse BT Role of matrix metalloproteinase-9 in angiogenesis caused by ocular infection with herpes simplex virus. Identification of NHLRC1 as a Novel AKT Activator from a Lung Cancer Epigenome-Wide Association Study (EWAS), 2002-10-01;110(8):1105-11. 2002-10-01 [PMID: 12393846] (In Vivo, Mouse)	In Vivo	Mouse
Oura H, Bertoncini J, Velasco P, Brown LF, Carmeliet P, Detmar M A critical role of placental growth factor in the induction of inflammation and edema formation. Blood, 2002-09-05;101(2):560-7. 2002-09-05 [PMID: 12393422] (In Vivo, Mouse)	In Vivo	Mouse
Gargett CE, Zaitseva M, Bucak K, Chu S, Fuller PJ, Rogers PA 17Beta-estradiol up-regulates vascular endothelial growth factor receptor-2 expression in human myometrial microvascular endothelial cells: role of estrogen receptor-alpha and -beta. J. Clin. Endocrinol. Metab., 2002-09-01;87(9):4341-9. 2002-09-01 [PMID: 12213896] (Bioassay, Human)	Bioassay	Human
Derevjanik NL, Vinores SA, Xiao WH, Mori K, Turon T, Hudish T, Dong S, Campochiaro PA Quantitative assessment of the integrity of the blood-retinal barrier in mice. Invest. Ophthalmol. Vis. Sci., 2002-07-01;43(7):2462-7. 2002-07-01 [PMID: 12091451] (In Vivo, Mouse)	In Vivo	Mouse
Chen CT, 2018, Lin J, Li Q, Phipps SS, Jakubczak JL, Stewart DA, Skripchenko Y, Forry-Schaudies S, Wood J, Schnell C, Hallenbeck PL Antiangiogenic gene therapy for cancer via systemic administration of adenoviral vectors expressing secretable endostatin. 132, 2000-09-20;11(14):1983-96. 2000-09-20 [PMID: 11020798] (Bioassay, In Vivo, Human, Mouse)	Bioassay, In Vivo	Human, Mouse
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