Recombinant Human VCAM-1/CD106 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Human VCAM-1 (CD106), a member of the Immunoglobulin Superfamily, is a cell surface protein expressed by activated endothelial cells and certain leukocytes (such as macrophages). VCAM-1 expression is induced by IL-1 beta , IL-4, TNF-alpha and IFN-gamma . VCAM-1 binds to leukocyte integrins VLA-4 and alpha 4 beta 7.During the inflammatory adhesion mechanism, activated integrins halt rolling leukocytes and attach them firmly to the vascular endothelium. They do this by binding to their ligands, for example VCAM-1, on endothelium. The VCAM-1: VLA-4/ alpha 4 beta 7 interaction is also thought to be involved in the extravasation of white blood cells through the blood vessel wall to sites of inflammation. ELISA techniques have shown that detectable levels of soluble VCAM-1 are present in the biological fluids of apparently normal individuals. Furthermore, a number of studies have reported that levels of VCAM-1 may be elevated or lowered in subjects with a variety of pathological conditions.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 1 application: Bioassay.

Showing Publications 1 - 9 of 9.

Publications using ADP5	Applications	Species
D Naci, S Berrazouan, F Barabé, F Aoudjit Cell adhesion to collagen promotes leukemia resistance to doxorubicin by reducing DNA damage through the inhibition of Rac1 activation Sci Rep, 2019-12-19;9(1):19455. 2019-12-19 [PMID: 31857649] (Bioassay, Human)	Bioassay	Human
F Caccuri, A Bugatti, S Corbellini, S Roversi, A Zani, P Mazzuca, S Marsico, A Caruso, C Giagulli The Synthetic Dipeptide Pidotimod Shows a Chemokine-Like Activity through CXC Chemokine Receptor 3 (CXCR3) Int J Mol Sci, 2019-10-24;20(21):. 2019-10-24 [PMID: 31653015] (Bioassay, Human)	Bioassay	Human
Soluble Siglec-5 associates to PSGL-1 and displays anti-inflammatory activity Sci Rep, 2016-11-28;6(0):37953. 2016-11-28 [PMID: 27892504] (Bioassay, Human)	Bioassay	Human
Bailon E, Ugarte-Berzal E, Amigo-Jimenez I, Van den Steen P, Opdenakker G, Garcia-Marco J, Garcia-Pardo A Overexpression of progelatinase B/proMMP-9 affects migration regulatory pathways and impairs chronic lymphocytic leukemia cell homing to bone marrow and spleen. J Leukoc Biol, 2014-08-01;96(2):185-99. 2014-08-01 [PMID: 25080557] (Bioassay, Human)	Bioassay	Human
Ugarte-Berzal E, Bailon E, Amigo-Jimenez I, Albar J, Garcia-Marco J, Garcia-Pardo A A novel CD44-binding peptide from the pro-matrix metalloproteinase-9 hemopexin domain impairs adhesion and migration of chronic lymphocytic leukemia (CLL) cells. J Biol Chem, 2014-04-16;289(22):15340-9. 2014-04-16 [PMID: 24739387] (Bioassay, Human)	Bioassay	Human
Barkho BZ, Song H, Aimone JB Identification of astrocyte-expressed factors that modulate neural stem/progenitor cell differentiation. Stem Cells Dev., 2006-06-01;15(3):407-21. 2006-06-01 [PMID: 16846377] (Bioassay, Rat)	Bioassay	Rat
Brooks AM, Bates ME, Vrtis RF, Jarjour NN, Bertics PJ, Sedgwick JB Urokinase-type plasminogen activator modulates airway eosinophil adhesion in asthma. Am. J. Respir. Cell Mol. Biol., 2006-05-25;35(4):503-11. 2006-05-25 [PMID: 16728704] (Bioassay, Human)	Bioassay	Human
Yamamoto H, Nagata M, Sakamoto Y CC chemokines and transmigration of eosinophils in the presence of vascular cell adhesion molecule 1. Ann. Allergy Asthma Immunol., 2005-02-01;94(2):292-300. 2005-02-01 [PMID: 15765748] (Bioassay, Human)	Bioassay	Human
Levesque JP, Liu F, Simmons PJ, Betsuyaku T, Senior RM, Pham C, Link DC Characterization of hematopoietic progenitor mobilization in protease-deficient mice. Blood, 2004-03-09;104(1):65-72. 2004-03-09 [PMID: 15010367] (Bioassay, Mouse)	Bioassay	Mouse

Array ADP5

• VCAM-1/CD106 Antibodies
• VCAM-1/CD106 Antibody Pair
• VCAM-1/CD106 ELISA Kits
• VCAM-1/CD106 Lysate
• VCAM-1/CD106 Proteins
• VCAM-1/CD106 ELISAs
• VCAM-1/CD106 Proteins and Enzymes