Recombinant Human IL-4R alpha Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interleukin 4 Receptor alpha (IL‑4 R alpha ), also known as CD124 and BSF receptor, is a widely expressed 140 kDa transmembrane glycoprotein in the class I cytokine receptor family. IL‑4 R alpha plays an important role in Th2‑biased immune responses, alternative macrophage activation, mucosal immunity, allergic inflammation, tumor progression, and atherogenesis (1‑5). Mature human IL‑4 R alpha consists of a 207 amino acid (aa) extracellular domain (ECD) that contains a cytokine binding region and one fibronectin type‑III domain, a 24 aa transmembrane segment, and a 569 aa cytoplasmic domain that contains one Box 1 motif and one ITIM motif (6, 7). Within the ECD, human IL‑4 R alpha shares 51% aa sequence identity with mouse and rat IL‑4 R alpha . Soluble forms of IL‑4 R alpha , generated by alternate splicing or proteolysis, retain ligand binding properties and inhibit IL‑4 bioactivity (8‑11). IL‑4 R alpha is a component of two distinct receptor complexes and shows species selectivity between human and mouse (6). It can associate with the common gamma chain ( gamma c) to form the IL‑4 responsive type I receptor in which gamma c increases the affinity for IL‑4 and enables signaling (12, 13). It can alternatively associate with IL‑13 R alpha 1 to form the type II receptor which is responsive to both IL‑4 and IL‑13 (14, 15). The use of shared receptor components contributes to the overlapping biological effects of IL‑4 and IL‑13 as well as other cytokines that utilize gamma c (i.e. IL‑2, IL‑7, IL‑9, IL‑15, and IL‑21) (16, 17).

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Direct ELISA.

Showing Publication 1 - 1 of 1.

Publication using 230-4RB	Applications	Species
Pan, HW;Guo, J;Zhu, L;Leung, SWS;Zhang, C;Lam, JKW; Enhanced powder dispersion of dual-excipient spray-dried powder formulations of a monoclonal antibody and its fragment for local treatment of severe asthma International journal of pharmaceutics 2023-07-25 [PMID: 37499774] (Direct ELISA, Human)	Direct ELISA	Human

Array 230-4RB

• IL-4R alpha Antibodies
• IL-4R alpha ELISA Kits
• IL-4R alpha Lysate
• IL-4R alpha Proteins
• IL-4R alpha Proteins and Enzymes