IL-4R alpha Products

Description

IL4 is a pleiotropic cytokine produced by activated T cells, mast cells and basophils. It is a ligand for Interleukin 4 receptor. The Interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. IL4 elicits many different biological responses, but has two dominant functions. The first is regulating differentiation of na ve CD4+ T cell to the Th2 type. Th2 cells produce IL4, IL5, IL10 and IL13, which tend to favor a humoral immune response while suppressing a cell mediated immune response controlled by Th1 cells. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. The second is regulating IgE and IgG1 production by B cells. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Bioinformatics

Entrez	16190 Mouse 3566 Human
Uniprot	NM_000418 Human NP_000409 Human P24394 Human
Product By Gene ID	3566
Alternate Names	CD124 antigen IL-4 receptor subunit alpha IL-4R subunit alpha IL-4RA IL4RACD124 IL-4R-alpha interleukin 4 receptor interleukin-4 receptor alpha chain interleukin-4 receptor subunit alpha

Research Areas for IL-4R alpha

Find related products by research area and learn more about each of the different research areas below.

Asthma
Cancer
Immunology