Recombinant Cotton Rat CCL5/RANTES Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CCL5, also known as RANTES (Regulated upon Activation, Normal T cell Expressed and presumably Secreted), is an 8 kDa beta -chemokine that plays a primary role in the inflammatory immune response by means of its ability to attract and activate leukocytes (1-3). Human and mouse RANTES exhibit cross-species activity on human and mouse cells (4). Mature cotton rat CCL5 shares 88% aa seqeuence identity with mouse and rat CCL5 and 71%-77% with canine, feline, and human CCL5. CCL5 is secreted by many cell types at inflammatory sites, and it exerts a wide range of activities through the receptors CCR1, CCR3, CCR4, and CCR5 (5, 6). Inflammatory responses can be impaired by the sequestration of CCL5 by the cytomegalovirus protein US28 (7). In humans, CCR5 binding to CCL5 inhibits the infectivity of R5 (M-tropic) but not X4 (T-tropic) strains of HIV-1 (8). The two N-terminal residues of CCL5 can be removed by CD26/DPPIV, generating a protein that functions as a chemotaxis inhibitor and more effectively blocks M-tropic HIV-1 infection of monocytes (9). Oligomerization of CCL5 on glycosaminoglycans is required for CCR1-mediated leukocyte adhesion and activation as well as CCL5’s interaction with the chemokine CXCL4/PF4 (10-12). The deposition of CCL5 on activated vascular endothelial cells is crucial for monocyte adhesion to damaged vasculature, but CCL5 oligomerization is not required for the extravasation of adherent leukocytes (13-15). CCL5 is up-regulated in breast cancer and promotes tumor progression through the attraction of proinflammatory macrophages in addition to its actions on tumor cells, stromal cells, and the vasculature (16).

We have publications tested in 1 confirmed species: Rat.

We have publications tested in 2 applications: Bioassay, In Vivo.

Showing Publications 1 - 3 of 3.

Publications using 1010-CR	Applications	Species
Nathalie Strazielle, Rita Creidy, Christophe Malcus, José Boucraut, Jean-François Ghersi-Eg T-Lymphocytes Traffic into the Brain across the Blood-CSF Barrier: Evidence Using a Reconstituted Choroid Plexus Epithelium. PLoS ONE, 2016-03-04;0(0):1932-6203. 2016-03-04 [PMID: 26942913] (Bioassay, Rat)	Bioassay	Rat
Kim H, Cha H, Kim H CCL5 upregulates activation of AMP-activated protein kinases in vascular smooth muscle cells of spontaneously hypertensive rats. Cytokine, 2014-03-20;67(2):77-84. 2014-03-20 [PMID: 24656927] (In Vivo, Rat)	In Vivo	Rat
Benamar K, Geller EB, Adler MW Elevated level of the proinflammatory chemokine, RANTES/CCL5, in the periaqueductal grey causes hyperalgesia in rats. Eur. J. Pharmacol., 2008-07-11;592(1):93-5. 2008-07-11 [PMID: 18656466] (In Vivo, Rat)	In Vivo	Rat

Array 1010-CR

• CCL5/RANTES Antibodies
• CCL5/RANTES Antibody Pair
• CCL5/RANTES ELISA Kit
• CCL5/RANTES Lysate
• CCL5/RANTES Proteins
• CCL5/RANTES ELISAs
• CCL5/RANTES Proteins and Enzymes