POMC Products

Description

POMC encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.

Bioinformatics

Entrez	18976 Mouse 24664 Rat 5443 Human
Uniprot	NM_001035256 Human NP_000930 Human NP_000930.1 Human NP_000930.1 Human NP_001030333 Human P01189 Human
Product By Gene ID	5443
Alternate Names	ACTH adrenocorticotropic hormone adrenocorticotropin alpha-melanocyte-stimulating hormone alpha-MSH beta-endorphin beta-LPH beta-melanocyte-stimulating hormone beta-MSH CLIP corticotropin-like intermediary peptide corticotropin-lipotropin Corticotropin-lipotropin gamma-LPH gamma-MSH lipotropin beta lipotropin gamma LPH melanotropin alpha melanotropin beta melanotropin gamma met-enkephalin MSH NPP POC pro-ACTH-endorphin proopiomelanocortin preproprotein proopiomelanocortin pro-opiomelanocortin

Research Areas for POMC

Find related products by research area and learn more about each of the different research areas below.

Neuroscience
Nutrient Sensing in the Brain