PIK3R4 Antibody

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Zebrafish.

We have publications tested in 3 applications: ICC/IF, IP, WB.

Showing Publications 1 - 10 of 12. Show All 12 Publications. Collapse Publications.

Publications using NBP1-30463	Applications	Species
Bork T, Liang W, Kretz O et al. BECLIN1 Is Essential for Podocyte Secretory Pathways Mediating VEGF Secretion and Podocyte-Endothelial Crosstalk International journal of molecular sciences 2022-03-30 [PMID: 35409185]
Mercer TJ, Ohashi Y, Boeing S et al. Phosphoproteomic identification of ULK substrates reveals VPS15-dependent ULK/VPS34 interplay in the regulation of autophagy The EMBO journal 2021-06-14 [PMID: 34121209]
Wang R, Simoneau CR, Kulsuptrakul J et al. Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses Cell 2020-12-09 [PMID: 33333024] (WB, Human)	WB	Human
Meena N, Ralston E, Raben N, Puertollano R Enzyme Replacement Therapy Can Reverse Pathogenic Cascade in Pompe Disease Mol Ther Methods Clin Dev 2020-07-17 [PMID: 32671132]
Franco-Iborra S, Plaza-Zabala A, Montpeyo M et al. Mutant HTT (huntingtin) impairs mitophagy in a cellular model of Huntington disease Autophagy 2020-02-24 [PMID: 32093570]
Gstrein T, Edwards A, PristoupilovA A et al. Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans. Nat. Neurosci. 2018-02-01 [PMID: 29311744] (WB, Human)	WB	Human
Liu Y, Hu M, Luo D et al. Class III PI3K Positively Regulates Platelet Activation and Thrombosis via PI(3)P-Directed Function of NADPH Oxidase Arterioscler. Thromb. Vasc. Biol. 2017-09-07 [PMID: 28882875] (Mouse)		Mouse
Stoetzel C, Bar S, De Craene JO et al. A mutation in VPS15 (PIK3R4) causes a ciliopathy and affects IFT20 release from the cis-Golgi. Nat Commun. 2016-11-24 [PMID: 27882921] (WB, Zebrafish)	WB	Zebrafish
Bejarano E, Yuste A, Patel B et al. Connexins modulate autophagosome biogenesis. Nat. Cell Biol. 2014-04-06 [PMID: 24705551] (WB, IP, Mouse)	WB, IP	Mouse
Pampliega O, Orhon I, Patel B et al. Functional interaction between autophagy and ciliogenesis. Nature. 2013-10-10 [PMID: 24089209] (ICC/IF, Mouse)	ICC/IF	Mouse
Martinez-Vicente M, Franco-Iborra S, Plaza-Zabala A et al. Impairment of neuronal mitophagy by mutant huntingtin bioRxiv 2018-05-24
Kaushik S, Cuervo AM Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis Nat Cell Biol. 2015-05-10 [PMID: 25961502] (ICC/IF, WB, Rat, Mouse)	ICC/IF, WB	Rat, Mouse
Show All 12 Publications. Collapse Publications.

Array NBP1-30463

• PIK3R4 Antibodies
• PIK3R4 Proteins