PEDFR/PNPLA2/ATGL Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

PEDF R (Pigment epithelium derived factor receptor; also known as ATGL, PNPLA2, and Desnutrin) is a 55 kDa member of the PNPLA family of proteins. It is expressed in adipocytes, hepatocytes, skeletal muscle, and pigment epithelium. PEDF R specifically hydrolyses triglycerides, releasing long-chain fatty acids. Mouse PEDF R is described as being a 486 amino acid (aa) type II transmembrane (TM) protein. Its TM segment is stated to span aa 9-29. Alternatively, it may have a hydrophobic lipid-association domain between aa 267-295. It contains a palatin domain (aa 10-179) with a conserved GxSxG enzymatic motif. There are multiple splice forms. Two show alternate start sites at Met57 and Met232, while two others show a deletion of aa 163-196 and aa 253-308, respectively. Over aa 162-253, mouse PEDF R shares 98% and 93% aa sequence identity with rat and human PEDF R, respectively.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 4 applications: ICC, IHC, Immunocytochemistry, Western Blot.

Showing Publications 1 - 10 of 10.

Publications using AF5365	Applications	Species
Sun, L;Zhang, X;Wu, S;Liu, Y;Guerrero-Juarez, CF;Liu, W;Huang, J;Yao, Q;Yin, M;Li, J;Ramos, R;Liao, Y;Wu, R;Xia, T;Zhang, X;Yang, Y;Li, F;Heng, S;Zhang, W;Yang, M;Tzeng, CM;Ji, C;Plikus, MV;Gallo, RL;Zhang, LJ; Dynamic interplay between IL-1 and WNT pathways in regulating dermal adipocyte lineage cells during skin development and wound regeneration Cell reports 2023-06-16 [PMID: 37330908] (Immunocytochemistry, Mouse)	Immunocytochemistry	Mouse
Tsung-Chuan Ho, Nai-Wen Fan, Shu-I Yeh, Show-Li Chen, Yeou-Ping Tsao The Therapeutic Effects of a PEDF-Derived Short Peptide on Murine Experimental Dry Eye Involves Suppression of MMP-9 and Inflammation Translational Vision Science & Technology 10/6/2022 [PMID: 36201200]
Sei Kuriyama, Gentaro Tanaka, Kurara Takagane, Go Itoh, Masamitsu Tanaka Pigment Epithelium Derived Factor Is Involved in the Late Phase of Osteosarcoma Metastasis by Increasing Extravasation and Cell-Cell Adhesion Frontiers in Oncology 1/31/2022 [PMID: 35174090]
JY Kim, S Park, SH Park, D Lee, GH Kim, JE Noh, KJ Lee, GJ Kim Overexpression of pigment epithelium-derived factor in placenta-derived mesenchymal stem cells promotes mitochondrial biogenesis in retinal cells Lab. Invest., 2020-07-28;0(0):. 2020-07-28 [PMID: 32724163] (Western Blot, Rat)	Western Blot	Rat
S Omri, H Tahiri, WC Pierre, M Desjarlais, I Lahaie, SE Loiselle, F Rezende, G Lodygensky, TE Hebert, H Ong, S Chemtob Propranolol Attenuates Proangiogenic Activity of Mononuclear Phagocytes: Implication in Choroidal Neovascularization Invest. Ophthalmol. Vis. Sci., 2019-11-01;60(14):4632-4642. 2019-11-01 [PMID: 31682714] (IHC, Mouse)	IHC	Mouse
W Eichler, H Savkovi?-C, S Bürger, M Beck, M Schmidt, P Wiedemann, A Reichenbac, JD Unterlauft M�ller Cell-Derived PEDF Mediates Neuroprotection via STAT3 Activation Cell. Physiol. Biochem., 2017-11-30;44(4):1411-1424. 2017-11-30 [PMID: 29186716] (Western Blot, Mouse, Rat)	Western Blot	Mouse, Rat
D Martinez-M, C Jarvis, T Nelius, W de Riese, OV Volpert, S Filleur PEDF increases the tumoricidal activity of macrophages towards prostate cancer cells in vitro PLoS ONE, 2017-04-12;12(4):e0174968. 2017-04-12 [PMID: 28403150] (ICC, Mouse)	ICC	Mouse
Jacqueline Talea Desjardin, S Patricia Becerra, Preeti Subramanian Searching for Alternatively Spliced Variants of Phospholipase Domain-Containing 2 (Pnpla2), a Novel Gene in the Retina Journal of Clinical & Experimental Ophthalmology 10/1/2013 [PMID: 24482734]
Deshpande M, Notari L, Subramanian P, Notario V, Becerra SP Inhibition of tumor cell surface ATP synthesis by pigment epithelium-derived factor: implications for antitumor activity. Int. J. Oncol., 2012-04-10;41(1):219-27. 2012-04-10 [PMID: 22504705] (Western Blot, Human)	Western Blot	Human
Preeti Subramanian, Matthew Rapp, S. Patricia Becerra Identification of Pigment Epithelium-Derived Factor Receptor (PEDF-R) Antibody Epitopes Retinal Degenerative Diseases 4/3/2013 [PMID: 22183409]

Array AF5365

• PEDFR/PNPLA2/ATGL Antibodies
• PEDFR/PNPLA2/ATGL ELISA Kits
• PEDFR/PNPLA2/ATGL Lysate
• PEDFR/PNPLA2/ATGL Proteins