Adiponutrin/PNPLA3 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Human Adiponutrin (ADPN; also PNPLA3 and patatin-like phospholipase domain-containing protein 3) is a 53 kDa member of the PNPLA family of phospholipase A2 enzymes. It is expressed in white adipocytes. Adiponutrin is elevated in response to insulin and appears to act not as a phospholipase, but a molecule involved in anabolic pathways. ADPN is likely to be a type II transmembrane protein that is 481 amino acids (aa) in length. It contains one patatin domain (aa 10‑179) that is associated with in vitro enzyme activity and a transmembrane segment between aa 42‑62. There appear to be two splice variants. One shows a four aa deletion of aa 59‑62 and a second shows an alternate start site at Met379. Over aa 160‑349, human ADPN shares 61% aa identity with mouse Adiponutrin.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: ICC.

Showing Publications 1 - 2 of 2.

Publications using AF5208	Applications	Species
D Hendriks, JF Brouwers, K Hamer, MH Geurts, L Luciana, S Massalini, C López-Igle, PJ Peters, MJ Rodríguez-, S Chuva de S, B Artegiani, H Clevers Engineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosis Nature Biotechnology, 2023-02-23;0(0):. 2023-02-23 [PMID: 36823355] (ICC, Human)	ICC	Human
Elke Ericson, Linnéa Bergenholm, Anne‐Christine Andréasson, Carly I. Dix, Jane Knöchel, Sara F. Hansson et al. Hepatic patatin‐like phospholipase domain‐containing 3 levels are increased in I148M risk allele carriers and correlate with NAFLD in humans Hepatology Communications 2022-10-01 [PMID: 35833455]

Array AF5208

• Adiponutrin/PNPLA3 Antibodies
• Adiponutrin/PNPLA3 Lysate
• Adiponutrin/PNPLA3 Proteins