Pax5/BSAP Antibody

PAX5 encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined. [provided by RefSeq]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Rat, Hamster.

We have publications tested in 2 applications: IF/IHC, IHC-P.

Showing Publications 1 - 5 of 5.

Publications using NBP2-38790	Applications	Species
Port JR, Yinda CK, Riopelle JC et al. Infection- or AZD1222 vaccine-mediated immunity reduces SARS-CoV-2 transmission but increases Omicron competitiveness in hamsters Nature communications 2023-10-18 [PMID: 37852960] (Hamster) Details: Dilution 1:500		Hamster
Port JR, Yinda CK, Riopelle JC et al. Infection- or vaccine mediated immunity reduces SARS-CoV-2 transmission, but increases competitiveness of Omicron in hamsters bioRxiv : the preprint server for biology 2022-07-29 [PMID: 35982658] (IHC-P, Hamster) Details: Dilution used for IHC 1:500	IHC-P	Hamster
Port JR, Adney DR, Schwarz B et al. High-Fat High-Sugar Diet-Induced Changes in the Lipid Metabolism Are Associated with Mildly Increased COVID-19 Severity and Delayed Recovery in the Syrian Hamster Viruses 2021-12-14 [PMID: 34960775] (IF/IHC, Hamster)	IF/IHC	Hamster
Port JR, Adney DR, Schwarz B et al. Western diet increases COVID-19 disease severity in the Syrian hamster bioRxiv : the preprint server for biology 2021-06-17 [PMID: 34159329] (IF/IHC, Hamster)	IF/IHC	Hamster
Tibaldi E, Gnudi F, Panzacchi S et al. Identification of aspartame-induced haematopoietic and lymphoid tumours in rats after lifetime treatment Acta Histochemica 2020-01-01 [PMID: 32622430] (IF/IHC, Rat)	IF/IHC	Rat

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	IHC-P	Rat	02/17/2018	View Summary Application Immunohistochemistry-Paraffin Sample Tested Spleen tissue Species Rat Lot R75047 Comments Comments Paraffin-embedded alcohol fixed tissue. Antigen retrieval pH9. PAX5 dilution 1:500 ON at 4°C.

Array NBP2-38790

• Pax5/BSAP Antibodies
• Pax5/BSAP Lysate
• Pax5/BSAP Proteins