p38 alpha Antibody

p38 Antibody Background: The MAPK (mitogen activated protein kinase) comprises a family of ubiquitous praline-directed, proteinserine/ threonine kinases which signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms. This super family consists of stress activated protein kinases (SAPKs); extracellular signal-regulated kinases (ERKs); and p38 kinases, each of which forms a separate pathway. The kinase members that populate each pathway are sequentially activated by phosphorylation. Upon activation, p38 MAPK/SAPK2 alpha translocates into the nucleus where it phosphorylates one or more nuclear substrates, effecting transcriptional changes and other cellular processes involved in cell growth, division, differentiation, inflammation, and death. Specifically p38 always acts as a pro-apoptotic factor with its activation leading to the release of cytochrome c from mitochondria and cleavage of caspase 3 and its downstream effector, PARP. p38 MAPK is activated by a variety of chemical stress inducers including hydrogen peroxide, heavy metals, anisomycin, sodium salicylate, LPS, and biological stress signals such as tumor necrosis factor, interleukin-1, ionizing and UV irradiation, hyperosmotic stress and chemotherapeutic drugs. As a result, p38 alpha has been widely validated as a target for inflammatory disease including rheumatoid arthritis, COPD and psoriasis and has also been implicated in cancer, CNS and diabetes.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 1 application: WB.

Showing Publications 1 - 3 of 3.

Publications using NB110-96907	Applications	Species
Cho E, Chen Z, Ding M et al. PMSA prevents osteoclastogenesis and estrogen-dependent bone loss in mice Bone [PMID: 33141068] (Mouse)		Mouse
Cho E, Chen Z et al. PSTP-3,5-Me Inhibits Osteoclast Differentiation and Bone Resorption. Molecules 2019-09-14 [PMID: 31540026] (WB, Mouse)	WB	Mouse
Su J, Zheng L, Luo J et al. Arsenic Trioxide (ATO)-Induced Pyroptosis and Activation of Natural Killer Cells in Acute Myeloid Leukemia Research Square 2022-04-14 (WB, Human)	WB	Human

Array NB110-96907

• p38 alpha Antibodies
• p38 alpha ELISA Kits
• p38 alpha Lysates
• p38 alpha Proteins
• p38 alpha ELISAs
• p38 alpha Proteins and Enzyme