NKG2C/CD159c/KLRC2 Antibody (134591) [Phycoerythrin]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Human NKG2C (NK cell Group 2 isoform C; Killer cell lectin-like receptor subfamily C, member 2) is a member of the C-type lectin-like superfamily of proteins. Natural killer (NK) receptors are expressed in both NK cells and cytotoxic CD8⁺ T cells and have both activating and inhibitory members (1-3). Regulation of the balance between the activating and inhibitory receptors is important and lack of such regulation has been implicated in autoimmunity (4). The NKG2 family includes seven receptors: NKG2A, -B, -C, -D, -E, -F, and -H, which is the longer isoform of NKG2E. Except for NKG2D and NKG2F, the NKG2 family members form heterodimers with CD94 (5, 6). NKG2C interacts with the adapter molecule DAP12 and acts as activating receptor when heterodimerized with CD94 (7). Human NKG2C is synthesized as a 231 amino acid (aa) protein that includes a 70 aa cytoplasmic domain, a 23 aa transmembrane segment, and a 138 aa extracellular domain (ECD). Within the ECD, human NKG2C shares 40% sequence identity with mouse NKG2C. NKG2C-CD94 heterodimers bind to the widely expressed nonclassical MHC-I molecule, HLA-E (Qa-1b in mouse), which presents a peptide derived from the signal peptide of classical MHC-I molecules (8, 9). Triggering the NKG2C-CD94 complex may activate the cytolytic activity and cytokine production of NK and CD8⁺ T cells (8, 10). Human cytomegalovirus (HCMV) infection promotes the differentiation and expansion of NKG2C⁺ NK cell subsets, possibly involving a cognate interaction of CD94/NKG2C with ligand(s) displayed by HCMV‑infected cells (11, 12).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 4 applications: Bioassay, Flow Cytometry, ICC, IHC.

Showing Publications 1 - 10 of 75. Show All 75 Publications. Collapse Publications.

Publications using FAB138P	Applications	Species
Sanchez-Gaona, N;Gallego-Cortés, A;Astorga-Gamaza, A;Rallón, N;Benito, J;Ruiz-Mateos, E;Curran, A;Burgos, J;Navarro, J;Suanzes, P;Falco, V;Genescà, M;Buzon, MJ; NKG2C and NKG2A Co-expression Defines a Highly Functional Antiviral NK Population in Spontaneous HIV Control JCI insight 2024-09-17 [PMID: 39288262] (Flow Cytometry, Human)	Flow Cytometry	Human
Lupo, KB;Panjwani, MK;Shahid, S;Sottile, R;Lawry, C;Kolk, G;Kontopolous, T;Daniyan, AF;Chandran, SS;Klebanoff, CA;Hsu, KC; Engineered NKG2C + NK-like T cells exhibit superior antitumor efficacy while mitigating cytokine release syndrome bioRxiv : the preprint server for biology 2024-08-01 [PMID: 39211122] (Flow Cytometry, Human)	Flow Cytometry	Human
Thangaraj, JL;Coffey, M;Lopez, E;Kaufman, DS; Disruption of TGF-? signaling pathway is required to mediate effective killing of hepatocellular carcinoma by human iPSC-derived NK cells Cell stem cell 2024-07-01 [PMID: 38986609] (Flow Cytometry, Human)	Flow Cytometry	Human
Felgueres, MJ;Esteso, G;García-Jiménez, ÁF;Dopazo, A;Aguiló, N;Mestre-Durán, C;Martínez-Piñeiro, L;Pérez-Martínez, A;Reyburn, HT;Valés-Gómez, M; BCG priming followed by a novel interleukin combination activates Natural Killer cells to selectively proliferate and become anti-tumour long-lived effectors Scientific reports 2024-06-07 [PMID: 38849432] (Flow Cytometry, Human)	Flow Cytometry	Human
Moreno-Cubero, E;Alrubayyi, A;Balint, S;Ogbe, A;Gill, US;Matthews, R;Kinloch, S;Burns, F;Rowland-Jones, SL;Borrow, P;Schurich, A;Dustin, M;Peppa, D; IL-15 reprogramming compensates for NK cell mitochondrial dysfunction in HIV-1 infection JCI insight 2024-01-16 [PMID: 38385747] (Flow Cytometry, Human)	Flow Cytometry	Human
Alekseeva, NA;Streltsova, MA;Vavilova, JD;Ustiuzhanina, MO;Palamarchuk, AI;Boyko, AA;Timofeev, ND;Popodko, AI;Kovalenko, EI; Obtaining Gene-Modified HLA-E-Expressing Feeder Cells for Stimulation of Natural Killer Cells Pharmaceutics 2024-01-19 [PMID: 38276503] (Flow Cytometry, Human)	Flow Cytometry	Human
Rubino, V;Carriero, F;Palatucci, AT;Giovazzino, A;Leone, S;Nicolella, V;Calabrò, M;Montanaro, R;Brancaleone, V;Pane, F;Chiurazzi, F;Ruggiero, G;Terrazzano, G; Adaptive and Innate Cytotoxic Effectors in Chronic Lymphocytic Leukaemia (CLL) Subjects with Stable Disease International journal of molecular sciences 2023-05-31 [PMID: 37298547] (Flow Cytometry, Human)	Flow Cytometry	Human
M Israr, F Lam, J DeVoti, EM Mace, C Papayannak, A Abramson, BM Steinberg, VR Bonagura PGE2 expression by HPV6/11-induced respiratory papillomas blocks NK cell activation in patients with recurrent respiratory papillomatosis European Journal of Immunology, 2023-01-31;0(0):e2250036. 2023-01-31 [PMID: 36608264] (Flow Cytometry, Human)	Flow Cytometry	Human
Avishai Shemesh, Yapeng Su, Daniel R. Calabrese, Daniel Chen, Janice Arakawa-Hoyt, Kole T. Roybal et al. Diminished cell proliferation promotes natural killer cell adaptive-like phenotype by limiting Fc epsilon RI gamma expression Journal of Experimental Medicine 11/7/2022 [PMID: 36066491]
S Wahlen, F Matthijsse, W Van Loocke, S Taveirne, L Kiekens, E Persyn, E Van Ammel, Z De Vos, S De Munter, P Matthys, F Van Nieuwe, T Taghon, B Vandekerck, P Van Vlierb, G Leclercq The transcription factor RUNX2 drives the generation of human NK cells and promotes tissue residency Elife, 2022-07-06;11(0):. 2022-07-06 [PMID: 35793229] (Flow Cytometry, Human)	Flow Cytometry	Human
V Mikhailova, P Grebenkina, E Khokhlova, A Davydova, Z Salloum, E Tyshchuk, V Zagainova, K Markova, I Kogan, S Selkov, D Sokolov Pro- and Anti-Inflammatory Cytokines in the Context of NK Cell-Trophoblast Interactions International Journal of Molecular Sciences, 2022-02-21;23(4):. 2/21/2022 [PMID: 35216502]
AI Palamarchu, NA Alekseeva, MA Streltsova, MO Ustiuzhani, PA Kobyzeva, SA Kust, MV Grechikhin, AA Boyko, OA Shustova, AM Sapozhniko, EI Kovalenko Increased Susceptibility of the CD57- NK Cells Expressing KIR2DL2/3 and NKG2C to iCasp9 Gene Retroviral Transduction and the Relationships with Proliferative Potential, Activation Degree, and Death Induction Response International Journal of Molecular Sciences, 2021-12-11;22(24):. 2021-12-11 [PMID: 34948123] (Flow Cytometry, Human)	Flow Cytometry	Human
VA Vieira, E Adland, DFG Malone, MP Martin, A Groll, MA Ansari, MC Garcia-Gue, MC Puertas, M Muenchhoff, CF Guash, C Brander, J Martinez-P, A Bamford, G Tudor-Will, T Ndung'u, BD Walker, V Ramsuran, J Frater, P Jooste, D Peppa, M Carrington, PJR Goulder An HLA-I signature favouring KIR-educated Natural Killer cells mediates immune control of HIV in children and contrasts with the HLA-B-restricted CD8+ T-cell-mediated immune control in adults PloS Pathogens, 2021-11-18;17(11):e1010090. 2021-11-18 [PMID: 34793581] (Flow Cytometry, Human)	Flow Cytometry	Human
J Tuengel, S Ranchal, A Maslova, G Aulakh, M Papadopoul, S Drissler, B Cai, C Mohsenzade, H Soudeyns, S Mostafavi, P van den El, D Vermijlen, L Cook, S Gantt Characterization of Adaptive-like gammadelta T Cells in Ugandan Infants during Primary Cytomegalovirus Infection Viruses, 2021-10-03;13(10):. 2021-10-03 [PMID: 34696417] (Flow Cytometry, Human)	Flow Cytometry	Human
KV Woan, H Kim, R Bjordahl, ZB Davis, S Gaidarova, J Goulding, B Hancock, S Mahmood, R Abujarour, H Wang, K Tuininga, B Zhang, CY Wu, B Kodal, M Khaw, L Bendzick, P Rogers, MQ Ge, G Bonello, M Meza, M Felices, J Huffman, T Dailey, TT Lee, B Walcheck, KJ Malmberg, BR Blazar, YT Bryceson, B Valamehr, JS Miller, F Cichocki Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy Cell Stem Cell, 2021-09-14;0(0):. 2021-09-14 [PMID: 34525347] (Flow Cytometry, Human)	Flow Cytometry	Human
MA Streltsova, MO Ustiuzhani, EV Barsov, SA Kust, RA Velichinsk, EI Kovalenko Telomerase Reverse Transcriptase Increases Proliferation and Lifespan of Human NK Cells without Immortalization Biomedicines, 2021-06-09;9(6):. 2021-06-09 [PMID: 34207853] (Flow Cytometry, Human)	Flow Cytometry	Human
Ralph Ja Maas, Janneke S Hoogstad-van Evert, Jolien Mr Van der Meer, Vera Mekers, Somayeh Rezaeifard, Alan J Korman et al. TIGIT blockade enhances functionality of peritoneal NK cells with altered expression of DNAM-1/TIGIT/CD96 checkpoint molecules in ovarian cancer OncoImmunology 11/23/2020 [PMID: 33224630]
RR Anderko, CR Rinaldo, RB Mailliard IL-18 Responsiveness Defines Limitations in Immune Help for Specialized FcR&gamma- NK Cells J Immunol, 2020-11-13;0(0):. 2020-11-13 [PMID: 33188073] (Flow Cytometry, Human)	Flow Cytometry	Human
HC Tseng, W Xiong, S Badeti, Y Yang, M Ma, T Liu, CA Ramos, G Dotti, L Fritzky, JG Jiang, Q Yi, J Guarrera, WX Zong, C Liu, D Liu Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma Nat Commun, 2020-09-23;11(1):4810. 2020-09-23 [PMID: 32968061] (Flow Cytometry, IHC, Human)	Flow Cytometry, IHC	Human
PA Kobyzeva, MA Streltsova, SA Erokhina, LM Kanevskiy, WG Telford, AM Sapozhniko, EI Kovalenko CD56dim CD57- NKG2C+ NK cells retaining proliferative potential are possible precursors of CD57+ NKG2C+ memory-like NK cells J. Leukoc. Biol., 2020-09-15;0(0):. 2020-09-15 [PMID: 32930385] (ICC, Human)	ICC	Human
Conor N. Gruber, Jorg J.A. Calis, Sofija Buta, Gilad Evrony, Jerome C. Martin, Skyler A. Uhl et al. Complex Autoinflammatory Syndrome Unveils Fundamental Principles of JAK1 Kinase Transcriptional and Biochemical Function Immunity 9/1/2020 [PMID: 32750333]
DR Makanga, F Da Rin de, G David, C Willem, L Dubreuil, N Legrand, T Guillaume, P Peterlin, A Lebourgeoi, MC Béné, A Garnier, P Chevallier, K Gendzekhad, A Cesbron, K Gagne, B Clemenceau, C Retière Genetic and Molecular Basis of Heterogeneous NK Cell Responses against Acute Leukemia Cancers (Basel), 2020-07-16;12(7):. 2020-07-16 [PMID: 32708751] (Flow Cytometry, Human)	Flow Cytometry	Human
H Zhu, RH Blum, D Bernareggi, EH Ask, Z Wu, HJ Hoel, Z Meng, C Wu, KL Guan, KJ Malmberg, DS Kaufman Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In�Vivo Persistence and Enhances Anti-tumor Activity Cell Stem Cell, 2020-06-11;0(0):. 2020-06-11 [PMID: 32531207] (Flow Cytometry, Human)	Flow Cytometry	Human
P Riese, S Trittel, RD Pathirana, F Klawonn, RJ Cox, CA Guzmán Responsiveness to Influenza Vaccination Correlates with NKG2C-Expression on NK Cells Vaccines (Basel), 2020-06-05;8(2):. 2020-06-05 [PMID: 32517137] (Flow Cytometry, Human)	Flow Cytometry	Human
HR Wagstaffe, EA Clutterbuc, V Bockstal, JN Stoop, K Luhn, MJ Douoguih, G Shukarev, MD Snape, AJ Pollard, EM Riley, M Goodier Ebola virus glycoprotein stimulates IL-18 dependent natural killer cell responses J. Clin. Invest., 2020-07-01;0(0):. 2020-07-01 [PMID: 32315287] (Flow Cytometry, Human)	Flow Cytometry	Human
Carissa Dege, Katherine H. Fegan, J. Philip Creamer, Melissa M. Berrien-Elliott, Stephanie A. Luff, Darren Kim et al. Potently Cytotoxic Natural Killer Cells Initially Emerge from Erythro-Myeloid Progenitors during Mammalian Development Developmental Cell 4/1/2020 [PMID: 32197069]
Samarani S, Sagala P, Jantchou P, Grimard G, Faure C, Deslandres C, Amre D, Ahmad A Phenotypic and Functional Changes in Peripheral Blood Natural Killer Cells in Crohn Disease Patients. Mediators Inflamm, 2020-02-19;2020(0):6401969. 2020-02-19 [PMID: 32148442] (Flow Cytometry, Human)	Flow Cytometry	Human
Pranay Dogra, Chiara Rancan, Wenji Ma, Marta Toth, Takashi Senda, Dustin J. Carpenter et al. Tissue Determinants of Human NK Cell Development, Function, and Residence Cell 2/13/2020 [PMID: 32059780]
EO Ojo, AA Sharma, R Liu, S Moreton, MA Checkley-L, K Gupta, G Lee, DA Lee, F Otegbeye, RP Sekaly, M de Lima, DN Wald Membrane bound IL-21 based NK cell feeder cells drive robust expansion and metabolic activation of NK cells Sci Rep, 2019-10-17;9(1):14916. 2019-10-17 [PMID: 31624330] (Bioassay, Human)	Bioassay	Human
E Oh, B Min, Y Li, C Lian, J Hong, GM Park, B Yang, SY Cho, YK Hwang, CO Yun Cryopreserved Human Natural Killer Cells Exhibit Potent Antitumor Efficacy against Orthotopic Pancreatic Cancer through Efficient Tumor-Homing and Cytolytic Ability (Running Title: Cryopreserved NK Cells Exhibit Antitumor Effect) Cancers (Basel), 2019-07-09;11(7):. 2019-07-09 [PMID: 31324057] (Flow Cytometry, Human)	Flow Cytometry	Human
WC Pump, T Kraemer, T Huyton, GT Hò, R Blasczyk, C Bade-Doedi Between Innate and Adaptive Immune Responses: NKG2A, NKG2C, and CD8? T Cell Recognition of HLA-E Restricted Self-Peptides Acquired in the Absence of HLA-Ia Int J Mol Sci, 2019-03-22;20(6):. 2019-03-22 [PMID: 30909402] (Flow Cytometry, Human)	Flow Cytometry	Human
Todd Bradley, Dimitra Peppa, Isabela Pedroza-Pacheco, Dapeng Li, Derek W. Cain, Ricardo Henao et al. RAB11FIP5 Expression and Altered Natural Killer Cell Function Are Associated with Induction of HIV Broadly Neutralizing Antibody Responses Cell 10/4/2018 [PMID: 30270043]
Cristina Capuano, Simone Battella, Chiara Pighi, Lavinia Franchitti, Ombretta Turriziani, Stefania Morrone et al. Tumor-Targeting Anti-CD20 Antibodies Mediate In Vitro Expansion of Memory Natural Killer Cells: Impact of CD16 Affinity Ligation Conditions and In Vivo Priming Frontiers in Immunology 5/11/2018 [PMID: 29867997]
ECY Wang, M Pjechova, K Nightingal, VM Vlahava, M Patel, E Ruckova, SK Forbes, L Nobre, R Antrobus, D Roberts, CA Fielding, S Seirafian, J Davies, I Murrell, B Lau, GS Wilkie, NM Suárez, RJ Stanton, B Vojtesek, A Davison, PJ Lehner, MP Weekes, GWG Wilkinson, P Tomasec Suppression of costimulation by human cytomegalovirus promotes evasion of cellular immune defenses Proc. Natl. Acad. Sci. U.S.A., 2018-04-24;0(0):. 2018-04-24 [PMID: 29691324] (Flow Cytometry, Human)	Flow Cytometry	Human
Mathieu Garand, Martin Goodier, Olumuyiwa Owolabi, Simon Donkor, Beate Kampmann, Jayne S. Sutherland Functional and Phenotypic Changes of Natural Killer Cells in Whole Blood during Mycobacterium tuberculosis Infection and Disease Frontiers in Immunology 2/19/2018 [PMID: 29520269]
D Feyaerts, T Kuret, B van Cranen, S van der Ze, OWH van der He, A van der Me, I Joosten, RG van der Mo Endometrial natural killer (NK) cells reveal a tissue-specific receptor repertoire Hum. Reprod., 2018-03-01;0(0):. 2018-03-01 [PMID: 29447367] (Flow Cytometry, Human)	Flow Cytometry	Human
AT Björklund, M Carlsten, E Sohlberg, LL Liu, T Clancy, M Karimi, S Cooley, JS Miller, M Klimkowska, M Schaffer, E Watz, KI Wikstrom, P Blomberg, BE Wahlin, M Palma, L Hansson, P Ljungman, E Hellström-, HG Ljunggren, KJ Malmberg Complete Remission with Reduction of High-risk Clones following Haploidentical NK Cell Therapy against MDS and AML Clin. Cancer Res., 2018-02-14;0(0):. 2018-02-14 [PMID: 29444931] (Flow Cytometry, Human)	Flow Cytometry	Human
A Podhorzer, M Dirchwolf, A Machicote, S Belen, S Montal, S Paz, H Fainboim, LG Podestá, L Fainboim The Clinical Features of Patients with Chronic Hepatitis C Virus Infections Are Associated with Killer Cell Immunoglobulin-Like Receptor Genes and Their Expression on the Surface of Natural Killer Cells Front Immunol, 2018-01-05;8(0):1912. 2018-01-05 [PMID: 29354127] (Flow Cytometry, Human)	Flow Cytometry	Human
M Larsen, C Bayard, H Lepetitcor, J Cohen-Bitt, V Appay, J Boddaert, D Sauce Elevated Neopterin Levels Predict Early Death in Older Hip-fracture Patients EBioMedicine, 2017-11-06;0(0):. 2017-11-06 [PMID: 29157836] (Flow Cytometry, Human)	Flow Cytometry	Human
M López-Mont, E Alari-Pahi, J Sintes, JE Martínez-R, A Muntasell, M López-Bote Antibody-Dependent NK Cell Activation Differentially Targets EBV-Infected Cells in Lytic Cycle and Bystander B Lymphocytes Bound to Viral Antigen-Containing Particles J. Immunol., 2017-06-19;0(0):. 2017-06-19 [PMID: 28630095] (Flow Cytometry, Human)	Flow Cytometry	Human
A Darboe, E Danso, E Clarke, A Umesi, E Touray, R Wegmuller, SE Moore, EM Riley, MR Goodier Enhancement of cytokine-driven NK cell IFN-? production after vaccination of HCMV infected Africans Eur. J. Immunol., 2017-04-24;0(0):. 2017-04-24 [PMID: 28383105] (Flow Cytometry, Human)	Flow Cytometry	Human
KS van der Ge, Q Wang, TM Eijsvogels, HJ Koenen, I Joosten, E Brouwer, MT Hopman, JF Jacobs, AM Boots Changes in peripheral immune cell numbers and functions in octogenarian walkers - an acute exercise study Immun Ageing, 2017-02-22;14(0):5. 2017-02-22 [PMID: 28250797] (Flow Cytometry, Human)	Flow Cytometry	Human
CD2-CD58 interactions are pivotal for the activation and function of adaptive natural killer cells in human cytomegalovirus infection Eur J Immunol, 2016-08-29;0(0):. 2016-08-29 [PMID: 27469079] (Flow Cytometry, Human)	Flow Cytometry	Human
Martin R Goodier Influenza Vaccination Generates Cytokine-Induced Memory-like NK Cells: Impact of Human Cytomegalovirus Infection J Immunol, 2016-05-27;197(1):313-25. 2016-05-27 [PMID: 27233958] (Flow Cytometry, Human)	Flow Cytometry	Human
P Rettman, C Willem, G David, R Riou, N Legrand, J Esbelin, A Cesbron, D Senitzer, K Gagne, C Retière New insights on the natural killer cell repertoire from a thorough analysis of cord blood cells J Leukoc Biol, 2016-04-11;0(0):. 2016-04-11 [PMID: 27067451] (Flow Cytometry, Human)	Flow Cytometry	Human
Frank Cichocki, Sarah Cooley, Zachary Davis, Todd E. DeFor, Heinrich Schlums, Bin Zhang et al. CD56dimCD57+NKG2C+ NK cell expansion is associated with reduced leukemia relapse after reduced intensity HCT Leukemia 2016-02-01 [PMID: 26416461] (Bioassay, Human)	Bioassay	Human
Frank Cichocki, Sarah Cooley, Zachary Davis, Todd E. DeFor, Heinrich Schlums, Bin Zhang et al. CD56dimCD57+NKG2C+ NK cell expansion is associated with reduced leukemia relapse after reduced intensity HCT Leukemia 2/1/2016 [PMID: 26416461]
Picardi A, Mengarelli A, Marino M, Gallo E, Benevolo M, Pescarmona E, Cocco R, Fraioli R, Tremante E, Petti M, De Fabritiis P, Giacomini P Up-regulation of activating and inhibitory NKG2 receptors in allogeneic and autologous hematopoietic stem cell grafts. J Exp Clin Cancer Res, 2015-09-11;34(0):98. 2015-09-11 [PMID: 26361968] (Flow Cytometry, Human)	Flow Cytometry	Human
Li W, Jiang Y, Wang X, Jin J, Qi Y, Chi X, Zhang H, Feng X, Niu J Natural Killer p46 Controls Hepatitis B Virus Replication and Modulates Liver Inflammation. PLoS ONE, 2015-08-20;10(8):e0135874. 2015-08-20 [PMID: 26291078] (Flow Cytometry, Human)	Flow Cytometry	Human
Marquardt N, Ivarsson M, Blom K, Gonzalez V, Braun M, Falconer K, Gustafsson R, Fogdell-Hahn A, Sandberg J, Michaelsson J The Human NK Cell Response to Yellow Fever Virus 17D Is Primarily Governed by NK Cell Differentiation Independently of NK Cell Education. J Immunol, 2015-08-17;195(7):3262-72. 2015-08-17 [PMID: 26283480] (Flow Cytometry, Human)	Flow Cytometry	Human
Moraru M, Black L, Muntasell A, Portero F, Lopez-Botet M, Reyburn H, Pandey J, Vilches C NK Cell and Ig Interplay in Defense against Herpes Simplex Virus Type 1: Epistatic Interaction of CD16A and IgG1 Allotypes of Variable Affinities Modulates Antibody-Dependent Cellular Cytotoxicity and Susceptibility to Clinical Reactivation. J Immunol, 2015-07-15;195(4):1676-84. 2015-07-15 [PMID: 26179905] (Flow Cytometry, Human)	Flow Cytometry	Human
Dunphy S, Guinan K, Chorcora C, Jayaraman J, Traherne J, Trowsdale J, Pende D, Middleton D, Gardiner C 2DL1, 2DL2 and 2DL3 all contribute to KIR phenotype variability on human NK cells. Genes Immun, 2015-05-07;16(5):301-10. 2015-05-07 [PMID: 25950617] (Flow Cytometry, Human)	Flow Cytometry	Human
Nielsen C, White M, Bottomley C, Lusa C, Rodriguez-Galan A, Turner S, Goodier M, Riley E Impaired NK Cell Responses to Pertussis and H1N1 Influenza Vaccine Antigens in Human Cytomegalovirus-Infected Individuals. J Immunol, 2015-04-08;194(10):4657-67. 2015-04-08 [PMID: 25855356] (Flow Cytometry, Human)	Flow Cytometry	Human
van Meijgaarden K, Haks M, Caccamo N, Dieli F, Ottenhoff T, Joosten S Human CD8+ T-cells recognizing peptides from Mycobacterium tuberculosis (Mtb) presented by HLA-E have an unorthodox Th2-like, multifunctional, Mtb inhibitory phenotype and represent a novel human T-cell subset. PLoS Pathog, 2015-03-24;11(3):e1004671. 2015-03-24 [PMID: 25803478] (Flow Cytometry, Human)	Flow Cytometry	Human
Marquardt N, Beziat V, Nystrom S, Hengst J, Ivarsson M, Kekalainen E, Johansson H, Mjosberg J, Westgren M, Lankisch T, Wedemeyer H, Ellis E, Ljunggren H, Michaelsson J, Bjorkstrom N Cutting edge: identification and characterization of human intrahepatic CD49a+ NK cells. J Immunol, 2015-02-11;194(6):2467-71. 2015-02-11 [PMID: 25672754] (Flow Cytometry, Human)	Flow Cytometry	Human
Castley , Alison, Berry , Cassandr, French , Martyn, Fernandez , Sonia, Krueger , Romano, Nolan , David Elevated plasma soluble CD14 and skewed CD16+ monocyte distribution persist despite normalisation of soluble CD163 and CXCL10 by effective HIV therapy: a changing paradigm for routine HIV laboratory monitoring? PLoS ONE, 2014-12-29;9(12):e115226. 2014-12-29 [PMID: 25544986] (Flow Cytometry, Human)	Flow Cytometry	Human
Mikulak J, Bozzo L, Roberto A, Pontarini E, Tentorio P, Hudspeth K, Lugli E, Mavilio D Dopamine inhibits the effector functions of activated NK cells via the upregulation of the D5 receptor. J Immunol, 2014-08-15;193(6):2792-800. 2014-08-15 [PMID: 25127864] (Flow Cytometry, Human)	Flow Cytometry	Human
Golden-Mason L, Hahn Y, Strong M, Cheng L, Rosen H Extracellular HCV-core protein induces an immature regulatory phenotype in NK cells: implications for outcome of acute infection. PLoS ONE, 2014-07-30;9(7):e103219. 2014-07-30 [PMID: 25076408] (Flow Cytometry, Human)	Flow Cytometry	Human
Killig M, Friedrichs B, Meisig J, Gentilini C, Bluthgen N, Loddenkemper C, Labopin M, Basara N, Pfrepper C, Niederwieser D, Uharek L, Romagnani C Tracking in vivo dynamics of NK cells transferred in patients undergoing stem cell transplantation. Eur J Immunol, 2014-06-30;44(9):2822-34. 2014-06-30 [PMID: 24895051] (Flow Cytometry, Human)	Flow Cytometry	Human
Hu X, Jiang Y, Li X, Gao Y, Guo X, Chi X, Yan H, Feng J, Zhong J, Sun B, Shao X, Xiao W, Pan Y, Niu J Long-term effect on natural killer cells by interferon-alpha therapy on the outcomes of HCV infection. J Interferon Cytokine Res, 2013-12-24;34(5):366-75. 2013-12-24 [PMID: 24367931] (Flow Cytometry, Human)	Flow Cytometry	Human
Achour , Abla, Baychelier , Florence, Besson , Caroline, Arnoux , Armelle, Marty , Michel, Hannoun , Laurent, Samuel , Didier, Debre , Patrice, Vieillard , Vincent Expansion of CMV-mediated NKG2C+ NK cells associates with the development of specific de novo malignancies in liver-transplanted patients. J Immunol, 2013-12-04;192(1):503-11. 2013-12-04 [PMID: 24307732] (Flow Cytometry, Human)	Flow Cytometry	Human
Siewiera J, El Costa H, Tabiasco J, Berrebi A, Cartron G, Le Bouteiller P, Jabrane-Ferrat N Human cytomegalovirus infection elicits new decidual natural killer cell effector functions. PLoS Pathog, 2013-04-04;9(4):e1003257. 2013-04-04 [PMID: 23592985] (Flow Cytometry, Human)	Flow Cytometry	Human
Charoudeh H, Terszowski G, Czaja K, Gonzalez A, Schmitter K, Stern M Modulation of the natural killer cell KIR repertoire by cytomegalovirus infection. Eur J Immunol, 2012-12-12;43(2):480-7. 2012-12-12 [PMID: 23161492] (Flow Cytometry, Human)	Flow Cytometry	Human
Zhao J, Li Y, Jin L, Zhang S, Fan R, Sun Y, Zhou C, Shang Q, Li W, Zhang Z, Wang F Natural killer cells are characterized by the concomitantly increased interferon-gamma and cytotoxicity in acute resolved hepatitis B patients. PLoS ONE, 2012-11-01;7(11):e49135. 2012-11-01 [PMID: 23133672] (Flow Cytometry, Human)	Flow Cytometry	Human
Foley , Bree, Cooley , Sarah, Verneris , Michael, Curtsinger , Julie, Luo , Xianghua, Waller , Edmund K, Anasetti , Claudio, Weisdorf , Daniel, Miller , Jeffrey Human Cytomegalovirus (CMV)-Induced Memory-like NKG2C+ NK Cells Are Transplantable and Expand In Vivo in Response to Recipient CMV Antigen. J Immunol, 2012-10-17;189(10):5082-8. 2012-10-17 [PMID: 23077239] (Flow Cytometry, Human)	Flow Cytometry	Human
Beziat V, Dalgard O, Asselah T, Halfon P, Bedossa P, Boudifa A, Hervier B, Theodorou I, Martinot M, Debre P, Bjorkstrom NK, Malmberg KJ, Marcellin P, Vieillard V CMV drives clonal expansion of NKG2C+ NK cells expressing self-specific KIRs in chronic hepatitis patients. Eur. J. Immunol., 2011-12-16;42(2):447-57. 2011-12-16 [PMID: 22105371] (Flow Cytometry, Human)	Flow Cytometry	Human
Bjorkstrom NK, Lindgren T, Stoltz M, Fauriat C, Braun M, Evander M, Michaelsson J, Malmberg KJ, Klingstrom J, Ahlm C, Ljunggren HG Rapid expansion and long-term persistence of elevated NK cell numbers in humans infected with hantavirus. J. Exp. Med., 2010-12-20;208(1):13-21. 2010-12-20 [PMID: 21173105] (Flow Cytometry, Human)	Flow Cytometry	Human
Le Garff-Tavernier M, Decocq J, de Romeuf C, Parizot C, Dutertre CA, Chapiro E, Davi F, Debre P, Prost JF, Teillaud JL, Merle-Beral H, Vieillard V Analysis of CD16+CD56dim NK cells from CLL patients: evidence supporting a therapeutic strategy with optimized anti-CD20 monoclonal antibodies. Leukemia, 2010-10-26;25(1):101-9. 2010-10-26 [PMID: 20975664] (Flow Cytometry, Human)	Flow Cytometry	Human
Angelini DF, Zambello R, Galandrini R, Diamantini A, Placido R, Micucci F, Poccia F, Semenzato G, Borsellino G, Santoni A, Battistini L NKG2A inhibits NKG2C effector functions of gammadelta T cells: implications in health and disease. J. Leukoc. Biol., 2010-10-15;89(1):75-84. 2010-10-15 [PMID: 20952657] (Flow Cytometry, Human)	Flow Cytometry	Human
Beziat V, Descours B, Parizot C, Debre P, Vieillard V NK cell terminal differentiation: correlated stepwise decrease of NKG2A and acquisition of KIRs. PLoS ONE, 2010-08-06;5(8):e11966. 2010-08-06 [PMID: 20700504] (Flow Cytometry, Human)	Flow Cytometry	Human
Spanholtz J, Tordoir M, Eissens D, Preijers F, van der Meer A, Joosten I, Schaap N, de Witte TM, Dolstra H High log-scale expansion of functional human natural killer cells from umbilical cord blood CD34-positive cells for adoptive cancer immunotherapy. PLoS ONE, 2010-02-15;5(2):e9221. 2010-02-15 [PMID: 20169160] (Flow Cytometry, Human)	Flow Cytometry	Human
Beziat V, Nguyen S, Exley M, Achour A, Simon T, Chevallier P, Sirvent A, Vigouroux S, Debre P, Rio B, Vieillard V, Lubrano-Berthelier C, Alatrakchi N Shaping of iNKT cell repertoire after unrelated cord blood transplantation. Clin. Immunol., 2010-02-13;135(3):364-73. 2010-02-13 [PMID: 20153980] (Flow Cytometry, Human)	Flow Cytometry	Human
Brunetta E, Fogli M, Varchetta S, Bozzo L, Hudspeth KL, Marcenaro E, Moretta A, Mavilio D The decreased expression of Siglec-7 represents an early marker of dysfunctional natural killer-cell subsets associated with high levels of HIV-1 viremia. Blood, 2009-08-26;114(18):3822-30. 2009-08-26 [PMID: 19710502] (Flow Cytometry, Human)	Flow Cytometry	Human
Dulphy N, Haas P, Busson M, Belhadj S, Peffault de Latour R, Robin M, Carmagnat M, Loiseau P, Tamouza R, Scieux C, Rabian C, Di Santo JP, Charron D, Janin A, Socie G, Toubert A An unusual CD56(bright) CD16(low) NK cell subset dominates the early posttransplant period following HLA-matched hematopoietic stem cell transplantation. J. Immunol., 2008-08-01;181(3):2227-37. 2008-08-01 [PMID: 18641363] (Flow Cytometry, Human)	Flow Cytometry	Human
Srivastava BI, Srivastava MD Establishment and characterization of SRIK-NKL: a novel CD8+ natural killer/T cell line derived from a patient with leukemic phase of acute lymphoblastic lymphoma. Leuk. Res., 2005-07-01;29(7):771-83. 2005-07-01 [PMID: 15927673] (Flow Cytometry, Human)	Flow Cytometry	Human
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Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Verified Customer	Flow	Human	05/18/2020	View Summary Application Flow Cytometry Sample Tested Human PBMC,Human PBMCs Species Human Lot LCN0819041
Enlarge	5 reviewed by: Verified Customer	Flow	Human	12/12/2016	View Summary Application Flow Cytometry Sample Tested Human PBMC Species Human Lot LCN0612051 Comments Comments Cryopreserved human PBMC thawed and ran immediately after thawing. Surface stained for CD56, CD3, NKG2A and NKG2C. Fixed with BD Fix/perm before running on a LSRFortessa.

Array FAB138P

• NKG2C/CD159c/KLRC2 Antibodies
• NKG2C/CD159c/KLRC2 Lysate
• NKG2C/CD159c/KLRC2 Proteins
• NKG2C/CD159c/KLRC2 Proteins and Enzyme