NKG2C/CD159c/KLRC2 Antibody (134591) [Alexa Fluor® 488]

This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Human NKG2C (NK cell Group 2 isoform C; Killer cell lectin-like receptor subfamily C, member 2) is a member of the C-type lectin-like superfamily of proteins. Natural killer (NK) receptors are expressed in both NK cells and cytotoxic CD8⁺ T cells and have both activating and inhibitory members (1-3). Regulation of the balance between the activating and inhibitory receptors is important and lack of such regulation has been implicated in autoimmunity (4). The NKG2 family includes seven receptors: NKG2A, -B, -C, -D, -E, -F, and -H, which is the longer isoform of NKG2E. Except for NKG2D and NKG2F, the NKG2 family members form heterodimers with CD94 (5, 6). NKG2C interacts with the adapter molecule DAP12 and acts as activating receptor when heterodimerized with CD94 (7). Human NKG2C is synthesized as a 231 amino acid (aa) protein that includes a 70 aa cytoplasmic domain, a 23 aa transmembrane segment, and a 138 aa extracellular domain (ECD). Within the ECD, human NKG2C shares 40% sequence identity with mouse NKG2C. NKG2C-CD94 heterodimers bind to the widely expressed nonclassical MHC-I molecule, HLA-E (Qa-1b in mouse), which presents a peptide derived from the signal peptide of classical MHC-I molecules (8, 9). Triggering the NKG2C-CD94 complex may activate the cytolytic activity and cytokine production of NK and CD8⁺ T cells (8, 10). Human cytomegalovirus (HCMV) infection promotes the differentiation and expansion of NKG2C⁺ NK cell subsets, possibly involving a cognate interaction of CD94/NKG2C with ligand(s) displayed by HCMV‑infected cells (11, 12).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Flow Cytometry.

Showing Publications 1 - 10 of 14. Show All 14 Publications. Collapse Publications.

Publications using FAB138G	Applications	Species
Ulvmoen, A;Greiff, V;Bechensteen, AG;Inngjerdingen, M; NKG2A discriminates natural killer cells with a suppressed phenotype in pediatric acute leukemia Journal of leukocyte biology 2023-09-21 [PMID: 37738462] (Flow Cytometry, Human)	Flow Cytometry	Human
Jani Huuhtanen, Henna He Kasanen, Katriina Peltola, Tapio Lönnberg, Virpi Glumoff, Oscar Brück et al. Single-cell characterization of anti–LAG-3 and anti–PD-1 combination treatment in patients with melanoma Journal of Clinical Investigation 2023-03-15 [PMID: 36719749]
Rafael Alonso Alonso Fernández, Jessica Encinas Mayoral, Laetitia Pierre-Louis, Yao Yao, Yan Xu, Shidai Mu et al. Improving NK cell function in multiple myeloma with NKTR-255, a novel polymer-conjugated human IL-15 Blood Advances 1/10/2023 [PMID: 35882498]
AI Palamarchu, NA Alekseeva, MA Streltsova, MO Ustiuzhani, PA Kobyzeva, SA Kust, MV Grechikhin, AA Boyko, OA Shustova, AM Sapozhniko, EI Kovalenko Increased Susceptibility of the CD57- NK Cells Expressing KIR2DL2/3 and NKG2C to iCasp9 Gene Retroviral Transduction and the Relationships with Proliferative Potential, Activation Degree, and Death Induction Response International Journal of Molecular Sciences, 2021-12-11;22(24):. 2021-12-11 [PMID: 34948123] (Flow Cytometry, Human)	Flow Cytometry	Human
S Nagano, T Maeda, H Ichise, S Kashima, M Ohtaka, M Nakanishi, T Kitawaki, N Kadowaki, A Takaori-Ko, K Masuda, H Kawamoto High Frequency Production of T Cell-Derived iPSC Clones Capable of Generating Potent Cytotoxic T Cells Mol Ther Methods Clin Dev, 2019-12-24;16(0):126-135. 2019-12-24 [PMID: 31970197] (Flow Cytometry, Human)	Flow Cytometry	Human
Daniel R. Calabrese, Tiffany Chong, Angelia Wang, Jonathan P. Singer, Marc Gottschall, Steven R. Hays et al. NKG2C Natural Killer Cells in Bronchoalveolar Lavage Are Associated With Cytomegalovirus Viremia and Poor Outcomes in Lung Allograft Recipients Transplantation 3/1/2019 [PMID: 30211828]
SY Nuñez, A Ziblat, F Secchiari, NI Torres, JM Sierra, XL Raffo Irao, RE Araya, CI Domaica, MB Fuertes, NW Zwirner Human M2 Macrophages Limit NK Cell Effector Functions through Secretion of TGF-? and Engagement of CD85j J. Immunol., 2017-12-27;0(0):. 2017-12-27 [PMID: 29282306] (Flow Cytometry, Human)	Flow Cytometry	Human
A Rechtien, L Richert, H Lorenzo, G Martrus, B Hejblum, C Dahlke, R Kasonta, M Zinser, H Stubbe, U Matschl, A Lohse, V Krähling, M Eickmann, S Becker, R Thiébaut, M Altfeld, M Addo Systems Vaccinology Identifies an Early Innate Immune Signature as a Correlate of Antibody Responses to the Ebola Vaccine rVSV-ZEBOV Cell Rep, 2017-08-29;20(9):2251-2261. 2017-08-29 [PMID: 28854372] (Flow Cytometry, Human)	Flow Cytometry	Human
Elena I. Kovalenko, Maria A. Streltsova, Leonid M. Kanevskiy, Sophia A. Erokhina, William G. Telford Identification of Human Memory‐Like NK Cells Current Protocols in Cytometry 1/6/2017 [PMID: 28055112]
Sim M, Stowell J, Sergeant R, Altmann D, Long E, Boyton R KIR2DL3 and KIR2DL1 show similar impact on licensing of human NK cells. Eur J Immunol, 2015-11-02;46(1):185-91. 2015-11-02 [PMID: 26467237] (Flow Cytometry, Human)	Flow Cytometry	Human
Spallanzani R, Torres N, Avila D, Ziblat A, Iraolagoitia X, Rossi L, Domaica C, Fuertes M, Rabinovich G, Zwirner N Regulatory Dendritic Cells Restrain NK Cell IFN-gamma Production through Mechanisms Involving NKp46, IL-10, and MHC Class I-Specific Inhibitory Receptors. J Immunol, 2015-07-31;195(5):2141-8. 2015-07-31 [PMID: 26232426] (Flow Cytometry, Human)	Flow Cytometry	Human
Dunphy S, Guinan K, Chorcora C, Jayaraman J, Traherne J, Trowsdale J, Pende D, Middleton D, Gardiner C 2DL1, 2DL2 and 2DL3 all contribute to KIR phenotype variability on human NK cells. Genes Immun, 2015-05-07;16(5):301-10. 2015-05-07 [PMID: 25950617] (Flow Cytometry, Human)	Flow Cytometry	Human
Katano I, Takahashi T, Ito R, Kamisako T, Mizusawa T, Ka Y, Ogura T, Suemizu H, Kawakami Y, Ito M Predominant development of mature and functional human NK cells in a novel human IL-2-producing transgenic NOG mouse. J Immunol, 2015-02-23;194(7):3513-25. 2015-02-23 [PMID: 25712215] (Flow Cytometry, Human)	Flow Cytometry	Human
Charoudeh H, Terszowski G, Czaja K, Gonzalez A, Schmitter K, Stern M Modulation of the natural killer cell KIR repertoire by cytomegalovirus infection. Eur J Immunol, 2012-12-12;43(2):480-7. 2012-12-12 [PMID: 23161492] (Flow Cytometry, Human)	Flow Cytometry	Human
Show All 14 Publications. Collapse Publications.

Array FAB138G

• NKG2C/CD159c/KLRC2 Antibodies
• NKG2C/CD159c/KLRC2 Lysate
• NKG2C/CD159c/KLRC2 Proteins
• NKG2C/CD159c/KLRC2 Proteins and Enzyme