NKG2C/CD159c/KLRC2 Antibody (134591) [Alexa Fluor® 700]

This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Human NKG2C (NK cell Group 2 isoform C; Killer cell lectin-like receptor subfamily C, member 2) is a member of the C-type lectin-like superfamily of proteins. Natural killer (NK) receptors are expressed in both NK cells and cytotoxic CD8⁺ T cells and have both activating and inhibitory members (1-3). Regulation of the balance between the activating and inhibitory receptors is important and lack of such regulation has been implicated in autoimmunity (4). The NKG2 family includes seven receptors: NKG2A, -B, -C, -D, -E, -F, and -H, which is the longer isoform of NKG2E. Except for NKG2D and NKG2F, the NKG2 family members form heterodimers with CD94 (5, 6). NKG2C interacts with the adapter molecule DAP12 and acts as activating receptor when heterodimerized with CD94 (7). Human NKG2C is synthesized as a 231 amino acid (aa) protein that includes a 70 aa cytoplasmic domain, a 23 aa transmembrane segment, and a 138 aa extracellular domain (ECD). Within the ECD, human NKG2C shares 40% sequence identity with mouse NKG2C. NKG2C-CD94 heterodimers bind to the widely expressed nonclassical MHC-I molecule, HLA-E (Qa-1b in mouse), which presents a peptide derived from the signal peptide of classical MHC-I molecules (8, 9). Triggering the NKG2C-CD94 complex may activate the cytolytic activity and cytokine production of NK and CD8⁺ T cells (8, 10). Human cytomegalovirus (HCMV) infection promotes the differentiation and expansion of NKG2C⁺ NK cell subsets, possibly involving a cognate interaction of CD94/NKG2C with ligand(s) displayed by HCMV‑infected cells (11, 12).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Flow Cytometry.

Showing Publications 1 - 6 of 6.

Publications using FAB138N	Applications	Species
Moreno-Cubero, E;Alrubayyi, A;Balint, S;Ogbe, A;Gill, US;Matthews, R;Kinloch, S;Burns, F;Rowland-Jones, SL;Borrow, P;Schurich, A;Dustin, M;Peppa, D; IL-15 reprogramming compensates for NK cell mitochondrial dysfunction in HIV-1 infection JCI insight 2024-01-16 [PMID: 38385747] (Flow Cytometry, Human)	Flow Cytometry	Human
Thibaudin, M;Fumet, JD;Chibaudel, B;Bennouna, J;Borg, C;Martin-Babau, J;Cohen, R;Fonck, M;Taieb, J;Limagne, E;Blanc, J;Ballot, E;Hampe, L;Bon, M;Daumoine, S;Peroz, M;Mananet, H;Derangère, V;Boidot, R;Michaud, HA;Laheurte, C;Adotevi, O;Bertaut, A;Truntzer, C;Ghiringhelli, F; First-line durvalumab and tremelimumab with chemotherapy in RAS-mutated metastatic colorectal cancer: a phase 1b/2 trial Nature medicine 2023-08-01 [PMID: 37563240] (Flow Cytometry, Human)	Flow Cytometry	Human
Anna Vyborova, Anke Janssen, Lucrezia Gatti, Froso Karaiskaki, Austin Yonika, Sanne van Dooremalen et al. gamma 9δ2 T-Cell Expansion and Phenotypic Profile Are Reflected in the CDR3δ Repertoire of Healthy Adults Frontiers in Immunology 7/7/2022 [PMID: 35874769]
G Moncunill, J Carnes, W Chad Young, L Carpp, S De Rosa, JJ Campo, A Nhabomba, M Mpina, C Jairoce, G Finak, P Haas, C Muriel, P Van, H Sanz, S Dutta, B Mordmüller, ST Agnandji, N Díez-Padri, NA Williams, JJ Aponte, C Valim, DE Neafsey, C Daubenberg, MJ McElrath, C Dobaño, K Stuart, R Gottardo Transcriptional correlates of malaria in RTS,S/AS01-vaccinated African children: a matched case-control study Elife, 2022-01-21;11(0):. 2022-01-21 [PMID: 35060479] (Flow Cytometry, Human)	Flow Cytometry	Human
KH Park, JH Ryu, H Bae, S Yun, JH Jang, K Han, BS Cho, HJ Kim, H Lee, EJ Oh Delayed NK Cell Reconstitution and Reduced NK Activity Increased the Risks of CMV Disease in Allogeneic-Hematopoietic Stem Cell Transplantation Int J Mol Sci, 2020-05-22;21(10):. 2020-05-22 [PMID: 32455959] (Flow Cytometry, Human)	Flow Cytometry	Human
Grzegorz Terszowski Human Cytomegalovirus Infection Enhances NK Cell Activity In Vitro Transplant Direct, 2016-06-17;2(7):e89. 2016-06-17 [PMID: 27830183] (Flow Cytometry, Human)	Flow Cytometry	Human

Array FAB138N

• NKG2C/CD159c/KLRC2 Antibodies
• NKG2C/CD159c/KLRC2 Lysate
• NKG2C/CD159c/KLRC2 Proteins
• NKG2C/CD159c/KLRC2 Proteins and Enzyme