MHC Class I Antibody (OX18) - BSA Free

MHC Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. MHC class I antigens are heterodimers consisting of one alpha chain (44kDa) with beta 2 microglobulin (11.5 kDa). The antigen is expressed by all somatic cells at varying levels. MHC Class I molecules are expressed on most nucleated cells where they present endogenously synthesized antigenic peptides to CD8+ T lymphocytes, which are usually cytotoxic T cells. Fibroblasts or neurons however only show a low level of antigen.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Rat.

We have publications tested in 5 applications: B/N, FLOW, ICC/IF, IHC-Fr, IP.

Showing Publications 1 - 10 of 33. Show All 33 Publications. Collapse Publications.

Publications using NB120-6405	Applications	Species
Stet, RJM et al. U9F4: A monoclonal antibody recognizing a rat polymorphic class I determinant. 1987-01-01
Farahi S, Hosseini S, Ghanbarian H et al. The Use of Trichostatin A during Pluripotent Stem Cell Generation Does Not Affect MHC Expression Level Stem Cells International 2022-02-15 [PMID: 35371264] (FLOW)	FLOW
Smith TA, Ghergherehchi CL, Mikesh M et al. Polyethylene glycol-fusion repair of sciatic allografts in female rats achieves immunotolerance via attenuated innate and adaptive responses J. Neurosci. Res. 2020-09-15 [PMID: 32931034]
Rabenstein M, Unverricht-Yeboah M, Keuters MH et al. Transcranial Current Stimulation Alters the Expression of Immune-Mediating Genes Front Cell Neurosci. 2019-10-25 [PMID: 31708742] (IHC-Fr, Rat)	IHC-Fr	Rat
Bereczky-Veress B, Abdelmagid N, Piehl F et al. Influence of perineurial cells and Toll-like receptors 2 and 9 on Herpes simplex type 1 entry to the central nervous system in rat encephalitis. PLoS One. 2010-08-27 [PMID: 20806060] (IHC-Fr, Rat)	IHC-Fr	Rat
Baca Jones, CC et al. Rat cytomegalovirus infection depletes MHC II in bone marrow derived dendritic cells. 2009-01-01 [PMID: 19349057]
Zhai, Y Knechtle, S et al. Two distinct forms of soluble MHC class I molecules synthesized by different mechanisms in normal rat cells in vitro. 1998-01-01 [PMID: 9684990]
Morrice NA, Powis SJ. A role for the thiol-dependent reductase ERp57 in the assembly of MHC class I molecules. Curr Biol. 1998-06-04 [PMID: 9637924] (IP, Rat)	IP	Rat
Lassmann H, Schmied M, Vass K, Hickey WF. Bone marrow derived elements and resident microglia in brain inflammation. Glia. 1993-01-01 [PMID: 7678581]
Mayrhofer G, Pugh CW, Barclay AN. The distribution, ontogeny and origin in the rat of Ia-positive cells with dendritic morphology and of Ia antigen in epithelia, with special reference to the intestine. Eur J Immunol. 1983-02-01 [PMID: 6403355]
Fukumoto, T et al. Mouse monoclonal antibodies against rat major histocompatibility antigens. 1982-01-01 [PMID: 6178598]
Bukovsky, A et al. Association of some cell surface antigens of lymphoid cells and cell surface differentiation antigens with early rat pregnancy. 1984-01-01 [PMID: 6146566]
Stettner M, Lohmann B, Wolffram K et al. Interleukin-17 impedes Schwann cell-mediated myelination. J Neuroinflammation 2014-03-29 [PMID: 24678820] (ICC/IF, Rat)	ICC/IF	Rat
Mayrhofer G, Schon-Hegrad MA. Ia antigens in rat kidney, with special reference to their expression in tubular epithelium. J Exp Med. 1983-06-01 [PMID: 6406641] (IHC-Fr, Rat)	IHC-Fr	Rat
Spencer SC, Fabre JW. Identification in rat liver and serum of water-soluble class I MHC molecules possibly homologous to the murine Q10 gene product. J Exp Med. 1987-06-01 [PMID: 3585249]
Matsumoto Y, Fujiwara M. In situ detection of class I and II major histocompatibility complex antigens in the rat central nervous system during experimental allergic encephalomyelitis. An immunohistochemical study. J Neuroimmunol. 1986-10-01 [PMID: 3489735]
Racioppi L, Carbone E, Grieco M et al. The relationship of modulation of major histocompatibility complex class I antigens to retrovirus transformation in rat cell lines. Cancer Res. 1988-07-01 [PMID: 3378218] (FLOW, Rat)	FLOW	Rat
Calder VL, Wolswijk G, Noble M. The differentiation of O-2A progenitor cells into oligodendrocytes is associated with a loss of inducibility of Ia antigens. Eur J Immunol. 1988-08-01 [PMID: 3138136]
Weetman AP, Green C, Borysiewicz LK. Regulation of major histocompatibility complex class II antigen expression by the FRTL-5 rat thyroid cell line. J Endocrinol. 1987-12-01 [PMID: 3127513]
Aten J, Bosman CB, Rozing J et al. Mercuric chloride-induced autoimmunity in the brown Norway rat. Cellular kinetics and major histocompatibility complex antigen expression. Am J Pathol. 1988-10-01 [PMID: 3052091]
Tanaka M, Shinohara K, Fukumoto T et al. Effect of Cyclosporin A on rat thymus: time course analysis by immunoperoxidase technique and flow cytofluorometry. Clin Exp Immunol. 1988-05-01 [PMID: 3044648] (FLOW, IHC-Fr, Rat)	FLOW, IHC-Fr	Rat
Yeoman H, Robins RA. The effect of interferon-gamma treatment of rat tumour cells on their susceptibility to natural killer cell, macrophage and cytotoxic T-cell killing. Immunology. 1988-02-01 [PMID: 2965096]
Jewtoukoff V, Lebar R, Bach MA. Oligodendrocyte-specific autoreactive T cells using an alpha/beta T-cell receptor kill their target without self restriction. Proc Natl Acad Sci U S A. 1989-04-01 [PMID: 2784860]
Fujikawa, L S et al. Class II antigens on retinal vascular endothelium, pericytes, macrophages, and lymphocytes of the rat. 1989-01-01 [PMID: 2783579]
Schultzberg M, Olsson T, Samuelsson EB et al. Early major histocompatibility complex (MHC) class I antigen induction in hypothalamic supraoptic and paraventricular nuclei in trypanosome-infected rats. J Neuroimmunol. 1989-09-01 [PMID: 2681260] (IHC-Fr, Rat)	IHC-Fr	Rat
Hanenberg H, Kolb-Bachofen V, Kantwerk-Funke G, Kolb H. Macrophage infiltration precedes and is a prerequisite for lymphocytic insulitis in pancreatic islets of pre-diabetic BB rats. Diabetologia. 1989-02-01 [PMID: 2656351] (ICC/IF, Rat)	ICC/IF	Rat
Osawa, H et al. Inhibition of IL 2-dependent proliferation of rat T lymphoblasts by the monoclonal antibody ART62 which reacts with MHC class 1 antigens. 1985-01-01 [PMID: 2580898]
Hess AD, Horwitz L, Beschorner WE, Santos GW. Development of graft-vs.-host disease-like syndrome in cyclosporine-treated rats after syngeneic bone marrow transplantation. I. Development of cytotoxic T lymphocytes with apparent polyclonal anti-Ia specificity, including autoreactivity. J Exp Med. 1985-04-01 [PMID: 2580038]
Fowler VJ, Dalchau SR, Fabre JW. Membrane-bound and water-soluble nonclassical class I MHC antigens on rat placenta. Immunogenetics. 1990-01-01 [PMID: 2318515]
Rada C, Lorenzi R, Powis SJ et al. Concerted evolution of class I genes in the major histocompatibility complex of murine rodents. Proc Natl Acad Sci U S A. 1990-03-01 [PMID: 2315309] (IP, Rat)	IP	Rat
Vass K, Lassmann H. Intrathecal application of interferon gamma. Progressive appearance of MHC antigens within the rat nervous system. Am J Pathol. 1990-10-01 [PMID: 2121041] (IHC-Fr, Rat)	IHC-Fr	Rat
Sedgwick JD, Hughes CC, Male DK, MacPhee IA, ter Meulen V. Antigen-specific damage to brain vascular endothelial cells mediated by encephalitogenic and nonencephalitogenic CD4+ T cell lines in vitro. J Immunol. 1990-10-15 [PMID: 1698855] (B/N)	B/N
Show All 33 Publications. Collapse Publications.

Array NB120-6405

• MHC Class I Antibodies
• MHC Class I Lysate