DAP12 Antibody

DAP12 is a transmembrane adaptor protein that is non-covalently associated with several cell surface receptors on natural killer (NK), myeloid, and presumably neuronal cells. DAP12 contains an ITAM domain that preferentially recruits the protein tyrosine kinase Syk to initiate signal transduction. Deficiency of DAP12 results in reduced antigen presentation function by myeloid cells and defects in function of certain NK cell receptors in mice, as well as presenile dementia and bone cysts in humans.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 2 of 2.

Publications using NBP1-85313	Applications	Species
Heike Kölbel, Corinna Preu beta e, Lukas Brand, Arpad von Moers, Adela Della Marina, Markus Schuelke, Andreas Roos, Hans-Hilmar Goebel, Ulrike Schara-Schmidt, Werner Stenzel Inflammation, fibrosis and skeletal muscle regeneration in LGMDR9 are orchestrated by macrophages. Neuropathology and applied neurobiology 2022-01-28 [PMID: 33973272]
Preusse C, Goebel HH, Pehl D et al. Th2-M2 immunity in lesions of muscular sarcoidosis and macrophagic myofasciitis. Neuropathol Appl Neurobiol 2015-02-25 [PMID: 25711697]

Array NBP1-85313

• DAP12 Antibodies
• DAP12 Lysates
• DAP12 Proteins