Recombinant Human Nesfatin-1/Nucleobindin-2 Protein

Nesfatin is a metabolic polypeptide and is the N-terminal region of the precursor protein, Nucleobindin2 (encoded by NUCB2 gene). It is a naturally occurring protein and originally identified as a hypothalamic neuropeptide. Additionally, Nucleobindin 2 (Nesfatin) can be found in other areas of brain, and in pancreatic islets beta-cells, gastric endocrine cells and adipocytes. It is responsible for regulating appetite and production of body fat. Excess nesfatin-1 in the brain leads to a loss of appetite, less frequent hunger, a 'sense of fullness', and a drop in body fat and weight. A lack of nesfatin-1 in the brain leads to an increase of appetite, more frequent episodes of hunger, an increase of body fat and weight, and the inability to 'feel full'.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 3 applications: ICC/IF, IHC-P, WB.

Showing Publications 1 - 4 of 4.

Publications using NBP2-35072	Applications	Species
Lahane GP, Dhar A Nesfatin-1 peptide protects rat renal epithelial cells against high glucose and H2O2 induced injury via inhibition of oxidative stress, apoptosis, and fibrosis Peptides 2023-04-25 [PMID: 37105355]
Mariarita Caroleo, Elvira Anna Carbone, Biagio Arcidiacono, Marta Greco, Amedeo Primerano, Maria Mirabelli, Gilda Fazia, Marianna Rania, Marta Letizia Hribal, Luca Gallelli, Daniela Patrizia Foti, Pasquale De Fazio, Cristina Segura-Garcia, Antonio Brunetti, Herbert Ryan Marini Does NUCB2/Nesfatin-1 Influence Eating Behaviors in Obese Patients with Binge Eating Disorder? Toward a Neurobiological Pathway Nutrients 2023-01-10 [PMID: 36678225]
Kmiecik A, Ratajczak-Wielgomas K, Grzegrzotka J et al. Expression of NUCB2/NESF-1 in Breast Cancer Cells International journal of molecular sciences 2022-08-16 [PMID: 36012443] (WB, ICC/IF, IHC-P, Human) Details: IHC-P and ICC/IF dilution 1:1000	WB, ICC/IF, IHC-P	Human
Goyal S, Dhar A Downregulation of nesfatin-1 expression in acute kidney injury in vivo in wistar rats and in vitro in cultured cells Life Sciences 2022-07-01 [PMID: 35787996]

Array NBP2-35072

• Nesfatin-1/Nucleobindin-2 Antibodies
• Nesfatin-1/Nucleobindin-2 ELISA Kits
• Nesfatin-1/Nucleobindin-2 Proteins
• Nesfatin-1/Nucleobindin-2 ELISA