Name: MuRF1/TRIM63 Antibody [Unconjugated]
Brand: Novus Biologicals
SKU: AF5366
Price: 489 USD

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	Hu, Mu, RtSpecies Glossary
Applications	WB, Simple Western
Clonality	Polyclonal
Host	Goat
Conjugate	Unconjugated
Concentration	LYOPH

Immunogen	E. coli-derived recombinant human MuRF1/TRIM63 Met1-Gly325 Accession # Q969Q1
Specificity	Detects human, mouse, and rat MuRF1/TRIM63 in direct ELISAs and Western blots.
Source	N/A
Isotype	IgG
Clonality	Polyclonal
Host	Goat
Gene	TRIM63
Purity	Immunogen affinity purified
Purity Statement	Antigen Affinity-purified
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Concentration	LYOPH
Purity	Immunogen affinity purified
Reconstitution Instructions	Reconstitute at 0.2 mg/mL in sterile PBS.

Publications using AF5366	Applications	Species
Stouth, DW;vanLieshout, TL;Mikhail, AI;Ng, SY;Raziee, R;Edgett, BA;Vasam, G;Webb, EK;Gilotra, KS;Markou, M;Pineda, HC;Bettencourt-Mora, BG;Noor, H;Moll, Z;Bittner, ME;Gurd, BJ;Menzies, KJ;Ljubicic, V; CARM1 drives mitophagy and autophagy flux during fasting-induced skeletal muscle atrophy Autophagy 2023-11-29 [PMID: 38018843] (Western Blot, Human)	Western Blot	Human
Sinha, S;Alluri, KV;Somepalli, V;Golakoti, T;Sengupta, K; A synergistic blend of Garcinia mangostana fruit rind and Cinnamomum tamala leaf extracts enhances myogenic differentiation and mitochondrial biogenesis in vitro and muscle growth and strength in mice Food & nutrition research 2023-10-30 [PMID: 37920678] (Western Blot, Mouse)	Western Blot	Mouse
Marko Rudar, Jane K. Naberhuis, Agus Suryawan, Hanh V. Nguyen, Marta L. Fiorotto, Teresa A. Davis Prematurity blunts protein synthesis in skeletal muscle independently of body weight in neonatal pigs Pediatric Research 2023-07-01 [PMID: 36627358]
DK Suh, WY Lee, WJ Yeo, BS Kyung, KW Jung, HK Seo, YS Lee, DW Suh A Novel Muscle Atrophy Mechanism: Myocyte Degeneration Due to Intracellular Iron Deprivation Cells, 2022-09-13;11(18):. 2022-09-13 [PMID: 36139428] (Mouse)		Mouse
Hyunseok Jee, Eunmi Park, Kyunghoon Hur, Minjeong Kang, Yoosik Kim High-Intensity Aerobic Exercise Suppresses Cancer Growth by Regulating Skeletal Muscle-Derived Oncogenes and Tumor Suppressors Frontiers in Molecular Biosciences 2022-06-21 [PMID: 35801156]
Marko Rudar, Jane K. Naberhuis, Agus Suryawan, Hanh V. Nguyen, Barbara Stoll, Candace C. Style et al. Intermittent bolus feeding does not enhance protein synthesis, myonuclear accretion, or lean growth more than continuous feeding in a premature piglet model American Journal of Physiology-Endocrinology and Metabolism 2021-12-01 [PMID: 34719946]
Arshiya Parveen, Kyle R. Bohnert, Meiricris Tomaz Tomaz da Silva, Yefei Wen, Raksha Bhat, Anirban Roy et al. MyD88‐mediated signaling intercedes in neurogenic muscle atrophy through multiple mechanisms The FASEB Journal 2021-08-01 [PMID: 34325487]
DG Campelj, CA Timpani, AC Petersen, A Hayes, CA Goodman, E Rybalka The Paradoxical Effect of PARP Inhibitor BGP-15 on Irinotecan-Induced Cachexia and Skeletal Muscle Dysfunction Cancers, 2020-12-17;12(12):. 2020-12-17 [PMID: 33348673] (Western Blot, Mouse)	Western Blot	Mouse
Liu L, Killoy Km, Vargas Mr Et Al. Effects of RAGE inhibition on the progression of the disease in hSOD1G93A ALS mice Pharmacol Res Perspect 8/1/2020 [PMID: 32776498]
M Noguchi, T Kitakaze, Y Kobayashi, K Mukai, N Harada, R Yamaji &beta-Cryptoxanthin Improves p62 Accumulation and Muscle Atrophy in the Soleus Muscle of Senescence-Accelerated Mouse-Prone 1 Mice Nutrients, 2020-07-22;12(8):. 2020-07-22 [PMID: 32708051] (Western Blot, Mouse)	Western Blot	Mouse
P Xia, J Chen, Y Liu, M Fletcher, BC Jensen, Z Cheng Doxorubicin induces cardiomyocyte apoptosis and atrophy through cyclin-dependent kinase 2-mediated activation of forkhead box O1 J. Biol. Chem., 2020-02-19;0(0):. 2020-02-19 [PMID: 32075913] (Western Blot, Mouse, Rat)	Western Blot	Mouse, Rat
Hazem Akkad, Nicola Cacciani, Monica Llano-Diez, Rebeca Corpeno Kalamgi, Tamara Tchkonia, James L. Kirkland et al. Vamorolone treatment improves skeletal muscle outcome in a critical illness myopathy rat model Acta Physiol (Oxf) 2019-02-01 [PMID: 30120816]
Samer Wassim El-Kadi, Ying Chen, Sydney R. McCauley, Kacie A. Seymour, Sally E. Johnson, Robert P. Rhoads Decreased abundance of eIF4F subunits predisposes low birth weight neonatal pigs to reduced muscle hypertrophy Journal of Applied Physiology 2018-10-01 [PMID: 30070606]
L Zhou, Y Huang, H Xie, X Mei Buyang Huanwu Tang improves denervation-dependent muscle atrophy by increasing ANGPTL4, and increases NF-?B and MURF1 levels Mol Med Rep, 2017-12-19;0(0):. 2017-12-19 [PMID: 29257347] (Western Blot, Rat)	Western Blot	Rat
Derek W. Stouth, Alexander Manta, Vladimir Ljubicic Protein arginine methyltransferase expression, localization, and activity during disuse-induced skeletal muscle plasticity American Journal of Physiology-Cell Physiology 2018-02-01 [PMID: 29092819]
H Shimizu, AD Langenbach, J Huang, K Wang, G Otto, R Geisler, Y Wang, JN Chen The Calcineurin-FoxO-MuRF1 signaling pathway regulates myofibril integrity in cardiomyocytes Elife, 2017-08-19;6(0):. 2017-08-19 [PMID: 28826496] (Western Blot, Zebrafish)	Western Blot	Zebrafish
Apichart Suksamrarn Effect of 20-Hydroxyecdysone on Proteolytic Regulation in Skeletal Muscle Atrophy In Vivo, 2016-11-12;30(6):869-877. 2016-11-12 [PMID: 27815474] (Western Blot, Rat)	Western Blot	Rat
Hernandez-Garcia AD, Columbus DA, Manjarin R et al. Leucine supplementation stimulates protein synthesis and reduces degradation signal activation in muscle of newborn pigs during acute endotoxemia Am. J. Physiol. Endocrinol. Metab. 9/13/2016 [PMID: 27624100]
Wadosky KM, Berthiaume JM, Tang W et al. MuRF1 mono-ubiquitinates TRalpha to inhibit T3-induced cardiac hypertrophy in vivo. J Mol Endocrinol 2/9/2016 [PMID: 26862156]
Ann-Kristin Fjällström, Kim Evertsson, Marlene Norrby, Sven Tågerud Forkhead box O1 and muscle RING finger 1 protein expression in atrophic and hypertrophic denervated mouse skeletal muscle Journal of Molecular Signaling 2014-09-24 [PMID: 25276226]
Sun , Hualin, Gong , Yanpei, Qiu , Jiaying, Chen , Yanfei, Ding , Fei, Zhao , Qing TRAF6 inhibition rescues dexamethasone-induced muscle atrophy. Int J Mol Sci, 2014-06-20;15(6):11126-41. 2014-06-20 [PMID: 24955790] (Western Blot, Mouse)	Western Blot	Mouse
Akkad , Hazem, Corpeno , Rebeca, Larsson , Lars Masseter muscle myofibrillar protein synthesis and degradation in an experimental critical illness myopathy model. PLoS ONE, 2014-04-04;9(4):e92622. 2014-04-04 [PMID: 24705179] (Western Blot, Rat)	Western Blot	Rat
Files D, Xiao K, Zhang T, Liu C, Qian J, Zhao W, Morris P, Delbono O, Feng X The posterior cricoarytenoid muscle is spared from MuRF1-mediated muscle atrophy in mice with acute lung injury. PLoS ONE, 2014-01-31;9(1):e87587. 2014-01-31 [PMID: 24498144] (Western Blot, Mouse)	Western Blot	Mouse
Wadosky K, Rodriguez J, Hite R, Min J, Walton B, Willis M Muscle RING finger-1 attenuates IGF-I-dependent cardiomyocyte hypertrophy by inhibiting JNK signaling. Am J Physiol Endocrinol Metab, 2014-01-14;306(7):E723-39. 2014-01-14 [PMID: 24425758] (Western Blot, Mouse)	Western Blot	Mouse
Wheatley S, El-Kadi S, Suryawan A, Boutry C, Orellana R, Nguyen H, Davis S, Davis T Protein synthesis in skeletal muscle of neonatal pigs is enhanced by administration of beta-hydroxy-beta-methylbutyrate. Am J Physiol Endocrinol Metab, 2013-11-05;306(1):E91-9. 2013-11-05 [PMID: 24192287] (Western Blot, Porcine)	Western Blot	Porcine
Rubel CE, Schisler JC, Hamlett ED et al. Diggin' on U(biquitin): A Novel Method for the Identification of Physiological E3 Ubiquitin Ligase Substrates. Cell Biochem Biophys. 9/1/2013 [PMID: 23695782]
Show All 26 Publications. Collapse Publications.

MuRF1/TRIM63 Antibody [Unconjugated]

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Catalog# & Formulation	Size	Price
Carrier Free AF5366-SP

Gene Symbol	TRIM63
Uniprot	Q969Q1(Human)