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Mouse TGF-beta 1 DuoSet ELISA, 15 Plate

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Summary
Reactivity MuSpecies Glossary
Applications ELISA
Conjugate
Biotin

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Mouse TGF-beta 1 DuoSet ELISA, 15 Plate Summary

Source
N/A
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
Tgfb1

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using DY1679.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse TGF-beta 1 DuoSet ELISA, 15 Plate

  • CEDLAP
  • DPD1
  • latency-associated peptide
  • TGF beta
  • TGF beta1
  • TGFB
  • TGFB1
  • TGF-beta 1 protein
  • TGFbeta 1
  • TGF-beta 1
  • TGFbeta
  • TGF-beta-1
  • transforming growth factor beta-1
  • transforming growth factor, beta 1

Background

Transforming Growth Factor Beta 1, 2, and 3 (TGF-beta 1, TGF-beta 2, and TGF-beta 3) are highly pleiotropic cytokines that virtually all cell types secrete. TGF-beta molecules are proposed to act as cellular switches that regulate processes such as immune function, proliferation, and epithelial-mesenchymal transition. Targeted deletions of these genes in mice show that each TGF-beta isoform has some non-redundant functions: TGF-beta 1 is involved in hematopoiesis and endothelial differentiation; TGF-beta 2 affects development of cardiac, lung, craniofacial, limb, eye, ear, and urogenital systems; and TGF-beta 3 influences palatogenesis and pulmonary development. The full range of in vitro biological activities of TGF-beta 5 has not yet been explored. However, TGF-beta 1, TGF-beta 2, TGF-beta 3, and TGF-beta 5 have been found to be largely interchangeable in an inhibitory bioassay, and it is anticipated that TGF-beta 5 will show a spectrum of activities similar to the other TGF-beta family members. To date, the production of TGF-beta 5 has only been demonstrated in Xenopus.

TGF-beta ligands are initially synthesized as precursor proteins that undergo proteolytic cleavage. The mature segments form active ligand dimers via a disulfide-rich core consisting of the characteristic 'cysteine knot'. TGF-beta signaling begins with binding to a complex of the accessory receptor betaglycan (also known as TGF-beta RIII) and a type II serine/threonine kinase receptor termed TGF-beta RII. This receptor then phosphorylates and activates a type I serine/threonine kinase receptor, either ALK-1 or TGF-beta RI (also called ALK-5). The activated type I receptor phosphorylates and activates Smad proteins that regulate transcription. Use of other signaling pathways that are Smad-independent allows for distinct actions observed in response to TGF-beta in different contexts.

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Publications for TGF-beta 1 (DY1679)(160)

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Transgenic Mouse.


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Human
(3)
Mouse
(151)
Rat
(5)
Transgenic Mouse
(8)
All Species
Showing Publications 1 - 10 of 160. Show All 160 Publications.
Publications using DY1679 Applications Species
Hussain, S;Majumder, N;Mazumder, MHH;Lewis, SE;Olapeju, O;Velayutham, M;Amin, MS;Brundage, K;Kelley, EE;Vanoirbeek, J; Intermittent ozone inhalation during house dust mite-induced sensitization primes for adverse asthma phenotype Redox biology 2024-10-01 [PMID: 39244793] (Mouse) Mouse
Blanco, T;Nakagawa, H;Musayeva, A;Krauthammer, M;Singh, RB;Narimatsu, A;Ge, H;Shoushtari, SI;Dana, R; Acquired Immunostimulatory Phenotype of Migratory CD103+ Dendritic Cells Promotes Alloimmunity Following Corneal Transplantation JCI insight 2024-09-05 [PMID: 39235864] (Mouse) Mouse
Munguia-Galaviz, FJ;Miranda-Diaz, AG;Gutierrez-Mercado, YK;Ku-Centurion, M;Gonzalez-Gonzalez, RA;Portilla-de Buen, E;Echavarria, R; The Sigma-1 Receptor Exacerbates Cardiac Dysfunction Induced by Obstructive Nephropathy: A Role for Sexual Dimorphism Biomedicines 2024-08-20 [PMID: 39200372] (Mouse) Mouse
Dole, NS;Betancourt-Torres, A;Kaya, S;Obata, Y;Schurman, CA;Yoon, J;Yee, CS;Khanal, V;Luna, CA;Carroll, M;Salinas, JJ;Miclau, E;Acevedo, C;Alliston, T; High-fat and high-carbohydrate diets increase bone fragility through TGF-?-dependent control of osteocyte function JCI insight 2024-07-09 [PMID: 39171528] (Transgenic Mouse) Transgenic Mouse
Gabele, L;Bochow, I;Rieke, N;Sieben, C;Michaelsen-Preusse, K;Hosseini, S;Korte, M; H7N7 viral infection elicits pronounced, sex-specific neuroinflammatory responses in vitro Frontiers in cellular neuroscience 2024-08-07 [PMID: 39171200] (Mouse) Mouse
Assayag, M;Obedeyah, T;Abutbul, A;Berkman, N; The integrin receptor beta7 subunit mediates airway remodeling and hyperresponsiveness in allergen exposed mice Respiratory research 2024-07-12 [PMID: 38997751] (Mouse) Mouse
Liang, L;Chung, SI;Guon, TE;Park, KH;Lee, JH;Park, JW; Statin administration or blocking PCSK9 alleviates airway hyperresponsiveness and lung fibrosis in high-fat diet-induced obese mice Respiratory research 2024-05-18 [PMID: 38762465] (Mouse) Mouse
Zhang, Y;Jiang, H;Dong, M;Min, J;He, X;Tan, Y;Liu, F;Chen, M;Chen, X;Yin, Q;Zheng, L;Shao, Y;Li, X;Chen, H; Macrophage MCT4 inhibition activates reparative genes and protects from atherosclerosis by histone H3 lysine 18 lactylation Cell reports 2024-05-28 [PMID: 38733581] (Mouse) Mouse
Krishnamohan, M;Kaplanov, I;Maudi-Boker, S;Yousef, M;Machluf-Katz, N;Cohen, I;Elkabets, M;Titus, J;Bersudsky, M;Apte, RN;Voronov, E;Braiman, A; Tumor Cell-Associated IL-1? Affects Breast Cancer Progression and Metastasis in Mice through Manipulation of the Tumor Immune Microenvironment International journal of molecular sciences 2024-04-02 [PMID: 38612760] (Mouse, Transgenic Mouse) Mouse, Transgenic Mouse
Allam, RM;El Kerdawy, AM;Gouda, AE;Ahmed, KA;Abdel-Mohsen, HT; Benzimidazole-oxindole hybrids as multi-kinase inhibitors targeting melanoma Bioorganic chemistry 2024-02-26 [PMID: 38457953] (Mouse) Mouse
Show All 160 Publications.

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Additional TGF-beta 1 Products

Blogs on TGF-beta 1.

TGF-beta 1 - a versatile signaling molecule with roles in development and disease
The transforming growth factor-beta (TGF-beta) family consists of a wide variety of signaling proteins with roles in development. TGF-beta signaling controls growth, differentiation, and immune responses and is often misregulated in cancer. TGF-beta ...  Read full blog post.

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Bioinformatics

Gene Symbol Tgfb1