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Mouse CCL5/RANTES DuoSet ELISA, 15 Plate

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Summary
Reactivity MuSpecies Glossary
Applications ELISA
Conjugate
Biotin

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Mouse CCL5/RANTES DuoSet ELISA, 15 Plate Summary

Source
N/A
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
Ccl5

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using DY478.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse CCL5/RANTES DuoSet ELISA, 15 Plate

  • CCL5
  • chemokine (C-C motif) ligand 5
  • D17S136Enormally T-expressed, and presumably secreted
  • EoCP
  • Eosinophil chemotactic cytokine
  • RANTES
  • SISd
  • SIS-delta
  • small inducible cytokine A5 (RANTES)
  • small inducible cytokine subfamily A (Cys-Cys), member 5
  • Small-inducible cytokine A5
  • T cell-specific protein P228
  • T-cell specific protein p288
  • TCP228T-cell-specific protein RANTES

Background

RANTES (Regulated upon Activation, Normal T cell-expressed, and presumably Secreted), also known as CCL5, a member of the CC chemokine family of inflammatory and immunoregulatory cytokines, initially discovered by subtractive hybridization as a T cell-specific molecule (1, 2). Mouse RANTES cDNA encodes a 91 amino acid (aa) residue precursor protein with a presumed signal peptide of 23 aa residues that is cleaved to generate the 68 aa residue mature protein (3). At the amino acid sequence level, mouse RANTES is 84% identical to human RANTES. Both human and mouse RANTES exhibit cross species activity. Naturally occurring human RANTES has been found to be a mixture of the 68 aa residue mature protein and a 66 aa residue amino-terminally truncated form (4, 5). Cells known to express RANTES include keratinocytes, eosinophils, platelets, endothelium, fibroblasts, respiratory epithelium, astrocytes, vascular smooth muscle, and CD4+ and CD8+ T cells (6-14). As suggested by its acronym, RANTES production by the various cell types is induced in response to cytokine stimulation (8-13). 
Like other CC chemokines, RANTES is a monocyte chemoattractant (2). RANTES can also chemoattract unstimulated CD4+/CD45RO+ memory T cells and stimulated CD4+ and CD8+ T cells with the naive and memory phenotypes. In addition, RANTES can chemoattract and degranulate eosinophils, as well as chemoattract and induce histamine release from basophils. Human RANTES has been shown to be an inhibitor of HIV infection of human mononuclear cells (15, 16). Several CC chemokine receptors, including CCR-1, CCR-3, CCR-4, and CCR-5, have been shown to bind RANTES and subsequently to transduce a signal by increasing the intracellular calcium ion level (2, 17-21).

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Publications for CCL5/RANTES (DY478)(89)

We have publications tested in 2 confirmed species: Human, Mouse.


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Human
(2)
Mouse
(87)
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Showing Publications 1 - 10 of 89. Show All 89 Publications.
Publications using DY478 Applications Species
Gabele, L;Bochow, I;Rieke, N;Sieben, C;Michaelsen-Preusse, K;Hosseini, S;Korte, M; H7N7 viral infection elicits pronounced, sex-specific neuroinflammatory responses in vitro Frontiers in cellular neuroscience 2024-08-07 [PMID: 39171200] (Mouse) Mouse
Spielbauer, J;Glotfelty, E;Sarlus, H;Harris, RA;Heijtz, RD;Karlsson, TE; Bacterial peptidoglycan signalling in microglia: Activation by MDP via the NF-?B/MAPK pathway Brain, behavior, and immunity 2024-07-04 [PMID: 38971207] (Mouse) Mouse
Lim, J;Rodriguez, R;Williams, K;Silva, J;Gutierrez, AG;Tyler, P;Baharom, F;Sun, T;Lin, E;Martin, S;Kayser, BD;Johnston, RJ;Mellman, I;Delamarre, L;West, NR;Müller, S;Qu, Y;Heger, K; The exonuclease TREX1 constitutes an innate immune checkpoint limiting cGAS/STING-mediated antitumor immunity Cancer immunology research 2024-03-18 [PMID: 38489753] (Mouse) Mouse
Pereira, M;Ramalho, T;Andrade, WA;Durso, DF;Souza, MC;Fitzgerald, KA;Golenbock, DT;Silverman, N;Gazzinelli, RT; The IRAK1/IRF5 axis initiates IL-12 response by dendritic cells and control of Toxoplasma gondii infection Cell reports 2024-02-15 [PMID: 38367238] (Mouse) Mouse
Moreo, E;Jarit-Cabanillas, A;Robles-Vera, I;Uranga, S;Guerrero, C;Gómez, AB;Mata-Martínez, P;Minute, L;Araujo-Voces, M;Felgueres, MJ;Esteso, G;Uranga-Murillo, I;Arias, M;Pardo, J;Martín, C;Valés-Gómez, M;Del Fresno, C;Sancho, D;Aguiló, N; Intravenous administration of BCG in mice promotes natural killer and T cell-mediated antitumor immunity in the lung Nature communications 2023-10-04 [PMID: 37794033] (Mouse) Mouse
Lin, HY;Cathomas, F;Li, L;Cuttoli, RD;Guevara, C;Bayrak, CS;Wang, Q;Gupta, S;Chan, KL;Shimo, Y;Parise, LF;Yuan, C;Aubry, AV;Chen, F;Wong, J;Morel, C;Huntley, GW;Zhang, B;Russo, SJ;Wang, J; Chemokine receptor 5 signaling in PFC mediates stress susceptibility in female mice bioRxiv : the preprint server for biology 2023-08-21 [PMID: 37662400] (Mouse) Mouse
Nyariki, JN;Kimani, NM;Kibet, PS;Kinuthia, GK;Isaac, AO; Coenzyme Q10 exhibits anti-inflammatory and immune-modulatory thereby decelerating the occurrence of experimental cerebral malaria Molecular and biochemical parasitology 2023-06-27 [PMID: 37385350] (Mouse) Mouse
Scheunemann, JF;Risch, F;Reichwald, JJ;Lenz, B;Neumann, AL;Garbe, S;Frohberger, SJ;Koschel, M;Ajendra, J;Rothe, M;Latz, E;Coch, C;Hartmann, G;Schumak, B;Hoerauf, A;H�bner, MP; Potential of Nucleic Acid Receptor Ligands to Improve Vaccination Efficacy against the Filarial Nematode Litomosoides sigmodontis Vaccines 2023-05-10 [PMID: 37243070] (Mouse) Mouse
Aguilera-Herce, J;Panadero-Medianero, C;S�nchez-Romero, MA;Balbont�n, R;Bernal-Bayard, J;Ramos-Morales, F; Salmonella Type III Secretion Effector SrfJ: A Glucosylceramidase Affecting the Lipidome and the Transcriptome of Mammalian Host Cells International journal of molecular sciences 2023-05-07 [PMID: 37176110] (Mouse) Mouse
S MacLauchla, P Kushwaha, A Tai, J Chen, C Manning, G Swarnkar, Y Abu-Amer, KA Fitzgerald, S Sharma, EM Gravallese STING-dependent interferon signatures restrict osteoclast differentiation and bone loss in mice Proceedings of the National Academy of Sciences of the United States of America, 2023-04-06;120(15):e2210409120. 2023-04-06 [PMID: 37023130] (Mouse) Mouse
Show All 89 Publications.

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Bioinformatics

Gene Symbol Ccl5