MMP-3 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Matrix metalloproteinases are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP-3 (stromelysin-1) can degrade a broad range of substrates including collagen alpha  chains, aggrecan, laminin, fibronectin, elastin, casein, alpha -1 antitrypsin, myelin basic protein, IL-1 beta , IGFBP-3, pro-MMP-1, pro-MMP-7, pro-MMP-8, pro-MMP-9, and pro-MMP-13. MMP-3 does not cleave the triple helical region of interstitial collagens, a characteristic which distinguishes the stromelysins from the collagenases. The MMP-3 substrate repertoire extends beyond extracellular matrix proteins and implicates MMP-3 in roles other than direct tissue remodelling, for instance, enzyme cascades and cytokine regulation. MMP-3 is expressed by fibroblasts, chrondrocytes, osteoblasts, endothelial cells, smooth muscle cells, and macrophages. Structurally, MMP-3 may be divided into several distinct domains; a pro-domain which is cleaved upon activation; a catalytic domain containing the zinc binding site; a short hinge region and a carboxyl terminal (hemopexin-like) domain.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 4 applications: ELISA Development, IHC-Fr, IHC-P, Western Blot.

Showing Publications 1 - 10 of 11. Show All 11 Publications. Collapse Publications.

Publications using AF513	Applications	Species
Khalid Muhammad, Delicia Xavier, Stefan Klein-Hessling, Muhammad Azeem, Tabea Rauschenberger, Krisna Murti et al. NFAT5 Controls the Integrity of Epidermis Frontiers in Immunology 12/9/2021 [PMID: 34956208]
S Liu, Y Hu, Y Wang, Y Sun, SL Qin, D Xu Endosulfan promotes cell proliferation and extracellular matrix accumulation through TGF-beta/Smad signaling pathway in HRMCs Ecotoxicology and environmental safety, 2021-11-30;228(0):113040. 2021-11-30 [PMID: 34856488] (Western Blot, Human)	Western Blot	Human
Yoshihiro Inamoto, Paul J. Martin, Lynn E. Onstad, Guang-Shing Cheng, Kirsten M. Williams, Iskra Pusic et al. Relevance of Plasma Matrix Metalloproteinase-9 for Bronchiolitis Obliterans Syndrome after Allogeneic Hematopoietic Cell Transplantation Transplantation and Cellular Therapy 9/1/2021 [PMID: 34126278]
DP Muñoz, SM Yannone, A Daemen, Y Sun, F Vakar-Lope, M Kawahara, AM Freund, F Rodier, JD Wu, PY Desprez, DH Raulet, PS Nelson, LJ van 't Vee, J Campisi, JP Coppé Targetable mechanisms driving immunoevasion of persistent senescent cells link chemotherapy-resistant cancer to aging JCI Insight, 2019-06-11;5(0):. 6/11/2019 [PMID: 31184599]
IL-3 Decreases Cartilage Degeneration by Downregulating Matrix Metalloproteinases and Reduces Joint Destruction in Osteoarthritic Mice J Immunol, 2016-05-13;0(0):. 2016-05-13 [PMID: 27183574] (Western Blot, Mouse)	Western Blot	Mouse
Marina Beltrami-M, Amélie Vromman, Galina K Sukhova, Eduardo J Folco, Peter Libby Redundancy of IL-1 Isoform Signaling and Its Implications for Arterial Remodeling. PLoS ONE, 2016-03-31;0(0):1932-6203. 2016-03-31 [PMID: 27032103] (IHC-Fr, Human)	IHC-Fr	Human
Zhao X, Qureshi F, Eastman PS, Manning WC, Alexander C, Robinson WH, Hesterberg LK Pre-analytical effects of blood sampling and handling in quantitative immunoassays for rheumatoid arthritis. J. Immunol. Methods, 2012-02-17;378(1):72-80. 2012-02-17 [PMID: 22366959] (ELISA Development, Human)	ELISA Development	Human
Lee YR, Lee JH, Noh EM, Kim EK, Song MY, Jung WS, Park SJ, Kim JS, Park JW, Kwon KB, Park BH Guggulsterone blocks IL-1beta-mediated inflammatory responses by suppressing NF-kappaB activation in fibroblast-like synoviocytes. Life Sci., 2008-04-20;82(23):1203-9. 2008-04-20 [PMID: 18495175] (Western Blot, Human)	Western Blot	Human
Nah SS, Choi IY, Yoo B, Kim YG, Moon HB, Lee CK Advanced glycation end products increases matrix metalloproteinase-1, -3, and -13, and TNF-alpha in human osteoarthritic chondrocytes. FEBS Lett., 2007-04-09;581(9):1928-32. 2007-04-09 [PMID: 17434489] (Western Blot, Human)	Western Blot	Human
Hagemann T, Bozanovic T, Hooper S, Ljubic A, Slettenaar VI, Wilson JL, Singh N, Gayther SA, Shepherd JH, Van Trappen PO Molecular profiling of cervical cancer progression. Br. J. Cancer, 2007-01-29;96(2):321-8. 2007-01-29 [PMID: 17242701] (IHC-P, Human)	IHC-P	Human
McCaig C, Duval C, Hemers E, Steele I, Pritchard DM, Przemeck S, Dimaline R, Ahmed S, Bodger K, Kerrigan DD, Wang TC, Dockray GJ, Varro A The role of matrix metalloproteinase-7 in redefining the gastric microenvironment in response to Helicobacter pylori. Gastroenterology, 2006-03-06;130(6):1754-63. 2006-03-06 [PMID: 16697739] (Western Blot, Human)	Western Blot	Human
Show All 11 Publications. Collapse Publications.

Array AF513

• MMP-3 Antibodies
• MMP-3 Antibody Pair
• MMP-3 ELISA Kits
• MMP-3 Lysate
• MMP-3 Proteins
• MMP-3 ELISAs
• MMP-3 Proteins and Enzymes