Species: Hu, Pm
Applications: WB, IHC, IP, ELISA(Cap)
Host: Goat Polyclonal
Species: Hu, Mu, Rt
Applications: WB, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, IHC, CyTOF-ready, Flow, ICC/IF
Host: Mouse Monoclonal
Species: Hu
Applications: ELISA
Host: Mouse Monoclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Mu
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: Enzyme Activity
Species: Hu
Applications: WB
Species: Mu
Applications: Enzyme Activity
Description
Effective inhibitors of matrix metalloproteinases (MMPs), a family of connective tissue-degrading enzymes, could be useful for the treatment of diseases such as cancer, multiple sclerosis, and arthritis (1). Matrix metalloproteinase-3 (MMP-3) is a protein involved in tumor invasion and metastasis. MMP3 (stromelysin) is a secreted metalloprotease with a wide range of substrate specificities. MMP3 is synthesized in a preproenzyme form with a calculated size of 54 kDa and a 17-amino acid long signal peptide. Data indicate that the expression and the possible involvement of secreted metalloproteases in tumorigenesis result from a specific interaction between the transforming factor and the target cell, which may vary in different species (2). In neural studies, matrix metalloproteinase-3 (MMP-3) was newly induced and activated in stressed dopamine cells, and the active form of MMP-3 (actMMP-3) was released into the medium. The released actMMP-3, as well as catalytically active recombinant MMP-3 (cMMP-3) led to microglial activation and superoxide generation in microglia and enhanced DA cell death. (3).
Bioinformatics
Entrez |
Rat Mouse Human |
Uniprot |
Human Human Human Human |
Product By Gene ID |
4314 |
Alternate Names |
- CHDS6
- EC 3.4.24
- EC 3.4.24.17
- matrix metallopeptidase 3 (stromelysin 1, progelatinase)
- matrix metalloproteinase 3 (stromelysin 1, progelatinase)
- Matrix metalloproteinase-3
- MGC126102
- MGC126103
- MMP-3
- proteoglycanase
- SL-1
- STMY
- STMY1MGC126104
- STR1
- stromelysin-1
- Transin-1
- transin-1
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