Human TIMP-2 Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.

We have publications tested in 2 confirmed species: Human, Mouse.

Showing Publications 1 - 10 of 35. Show All 35 Publications. Collapse Publications.

Publications using DTM200	Applications	Species
I Tsomidis, G Notas, C Xidakis, A Voumvourak, DN Samonakis, M Koulentaki, E Kouroumali Enzymes of Fibrosis in Chronic Liver Disease Biomedicines, 2022-12-08;10(12):. 2022-12-08 [PMID: 36551935] (Human)		Human
N Nasiri-Ans, E Spilioti, I Kyrou, V Kalotychou, A Chatzigeor, D Sanoudou, K Dahlman-Wr, HS Randeva, AG Papavassil, P Moutsatsou, E Kassi Estrogen Receptor Subtypes Elicit a Distinct Gene Expression Profile of Endothelial-Derived Factors Implicated in Atherosclerotic Plaque Vulnerability International Journal of Molecular Sciences, 2022-09-19;23(18):. 2022-09-19 [PMID: 36142876] (Human)		Human
TE Peterson, C Landon, SA Haberlen, F Bhondoekha, MW Plankey, FJ Palella, DA Piggott, JB Margolick, TT Brown, WS Post, KC Wu Circulating biomarker correlates of left atrial size and myocardial extracellular volume fraction among persons living with and without HIV BMC cardiovascular disorders, 2022-09-03;22(1):393. 2022-09-03 [PMID: 36057773] (Human)		Human
JJ Wu, ZL Sun, SY Liu, ZH Chen, ZD Yuan, ML Zou, YY Teng, YY Li, DY Guo, FL Yuan The ASIC3-M-CSF-M2 macrophage-positive feedback loop modulates fibroblast-to-myofibroblast differentiation in skin fibrosis pathogenesis Cell Death & Disease, 2022-06-06;13(6):527. 2022-06-06 [PMID: 35661105] (Human)		Human
X Tao, C Chen, W Luo, J Zhou, J Tian, X Yang, FF Hou Combining renal cell arrest and damage biomarkers to predict progressive AKI in patient with sepsis Bmc Nephrology, 2021-12-15;22(1):415. 2021-12-15 [PMID: 34906098] (Human)		Human
K Moriya, N Nishimura, T Namisaki, H Takaya, Y Sawada, H Kawaratani, K Kaji, N Shimozato, S Sato, M Furukawa, A Douhara, T Akahane, A Mitoro, J Yamao, H Yoshiji Zinc Administration and Improved Serum Markers of Hepatic Fibrosis in Patients with Autoimmune Hepatitis Journal of Clinical Medicine, 2021-06-02;10(11):. 2021-06-02 [PMID: 34199421] (Human)		Human
K Esmeijer, A Schoe, LR Ruhaak, EK Hoogeveen, D Soonawala, FPHTM Romijn, MR Shirzada, JT van Dissel, CM Cobbaert, JW de Fijter The predictive value of TIMP-2 and IGFBP7 for kidney failure and 30-day mortality after elective cardiac surgery Scientific Reports, 2021-01-13;11(1):1071. 2021-01-13 [PMID: 33441876] (Human)		Human
A Waszczykow, M Podgórski, M Waszczykow, Z Gerlicz-Ko, P Jurowski Matrix Metalloproteinases MMP-2 and MMP-9, Their Inhibitors TIMP-1 and TIMP-2, Vascular Endothelial Growth Factor and sVEGFR-2 as Predictive Markers of Ischemic Retinopathy in Patients with Systemic Sclerosis-Case Series Report Int J Mol Sci, 2020-11-18;21(22):. 2020-11-18 [PMID: 33218057] (Human)		Human
G Morad, CC Daisy, HH Otu, TA Libermann, ST Dillon, MA Moses Cdc42-Dependent Transfer of mir301 from Breast Cancer-Derived Extracellular Vesicles Regulates the Matrix Modulating Ability of Astrocytes at the Blood-Brain Barrier Int J Mol Sci, 2020-05-28;21(11):. 2020-05-28 [PMID: 32481745] (Mouse)		Mouse
AE Stanciu, A Zamfir-Chi, MM Stanciu, A Pantea-Sto, C Nitipir, DC Gheorghe Serum melatonin is inversely associated with matrix metalloproteinase-9 in oral squamous cell carcinoma Oncol Lett, 2020-02-13;19(4):3011-3020. 2020-02-13 [PMID: 32218858] (Human)		Human
A Kobus, J Bagi?ska, J ?api?ska-A, S ?awicki, A Kierklo Levels of Selected Matrix Metalloproteinases, Their Inhibitors in Saliva, and Oral Status in Juvenile Idiopathic Arthritis Patients vs. Healthy Controls Biomed Res Int, 2019-10-28;2019(0):7420345. 2019-10-28 [PMID: 31781639] (Human)		Human
DP Zhang, YF Peng, HL Zhang, JG Ma, M Zhao, S Yin, TT Wei Basilar Artery Tortuosity Is Associated With White Matter Hyperintensities by TIMP-1 Front Neurosci, 2019-08-14;13(0):836. 2019-08-14 [PMID: 31474817] (Human)		Human
SEI Dekker, LR Ruhaak, FPHTM Romijn, E Meijer, CM Cobbaert, JW de Fijter, D Soonawala Urinary Tissue Inhibitor of�Metalloproteinases-2 and Insulin-Like Growth Factor-Binding Protein 7 Do Not Correlate With Disease Severity in ADPKD Patients Kidney Int Rep, 2019-03-22;4(6):833-841. 2019-03-22 [PMID: 31194166] (Human)		Human
R Schmitt, A Tscheuschl, P Laschinski, X Uffelmann, P Discher, J Fuchs, M Kreibich, R Peyronnet, FA Kari A potential key mechanism in ascending aortic aneurysm development: Detection of a linear relationship between MMP-14/TIMP-2 ratio and active MMP-2 PLoS ONE, 2019-02-22;14(2):e0212859. 2019-02-22 [PMID: 30794673] (Human)		Human
M ?ukaszewic, M Gryko, S P?czek, M Szmitkowsk, B K?dra, B Mroczko Matrix metalloproteinase 2 (MMP-2) and its tissue inhibitor 2 (TIMP-2) in pancreatic cancer (PC) Oncotarget, 2019-01-08;10(3):395-403. 2019-01-08 [PMID: 30719232] (Human)		Human
MY Ahn, BJ Kim, HJ Kim, JM Jin, HJ Yoon, JS Hwang, KK Park Anti-cancer effect of dung beetle glycosaminoglycans on melanoma BMC Cancer, 2019-01-05;19(1):9. 2019-01-05 [PMID: 30611221] (Human)		Human
CK Wu, MM Su, YF Wu, JJ Hwang, LY Lin Combination of Plasma Biomarkers and Clinical Data for the Detection of Myocardial Fibrosis or Aggravation of Heart Failure Symptoms in Heart Failure with Preserved Ejection Fraction Patients J Clin Med, 2018-11-08;7(11):. 2018-11-08 [PMID: 30413105] (Human)		Human
JM Castellano, KI Mosher, RJ Abbey, AA McBride, ML James, D Berdnik, JC Shen, B Zou, XS Xie, M Tingle, IV Hinkson, MS Angst, T Wyss-Coray Human umbilical cord plasma proteins revitalize hippocampal function in aged mice Nature, 2017-04-19;544(7651):488-492. 2017-04-19 [PMID: 28424512] (Human)		Human
ME Niño, SE Serrano, DC Niño, DM McCosham, ME Cardenas, VP Villareal, M Lopez, A Pazin-Filh, FA Jaimes, F Cunha, R Schulz, D Torres-Due TIMP1 and MMP9 are predictors of mortality in septic patients in the emergency department and intensive care unit unlike MMP9/TIMP1 ratio: Multivariate model PLoS ONE, 2017-02-13;12(2):e0171191. 2017-02-13 [PMID: 28192449] (Human)		Human
Braicu E, Gasimli K, Richter R, Nassir M, Kummel S, Blohmer J, Yalcinkaya I, Chekerov R, Ignat I, Ionescu A, Mentze M, Fotopoulou C, Pop C, Lichtenegger W, Sehouli J Role of serum VEGFA, TIMP2, MMP2 and MMP9 in monitoring response to adjuvant radiochemotherapy in patients with primary cervical cancer--results of a companion protocol of the randomized NOGGO-AGO phase III clinical trial. Anticancer Res, 2014-01-01;34(1):385-91. 2014-01-01 [PMID: 24403492] (Human)		Human
Braicu E, Fotopoulou C, Chekerov R, Richter R, Blohmer J, Kummel S, Stamatian F, Yalcinkaya I, Mentze M, Lichtenegger W, Sehouli J Role of serum concentration of VEGFR1 and TIMP2 on clinical outcome in primary cervical cancer: results of a companion protocol of the randomized, NOGGO-AGO phase III adjuvant trial of simultaneous cisplatin-based radiochemotherapy vs. carboplatin and paclitaxel containing sequential radiotherapy. Cytokine, 2013-02-14;61(3):755-8. 2013-02-14 [PMID: 23415672] (Human)		Human
Wilcock DM, Morgan D, Gordon MN, Taylor TL, Ridnour LA, Wink DA, Colton CA Activation of matrix metalloproteinases following anti-Abeta immunotherapy; implications for microhemorrhage occurrence. J Neuroinflammation, 2011-09-09;8(0):115. 2011-09-09 [PMID: 21906275] (Mouse)		Mouse
Jonasson S, Lundberg A, Kalvegren H, Bergstrom I, Szymanowski A, Jonasson L Increased levels of leukocyte-derived MMP-9 in patients with stable angina pectoris. PLoS ONE, 2011-04-29;6(4):e19340. 2011-04-29 [PMID: 21559401] (Human)		Human
Reikvam H, Hatfield KJ, Oyan AM, Kalland KH, Kittang AO, Bruserud O Primary human acute myelogenous leukemia cells release matrix metalloproteases and their inhibitors: release profile and pharmacological modulation. Eur. J. Haematol., 2009-11-17;84(3):239-51. 2009-11-17 [PMID: 19922462] (Human)		Human
Sesso R, Franco MC Abnormalities in metalloproteinase pathways and IGF-I axis: a link between birth weight, hypertension, and vascular damage in childhood. Am. J. Hypertens., 2009-11-05;23(1):6-11. 2009-11-05 [PMID: 19893495] (Human)		Human
O'Kane CM, McKeown SW, Perkins GD, Bassford CR, Gao F, Thickett DR, McAuley DF Salbutamol up-regulates matrix metalloproteinase-9 in the alveolar space in the acute respiratory distress syndrome. Crit. Care Med., 2009-07-01;37(7):2242-9. 2009-07-01 [PMID: 19487934] (Human)		Human
Glass-Marmor L, Paperna T, Galboiz Y, Miller A Immunomodulation by chronobiologically-based glucocorticoids treatment for multiple sclerosis relapses. J. Neuroimmunol., 2009-03-28;210(1):124-7. 2009-03-28 [PMID: 19329193] (Human)		Human
Kapsoritakis AN, Kapsoritaki AI, Davidi IP, Lotis VD, Manolakis AC, Mylonis PI, Theodoridou AT, Germenis AE, Potamianos SP Imbalance of tissue inhibitors of metalloproteinases (TIMP) - 1 and - 4 serum levels, in patients with inflammatory bowel disease. BMC Gastroenterol, 2008-11-26;8(1):55. 2008-11-26 [PMID: 19036126] (Human)		Human
McKeown S, Richter AG, O'Kane C, O'Kane C, McAuley DF, Thickett DR MMP expression and abnormal lung permeability are important determinants of outcome in IPF. Eur. Respir. J., 2008-10-01;33(1):77-84. 2008-10-01 [PMID: 18829682] (Human)		Human
Glader P, Eldh B, Bozinovski S, Andelid K, Sjostrand M, Malmhall C, Anderson GP, Riise GC, Qvarfordt I, Linden A Impact of acute exposure to tobacco smoke on gelatinases in the bronchoalveolar space. Eur. Respir. J., 2008-04-16;32(3):644-50. 2008-04-16 [PMID: 18417512] (Human)		Human
Huh JW, Kim DS, Oh YM, Shim TS, Lim CM, Lee SD, Koh Y, Kim WS, Kim WD, Kim KR Is metalloproteinase-7 specific for idiopathic pulmonary fibrosis? Chest, 2007-12-10;133(5):1101-6. 2007-12-10 [PMID: 18071010] (Human)		Human
Thrailkill KM, Bunn RC, Moreau CS, Cockrell GE, Simpson PM, Coleman HN, Frindik JP, Kemp SF, Fowlkes JL Matrix metalloproteinase-2 dysregulation in type 1 diabetes. Diabetes Care, 2007-06-11;30(9):2321-6. 2007-06-11 [PMID: 17563344] (Human)		Human
Bodet C, Andrian E, Tanabe S, Grenier D Actinobacillus actinomycetemcomitans lipopolysaccharide regulates matrix metalloproteinase, tissue inhibitors of matrix metalloproteinase, and plasminogen activator production by human gingival fibroblasts: a potential role in connective tissue destruction. J. Cell. Physiol., 2007-07-01;212(1):189-94. 2007-07-01 [PMID: 17299802] (Human)		Human
Kuyvenhoven JP, Molenaar IQ, Verspaget HW, Veldman MG, Palareti G, Legnani C, Moolenburgh SE, Terpstra OT, Lamers CB, van Hoek B, Porte RJ Plasma MMP-2 and MMP-9 and their inhibitors TIMP-1 and TIMP-2 during human orthotopic liver transplantation. The effect of aprotinin and the relation to ischemia/reperfusion injury. Thromb. Haemost., 2004-03-01;91(3):506-13. 2004-03-01 [PMID: 14983226] (Human)		Human
Ulrich D, Hrynyschyn K, Pallua N Matrix metalloproteinases and tissue inhibitors of metalloproteinases in sera and tissue of patients with Dupuytren's disease. Plast. Reconstr. Surg., 2003-10-01;112(5):1279-86. 2003-10-01 [PMID: 14504511] (Human)		Human
Show All 35 Publications. Collapse Publications.

Array DTM200

• TIMP-2 Antibodies
• TIMP-2 ELISA Kit
• TIMP-2 Lysate
• TIMP-2 Proteins
• TIMP-2 Proteins and Enzymes
• TIMP-2 ELISAs