Mouse Neutrophil Elastase/ELA2 DuoSet ELISA, 5 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Neutrophil Elastase (ELA2), also known as polymorphonuclear leukocyte elastase, is a serine protease belonging to the chymotrypsin family. Located primarily in the azurophil granules of polymorphonuclear leukocytes, ELA2 function results in the degradation of many extracellular matrix macromolecules. Alpha-1 Antitrypsin (Serpin A1) and secretory leukocyte protease inhibitor (SLPI) have been shown to inhibit ELA2 activity. ELA2 may be involved in lung emphysema, cystic fibrosis, the adult respiratory distress syndrome (ARDS), rheumatoid arthritis, tumor invasion and infectious diseases.

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Transgenic Mouse.

We have publications tested in 1 application: ELISA.

Showing Publications 1 - 10 of 14. Show All 14 Publications. Collapse Publications.

Publications using DY4517-05	Applications	Species
M Costa Fuji, A Yazdanpana, S Horne, A Lamont, P Lopez, C Farr Zuend, K Birse, M Taverner, R Greenslade, M Abou, L Noel-Romas, B Abrenica, O Ajibola, N Ikeogu, RC Su, LR McKinnon, H Pymar, V Poliquin, AR Berard, A Burgener, TT Murooka Non-optimal bacteria species induce neutrophil-driven inflammation and barrier disruption in the female genital tract Mucosal Immunology, 2023-04-29;0(0):. 2023-04-29 [PMID: 37121385] (ELISA, Mouse)	ELISA	Mouse
J Zhao, N Zhen, Q Zhou, J Lou, W Cui, G Zhang, B Tian NETs Promote Inflammatory Injury by Activating cGAS-STING Pathway in Acute Lung Injury International Journal of Molecular Sciences, 2023-03-07;24(6):. 2023-03-07 [PMID: 36982193] (Mouse)		Mouse
P Kumar, A Mittal, P Bansal, S Aggarwal, RK Rajnish, A Dadra, S Sharma Wound alpha defensin levels are significantly higher in patients with fracture related infection: A pilot, prospective cohort study Injury, 2022-12-13;0(0):. 2022-12-13 [PMID: 36567156] (Human)		Human
RA Keogh, AL Haeberle, CJ Langouët-A, JS Kavanaugh, EP Schmidt, GD Moore, AR Horswill, KS Doran Group B Streptococcus adaptation promotes survival in a hyperinflammatory diabetic wound environment Science Advances, 2022-11-11;8(45):eadd3221. 2022-11-11 [PMID: 36367946] (Mouse, Transgenic Mouse)		Mouse, Transgenic Mouse
A Gupta, K Singh, S Fatima, S Ambreen, S Zimmermann, R Younis, S Krishnan, R Rana, I Gadi, C Schwab, R Biemann, K Shahzad, V Rani, S Ali, PR Mertens, S Kohli, B Isermann Neutrophil Extracellular Traps Promote NLRP3 Inflammasome Activation and Glomerular Endothelial Dysfunction in Diabetic Kidney Disease Nutrients, 2022-07-20;14(14):. 2022-07-20 [PMID: 35889923] (Mouse)		Mouse
KC Ngamsri, RA Putri, C Jans, K Schindler, A Fuhr, Y Zhang, J Gamper-Tsi, S Ehnert, FM Konrad CXCR4 and CXCR7 Inhibition Ameliorates the Formation of Platelet-Neutrophil Complexes and Neutrophil Extracellular Traps through Adora2b Signaling International Journal of Molecular Sciences, 2021-12-17;22(24):. 2021-12-17 [PMID: 34948374] (Mouse)		Mouse
P Saha, BS Yeoh, X Xiao, RM Golonka, V Singh, Y Wang, M Vijay-Kuma PAD4-dependent NETs generation are indispensable for intestinal clearance of Citrobacter rodentium Mucosal Immunol, 2019-02-01;0(0):. 2019-02-01 [PMID: 30710097] (Mouse)		Mouse
S Aggarwal, I Ahmad, A Lam, MA Carlisle, C Li, JM Wells, SV Raju, M Athar, SM Rowe, MT Dransfield, S Matalon Heme scavenging reduces pulmonary endoplasmic reticulum stress, fibrosis, and emphysema JCI Insight, 2018-11-02;3(21):. 2018-11-02 [PMID: 30385726] (Mouse)		Mouse
S Al-Salam, S Hashmi Myocardial Ischemia Reperfusion Injury: Apoptotic, Inflammatory and Oxidative Stress Role of Galectin-3 Cell. Physiol. Biochem., 2018-10-24;50(3):1123-1139. 2018-10-24 [PMID: 30355930] (Mouse)		Mouse
P Ochieng, S Nath, R Macarulay, E Eden, A Dabo, M Campos, XC Jiang, RF Foronjy, P Geraghty Phospholipid transfer protein and alpha-1 antitrypsin regulate Hck kinase activity during neutrophil degranulation Sci Rep, 2018-10-18;8(1):15394. 2018-10-18 [PMID: 30337619] (Mouse)		Mouse
X Xiao, P Saha, BS Yeoh, JA Hipp, V Singh, M Vijay-Kuma Myeloperoxidase deficiency attenuates systemic and dietary iron-induced adverse effects J. Nutr. Biochem., 2018-08-21;62(0):28-34. 2018-08-21 [PMID: 30218980] (Mouse)		Mouse
G Wen, W An, J Chen, EM Maguire, Q Chen, F Yang, SWA Pearce, M Kyriakides, L Zhang, S Ye, S Nourshargh, Q Xiao Genetic and Pharmacologic Inhibition of the Neutrophil Elastase Inhibits Experimental Atherosclerosis J Am Heart Assoc, 2018-02-08;7(4):. 2018-02-08 [PMID: 29437605] (Mouse)		Mouse
A Bao, KF Che, S Bozinovski, J Ji, JA Gregory, S Kumlien Ge, M Adner, LO Cardell, A Lindén Recombinant human IL-26 facilitates the innate immune response to endotoxin in the bronchoalveolar space of mice in vivo PLoS ONE, 2017-12-05;12(12):e0188909. 2017-12-05 [PMID: 29206862] (Mouse)		Mouse
XS Ren, L Ling, B Zhou, Y Han, YB Zhou, Q Chen, YH Li, YM Kang, GQ Zhu Silencing salusin-? attenuates cardiovascular remodeling and hypertension in spontaneously hypertensive rats Sci Rep, 2017-02-23;7(0):43259. 2017-02-23 [PMID: 28230187] (Rat)		Rat
Show All 14 Publications. Collapse Publications.

Array DY4517-05

• Neutrophil Elastase/ELA2 Antibodies
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• Neutrophil Elastase/ELA2 Lysate
• Neutrophil Elastase/ELA2 Protein
• Neutrophil Elastase/ELA2 Proteins and Enzymes
• Neutrophil Elastase/ELA2 ELISAs