MKLP1 Antibody

Using the CHO1 monoclonal antibody, Sellitto and Kuriyama (1988) identified a spindle antigen that was shown by Nislow et al. (1990) to be required for mitotic progression. By using the CHO1 antibody to screen a HeLa cell cDNA library, Nislow et al. (1992) isolated a KNSL5 cDNA, which they called MKLP1 (mitotic kinesin-like protein-1), that encodes this antigen. The N-terminal region of the deduced 961-amino acid protein contains a 350-residue domain that shares 30 to 45% identity with the motor domains of other members of the kinesin superfamily. The C-terminal region shows little identity with other kinesins. A central region contains heptad repeats of hydrophobic residues that may assemble into a coiled-coil structure similar to kinesin and myosin heavy chain proteins. The protein also contains a putative nuclear localization signal and 2 consensus phosphorylation sites characteristic of nuclear proteins.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Hamster.

We have publications tested in 1 application: ICC/IF.

Showing Publications 1 - 5 of 5.

Publications using NBP2-56923	Applications	Species
Park S, Dahn R, Kurt E et al. The midbody and midbody remnant are assembly sites for RNA and active translation Research Square 2022-11-23 (ICC/IF, Hamster, Human)	ICC/IF	Hamster, Human
Gyu Ik Jung, Daniela Londoño-Vásquez, Sungjin Park, Ahna R. Skop, Ahmed Z. Balboula, Karen Schindler An oocyte meiotic midbody cap is required for developmental competence in mice Nature Communications 2023-11-16 [PMID: 37973997]
Schindler K, Jung GI, Londoño-Vásquez D et al. An oocyte meiotic midbody cap is required for developmental competence in mice Research square 2023-10-05 [PMID: 37886573] (ICC/IF, Mouse)	ICC/IF	Mouse
Park S, Patel SA, Torr EE et al. A protocol for isolating and imaging large extracellular vesicles or midbody remnants from mammalian cell culture STAR protocols 2023-09-09 [PMID: 37690025] (ICC/IF, Human) Details: 1:2000 ICC/IF dilution	ICC/IF	Human
Park S, Dahn R, Kurt E et al. The mammalian midbody and midbody remnant are assembly sites for RNA and localized translation Developmental cell 2023-08-07 [PMID: 37552987]

Array NBP2-56923

• MKLP1 Antibodies
• MKLP1 Proteins