CDC2/CDK1 Antibody

The cell division control protein cdc2, also known as cyclin-dependent kinase 1 (Cdk1) or p34/cdk1, plays a key role in the control of the eukaryotic cell cycle, where it is required for entry into S-phase and mitosis. Cdc2 exists as a complex with both cyclin A and cyclin B. The best characterized of these associations is the Cdc2 p34 cyclin B complex, which is required for the G2 to M phase transition. Activation of Cdc2 is controlled at several steps including cyclin binding and phosphorylation of threonine 161. However, the critical regulatory step in activating cdc2 during progression into mitosis appears to be dephosphorylation of Tyr15 and Tyr14. Phosphorylation at Tyr15 and inhibition of Cdc2 is carried out by WEE1 and MIK protein kinases while Tyr15 dephosphorylation and activation of Cdc2 is carried out by the cdc25 phosphatase. The isoform CDC2deltaT is found in breast cancer tissues. Furthermore, cdc2/Cdk1 is a key mediator of neuronal cell death in brain development and degeneration.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 1 application: WB.

Showing Publications 1 - 6 of 6.

Publications using NBP1-85729	Applications	Species
Kanhai A, Sánchez-López E, Kuipers T et al. Short salsalate administration affects cell proliferation, metabolism and inflammation in polycystic kidney disease iScience 2023-10-01 [PMID: 38026227] (WB, Mouse)	WB	Mouse
S Zhu, M Al-Mathkou, L Cao, S Khalafi, Z Chen, J Poveda, D Peng, H Lu, M Soutto, T Hu, OG McDonald, A Zaika, W El-Rifai CDK1 bridges NF-kappaB and beta-catenin signaling in response to H.�pylori infection in gastric tumorigenesis Cell Reports, 2023-01-21;42(1):112005. 2023-01-21 [PMID: 36681899]
Qu J, Ke F, Liu Z et al. Uncovering the mechanisms of dandelion against triple-negative breast cancer using a combined network pharmacology, molecular pharmacology and metabolomics approach Phytomedicine : international journal of phytotherapy and phytopharmacology 2022-02-11 [PMID: 35183931] (WB, Mouse)	WB	Mouse
Grazvydas Lukinavicius, Darja Lavogina, Pierre Gonczy et al. Commercial Cdk1 antibodies recognize the centrosomal protein Cep152. BioTechniques [PMID: 24137814] (WB)	WB
Sousa MM, Zub KA, Aas PA et al. An inverse switch in DNA base excision and strand break repair contributes to melphalan resistance in multiple myeloma cells. PLoS One. 2013-02-06 [PMID: 23405159]
Liu L, Zhao L, She H et al. Clinically relevant progestins regulate neurogenic and neuroprotective responses in vitro and in vivo. Endocrinology 2010-12-01 [PMID: 20943809] (WB, Rat)	WB	Rat

Array NBP1-85729

• CDC2/CDK1 Antibodies
• CDC2/CDK1 ELISA Kit
• CDC2/CDK1 Lysate
• CDC2/CDK1 Proteins