MHC Class I Antibody (JF10-38)

The antigenic agglomerate major histocompatibility complex (MHC) class I molecules present antigenic peptides to CD8-positive T cells. It is now recognized that the products of the MHC genes are antigen-presenting molecules (APM) designed for the presentation of antigen fragments (peptides) to the T-cell receptor, thus participating in the immune response (1). Recently shown is a mechanism of antigen acquisition for cross-presentation that couples the antigen presentation system of two adjacent cells and is lost in most tumours: gap-junction-mediated intercellular peptide coupling for presentation by bystander MHC class I molecules and transfer to professional antigen presenting cells for cross-priming (2). The mammalian vomeronasal organ detects social information about gender, status, and individuality. It has been shown that small peptides that serve as ligands for major histocompatibility complex (MHC) class I molecules function also as sensory stimuli for a subset of vomeronasal sensory neurons located in the basal Gao- and V2R receptor-expressing zone of the vomeronasal epithelium (3).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 1 application: WB.

Showing Publications 1 - 2 of 2.

Publications using NBP2-66946	Applications	Species
Kim MS, Cho K, Cho MH et al. Neuronal MHC-I complex is destabilized by amyloid-? and its implications in Alzheimer's disease Cell & bioscience 2023-09-29 [PMID: 37773139] (WB, Human, Mouse)	WB	Human, Mouse
Beckman D, Bonillas A, Diniz GB et al. SARS-CoV-2 infects neurons and induces neuroinflammation in a non-human primate model of COVID-19 Cell reports 2022-11-01 [PMID: 36288725]

Array NBP2-66946

• MHC Class I Antibodies
• MHC Class I Lysate