MD-2 Antibody

MD2 is a secreted glycoprotein associating with the extracellular domain of Toll-like receptor 4 (TLR4) and trafficking to and from the cell surface and the Golgi apparatus. It has a signal peptide, two N terminal glycosylation sites, and seven Cys residues and consists of a heterogeneous collection of disulfide-linked oligomers. MD2 is an essential accessory glycoprotein required for LPS recognition and associates with toll-like receptor 4 on the cell surface to confer responsiveness to lipopolysaccyaride (LPS), and hence provides a link between the receptor and LPS signaling. It can also function as a soluble receptor for cells that do not otherwise express it. MD2 contains multiple trypsin cleavage sites and its expression is correlated inversely with trypsin activity.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 1 application: WB.

Showing Publications 1 - 8 of 8.

Publications using NB100-56655	Applications	Species
Jung F, Staltner R, Baumann A et al. A Xanthohumol-Rich Hop Extract Diminishes Endotoxin-Induced Activation of TLR4 Signaling in Human Peripheral Blood Mononuclear Cells: A Study in Healthy Women International journal of molecular sciences 2022-10-21 [PMID: 36293555] (WB, Human)	WB	Human
Rychkov D, Neely J, Oskotsky T et al. Cross-Tissue Transcriptomic Analysis Leveraging Machine Learning Approaches Identifies New Biomarkers for Rheumatoid Arthritis Frontiers in immunology 2021-06-08 [PMID: 34177888] (WB, Human)	WB	Human
Harada Y, Zhang J, Imari K et al. Cathepsin E in neutrophils contributes to the generation of neuropathic pain in experimental autoimmune encephalomyelitis Pain 2019-09-01 [PMID: 31095099] (WB, Mouse)	WB	Mouse
Ellison MA, Gearheart CM, Porter CC, Ambruso DR. IFN-g alters the expression of diverse immunity related genes in a cell culture model designed to represent maturing neutrophils. PLoS ONE. 2017-10-05 [PMID: 28982143] (WB, Human)	WB	Human
Xiong X, Liu Y, Mei Y et al. Novel Protective Role of Myeloid Differentiation 1 in Pathological Cardiac Remodelling. Sci Rep. 2017-02-06 [PMID: 28165494] (WB, Mouse)	WB	Mouse
Martin I, Caban-Hernandez K, Figueroa-Santiago O, Espino AM. Fasciola hepatica Fatty Acid Binding Protein Inhibits TLR4 Activation and Suppresses the Inflammatory Cytokines Induced by Lipopolysaccharide In Vitro and In Vivo J. Immunol. 2015-03-16 [PMID: 25780044] (WB, Human)	WB	Human
Yang H, Wang H, Ju Z et al. MD-2 is required for disulfide HMGB1-dependent TLR4 signaling J. Exp. Med. 2015-01-12 [PMID: 25559892] (WB, Human) Details: MD-2 antibody used for WB analysis on mixture of CBP-tagged HMGB1 or CBP alone with supernatant of yeast Sf9 cells expressing human MD-2 immunoprecipitated with calmodulin beads (Figure 1C). Antibody also used for WB on lysate of RAW 264.7 cells that were subjected or not to the knockdown of MD-2 / with siRNA-MD2 (Figure 2A).	WB	Human
Kunda PE, Cavicchia JC, Acosta CG. Lipopolysaccharides and trophic factors regulate the LPS receptor complex in nodose and trigeminal neurons. Neuroscience. 2014-09-11 [PMID: 25218806] (WB, Mouse) Details: MD1/LY86 antibody used for WB on lysates of neurons from trigeminal and nodose ganglia of CD-1 mice /postnatal day 5. Spleen lysate was used as positive control and the WB Images are shown in Fig. 1A.	WB	Mouse

Array NB100-56655

• MD-2 Antibodies
• MD-2 ELISA Kits
• MD-2 Lysate
• MD-2 Proteins
• MD-2 Proteins and Enzymes