MD-1/LY86 Antibody

Mammalian MD-1 is a homolog of Chicken MD-1, which was previously isolated as a v-myb-regulated gene, since its transcription increases rapidly after v-myb induction. MD-1 is associated at the cell surface with RP105. RP105 is a leucine-rich repaeat (LRR) molecule that is expressed on B-lymphocytes. It was first identified by a mAb that protects spleen B cells from irradiation-induced apoptosis (2). LRR proteins, such as Toll receptors, have a role in innate immunity. MD-1 does not have any homology to other molecules. MD-1 when expressed alone behaves as a secretory protein. Expression of MD-1 in a cell increases the expression of RP105.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: WB.

Showing Publications 1 - 3 of 3.

Publications using NB100-56700	Applications	Species
Kunda PE, Cavicchia JC, Acosta CG. Lipopolysaccharides and trophic factors regulate the LPS receptor complex in nodose and trigeminal neurons. Neuroscience. 2014-09-11 [PMID: 25218806] (WB, Mouse) Details: MD1/LY86 antibody used for WB on lysates of neurons from trigeminal and nodose ganglia of CD-1 mice /postnatal day 5. Spleen lysate was used as positive control and the WB Images are shown in Fig. 1A.	WB	Mouse
Malek RL, Wang HY, Kwitek AE et al. Physiogenomic resources for rat models of heart, lung and blood disorders. Nat Genet. 2006-02-01 [PMID: 16415889]
Srivastava MD, Srivastava BI. Expression of mRNA and proteins for toll-like receptors, associated molecules, defensins and LL-37 by SRIK-NKL, a CD8+ NK/T cell line. Leuk Res. 2005-07-01 [PMID: 15927677] Details: IF/ICC in SRIK-NKL cells: TLR2 (IMG416), TLR4 (IMG-417), TLR7 (IMG-581), and TLR9 (IMG-305).

Array NB100-56700

• MD-1/LY86 Antibodies
• MD-1/LY86 Lysate
• MD-1/LY86 Proteins