Lyp/PTPN22 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Lymphoid phosphatase (Lyp), also called LyPTP, Protein Tyrosine Phosphatase, Nonreceptor-type 22 (PTPN22), and PEST-domain Phosphatase (PEP), dephosphorylates tyrosine residues in proteins. Found primarily in bone marrow and lymphoid cell lines, an R620W gain-of-function mutation in Lyp has been associated with susceptibility to autoimmune diseases such as type I diabetes, rheumatoid arthritis, and lupus erythematosus. Mature PEP knockout mice have an excess of CD8 positive T-cells and an exaggerated antigen-induced proliferative response.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Primate - Cholrocebus pygerythrus (Vervet Monkey).

We have publications tested in 3 applications: Co-Immunoprecipitation, Immunoprecipitation, Western Blot.

Showing Publications 1 - 9 of 9.

Publications using AF3428	Applications	Species
Newman, JRB;Concannon, P;Ge, Y; UBASH3A Interacts with PTPN22 to Regulate IL2 Expression and Risk for Type 1 Diabetes International journal of molecular sciences 2023-05-12 [PMID: 37240014] (Co-Immunoprecipitation, Human)	Co-Immunoprecipitation	Human
Warren Anderson, Jerill Thorpe, S. Alice Long, David J. Rawlings Efficient CRISPR/Cas9 Disruption of Autoimmune-Associated Genes Reveals Key Signaling Programs in Primary Human T Cells The Journal of Immunology 12/15/2019 [PMID: 31722988]
Hui-Hsin Chang, Guang-Yaw Liu, Nishant Dwivedi, Bo Sun, Yuko Okamoto, Jennifer D. Kinslow et al. A molecular signature of preclinical rheumatoid arthritis triggered by dysregulated PTPN22 JCI Insight 10/20/2016 [PMID: 27777982]
Ge Y, Onengut-Gumuscu S, Quinlan AR et al. Targeted Deep Sequencing in Multiple-Affected Sibships of European Ancestry Identifies Rare Deleterious Variants in PTPN22 That Confer Risk for Type 1 Diabetes. Diabetes 3/1/2016 [PMID: 26631741]
Hui-Hsin Chang, William Tseng, Jing Cui, Karen Costenbader, I-Cheng Ho Altered expression of protein tyrosine phosphatase, non-receptor type 22 isoforms in systemic lupus erythematosus Arthritis Research & Therapy 1/17/2014 [PMID: 24433447]
Hui-Hsin Chang, Shi-Chuen Miaw, William Tseng, Yi-Wei Sun, Chih-Chun Liu, Hsiao-Wei Tsao et al. PTPN22 Modulates Macrophage Polarization and Susceptibility to Dextran Sulfate Sodium–Induced Colitis The Journal of Immunology 9/1/2013 [PMID: 23913970]
Rebecca J. Brownlie, Lisa A. Miosge, Demetrios Vassilakos, Lena M. Svensson, Andrew Cope, Rose Zamoyska Lack of the Phosphatase PTPN22 Increases Adhesion of Murine Regulatory T Cells to Improve Their Immunosuppressive Function Science Signaling 11/27/2012 [PMID: 23193160]
Chang HH, Tai TS, Lu B PTPN22.6, a dominant negative isoform of PTPN22 and potential biomarker of rheumatoid arthritis. PLoS ONE, 2012-03-12;7(3):e33067. 2012-03-12 [PMID: 22427951] (Immunoprecipitation, Western Blot, Human)	Immunoprecipitation, Western Blot	Human
Fiorillo E, Orru V, Stanford SM, Liu Y, Salek M, Rapini N, Schenone AD, Saccucci P, Delogu LG, Angelini F, Manca Bitti ML, Schmedt C, Chan AC, Acuto O, Bottini N Autoimmune-associated PTPN22 R620W variation reduces phosphorylation of lymphoid phosphatase on an inhibitory tyrosine residue. J. Biol. Chem., 2010-06-09;285(34):26506-18. 2010-06-09 [PMID: 20538612] (Immunoprecipitation, Human, Primate - Cholrocebus pygerythrus (Vervet Monkey))	Immunoprecipitation	Human, Primate - Cholrocebus pygerythrus (Vervet Monkey)

Array AF3428

• Lyp/PTPN22 Antibodies
• Lyp/PTPN22 Lysate
• Lyp/PTPN22 Proteins