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LIMPII/SR-B2 Antibody [HRP]

 
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Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, Simple Western, ELISA, ICC/IF, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
HRP

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP1-77326AF350
Alexa Fluor 405
NBP1-77326AF405
Alexa Fluor 488
NBP1-77326AF488
Alexa Fluor 532
NBP1-77326AF532
Alexa Fluor 594
NBP1-77326AF594
Alexa Fluor 647
NBP1-77326AF647
Alexa Fluor 700
NBP1-77326AF700
Alexa Fluor 750
NBP1-77326AF750
Biotin
NBP1-77326B
DyLight 350
NBP1-77326UV
DyLight 405
NBP1-77326V
DyLight 488
NBP1-77326G
DyLight 550
NBP1-77326R
DyLight 594
NBP1-77326DL594
DyLight 650
NBP1-77326C
DyLight 680
NBP1-77326FR
DyLight 755
NBP1-77326IR
FITC
NBP1-77326F
Janelia Fluor 549
NBP1-77326JF549
Janelia Fluor 646
NBP1-77326JF646
PerCP
NBP1-77326PCP
Unconjugated
NBP1-77326
mFluor Violet 450 SE
NBP1-77326MFV450
mFluor Violet 500 SE
NBP1-77326MFV500
mFluor Violet 610 SE
NBP1-77326MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP1-77326
BSA Free
NBP1-77326
BSA Free
NBP1-77326-0.025mg
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LIMPII/SR-B2 Antibody [HRP] Summary

Immunogen
Antibody was raised against a 16 amino acid synthetic peptide from near the center of human LIMP2. The immunogen is located within amino acids 70 - 120 of LIMP2. Amino Acid Squence: EEVGPYTYRELRNKAN
Marker
Lysosome Marker
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SCARB2
Purity
Peptide affinity purified
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Applications/Dilutions

Dilutions
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
  • Simple Western
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Rat reactivity reported in the scientific literature (PMID: 23825416) and by customer review.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
No Preservative
Purity
Peptide affinity purified

Alternate Names for LIMPII/SR-B2 Antibody [HRP]

  • AMRF
  • CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2(lysosomal integral membrane protein II)
  • CD36 antigen
  • CD36L2
  • CD36L2LIMP II
  • HLGP85
  • LGP85
  • LIMP-2,85 kDa lysosomal sialoglycoprotein scavenger receptor class B, member 2
  • LIMPII
  • LIMPIICD36 antigen-like 2
  • LPG85
  • lysosome membrane protein 2
  • Lysosome membrane protein II
  • SCARB2
  • Scavenger receptor class B member 2,85 kDa lysosomal membrane sialoglycoprotein
  • scavenger receptor class B, member 2
  • SRB2
  • SR-B2
  • SR-BII

Background

High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. SR-BI and SR-BII (previously known as SR-BI.2) are the alternatively spliced products of a single gene. SR-BII differs from SR-BI in that the encoded c-terminal cytoplasmic domain is almost completely different. SR-BII binds HDLs and mediates selective uptake of HDL cholesteryl ester, but with an approximately 4-fold lower efficiency than SR-BI. Nuclease protection assays show SR-BII to be abundant in mouse tissues expressing SR-BI, with SR-BII expression found in liver, adrenal glands, and testes. Although the role of SR-BII is not completely clear, research suggests that it may be a functional HDL receptor. In addition, SR-BII mRNA results from the alternative splicing of SR-BI precursor transcripts with the SR-BII isoform mediating selective transfer of lipid between HDL and cells. The relative expression and functional activities of these two isoforms create a potential means of regulating selective lipid transfer between HDL and cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol SCARB2