Species: Hu, Mu, Rt, Ca, Pm
Applications: WB, Simple Western, ICC/IF, IHC, IP
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt, Bv, ChHa, Ha, Md
Applications: WB, Flow, ICC/IF, IHC, KD
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, ELISA(Cap)
Host: Goat Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: Binding Activity
Species: Mu
Applications: Binding Activity
Species: Mu
Applications: AC
Description
High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. SR-BI and SR-BII (previously known as SR-BI.2) are the alternatively spliced products of a single gene. SR-BII differs from SR-BI in that the encoded c-terminal cytoplasmic domain is almost completely different. SR-BII binds HDLs and mediates selective uptake of HDL cholesteryl ester, but with an approximately 4-fold lower efficiency than SR-BI. Nuclease protection assays show SR-BII to be abundant in mouse tissues expressing SR-BI, with SR-BII expression found in liver, adrenal glands, and testes. Although the role of SR-BII is not completely clear, research suggests that it may be a functional HDL receptor. In addition, SR-BII mRNA results from the alternative splicing of SR-BI precursor transcripts with the SR-BII isoform mediating selective transfer of lipid between HDL and cells. The relative expression and functional activities of these two isoforms create a potential means of regulating selective lipid transfer between HDL and cells.
Bioinformatics
| Entrez |
Rat
Mouse
Human
|
| Uniprot |
Human
Human
Human
Mouse
Human
|
| Product By Gene ID |
950 |
| Alternate Names |
- AMRF
- CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2(lysosomal integral membrane protein II)
- CD36 antigen
- CD36L2LIMP II
- HLGP85
- LGP85
- LIMP-2,85 kDa lysosomal sialoglycoprotein scavenger receptor class B, member 2
- LIMPIICD36 antigen-like 2
- lysosome membrane protein 2
- Lysosome membrane protein II
- Scavenger receptor class B member 2,85 kDa lysosomal membrane sialoglycoprotein
- scavenger receptor class B, member 2
- SR-BII
|
