LAP (TGF-beta 1) Antibody (27235) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

The TGF-beta family includes several related proteins (70-80% sequence homology) from mammalian, avian, or Xenopus systems that are now designated TGF-beta 1, TGF‑ beta 2, TGF-beta 1.2, TGF-beta 3, TGF-beta 4, and TGF-beta 5. These proteins are secreted by cells in the form of an inactive complex, referred to as latent TGF-beta , that consists of TGF-beta associated non-covalently with a Latency-associated peptide (LAP). These two proteins are synthesized as a single pro-peptide that is cleaved in a post Golgi compartment prior to secretion. Different TGF-beta family members are naturally associated with their own distinct LAPs.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 4 confirmed species: Human, Rat, Complex Species Category, Virus - HIV-1.

We have publications tested in 5 applications: Flow Cytometry, IHC, Multiplex Assay, Neutralization, Western Blot.

Showing Publications 1 - 10 of 13. Show All 13 Publications. Collapse Publications.

Publications using MAB246	Applications	Species
Bhuyan S, Pal B, Pathak L, Saikia P, Mitra S, Gayan S, Mokhtari R, Li H, Ramana C, Baishya D, Das B Targeting hypoxia-induced tumor stemness by activating pathogen-induced stem cell niche defense. Front Immunol, 2022-09-29;13(0):933329. 2022-09-29 [PMID: 36248858] (Neutralization, Complex Species Category)	Neutralization	Complex Species Category
L Gorchs, M Oosthoek, T Yucel-Lind, CF Moro, H Kaipe Chemokine Receptor Expression on T Cells Is Modulated by CAFs and Chemokines Affect the Spatial Distribution of T Cells in Pancreatic Tumors Cancers, 2022-08-06;14(15):. 2022-08-06 [PMID: 35954489] (Neutralization, Human)	Neutralization	Human
G Zhen, Q Guo, Y Li, C Wu, S Zhu, R Wang, XE Guo, BC Kim, J Huang, Y Hu, Y Dan, M Wan, T Ha, S An, X Cao Mechanical stress determines the configuration of TGF&beta activation in articular cartilage Nature Communications, 2021-03-17;12(1):1706. 2021-03-17 [PMID: 33731712] (Western Blot, Human)	Western Blot	Human
L Gorchs, S Ahmed, C Mayer, A Knauf, C Fernández, M Svensson, R Heuchel, E Rangelova, P Bergman, H Kaipe The vitamin D analogue calcipotriol promotes an anti-tumorigenic phenotype of human pancreatic CAFs but reduces T cell mediated immunity Sci Rep, 2020-10-15;10(1):17444. 2020-10-15 [PMID: 33060625] (Flow Cytometry, Human)	Flow Cytometry	Human
A Arakelyan, JD Petersen, J Blazkova, L Margolis Macrophage-derived HIV-1 carries bioactive TGF-beta Sci Rep, 2019-12-13;9(1):19100. 2019-12-13 [PMID: 31836798] (Multiplex Assay, Virus - HIV-1)	Multiplex Assay	Virus - HIV-1
Laia Gorchs, Carlos Fernández Moro, Peter Bankhead, Katharina P. Kern, Imrul Sadeak, Qingda Meng et al. Human Pancreatic Carcinoma-Associated Fibroblasts Promote Expression of Co-inhibitory Markers on CD4+ and CD8+ T-Cells Frontiers in Immunology 2019-04-24 [PMID: 31068935]
H Sun, J Xu, Q Huang, M Huang, K Li, K Qu, H Wen, R Lin, M Zheng, H Wei, W Xiao, R Sun, Z Tian, C Sun Reduced CD160 expression contributes to impaired NK cell function and poor clinical outcomes in patients with HCC Cancer Res., 2018-09-19;0(0):. 2018-09-19 [PMID: 30232222] (Neutralization, Human)	Neutralization	Human
YD Boakye, C Agyare, GP Ayande, N Titiloye, EA Asiamah, KO Danquah Assessment of Wound-Healing Properties of Medicinal Plants: The Case of Phyllanthus muellerianus Front Pharmacol, 2018-08-21;9(0):945. 2018-08-21 [PMID: 30186175] (IHC, Rat)	IHC	Rat
Takashi Maehara, Hamid Mattoo, Miho Ohta, Vinay S Mahajan, Masafumi Moriyama, Masaki Yamauchi et al. Lesional CD4+ IFN-gamma + cytotoxic T lymphocytes in IgG4-related dacryoadenitis and sialoadenitis Annals of the Rheumatic Diseases 2017-02-01 [PMID: 27358392]
Mitsuko Hara, Akiko Kirita, Wakako Kondo, Tomokazu Matsuura, Keisuke Nagatsuma, Naoshi Dohmae et al. LAP degradation product reflects plasma kallikrein-dependent TGF-beta activation in patients with hepatic fibrosis SpringerPlus 2014-12-01 [PMID: 24877031]
Boswell S, Sharif S, Alisa A, Pereira SP, Williams R, Behboudi S Induction of latency-associated peptide (transforming growth factor-beta(1)) expression on CD4+ T cells reduces Toll-like receptor 4 ligand-induced tumour necrosis factor-alpha production in a transforming growth factor-beta-dependent manner. Immunology, 2011-03-23;133(3):278-87. 2011-03-23 [PMID: 21426338] (Neutralization, Human)	Neutralization	Human
Birebent B, Lorho R, Lechartier H, de Guibert S, Alizadeh M, Vu N, Beauplet A, Robillard N, Semana G Suppressive properties of human CD4+CD25+ regulatory T cells are dependent on CTLA-4 expression. Eur. J. Immunol., 2004-12-01;34(12):3485-96. 2004-12-01 [PMID: 15484187] (Flow Cytometry, Human)	Flow Cytometry	Human
Godfrey WR, Spoden DJ, Ge YG, Baker SR, Liu B, Levine BL, June CH, Blazar BR, Porter SB Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function. Blood, 2004-09-16;105(2):750-8. 2004-09-16 [PMID: 15374887] (Neutralization, Human)	Neutralization	Human
Show All 13 Publications. Collapse Publications.

Array MAB246

• LAP (TGF-beta 1) Antibodies
• LAP (TGF-beta 1) Protein
• LAP (TGF-beta 1) Proteins and Enzymes
• LAP (TGF-beta 1) ELISAs