Integrin alpha V/CD51 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Integrin alpha V, also known as CD51 and vitronectin receptor subunit  alpha , is a 140-150 kDa integrin alpha chain that forms dimers with at least five beta chains including beta 1, 3, 5, 6, and 8. It is a 1018 amino acid (aa) residue type I membrane protein with a large (962 aa) extracellular domain (ECD) and a short (32 aa) cytoplasmic tail. The N-terminal region of alpha V, which is important for ligand binding, contains seven FG-GAP (phenylalanyl-glycyl and glycyl-alanyl-prolyl) concensus repeats that fold into a beta -propellar domain. Furin cleavage of the alpha V ECD occurs after Gly 889, generating a disulfide-linked, heteromeric subunit alpha V chain. alpha V-containing integrins bind multiple ECM molecules, including vitronectin, osteopontin, MMP-2, and TSP. The ECD of human Integrin  alpha V shares 92% aa sequence identity with mouse Integrin  alpha V ECD.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 6 applications: Flow Cytometry, Flow Cytometry Control, ICC, IHC, Immunoprecipitation, Western Blot.

Showing Publications 1 - 9 of 9.

Publications using AF1219	Applications	Species
Valeria Fernández Vallone, Francisco Raúl Borzone, Leandro Marcelo Martinez, María Belén Giorello, Hosoon Choi, Federico Dimase et al. Spontaneous Osteoclastogenesis, a risk factor for bone metastasis in advanced luminal A-type breast cancer patients Frontiers in Oncology 2/20/2023 [PMID: 36890825]
SI Gringhuis, TM Kaptein, EBM Remmerswaa, A Drewniak, BA Wevers, B Theelen, GRAM D'Haens, T Boekhout, TBH Geijtenbee Fungal sensing by dectin-1 directs the non-pathogenic polarization of TH17 cells through balanced type I IFN responses in human DCs Nature Immunology, 2022-12-01;0(0):. 2022-12-01 [PMID: 36456734] (Flow Cytometry Control, Human)	Flow Cytometry Control	Human
K Kondo, Y Harada, M Nakano, T Suzuki, T Fukushige, K Hanzawa, H Yagi, K Takagi, K Mizuno, Y Miyamoto, N Taniguchi, K Kato, T Kanekura, N Dohmae, K Machida, I Maruyama, H Inoue Identification of distinct N-glycosylation patterns on extracellular vesicles from small-cell and non-small-cell lung cancer cells The Journal of Biological Chemistry, 2022-04-18;0(0):101950. 2022-04-18 [PMID: 35447118] (Western Blot, Human)	Western Blot	Human
H Odaka, K Hiemori, A Shimoda, K Akiyoshi, H Tateno Platelet-derived extracellular vesicles are increased in sera of Alzheimer's disease patients, as revealed by Tim4-based assays FEBS Open Bio, 2021-02-03;0(0):. 2021-02-03 [PMID: 33345458] (Western Blot, Human)	Western Blot	Human
E Gjika, S Pal-Ghosh, ME Kirschner, L Lin, JH Sherman, MA Stepp, M Keidar Combination therapy of cold atmospheric plasma (CAP) with temozolomide in the treatment of U87MG glioblastoma cells Sci Rep, 2020-10-05;10(1):16495. 2020-10-05 [PMID: 33020527] (ICC, Human)	ICC	Human
Chun-Chun Cheng, Ko Tsutsui, Toru Taguchi, Noriko Sanzen, Asako Nakagawa, Kisa Kakiguchi et al. Hair follicle epidermal stem cells define a niche for tactile sensation eLife 10/25/2018 [PMID: 30355452]
Characterization of human and murine T-cell immunoglobulin mucin domain 4 (TIM-4) IgV domain residues critical for Ebola virus entry J Virol, 2016-06-10;0(0):. 2016-06-10 [PMID: 27122575] (Flow Cytometry, Human)	Flow Cytometry	Human
Hussain , Sajid, Rodriguez-Fernandez , Maria, Braun , Gary B, Doyle , Francis, Ruoslahti , Erkki Quantity and accessibility for specific targeting of receptors in tumours. Sci Rep, 2014-06-10;4(0):5232. 2014-06-10 [PMID: 24912981] (IHC, Human)	IHC	Human
Bass R, Wagstaff L, Ravenhill L, Ellis V Binding of extracellular maspin to beta1 integrins inhibits vascular smooth muscle cell migration. J. Biol. Chem., 2009-07-28;284(40):27712-20. 2009-07-28 [PMID: 19638634] (Immunoprecipitation, Western Blot, Human)	Immunoprecipitation, Western Blot	Human

Array AF1219

• Integrin alpha V/CD51 Antibodies
• Integrin alpha V/CD51 ELISA Kits
• Integrin alpha V/CD51 Lysates
• Integrin alpha V/CD51 Protein