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Integrin alpha 3/CD49c Antibody [Unconjugated]

 (12 Publications)
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Product Details

Summary
Reactivity MuSpecies Glossary
Applications WB, Flow, CyTOF-ready
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 488
FAB2787G
Allophycocyanin
FAB2787A
Phycoerythrin
FAB2787P
View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
FAB2787A
Carrier Free
FAB2787G
Carrier Free
FAB2787P
Carrier Free
AF2787-SP
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Integrin alpha 3/CD49c Antibody [Unconjugated] Summary

Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse Integrin alpha 3/CD49c
Phe33-Glu993
Accession # Q62470
Specificity
Detects mouse Integrin alpha 3/CD49c in direct ELISAs and Western blots. In direct ELISAs, less than 10% cross-reactivity with recombinant human (rh) Integrin alpha 3 is observed.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
ITGA3
Purity Statement
Antigen Affinity-purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry 0.25 ug/10^6 cells
  • Western Blot 0.1 ug/mL
Publications
Read Publications using
AF2787 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Integrin alpha 3/CD49c Antibody [Unconjugated]

  • antigen identified by monoclonal J143
  • CD49 antigen-like family member C
  • CD49c antigen
  • CD49c
  • FLJ34631
  • FLJ34704
  • FRP-2
  • Galactoprotein B3
  • GAP-B3
  • GAPB3CD49C
  • Integrin alpha 3
  • integrin alpha-3
  • integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
  • ITGA3
  • MSK18
  • VCA-2
  • very late activation protein 3 receptor, alpha-3 subunit
  • VL3A
  • VLA-3 subunit alpha
  • VLA3a

Background

Integrin alpha 3, also known as CD49c and VLA-3 alpha , is a type I membrane protein that heterodimerizes with Integrin beta 1. alpha 3 beta 1 is a cell surface adhesion molecule that functions as a receptor for laminin, fibronectin, collagen, epiligrin, thrombospondin and chondroitin sulfate proteoglycan 4. The extracellular domain of human and mouse Integrin alpha 3 share approximately 87% amino acid sequence homology.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Integrin alpha 3/CD49c Antibody (AF2787)(12)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 3 applications: Flow Cytometry, Neutralization, Western Blot.


Filter By Application
Flow Cytometry
(1)
Neutralization
(1)
Western Blot
(4)
All Applications
Filter By Species
Mouse
(6)
All Species
Showing Publications 1 - 10 of 12. Show All 12 Publications.
Publications using AF2787 Applications Species
Veronika Ramovs, Ana Krotenberg Garcia, Ji-Ying Song, Iris de Rink, Maaike Kreft, Roel Goldschmeding et al. Integrin alpha 3 beta 1 in hair bulge stem cells modulates CCN2 expression and promotes skin tumorigenesis Life Science Alliance 7/1/2020 [PMID: 32423907]
Chun-Chun Cheng, Ko Tsutsui, Toru Taguchi, Noriko Sanzen, Asako Nakagawa, Kisa Kakiguchi et al. Hair follicle epidermal stem cells define a niche for tactile sensation eLife 10/25/2018 [PMID: 30355452]
Eugenia M. Yazlovitskaya, Olga M. Viquez, Tianxiang Tu, Adele De Arcangelis, Elisabeth Georges-Labouesse, Arnoud Sonnenberg et al. The laminin binding alpha 3 and alpha 6 integrins cooperate to promote epithelial cell adhesion and growth Matrix Biology 4/1/2019 [PMID: 30193894]
PP Sarangi, HW Lee, YV Lerman, A Trzeciak, EJ Harrower, AR Rezaie, M Kim Activated Protein C Attenuates Severe Inflammation by Targeting VLA-3(high) Neutrophil Subpopulation in Mice J. Immunol., 2017-09-06;0(0):. 2017-09-06 [PMID: 28877991] (Flow Cytometry, Mouse) Flow Cytometry Mouse
Olga M Viquez Integrin alpha6 maintains the structural integrity of the kidney collecting system Matrix Biol, 2016-12-30;0(0):. 2016-12-30 [PMID: 28043890] (Western Blot, Mouse) Western Blot Mouse
Eugenia M. Yazlovitskaya, Hui-Yuan Tseng, Olga Viquez, Tianxiang Tu, Glenda Mernaugh, Karen K. McKee et al. Integrin alpha 3 beta 1 regulates kidney collecting duct development via TRAF6-dependent K63-linked polyubiquitination of Akt Molecular Biology of the Cell 5/15/2015 [PMID: 25808491]
Cagnet S, Faraldo M, Kreft M, Sonnenberg A, Raymond K, Glukhova M Signaling events mediated by alpha3beta1 integrin are essential for mammary tumorigenesis. Oncogene, 2013-09-30;33(34):4286-95. 2013-09-30 [PMID: 24077284] (Western Blot, Mouse) Western Blot Mouse
Wang Y, Huang Z, Nayak P, Matthews B, Warburton D, Shi W, Sanchez-Esteban J Strain-induced differentiation of fetal type II epithelial cells is mediated via the integrin alpha6beta1-ADAM17/tumor necrosis factor-alpha-converting enzyme (TACE) signaling pathway. J Biol Chem, 2013-07-25;288(35):25646-57. 2013-07-25 [PMID: 23888051] (Neutralization, Mouse) Neutralization Mouse
Nicolaou N, Margadant C, Kevelam S, Lilien M, Oosterveld M, Kreft M, van Eerde A, Pfundt R, Terhal P, van der Zwaag B, Nikkels P, Sachs N, Goldschmeding R, Knoers N, Renkema K, Sonnenberg A Gain of glycosylation in integrin alpha3 causes lung disease and nephrotic syndrome. J Clin Invest, 2012-11-01;122(12):4375-87. 2012-11-01 [PMID: 23114595] (Western Blot, Mouse) Western Blot Mouse
Hyun YM, Sumagin R, Sarangi PP Uropod elongation is a common final step in leukocyte extravasation through inflamed vessels. J. Exp. Med., 2012-06-18;209(7):1349-62. 6/18/2012 [PMID: 22711877]
Show All 12 Publications.

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Bioinformatics

Gene Symbol ITGA3
Uniprot