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Insulin Antibody (182410) [DyLight 550]

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Product Details

Summary
Reactivity Hu, Mu, BvSpecies Glossary
Applications IHC, CyTOF-ready, Flow, ICC/IF
Clone
182410
Clonality
Monoclonal
Host
Rat
Conjugate
DyLight 550

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Support & Research

Insulin Antibody (182410) [DyLight 550] Summary

Immunogen
E. coli-derived recombinant human Insulin
Specificity
Detects bovine, human, and mouse insulin.
Isotype
IgG2a
Clonality
Monoclonal
Host
Rat
Gene
INS
Purity
Protein A or G purified from hybridoma culture supernatant
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Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Immunocytochemistry
  • Immunohistochemistry
  • Intracellular Staining by Flow Cytometry
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified from hybridoma culture supernatant

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Insulin Antibody (182410) [DyLight 550]

  • IDDM2
  • ILPR
  • INS
  • Insulin
  • IRDN
  • MODY10
  • proinsulin

Background

After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds. Binding of this mature form of insulin to the insulin receptor (INSR) stimulates glucose uptake. A variety of mutant alleles with changes in the coding region have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. (provided by RefSeq)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol INS