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INSIG-1 Antibody [DyLight 488]

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Product Details

Summary
Reactivity Hu, RtSpecies Glossary
Applications WB, ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
DyLight 488

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NB110-55244AF350
Alexa Fluor 405
NB110-55244AF405
Alexa Fluor 488
NB110-55244AF488
Alexa Fluor 532
NB110-55244AF532
Alexa Fluor 594
NB110-55244AF594
Alexa Fluor 647
NB110-55244AF647
Alexa Fluor 700
NB110-55244AF700
Alexa Fluor 750
NB110-55244AF750
Allophycocyanin
NB110-55244APC
Biotin
NB110-55244B
CoraFluor 1
NB110-55244CL1
DyLight 350
NB110-55244UV
DyLight 405
NB110-55244V
DyLight 550
NB110-55244R
DyLight 594
NB110-55244DL594
DyLight 650
NB110-55244C
DyLight 680
NB110-55244FR
DyLight 755
NB110-55244IR
FITC
NB110-55244F
HRP
NB110-55244H
Janelia Fluor 525
NB110-55244JF525
Janelia Fluor 549
NB110-55244JF549
Janelia Fluor 646
NB110-55244JF646
Janelia Fluor 669
NB110-55244JF669
PE
NB110-55244PE
PerCP
NB110-55244PCP
Unconjugated
NB110-55244
mFluor Violet 450 SE
NB110-55244MFV450
mFluor Violet 500 SE
NB110-55244MFV500
mFluor Violet 610 SE
NB110-55244MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NB110-55244
BSA Free
NB110-55244SS
BSA Free
NB110-55244
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INSIG-1 Antibody [DyLight 488] Summary

Immunogen
A synthetic peptide representing an internal region of the human INSIG-1 protein (between residues 1-100) according to Swiss-Prot# O15503.
Localization
ER Membrane
Specificity
This is specific for Insig1 but not Insig2.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
INSIG1
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for INSIG-1 Antibody [DyLight 488]

  • CL6
  • CL-6
  • INSIG-1 membrane protein
  • INSIG-1
  • insulin induced gene 1
  • insulin-induced gene 1 protein
  • MGC1405

Background

Oxysterols regulate cholesterol homeostasis through liver X receptor (LXR) and sterol regulatory element-binding protein (SREBP) mediated signaling pathway. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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INSIG-1 Antibody
[DyLight 488]
NB110-55244G
INSIG-1 Antibody [DyLight 488]
Species: Hu, Rt
Applications: WB, ICC/IF

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Bioinformatics

Gene Symbol INSIG1