INSIG-1 Products

Description

Insig1 is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells.

Oxysterols regulate cholesterol homeostasis through liver X receptor (LXR) and sterol regulatory element-binding protein (SREBP) mediated signaling pathway. Insig1 binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Bioinformatics

Entrez	3638 Human
Uniprot	A4D2M9 Human NM_005542 Human NP_938150 Human O15503 Human
Product By Gene ID	3638
Alternate Names	CL6 CL-6 INSIG-1 membrane protein INSIG-1 insulin induced gene 1 insulin-induced gene 1 protein MGC1405

Research Areas for INSIG-1

Find related products by research area and learn more about each of the different research areas below.

Cholesterol Metabolism
ER Markers
Lipid and Metabolism
Signal Transduction