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IL-27R alpha/WSX-1/TCCR Antibody (34N4G11) - BSA Free

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Immunohistochemistry-Paraffin: IL-27 R alpha/WSX-1/TCCR Antibody (34N4G11) [NBP2-19015] - IHC-P detection of IL27RA protein in a section of human renal/kidney cancer tissue using IL27RA antibody (34N4G11) at a ...read more
Flow (Cell Surface): IL-27 R alpha/WSX-1/TCCR Antibody (34N4G11) [NBP2-19015] - Analysis using the Alexa Fluor (R) 647 conjugate of NBP2-19015. Surface staining of IL27R on freshly isolated (PPI negative) human PBMCs ...read more
Immunohistochemistry-Paraffin: IL-27 R alpha/WSX-1/TCCR Antibody (34N4G11) [NBP2-19015] - Adenocarcinoma of the stomach probed with IL-27R antibody at 5 ug/ml.
Immunohistochemistry-Paraffin: IL-27 R alpha/WSX-1/TCCR Antibody (34N4G11) [NBP2-19015] - FFPE human prostate probed with IL-27R antibody at 5 ug/ml.
Immunohistochemistry-Paraffin: IL-27 R alpha/WSX-1/TCCR Antibody (34N4G11) [NBP2-19015] - IHC-P detection of IL27RA protein in a section of normal human colon tissue using IL27RA antibody (34N4G11) at a concentration of ...read more
Immunohistochemistry-Paraffin: IL-27 R alpha/WSX-1/TCCR Antibody (34N4G11) [NBP2-19015] - IHC-P detection of IL27RA protein in a section of human colo-rectal cancer tissue using IL27RA antibody (34N4G11) at a ...read more
Immunohistochemistry-Paraffin: IL-27 R alpha/WSX-1/TCCR Antibody (34N4G11) [NBP2-19015] - IHC-P detection of IL27RA protein in a section of human stomach cancer tissue using IL27RA antibody (34N4G11) at a concentration ...read more
Flow Cytometry: IL-27 R alpha/WSX-1/TCCR Antibody (34N4G11) [NBP2-19015] - Surface staining on human peripheral blood monocytes using IL-27R antibody at 1 ug/10^6 cells (red represents specific antibody and green ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, IHC, CyTOF-ready
Clone
34N4G11
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Format
BSA Free
Concentration
1.0 mg/ml

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IL-27R alpha/WSX-1/TCCR Antibody (34N4G11) - BSA Free Summary

Immunogen
A portion of amino acids 200-250 of human IL-27R (WSX-1) was used as the immunogen for this antibody.
Localization
Membrane (with Extracellular and Cytoplasmic domains)
Specificity
IL-27R (WSX-1) is 65-70 kDa protein and is highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes including CD4+ and CD8+ T cells, monocytes, DCs and NK cells
Isotype
IgG2b Kappa
Clonality
Monoclonal
Host
Mouse
Gene
IL27RA
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow (Cell Surface) 1 ug/ml
  • Flow Cytometry 1 ug/ml
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 5 ug/ml
Application Notes
This antibody is Cytof ready.
Publications
Read Publication using NBP2-19015.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein G purified

Alternate Names for IL-27R alpha/WSX-1/TCCR Antibody (34N4G11) - BSA Free

  • class I cytokine receptor
  • CRL1IL-27R
  • Cytokine receptor-like 1
  • IL-27 R alpha
  • IL27R alpha
  • IL27R
  • IL27RA
  • IL-27Ra
  • IL-27R-alpha
  • interleukin 27 receptor, alpha
  • interleukin-27 receptor subunit alpha
  • TCCR
  • TCCRIL-27 receptor subunit alpha
  • T-cell cytokine receptor type 1
  • Type I T-cell cytokine receptor
  • WSX-1
  • WSX1IL-27R subunit alpha
  • zcytor1

Background

The IL-27 Receptor complex includes WSX-1 and gp130. IL-27R (WSX-1) is 65-70 kDa protein and is highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes including CD4+ and CD8+ T cells, monocytes, DCs and NK cells (1-3). IL-27R activation includes STAT1, STAT3, STAT4 and STAT5, leading to differing pathway dependent effector activities. Like the IL12/IL-12R complex, the IL-27/IL-27R complex also has Th1 enhancing activity especially enhancement of IFNg production by naive T cells and NK cells (1). IL-27R mediates downregulation of Th2 activity by findings that IL-27R deficiencies mitigate inflammatory pathology in helminthic infections in mice (1, 4, 5). The possibility of utilizing IL-27R as a target for autoimmune inflammatory diseases, especially of mucosal surfaces as in human IBD, is under investigation, measured by Th2 type cytokines and bolstered through Th2

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol IL27RA
Entrez
OMIM
Uniprot