EBI3 Antibody (15k8D10) - BSA Free

IL-35 is a novel heterodimeric cytokine composed of the IL-12p35 subunit and the Epstein-Barr virus-induced gene 3 (EBI3) protein. As one of the IL-12 family members, IL-35 is known to play an essential role in immune regulation of the CD4+CD25+ regulatory T (Treg) cells, from which IL-35 is also specifically produced. IL-35 is able to expand CD4+CD25+ Treg cells whereas it can inhibit proliferation of CD4+CD25- effector T (Teff) cells and development of proinflammatory Th17 cells, suppressing inflammatory responses.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 3 applications: ICC/IF, IF/IHC, IHC-P.

Showing Publications 1 - 10 of 11. Show All 11 Publications. Collapse Publications.

Publications using NBP2-27362	Applications	Species
Ito T, Tanaka T, Nakamaru K et al. Interleukin-35 promotes the differentiation of regulatory T cells and suppresses Th2 response in IgG4-related type 1 autoimmune pancreatitis J. Gastroenterol. 2020-05-06 [PMID: 32377945]
Liu J, Hao S, Chen X et al. Human placental trophoblast cells contribute to maternal-fetal tolerance through expressing IL-35 and mediating iTR35 conversion. Nat Commun. 2019-10-10 [PMID: 31601798] (ICC/IF, Human)	ICC/IF	Human
Larousserie F, Kebe D, Huynh T et al. Evidence for IL-35 Expression in Diffuse Large B-Cell Lymphoma and Impact on the Patient's Prognosis Front Oncol 2019-06-28 [PMID: 31316915] (IHC-P, Human)	IHC-P	Human
Javvadi LR, Parachuru VPB, Milne TJ et al. Expression of IL33 and IL35 in oral lichen planus. Arch. Dermatol. Res. 2018-04-09 [PMID: 29633015] (IHC-P)	IHC-P
Ma Y, Chen L, Xie G et al. Elevated level of interleukin-35 in colorectal cancer induces conversion of T cells into iTr35 by activating STAT1/STAT3. Oncotarget. 2016-11-08 [PMID: 27682874] (IF/IHC, Human)	IF/IHC	Human
Zhao Z, Chen X, Hao S et al. Increased interleukin-35 expression in tumor-infiltrating lymphocytes correlates with poor prognosis in patients with breast cancer Cytokine 2016-09-24 [PMID: 27681506] (IF/IHC, Human)	IF/IHC	Human
Horlad H, Ma C, Yano H et al. An IL-27/Stat3 axis induces expression of programmed cell death 1 ligands (PD-L1/2) on infiltrating macrophages in lymphoma. Cancer Sci. 2016-11-01 [PMID: 27564404] (IF/IHC, Human)	IF/IHC	Human
Long J, Guo H, Cui S et al. IL-35 expression in hepatocellular carcinoma cells is associated with tumor progression Oncotarget. 2016-07-19 [PMID: 27329841] (IF/IHC, Human)	IF/IHC	Human
Fu YP, Yi Y, Cai XY et al. Overexpression of interleukin-35 associates with hepatocellular carcinoma aggressiveness and recurrence after curative resection. Br. J. Cancer. 2016-03-29 [PMID: 27002937] (IHC-P, Human)	IHC-P	Human
Mao H, Gao W, Ma C et al. Human placental trophoblasts express the immunosuppressive cytokine IL-35. Hum Immunol. 2013-07-01 [PMID: 23619469] (IHC-P, Human) Details: IHC (P), Fig 1: first-trimester human placentae.	IHC-P	Human
Wang Z, Liu JQ, Liu Z et al. Tumor-derived IL-35 promotes tumor growth by enhancing myeloid cell accumulation and angiogenesis. J Immunol. 2013-03-01 [PMID: 23345334] (IHC-P, Human) Details: IHC (P), Fig 1: human large B cell lymphoma, nasopharyngeal carcinoma, skin, melanoma, lymph node metastatic melanoma.	IHC-P	Human
Show All 11 Publications. Collapse Publications.

Array NBP2-27362

• EBI3 Antibodies
• EBI3 Lysate
• EBI3 Proteins
• EBI3 Proteins and Enzyme
• EBI3 ELISA