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IL-21 Antibody (14k5H3) - Azide and BSA Free

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Western Blot: IL-21 Antibody (14k5H3) - Azide and BSA Free [NBP2-80800] - Analysis of IL-21. Full-length recombinant IL-21 protein probed with 1 ug/ml of IL-21 monoclonal antibody. Goat anti-mouse Ig HRP secondary ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ICC/IF, IHC
Clone
14k5H3
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Format
Azide and BSA Free
Concentration
0.5 mg/ml

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IL-21 Antibody (14k5H3) - Azide and BSA Free Summary

Immunogen
Full length recombinant protein
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
IL21
Purity
Protein G purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence reported in scientific literature (PMID 27531854)
  • Immunohistochemistry reported in scientific literature (PMID 27531854)
  • Western Blot 1-3ug/ml

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
No Preservative
Concentration
0.5 mg/ml
Purity
Protein G purified

Alternate Names for IL-21 Antibody (14k5H3) - Azide and BSA Free

  • CVID11
  • IL21
  • IL-21
  • IL-21Za11interleukin-21
  • interleukin 21
  • interleukin-21 isoform
  • Za11

Background

Interleukin-21, also alternatively named IL-17C, is a pro-inflammatory cytokine and member of the IL-17 family. The IL-17 family is comprised of at least six members: IL-17A-F (1, 2). Interleukin-21, along with IL-17B, appears to stimulate release of TNF and IL-1 from the monocytic THP-1 line thus appearing to have a different receptor and induction pattern than IL-17A (1, 2). As a pro-inflammatory cytokine IL-21 augments the inflammatory process in arthritis models (2, 3). Interleukin-21 is induced in epithelial cells by bacterial antigens and other inflammatory ligands such as imiquimod, exhibiting a direct linkage with innate immune receptors such as TLRs (2, 3). The IL-21 receptor complex appears to be comprised of IL-17RA or IL-17RE. Antibody to IL-21 allows further analysis of the unique regulatory activity, cellular receptors and cellular targets of IL-21 (IL-17C) versus other members of the IL-17 family such as IL-17A. The study of Interleukin-21 and its contribution to diseases caused by impaired epithelial barriers in autoimmune and inflammatory diseases such as psoriasis, asthma or inflammatory bowel disease potentiate development of new therapies directed at regulation of IL-21 or other IL-17 family members (4). The linkage of IL-21 with epithelial cells also furthers the study of the innate immune functions of epithelial cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

Additional IL-21 Products

Research Areas for IL-21 Antibody (NBP2-80800)

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Blogs on IL-21.

Perforin Antibodies Reveal Links to Apoptosis and Immune Response
Perforin, also known as the pore-forming protein, pfp, is a 70 kD cytolytic protein expressed in the cytoplasmic granules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. It is one of the major effector molecules used by CTL and NK cel...  Read full blog post.

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Bioinformatics

Gene Symbol IL21