IL-21 Antibody (14k5H3)

Interleukin-21, also alternatively named IL-17C, is a pro-inflammatory cytokine and member of the IL-17 family. The IL-17 family is comprised of at least six members: IL-17A-F (1, 2). Interleukin-21, along with IL-17B, appears to stimulate release of TNF and IL-1 from the monocytic THP-1 line thus appearing to have a different receptor and induction pattern than IL-17A (1, 2). As a pro-inflammatory cytokine IL-21 augments the inflammatory process in arthritis models (2, 3). Interleukin-21 is induced in epithelial cells by bacterial antigens and other inflammatory ligands such as imiquimod, exhibiting a direct linkage with innate immune receptors such as TLRs (2, 3). The IL-21 receptor complex appears to be comprised of IL-17RA or IL-17RE. Antibody to IL-21 allows further analysis of the unique regulatory activity, cellular receptors and cellular targets of IL-21 (IL-17C) versus other members of the IL-17 family such as IL-17A. The study of Interleukin-21 and its contribution to diseases caused by impaired epithelial barriers in autoimmune and inflammatory diseases such as psoriasis, asthma or inflammatory bowel disease potentiate development of new therapies directed at regulation of IL-21 or other IL-17 family members (4). The linkage of IL-21 with epithelial cells also furthers the study of the innate immune functions of epithelial cells.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: ICC/IF, IHC.

Showing Publications 1 - 3 of 3.

Publications using NBP2-27336	Applications	Species
Guan-Ting Zhai, Hai Wang, Jing-Xian Li, Ping-Ping Cao, Wen-Xiu Jiang, Jia Song, Yin Yao, Zhi-Chao Wang, Zhe-Zheng Wang, Meng-Chen Wang, Bo Liao, Qi-Miao Feng, Xiang Lu, Heng Wang, Peisong Gao, Zheng Liu IgD-activated mast cells induce IgE synthesis in B cells in nasal polyps. The Journal of allergy and clinical immunology 2019-09-17 [PMID: 30102935]
Chen MM, Xiao X, Lao XM et al. Polarization of Tissue-Resident TFH-Like Cells in Human Hepatoma Bridges Innate Monocyte Inflammation and M2b Macrophage Polarization. Cancer Discov. Aug 16 2016 [PMID: 27531854] (IHC, ICC/IF, Human)	IHC, ICC/IF	Human
Chen MM, Xiao X, Lao XM et al. Polarization of Tissue-Resident TFH-Like Cells in Human Hepatoma Bridges Innate Monocyte Inflammation and M2b Macrophage Polarization. Cancer discovery 2017-10-27 [PMID: 27531854]

Array NBP2-27336

• IL-21 Antibodies
• IL-21 ELISA Kits
• IL-21 Kit
• IL-21 Lysate
• IL-21 Proteins
• IL-21 Proteins and Enzymes
• IL-21 ELISAs