Name: IL-2 Antibody (5355) [Unconjugated]
Brand: Novus Biologicals
SKU: MAB602
Price: 489 USD

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	Hu, PmSpecies Glossary
Applications	ELISA(Cap), ICC/IF
Clone	5355
Clonality	Monoclonal
Host	Mouse
Conjugate	Unconjugated

Catalog# & Formulation	Size	Price
Carrier Free MAB602-SP

Carrier Free MAB602-500

Immunogen	E. coli-derived recombinant human IL-2 Ala21-Thr153 Accession # NP_000577
Specificity	Detects human and primate IL-2 in ELISAs. In sandwich immunoassays, no cross-reactivity with recombinant human (rh) IL-1 alpha , rhIL-1 beta , rhIL-3, rhIL-4, rhIL‑6, rhIL-7, rhIL-8, recombinant mouse (rm) IL-1 beta , rmIL-2, rmIL-3, rmIL-4, rmIL-5, rmIL-6, or rmIL-7 is observed.
Source	N/A
Isotype	IgG2a
Clonality	Monoclonal
Host	Mouse
Gene	IL2
Purity Statement	Protein A or G purified from hybridoma culture supernatant
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Reconstitution Instructions	Reconstitute at 0.5 mg/mL in sterile PBS.

IL-2 Antibody (5355) [Unconjugated]

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IL-2 Antibody (5355) [Unconjugated] Summary

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Publications for IL-2 Antibody (MAB602)(29)

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Bioinformatics

Publications using MAB602	Applications	Species
Girija Goyal, Pranav Prabhala, Gautam Mahajan, Bruce Bausk, Tal Gilboa, Liangxia Xie et al. Ectopic Lymphoid Follicle Formation and Human Seasonal Influenza Vaccination Responses Recapitulated in an Organ‐on‐a‐Chip Advanced Science 5/1/2022 [PMID: 35289122]
Pavithra Sukumar, Muhammedin Deliorman, Ayoola T. Brimmo, Roaa Alnemari, Deena Elsori, Weiqiang Chen et al. Airplug‐Mediated Isolation and Centralization of Single T Cells in Rectangular Microwells for Biosensing Advanced Therapeutics 10/29/2020 [PMID: 33117882]
CJ Dwyer, DC Arhontouli, GO Rangel Riv, HM Knochelman, AS Smith, MM Wyatt, MP Rubinstein, C Atkinson, JE Thaxton, DM Neskey, CM Paulos Ex vivo blockade of PI3K gamma or delta signaling enhances the antitumor potency of adoptively transferred CD8+ T cells Eur. J. Immunol., 2020-05-28;0(0):. 2020-05-28 [PMID: 32383488] (In Vivo, Mouse)	In Vivo	Mouse
Valentin Haug, Branislav Kollar, Sotirios Tasigiorgos, Yori Endo, Martin Kauke, Ali-Farid Safi et al. Hypothermic Ex Situ Perfusion of Human Limbs With Acellular Solution for 24 Hours Transplantation 9/1/2020 [PMID: 32168040]
Jun-Young Lee, Eunjin Lee, Sung-Wook Hong, Daeun Kim, O. Eunju, Jonathan Sprent et al. TCB2, a new anti-human interleukin-2 antibody, facilitates heterodimeric IL-2 receptor signaling and improves anti-tumor immunity OncoImmunology 1/1/2020 [PMID: 32002288]
BD Bryson, TR Rosebrock, FG Tafesse, CY Itoh, A Nibasumba, GH Babunovic, B Corleis, C Martin, C Keegan, P Andrade, S Realegeno, D Kwon, RL Modlin, SM Fortune Heterogeneous GM-CSF signaling in macrophages is associated with control of Mycobacterium tuberculosis Nat Commun, 2019-05-27;10(1):2329. 2019-05-27 [PMID: 31133636] (Neutralization, Human)	Neutralization	Human
P Caudana, N Núñez, P DelaRocher, A Pinto, J Denizeau, R Alonso, L Niborski, O Lantz, C Sedlik, E Piaggio IL2/anti-IL2 complex combined with CTLA-4, but not PD-1, blockade rescues antitumor NK cell function by regulatory T-cell modulation Cancer Immunol Res, 2019-01-16;0(0):. 2019-01-16 [PMID: 30651291] (In Vivo, Human)	In Vivo	Human
Eleonora Trotta, Paul H. Bessette, Stephanie L. Silveria, Lauren K. Ely, Kevin M. Jude, Duy T. Le et al. A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism Nature Medicine 7/1/2018 [PMID: 29942088]
Hussein Sultan, Takumi Kumai, Valentyna I. Fesenkova, Aaron E. Fan, Juan Wu, Hyun-Il Cho et al. Sustained Persistence of IL2 Signaling Enhances the Antitumor Effect of Peptide Vaccines through T-cell Expansion and Preventing PD-1 Inhibition Cancer Immunology Research 5/1/2018 [PMID: 29483127]
Rodrigo Vazquez-Lombardi, Claudia Loetsch, Daniela Zinkl, Jennifer Jackson, Peter Schofield, Elissa K. Deenick et al. Potent antitumour activity of interleukin-2-Fc fusion proteins requires Fc-mediated depletion of regulatory T-cells Nature Communications 5/12/2017 [PMID: 28497796]
SJ Whitfield, C Taylor, JE Risdall, GD Griffiths, JT Jones, ED Williamson, S Rijpkema, L Saraiva, S Vessillier, AC Green, AJ Carter Interference of the T Cell and Antigen-Presenting Cell Costimulatory Pathway Using CTLA4-Ig (Abatacept) Prevents Staphylococcal Enterotoxin B Pathology J. Immunol, 2017-03-20;0(0):. 2017-03-20 [PMID: 28320831] (Human)		Human
Kenji Chamoto Key Residues at Third CDR3? Position Impact Structure and Antigen Recognition of Human Invariant NK TCRs J. Immunol, 2016-12-21;0(0):. 2016-12-21 [PMID: 28003379] (ELISA Development (Capture), Human)	ELISA Development (Capture)	Human
Lauryn E. Klevorn, Melissa M. Berrien-Elliott, Jinyun Yuan, Lindsey M. Kuehm, Gregory D. Felock, Sean A. Crowe et al. Rescue of Tolerant CD8+ T Cells during Cancer Immunotherapy with IL2:Antibody Complexes Cancer Immunology Research 12/1/2016 [PMID: 27803062]
Karin Schilbach, Mohammed Alkhaled, Christian Welker, Franziska Eckert, Gregor Blank, Hendrik Ziegler et al. Cancer-targeted IL-12 controls human rhabdomyosarcoma by senescence induction and myogenic differentiation OncoImmunology 7/3/2015 [PMID: 26140238]
Rochman Y, Yukawa M, Kartashov A, Barski A Functional characterization of human T cell hyporesponsiveness induced by CTLA4-Ig. PLoS ONE, 2015-04-10;10(4):e0122198. 2015-04-10 [PMID: 25860138] (ELISA Development (Capture), Human)	ELISA Development (Capture)	Human
Levin AM, Bates DL, Ring AM, Krieg C, Lin JT, Su L, Moraga I, Raeber ME, Bowman GR, Novick P, Pande VS, Fathman CG, Boyman O, Garcia KC Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'. Nature, 2012-03-25;484(7395):529-33. 2012-03-25 [PMID: 22446627] (Neutralization, Human)	Neutralization	Human
E J Cheadle, D G Rothwell, J S Bridgeman, V E Sheard, R E Hawkins, D E Gilham Ligation of the CD2 co-stimulatory receptor enhances IL-2 production from first-generation chimeric antigen receptor T cells Gene Therapy 11/1/2012 [PMID: 22130449]
David C. Appleyard, Stephen C. Chapin, Patrick S. Doyle Multiplexed Protein Quantification with Barcoded Hydrogel Microparticles Analytical Chemistry 1/1/2011 [PMID: 21142122]
Carsten Krieg, Sven Létourneau, Giuseppe Pantaleo, Onur Boyman Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothelial cells Proceedings of the National Academy of Sciences 6/29/2010 [PMID: 20547866]
Won Sik Lee, Yasuhiro Suzuki, Scott S. Graves, Mineo Iwata, G.M. Venkataraman, Marco Mielcarek et al. Canine Bone Marrow Derived Mesenchymal Stromal Cells Suppress Allo-Reactive Lymphocyte Proliferation in Vitro but Fail to Enhance Engraftment in Canine Bone Marrow Transplantation Biology of Blood and Marrow Transplantation 4/1/2011 [PMID: 20457265]
Sven Létourneau, Ester M. M. van Leeuwen, Carsten Krieg, Chris Martin, Giuseppe Pantaleo, Jonathan Sprent et al. IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor alpha subunit CD25 Proceedings of the National Academy of Sciences 2/2/2010 [PMID: 20133862]
Rubinstein MP, Lind NA, Purton JF, Filippou P, Best JA, McGhee PA, Surh CD, Goldrath AW IL-7 and IL-15 differentially regulate CD8+ T-cell subsets during contraction of the immune response. Blood, 2008-08-08;112(9):3704-12. 2008-08-08 [PMID: 18689546] (Stimulation, Human)	Stimulation	Human
Biancotto A, Iglehart SJ, Lisco A, Vanpouille C, Grivel JC, Lurain NS, Reichelderfer PS, Margolis LB Upregulation of human cytomegalovirus by HIV type 1 in human lymphoid tissue ex vivo. AIDS Res. Hum. Retroviruses, 2008-03-01;24(3):453-62. 2008-03-01 [PMID: 18327985] (Luminex Development, Human)	Luminex Development	Human
Pfleger C, Schloot N, ter Veld F Effect of serum content and diluent selection on assay sensitivity and signal intensity in multiplex bead-based immunoassays. J. Immunol. Methods, 2007-10-22;329(1):214-8. 2007-10-22 [PMID: 17964594] (Luminex Development, Human)	Luminex Development	Human
Grivel JC, Elliott J, Lisco A, Biancotto A, Condack C, Shattock RJ, McGowan I, Margolis L, Anton P HIV-1 pathogenesis differs in rectosigmoid and tonsillar tissues infected ex vivo with CCR5- and CXCR4-tropic HIV-1. AIDS, 2007;21(10):1263-72. 2007 [PMID: 17545702] (Luminex Development, Human)	Luminex Development	Human
Biancotto A, Grivel JC, Iglehart SJ, Vanpouille C, Lisco A, Sieg SF, Debernardo R, Garate K, Rodriguez B, Margolis LB, Lederman MM Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1. Blood, 2007-02-08;109(10):4272-9. 2007-02-08 [PMID: 17289812] (Luminex Development, Human)	Luminex Development	Human
Jason F. Kreisberg, Wes Yonemoto, Warner C. Greene Endogenous factors enhance HIV infection of tissue naive CD4 T cells by stimulating high molecular mass APOBEC3G complex formation The Journal of Experimental Medicine 4/17/2006 [PMID: 16606671]
Kiryushko D, Pavon L, Novitskaya V, Sandoval-Lopez G, Soroka V, Eugenia Hernandez M, Klingelhofer J, Loria F, Lukanidin E, Estrada I, Berezin V, Perez M, Bock E, Moreno J, Avila U, Leff P, Anton B, Heinze G Th2 cytokine response in Major Depressive Disorder patients before treatment. J. Neuroimmunol., 2006-02-02;172(1):156-65. 2006-02-02 [PMID: 16457895] (ELISA Development, Human)	ELISA Development	Human
Farah IO, Mola PW, Kariuki TM, Nyindo M, Blanton RE, King CL Repeated exposure induces periportal fibrosis in Schistosoma mansoni-infected baboons: role of TGF-beta and IL-4. J. Immunol., 2000-05-15;164(10):5337-43. 2000-05-15 [PMID: 10799896] (ELISA Development, Primate - Papio anubis (Olive Baboon))	ELISA Development	Primate - Papio anubis (Olive Baboon)
Show All 29 Publications. Collapse Publications.

Gene Symbol	IL2
Uniprot	NP_000577()